Journal Article

• Marvin Reich, Matthew J Simon, Beate Polke, Iñaki Paris, Georg Werner, Christian Schrader, Lena Spieth, Sonnet S Davis, Sophie Robinson, Gabrielly Lunkes de Melo, Lennart Schlaphoff, Katrin Buschmann, Stefan Berghoff, Todd Logan, Brigitte Nuscher , Lis de Weerd, Dieter Edbauer, Mikael Simons, Jung H Suh, Thomas Sandmann, Mihalis S Kariolis, Sarah L DeVos, Joseph W Lewcock, Dominik Paquet , Anja Capell , Gilbert Di Paolo, Christian Haass (2024)
  Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration
  Sci Transl Med. 2024 Jun 5;16(750):eadj7308.
• Schmidt FC, Fitz K, Feilen LP, Okochi M, Steiner H, Langosch D (2023)
  Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin
  J Biol Chem. 2023 Mar 20;299(5):104626.
• Werner NT, Högel P, Güner G, Stelzer W, Wozny M, Aßfalg M, Lichtenthaler SF, Steiner H, Langosch D (2023)
  Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase
  Commun Biol. 2023 Feb 15;6(1):177
• Dawkins E, Derks RJE, Schifferer M, Trambauer J, Winkler E, Simons M, Paquet D, Giera M, Kamp F, Steiner H (2023)
  Membrane lipid remodeling modulates γ-secretase processivity
  J Biol Chem. 2023 Apr;299(4):103027.
• Domenighetti C, ..., Burbulla LF, et al. (2022)
  Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study
  Mov Disord. 2022 Jan 8. doi: 10.1002/mds.28902. Online ahead of print.
• Morenas-Rodríguez E, Li Y, Nuscher B, Franzmeier N, Xiong C, Suárez-Calvet M, Fagan AM, Schultz S, Gordon BA, Benzinger TLS, Hassenstab J, McDade E, Feederle R, Karch CM, Schlepckow K, Morris JC, Kleinberger G, Nellgard B, Vöglein J, Blennow K, Zetterberg H, Ewers M, Jucker M, Levin J, Bateman RJ, Haass C, on behalf of the Dominantly Inherited Alzheimer Network (2022)
  Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer´s disease: a longitudinal observational study
  The Lancet Neurology Volume 21, Issue 4, April 2022, Pages 329-341
• Anika Reifschneider, Sophie Robinson, Bettina van Lengerich, Johannes Gnörich, Todd Logan, Steffanie Heindl, Miriam A Vogt, Endy Weidinger, Lina Riedl, Karin Wind, Artem Zatcepin, Ida Pesämaa, Sophie Haberl, Brigitte Nuscher, Gernot Kleinberger, Julien Klimmt, Julia K Götzl, Arthur Liesz, Katharina Bürger, Matthias Brendel, Johannes Levin, Janine Diehl-Schmid, Jung Suh, Gilbert Di Paolo, Joseph W Lewcock, Kathryn M Monroe, Dominik Paquet, Anja Capell, Christian Haass (2022)
  Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency
  EMBO J. 2022 Jan 12; e109108
• Domenighetti C, Sugier PE, Sreelatha AAK, Schulte C, Grover S, Mohamed O, Portugal B, May P, Bobbili DR, Radivojkov-Blagojevic M, Lichtner P, Singleton AB, Hernandez DG, Edsall C, Mellick GD, Zimprich A, Pirker W, Rogaeva E, Lang AE, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschländer AB, Hadjigeorgiou GM, Dardiotis E, Stefanis L, Simitsi AM, Valente EM, Petrucci S, Duga S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Matsuo H, Kawamura Y, Hattori N, Nishioka K, Chung SJ, Kim YJ, Kolber P, van de Warrenburg BP, Bloem BR, Aasly J, Toft M, Pihlstrøm L, Guedes LC, Ferreira JJ, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Diez-Fairen M, Wirdefeldt K, Pedersen NL, Ran C, Belin AC, Puschmann A, Hellberg C, Clarke CE, Morrison KE, Tan M, Krainc D, Burbulla LF, Farrer MJ, Krüger R, Gasser T, Sharma M, Elbaz A, Comprehensive Unbiaised Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (Courage-PD) consortium (2022)
  Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson's Disease
  J Parkinsons Dis. 2022;12(1):267-282.
• Feilen LP, Chen SY, Fukumori A, Feederle R, Zacharias M, Steiner H (2022)
  Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis
  Elife. 2022 May 17;11:e76090.
• Güner G, Aßfalg M, Zhao K, Dreyer T, Lahiri S, Lo Y, Slivinschi BI, Imhof A, Jocher G, Strohm L, Behrends C, Langosch D, Bronger H, Nimsky C, Bartsch JW, Riddell SR, Steiner H, Lichtenthaler SF (2022)
  Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ-secretase activity
  EMBO Mol Med. 2022 Oct 10;14(10):e16084
• Ariane Schumski, Almudena Ortega-Gómez, Kanin Wichapong, Carla Winter, Patricia Lemnitzer, Joana R Viola, Mayra Pinilla-Vera, Eduardo Folco, Victor Solis-Mezarino, Moritz Völker-Albert, Sanne L Maas, Chang Pan, Laura Perez Olivares, Janine Winter, Tilman Hackeng, Mikael C I Karlsson, Tanja Zeller, Axel Imhof, Rebecca M Baron, Gerry A F Nicolaes, Peter Libby, Lars Maegdefessel, Frits Kamp, Martin Benoit, Yvonne Döring, Oliver Soehnlein (2021)
  Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge-Mediated Monocyte Adhesion
  Circulation. 2021 Jan 19;143(3):254-266
• Xianyuan Xiang, Karin Wind, Thomas Wiedemann, Tanja Blume, Yuan Shi, Nils Briel, Leonie Beyer, Gloria Biechele, Florian Eckenweber, Artem Zatcepin, Sven Lammich, Sara Ribicic, Sabina Tahirovic, Michael Willem, Maximilian Deussing, Carla Palleis, Boris-Stephan Rauchmann, Franz-Josef Gildehaus, Simon Lindner, Nicolai Franzmeier, Karlheinz Baumann, Axel Rominger, Peter Bartenstein, Sibylle Ziegler, Alexander Drzezga, Gesine Respondek, Katharina Buerger, Robert Perneczky, Johannes Levin, Günter U Höglinger, Jochen Herms, Christian Haass, Matthias Brendel (2021)
  Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases
  Sci Transl Med. 2021 Oct 13;13(615):eabe5640.
• Junker J, Kamp F, Winkler E, Steiner H, Bracher F, Müller C (2021)
  Effective sample preparation procedure for the analysis of free neutral steroids, free steroid acids and sterol sulfates in different tissues by GC-MS
  J Steroid Biochem Mol Biol. 2021 Jul;211:105880
• Saretz S, Basset G, Useini L, Laube M, Pietzsch J, Draca D, Maksimovic-Ivanic D, Trambauer J, Steiner H, Hey-Hawkins E (2021)
  Modulation of γ-secretase activity by a carborane-based flurbiprofen analogue
  Molecules. 2021 May 11;26(10):2843
• Colombo A, Sadler RK, Llovera G, Singh V, Roth S, Heindl S, Sebastian Monasor L, Verhoeven A, Peters F, Parhizkar S, Kamp F, Gomez de Aguero M, MacPherson AJ, Winkler E, Herms J, Benakis C, Dichgans M, Steiner H, Giera M, Haass C, Tahirovic S, Liesz A (2021)
  Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
  Elife. 2021 Apr 13;10:e59826
• Burbulla LF, Zheng J, Song P, Jiang W, Johnson ME, Brundin P, Krainc D (2021)
  Direct targeting of wild-type glucocerebrosidase by antipsychotic quetiapine improves pathogenic phenotypes in Parkinson's disease models
  JCI Insight. 2021 Oct 8;6(19):e148649.
• Burbulla LF, Mc Donald JM, Valdez C, Gao F, Bigio EH, Krainc D (2021)
  Modeling Brain Pathology of Niemann-Pick Disease Type C Using Patient-Derived Neurons
  Mov Disord. 2021 Apr;36(4):1022-1027.
• Earley AM, Burbulla LF, Krainc D, Awatramani R (2021)
  Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons
  Sci Rep. 2021 Nov 15;11(1):22257.
• Yoshihiro Nihei, Kohji Mori, Georg Werner, Thomas Arzberger, Qihui Zhou, Barham Khosravi, Julia Japtok, Andreas Hermann, Andreas Sommacal, Markus Weber, German Consortium for Frontotemporal Lobar Degeneration, Bavarian Brain Banking Alliance, Frits Kamp, Brigitte Nuscher, Dieter Edbauer, Christian Haass (2020)
  Poly-glycine-alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3
  Acta Neuropathol 2020 Jan;139(1):99-118.
• Georg S Nuebling, Eva Plesch, Viktoria C Ruf, Tobias Högen, Stefan Lorenzl, Frits Kamp, Armin Giese, Johannes Levin (2020)
  Binding of Metal-Ion-Induced Tau Oligomers to Lipid Surfaces Is Enhanced by GSK-3β-Mediated Phosphorylation
  ACS Chem Neurosci. 2020 Mar 18;11(6):880-887
• Boussaad I, Obermaier CD, Hanss Z, Bobbili DR, Bolognin S, Glaab E, Wołyńska K, Weisschuh N, De Conti L, May C, Giesert F, Grossmann D, Lambert A, Kirchen S, Biryukov M, Burbulla LF, Massart F, Bohler J, Cruciani G, Schmid B, Kurz-Drexler A, May P, Duga S, Klein C, Schwamborn JC, Marcus K, Woitalla D, Vogt Weisenhorn DM, Wurst W, Barrale M, Krainc D, Gasser T, Wissinger B, Krüger R (2020)
  A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease
  Sci Transl Med. 2020 Sep 9;12(560):eaau3960
• Godbe JM, Freeman R, Burbulla LF, Lewis J, Krainc D, Stupp SI (2020)
  Gelator length precisely tunes supramolecular hydrogel stiffness and neuronal phenotype in 3D culture
  ACS Biomater Sci Eng. 2020 Feb 10;6(2):1196-1207.
• Kai Schlepckow, Kathryn M. Monroe, Gernot Kleinberger, Ludovico Cantuti-Castelvetri, Samira Parhizkar, Dan Xia, Michael Willem, Georg Werner, Nadine Pettkus, Bettina Brunner, Alice Sülzen, Brigitte Nuscher, Heike Hampel, Xianyuan Xiang, Regina Feederle, Sabina Tahirovic, Joshua I. Park, Rachel Prorok, Cathal Mahon, Chun-Chi Liang, Ju Shi, Do Jin Kim, Hanna Sabelström, Fen Huang, Gilbert Di Paolo, Mikael Simons, Joseph W. Lewcock, Christian Haass (2020)
  Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region
  EMBO Mol Med. 2020 Apr 7;12(4):e11227.
• Trambauer J, Rodríguez Sarmiento RM, Fukumori A, Feederle R, Baumann K, Steiner H (2020)
  Aβ43-producing PS1 FAD mutants cause altered substrate interactions and respond to γ-secretase modulation
  EMBO Rep. 2020 Jan 7;21(1):e47996
• Lüningschrör P, Werner G, Stroobants S, Kakuta S, Dombert B, Sinske D, Wanner R, Lüllmann-Rauch R, Wefers B, Wurst W, D'Hooge R, Uchiyama Y, Sendtner M, Haass C, Saftig P, Knöll B, Capell A, Damme M (2020)
  The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons
  Cell Rep. 2020 Mar 10;30(10):3506-3519.
• Tasnim Chakroun, Valentin Evsyukov, Niko-Petteri Nykänen, Matthias Höllerhage, Andreas Schmidt, Frits Kamp, Viktoria C Ruf, Wolfgang Wurst, Thomas W Rösler, Günter U Höglinger (2020)
  Alpha-synuclein fragments trigger distinct aggregation pathways
  Cell Death Dis. 2020 Feb 3;11(2):84
• Graves SM, Xie Z, Stout KA, Zampese E, Burbulla LF, Shih JC, Kondapalli J, Patriarchi T, Tian L, Brichta L, Greengard P, Krainc D, Schumacker PT, Surmeier DJ (2020)
  Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain
  Nat Neurosci. 2020 Jan;23(1):15-20.
• Steiner A, Schlepckow K, Brunner B, Steiner H, Haass C, Hagn F (2020)
  γ-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics
  EMBO J. 2020 Oct 15;39(20):e104247
• Kong L, Dawkins E, Campbell F, Winkler E, Derks RJE, Giera M, Kamp F, Steiner H, Kros A (2020)
  Photo-controlled delivery of very long chain fatty acids to cell membranes and modulation of membrane protein function
  Biochim Biophys Acta Biomembr. 2020 May 1;1862(5):183200
• Angelique Camilleri, Stephanie Ghio, Mario Caruana, Daniel Weckbecker, Felix Schmidt, Frits Kamp, Andrei Leonov, Sergey Ryazanov, Christian Griesinger, Armin Giese, Ruben J Cauchi, Neville Vassallo (2020)
  Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin
  Biochim Biophys Acta Biomembr. 2020 Feb 1;1862(2):183064
• Georg Werner, Markus Damme, Martin Schludi, Johannes Gnörich, Karin Wind, Katrin Fellerer, Benedikt Wefers, Wolfgang Wurst, Dieter Edbauer, Matthias Brendel, Christian Haass, Anja Capell (2020)
  Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice
  EMBO Rep. 2020 Oct 5;21(10):e50241.
• Burbulla LF, Jeon S, Zheng J, Song P, Silverman RB, Krainc D (2019)
  A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson's disease
  Sci Transl Med. 2019 Oct 16;11(514):eaau6870.
• Iris Marti Fernandez, Caterina Macrini, Markus Krumbholz, Paul J Hensbergen, Agnes L Hipgrave Ederveen, Stephan Winklmeier, Atay Vural, Asli Kurne, Dieter Jenne, Frits Kamp, Lisa Ann Gerdes, Reinhard Hohlfeld, Manfred Wuhrer, Tania Kümpfel, Edgar Meinl (2019)
  The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients
  Front Immunol. 2019 Jun 11;10:1189
• Vöglein J, Paumier K, Jucker M, Preische O, McDade E, Hassenstab J, Benzinger TL, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal J, Salloway S, Xiong C, Karch CM, Cairns N, Mori H, Schofield PR, Masters CL, Goate A, Buckles V, Fox N, Rossor M, Chrem P, Allegri R, Ringman JM, Höglinger G, Steiner H, Dieterich M, Haass C, Laske C, Morris JC, Bateman RJ, Danek A, Levin J, Dominantly Inherited Alzheimer Network (2019)
  Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease
  Brain 2019 May 1;142(5):1429-1440
• Junker J, Chong I, Kamp F, Steiner H, Giera M, Müller C, Bracher F (2019)
  Comparison of strategies for the determination of sterol sulfates via GC-MS leading to a novel deconjugation-derivatization protocol
  Molecules. 2019 Jun 26;24(13):2353
• Johannes Niemeyer, Torben Mentrup, Ronny Heidasch, Stephan A Müller, Uddipta Biswas, Rieke Meyer, Alkmini A Papadopoulou, Verena Dederer, Martina Haug-Kröper, Vivian Adamski, Renate Lüllmann-Rauch, Martin Bergmann, Artur Mayerhofer, Paul Saftig, Gunther Wennemuth, Rolf Jessberger, Regina Fluhrer, Stefan F Lichtenthaler, Marius K Lemberg, Bernd Schröder (2019)
  The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban
  EMBO Rep. 2019 Feb 7
• Michael Ewers, Nicolai Franzmeier, Marc Suárez-Calvet, Estrella Morenas-Rodriguez, Miguel Angel Araque Caballero, Gernot Kleinberger, Laura Piccio, Carlos Cruchaga, Yuetiva Deming, Martin Dichgans, John Q. Trojanowski, Leslie M. Shaw, Michael W. Weiner, Christian Haass, for the Alzheimer’s Disease Neuroimaging Initiative (2019)
  Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease
  Science Translational Medicine, 28 Aug 2019
• Viktoria C. Ruf, Georg S. Nübling, Sophia Willikens, Song Shi, Felix Schmidt, Johannes Levin, Kai Bötzel, Frits Kamp, Armin Giese (2019)
  Different effects of alpha-Synuclein mutants on lipid binding and aggregation detected by single molecule fluorescence spectroscopy and ThT fluorescence-based measurements
  ACS Chem Neurosci. 2019 Mar 20;10(3):1649-1659
• Carlos Silvestre-Roig, Quinte Braster, Kanin Wichapong, Ernest Y Lee, Jean Marie Teulon, Nihel Berrebeh, Janine Winter, José M Adrover, Giancarlo Santiago Santos, Alexander Froese, Patricia Lemnitzer, Almudena Ortega-Gómez, Raphael Chevre, Julian Marschner, Ariane Schumski, Carla Winter, Laura Perez-Olivares, Chang Pan, Nicole Paulin, Tom Schoufour, Helene Hartwig, Silvia González-Ramos, Frits Kamp, Remco T A Megens, Kerri A Mowen, Matthias Gunzer, Lars Maegdefessel, Tilman Hackeng, Esther Lutgens, Mat Daemen, Julia von Blume, Hans-Joachim Anders, Viacheslav O Nikolaev, Jean-Luc Pellequer, Christian Weber, Andrés Hidalgo, Gerry A F Nicolaes, Gerard C L Wong, Oliver Soehnlein (2019)
  Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death
  Nature. 2019 May;569(7755):236-240
• Götzl J, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, Colombo A, Deussing M, Wagner M, Winkelmann J, Diehl-Schmid J, Levin J, Fellerer K, Reifschneider A, Bultmann S, Bartenstein P, Rominger A, Tahirovic S, Smith ST, Madore C, Butovsky O, Capell A, Haass C (2019)
  Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism
  EMBO Mol Med. 2019 Jun;11(6):e9711.
• Stephanie Ghio, Angelique Camilleri, Mario Caruana, Viktoria C Ruf, Felix Schmidt, Andrei Leonov, Sergey Ryazanov, Christian Griesinger, Ruben J Cauchi, Frits Kamp, Armin Giese, Neville Vassallo (2019)
  Cardiolipin Promotes Pore-Forming Activity of Alpha-Synuclein Oligomers in Mitochondrial Membranes
  ACS Chem Neurosci. 2019 Aug 21;10(8):3815-3829
• Berenguer-Escuder C, Grossmann D, Massart F, Antony P, Burbulla LF, Glaab E, Imhoff S, Trinh J, Seibler P, Grünewald A, Krüger R (2019)
  Variants in Miro1 Cause Alterations of ER-Mitochondria Contact Sites in Fibroblasts from Parkinson's Disease Patients
  J Clin Med. 2019 Dec 16;8(12):2226.
• Vöglein J, Willem M, Trambauer J, Schönecker S, Dieterich M, Biskup S, Giudici C, Utz K, Oberstein T, Brendel M, Rominger A, Danek A, Steiner H, Haass C, Levin J (2019)
  Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-β processing effects
  Neurobiol Aging. 2019 Dec;84:241.e5-241.e11
• Torben Mentrup, Kosta Theodorou, Florencia Cabrera-Cabrera, Andreas O. Helbig, Kathrin Happ, Marion Gijbels, Ann-Christine Gradtke, Björn Rabe, Akio Fukumori, Harald Steiner, Andreas Tholey, Regina Fluhrer, Marjo Donners, Bernd Schröder (2019)
  Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis
  J Exp Med. 2019 Apr 1;216(4):807-830
• Alkmini A Papadopoulou, Stephan A Müller, Torben Mentrup, Merav D Shmueli, Johannes Niemeyer, Martina Haug-Kröper, Julia von Blume, Artur Mayerhofer, Regina Feederle, Bernd Schröder, Stefan F Lichtenthaler, Regina Fluhrer (2019)
  Signal Peptide Peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins
  EMBO Rep. 2019 May;20(5). pii: e48133
• Samira Parhizkar, Thomas Arzberger, Matthias Brendel, Gernot Kleinberger, Maximilian Deussing, Carola Focke, Brigitte Nuscher, Monica Xiong, Alireza Ghasemigharagoz, Natalie Katzmarski, Susanne Krasemann, Stefan F. Lichtenthaler, Stephan A. Müller, Alessio Colombo, Laura Sebastian Monasor, Sabina Tahirovic, Jochen Herms, Michael Willem, Nadine Pettkus, Oleg Butovsky, Peter Bartenstein, Dieter Edbauer, Axel Rominger, Ali Ertürk, Stefan A. Grathwohl, Jonas J. Neher, David M. Holtzman, Melanie Meyer-Luehmann, Christian Haass (2019)
  Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
  Nat Neurosci. 2019 Feb;22(2):191-204
• Zheng J, Jeon S, Jiang W, Burbulla LF, Ysselstein D, Oevel K, Krainc D, Silverman RB (2019)
  Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase
  J Med Chem. 2019 Feb 14;62(3):1218-1230.
• Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Kai Schlepckow, Miguel Ángel Araque Caballero, Nicolai Franzmeier, Anja Capell, Katrin Fellerer, Brigitte Nuscher, Erden Eren, Johannes Levin, Yuetiva Deming, Laura Piccio, Celeste M. Karch, Carlos Cruchaga, Leslie M. Shaw, John Q. Trojanowski, Michael Weiner, Michael Ewers, Christian Haass, for the Alzheimer’s Disease Neuroimaging Initiative (2019)
  Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology
  Mol Neurodegener. 2019 Jan 10;14(1):1
• Matthias Brendel, Anna Jaworska, Felix Overhoff, Tanja Blume, Federico Probst, Franz-Josef Gildehaus, Peter Bartenstein, Christian Haass, Bernd Bohrmann, Jochen Herms, Michael Willem, Axel Rominger (2018)
  Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation
  Theranostics. 2018 Sep 9;8(18):4957-4968
• Cornelis Blauwendraat, Carlo Wilke, Javier Simón-Sánchez, Iris E. Jansen, Anika Reifschneider, Anja Capell, Christian Haass, Melissa Castillo-Lizardo, Saskia Biskup, Walter Maetzler, Patrizia Rizzu, Peter Heutink, Matthis Synofzik (2018)
  The wide genetic landscape of clinical frontotemporal dementia: systematic combined sequencing of 121 consecutive subjects
  Genet Med. 2018 Feb;20(2):240-249
• Tretter JY, Schorpp K, Luxenburger E, Trambauer J, Steiner H, Hadian K, Gires O, Niessing D (2018)
  A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor
  J Biol Chem. 2018 Jun 8;293(23):8994-9005
• Frits Kamp, Holger A. Scheidt, Edith Winkler, Gabriele Basset, Hannes Heinel, James M. Hutchison, Loren M. LaPointe, Charles R. Sanders, Harald Steiner, Daniel Huster (2018)
  Bexarotene binds to the amyloid precursor protein transmembrane domain, alters its α-helical conformation, and inhibits γ-secretase nonselectively in liposomes
  ACS Chem Neurosci. 2018 Jul 18;9(7):1702-1713.
• Kim MJ, Jeon S, Burbulla LF, Krainc D (2018)
  Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function
  Hum Mol Genet. 2018 Jun 1;27(11):1972-1988.
• Seibler P, Burbulla LF, Dulovic M, Zittel S, Heine J, Schmidt T, Rudolph F, Westenberger A, Rakovic A, Münchau A, Krainc D, Klein C (2018)
  Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells
  Brain. 2018 Oct 1;141(10):3052-3064.
• Marc Suárez-Calvet, Anja Capell, Miguel Ángel Araque Caballero, Estrella Morenas-Rodríguez, Katrin Fellerer, Nicolai Franzmeier, Gernot Kleinberger, Erden Eren, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Katrina Paumier, Randall J Bateman, Anne M Fagan, John C Morris, Johannes Levin, Adrian Danek, Mathias Jucker, Colin L Masters, Martin N Rossor, John M Ringman, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers , Christian Haass, for the Dominantly Inherited Alzheimer Network, & for the Alzheimer's Disease Neuroimaging Initiative (2018)
  CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline
  EMBO Mol Med. 2018 Dec;10(12). pii: e9712.
• Melania Spadaro, Stephan Winklmeier, Eduardo Beltrán, Caterina Macrini, Romana Höftberger, Elisabeth Schuh, Franziska S. Thaler, Lisa Ann Gerdes, Sarah Laurent, Ramona Gerhards, Simone Brändle, Klaus Dornmair, Constanze Breithaupt, Markus Krumbholz, Markus Moser, Gurumoorthy Krishnamoorthy, Frits Kamp, Dieter Jenne, Reinhard Hohlfeld, Tania Kümpfel, Hans Lassmann, Naoto Kawakami, Edgar Meinl (2018)
  Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein
  Ann Neurol. 2018 Aug;84(2):315-328.
• Julia K. Götzl, Alessio-Vittorio Colombo, Katrin Fellerer, Anika Reifschneider, Georg Werner, Sabina Tahirovic, Christian Haass, Anja Capell (2018)
  Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice
  Mol Neurodegener. 2018 Sep 4;13(1):48
• Alexander Götz, Nadine Mylonas, Philipp Högel, Mara Silber, Hannes Heinel, Simon Menig, Alexander Vogel, Hannes Feyrer, Daniel Huster, Burkhard Luy, Dieter Langosch, Christina Scharnagl, Claudia Muhle-Goll, Frits Kamp, Harald Steiner (2018)
  Modulating hinge flexibility in the APP transmembrane domain alters γ-secretase
  Biophys J. 2019 Jun 4;116(11):2103-2120
• Karim S. Echtay, Martin Bienengraeber, Peter Mayinger, Simone Heimpel, Doerthe Druhmann, Karina Frischmuth, Frits Kamp, Shu-Gui Huang (2018)
  Uncoupling proteins: Martin Klingenberg's contributions for 40 years
  Arch Biochem Biophys. 2018 Nov 1;657:41-55
• Burbulla LF, Song P, Mazzulli JR, Zampese E, Wong YC, Jeon S, Santos DP, Blanz J, Obermaier CD, Strojny C, Savas JN, Kiskinis E, Zhuang X, Krüger R, Surmeier DJ, Krainc D (2017)
  Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease
  Science. 2017 Sep 22;357(6357):1255-1261.
• Yu Ohki, Andrea Wenninger-Weinzierl, Alexander Hruscha, Kazuhide Asakawa, Koichi Kawakami, Christian Haass, Dieter Edbauer, Bettina Schmid (2017)
  Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration
  Mol Neurodegener. 2017 Jan 14;12(1):6. doi: 10.1186/s13024-016-0146-8.
• Gernot Kleinberger, Matthias Brendel, Eva Mracsko, Benedikt Wefers, Linda Groeneweg, Xianyuan Xiang, Carola Focke, Maximilian Deußing, Marc Suárez-Calvet, Fargol Mazaheri, Samira Parhizkar, Nadine Pettkus, Wolfgang Wurst, Regina Feederle, Peter Bartenstein, Thomas Mueggler, Thomas Arzberger, Irene Knuesel, Axel Rominger, Christian Haass (2017)
  The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion and glucose metabolism
  EMBO J. 2017 Jul 3;36(13):1837-1853
• Kai Schlepckow, Gernot Kleinberger, Akio Fukumori, Regina Feederle, Stefan F. Lichtenthaler, Harald Steiner, Christian Haass (2017)
  An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function
  EMBO Mol Med. 2017 Oct;9(10):1356-1365
• Trambauer J, Fukumori A, Kretner B, Steiner H (2017)
  Analyzing amyloid-β peptide modulation profiles and binding sites of γ-secretase modulators
  Methods Enzymol. 2017;584:157-183
• Mentrup T, Loock AC, Fluhrer R, Schröder B (2017)
  Signal peptide peptidase and SPP-like proteases - Possible therapeutic targets?
  Biochim Biophys Acta. 2017 Nov;1864(11 Pt B):2169-2182.
• Mentrup T, Fluhrer R, Schröder B (2017)
  Latest emerging functions of SPP/SPPL intramembrane proteases
  Eur J Cell Biol. 2017 Aug;96(5):372-382
• Fargol Mazaheri, Nicolas Snaidero, Gernot Kleinberger, Charlotte Madore, Anna Daria, Georg Werner, Susanne Krasemann, Anja Capell, Dietrich Trümbach, Wolfgang Wurst, Bettina Brunner, Sebastian Bultmann, Sabina Tahirovic, Martin Kerschensteiner, Thomas Misgeld, Oleg Butovsky, Christian Haass (2017)
  TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury
  EMBO Rep. 2017 Jul;18(7):1186-1198
• Jules F, Sauvageau E, Dumaresq-Doiron K, Mazzaferri J, Haug-Kröper M, Fluhrer R, Costantino S, Lefrancois S (2017)
  CLN5 is cleaved by members of the SPP/SPPL family to produce a mature soluble protein
  Exp Cell Res. 2017 Aug 1;357(1):40-50
• Benedikt Kretner, Johannes Trambauer, Janina Mielke, Peer-Hendrik Kuhn, Elisabeth Kremmer, Armin Giese, Stefan Lichtenthaler, Christian Haass, Thomas Arzberger, Harald Steiner (2016)
  Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer’s disease
  EMBO Mol Med. 2016 May 2;8(5):458-65
• Susann Hüttl, Felix Helfrich, Torben Mentrup, Sebastian Held, Harald Steiner, Paul Saftig, Regina Fluhrer, Bernd Schröder (2016)
  Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74
  Biochem J. 2016 May 15;473(10):1405-22.
• Hsieh CH, Shaltouki A, Gonzalez AE, Bettencourt da Cruz A, Burbulla LF, St Lawrence E, Schüle B, Krainc D, Palmer TD, Wang X (2016)
  Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease
  Cell Stem Cell. 2016 Dec 1;19(6):709-724.
• Felix Overhoff, Matthias Brendel, Anna Jaworska, Viktoria Korzhova, Andreas Delker, Federico Probst, Carola Focke, Franz-Josef Gildehaus, Janette Carlsen, Karlheinz Baumann, Christian Haass, Peter Bartenstein, Jochen Herms, Axel Rominger (2016)
  Automated Spatial Brain Normalization and Hindbrain White Matter Reference Tissue Give Improved [(18)F]-Florbetaben PET Quantitation in Alzheimer's Model Mice
  Front Neurosci. 2016 Feb 29;10:45
• Marc Suárez-Calvet, Manuela Neumann, Thomas Arzberger, Claudia Abou-Ajram, Eva Funk, Hannelore Hartmann, Dieter Edbauer, Elisabeth Kremmer, Christoph Göbl, Moritz Resch, Benjamin Bourgeois, Tobias Madl, Stefan Reber, Daniel Jutzi, Marc-David Ruepp, Ian R. A. Mackenzie, Olaf Ansorge, Dorothee Dormann, Christian Haass (2016)
  Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS
  Acta Neuropathol. 2016 Apr;131(4):587-604
• Matthias Brendel, Federico Probst, Anna Jaworska, Felix Overhoff, Viktoria Korzhova, Nathalie L. Albert, Roswitha Beck, Simon Lindner, Franz-Josef Gildehaus, Karlheinz Baumann, Peter Bartenstein, Gernot Kleinberger, Christian Haass, Jochen Herms, Axel Rominger (2016)
  Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple-Tracer PET Study
  J Nucl Med. 2016 Jun;57(6):954-60
• Juan Domingo Gispert, Gemma C. Monté, Marc Suárez-Calvet, Carles Falcon, Alan Tucholka, Santiago Rojas, Lorena Rami, Raquel Sánchez-Valle, Albert Lladó, Gernot Kleinberger, Christian Haass, José Luis Molinuevo (2016)
  The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2
  Alzheimers Dement (Amst). 2016 Dec 22;6:50-59
• Marc Suárez-Calvet, Gernot Kleinberger, Miguel Ángel Araque Caballero, Matthias Brendel, Axel Rominger, Daniel Alcolea, Juan Fortea, Alberto Lleó, Rafael Blesa, Juan Domingo Gispert, Raquel Sánchez-Valle, Anna Antonell, Lorena Rami, José L. Molinuevo, Frederic Brosseron, Andreas Traschütz, Michael T. Heneka, Hanne Struyfs, Sebastiaan Engelborghs, Kristel Sleegers, Christine Van Broeckhoven, Henrik Zetterberg, Bengt Nellgard, Kaj Blennow, Alexander Crispin, Michael Ewers, Christian Haass (2016)
  sTREM2 cerebrospinal fluid levels are a potent biomarker for microglia activity in early-stage Alzheimer’s disease and associate with neuronal injury markers
  EMBO Mol Med. 2016 May 2;8(5):466-76
• Xianyuan Xiang, Georg Werner, Bernd Bohrmann, Arthur Liesz, Fargol Mazaheri, Anja Capell, Regina Feederle, Irene Knuesel, Gernot Kleinberger, Christian Haass (2016)
  TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
  EMBO Molecular Medicine (2016) e201606370, Published online 08.07.2016
• Mazzulli JR, Burbulla LF, Krainc D, Ischiropoulos H (2016)
  Detection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence
  Anal Chem. 2016 Feb 16;88(4):2399-405.
• Anna Daria, Alessio Colombo, Gemma llovera, Heike Hampel, Michael Willem, Arthur Liesz, Christian Haass, Sabina Tahirovic (2016)
  Young microglia restore amyloid plaque clearance of aged microglia
  EMBO J. 2016 Dec 21. pii: e201694591. doi: 10.15252/embj.201694591. [Epub ahead of print]
• Kaichuan Zhu, Xianyuan Xiang, Severin Filser, Petar Marinkovic, Mario M. Dorostkar, Sophie Crux, Ulf Neumann, Derya R. Shimshek, Gerhard Rammes, Christian Haass, Stefan F. Lichtenthaler, Jenny M. Gunnersen, Jochen Herms (2016)
  Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6
  Biol Psychiatry. 2016 Dec 26. pii: S0006-3223(16)33157-2. doi: 10.1016/j.biopsych.2016.12.023.
• Juan Domingo Gispert, Marc Suárez-Calvet, Gemma C. Monte, Alan Tucholka, Carles Falcon, Santiago Rojas, Lorena Rami, Raquel Sanchez-Valle, Albert Lladó, Gernot Kleinberger, Christian Haass, José Luis Molinuevo (2016)
  Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease
  Alzheimers Dement. 2016 Jul 13. pii: S1552-5260(16)30026-7.
• Marc Suárez-Calvet, Miguel Ángel Araque Caballero, Gernot Kleinberger, Randall J. Bateman, Anne M. Fagan, John C. Morris, Johannes Levin, Adrian Danek, Michael Ewers, Christian Haass, for the Dominantly Inherited Alzheimer Network (2016)
  Early changes in CSF sTREM2 in dominantly inherited Alzheimer’s disease occur after amyloid deposition and neuronal injury
  Science Translational Medicine 14 Dec 2016: Vol. 8, Issue 369, pp. 369ra178 DOI: 10.1126/scitranslmed.aag1767
• Saoussen Ben Halima, Sabyashachi Mishra, K. Muruga Poopathi Raja, Michael Willem, Antonio Baici, Kai Simons, Oliver Brüstle, Philipp Koch, Christian Haass, Amedeo Caflisch, Lawrence Rajendran (2016)
  Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein
  Cell Rep. 2016 Mar 8;14(9):2127-41
• Matthias Brendel, Anna Jaworska, Federico Probst, Felix Overhoff, Viktoria Korzhova, Simon Lindner, Janette Carlsen, Peter Bartenstein, Ryuichi Harada, Yukitsuka Kudo, Christian Haass, Fred van Leuven, Nobuyuki Okamura, Jochen Herms, Axel Rominger (2016)
  Small-Animal PET Imaging of Tau Pathology with 18F-THK5117 in 2 Transgenic Mouse Models
  J Nucl Med. 2016 May;57(5):792-8
• Rashi Halder, Magali Hennion, Ramon O Vidal, Orr Shomroni, Raza-Ur Rahman, Ashish Rajput, Tonatiuh Pena Centeno, Frauke van Bebber, Vincenzo Capece, Julio C Garcia Vizcaino, Anna-Lena Schuetz, Susanne Burkhardt, Eva Benito, Magdalena Navarro Sala, Sanaz Bahari Javan, Christian Haass, Bettina Schmid, Andre Fischer, Stefan Bonn (2016)
  DNA methylation changes in plasticity genes accompany the formation and maintenance of memory
  Nat Neurosci. 2016 Jan;19(1):102-10
• Kohji Mori, Yoshihiro Nihei, Thomas Arzberger, Qihui Zhou, Ian R Mackenzie, Andreas Hermann, Frank Hanisch, German Consortium for Frontotemporal Lobar Degeneration, Bavarian Brain Banking Alliance, Frits Kamp, Brigitte Nuscher, Denise Orozco, Dieter Edbauer, Christian Haass (2016)
  Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition
  EMBO Reports, published online 26.07.2016
• Mazzulli JR, Zunke F, Tsunemi T, Toker NJ, Jeon S, Burbulla LF, Patnaik S, Sidransky E, Marugan JJ, Sue CM, Krainc D (2016)
  Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons
  J Neurosci. 2016 Jul 20;36(29):7693-706.
• Gernot Kleinberger, Anja Capell, Nathalie Brouwers, Katrin Fellerer, Kristel Sleegers, Marc Cruts, Christina Van Broeckhoven, Christian Haass (2016)
  Reduced secretion and altered proteolytic processing caused by missense mutations in progranulin
  Neurobiol Aging. 2016 Mar;39:220.e17-26
• Burbulla LF, Beaumont KG, Mrksich M, Krainc D (2016)
  Micropatterning Facilitates the Long-Term Growth and Analysis of iPSC-Derived Individual Human Neurons and Neuronal Networks
  Adv Healthc Mater. 2016 Aug;5(15):1894-903.
• Matthias Brendel, Anna Jaworska, Eric Grießinger, Christina Rötzer, Steffen Burgold, Franz-Josef Gildehaus, Janette Carlsen, Paul Cumming, Karlheinz Baumann, Christian Haass, Harald Steiner, Peter Bartenstein, Jochen Herms, Axel Rominger (2015)
  Cross-sectional comparison of small animal [18F]-florbetaben amyloid-PET between transgenic AD mouse models
  PLoS One. 2015 Feb 23;10(2):e0116678
• M Brendel, A Jaworska, J Herms, J Trambauer, C Rötzer, F-J Gildehaus, J Carlsen, P Cumming, J Bylund, T Luebbers, P Bartenstein, H Steiner, C Haass, K Baumann, A Rominger (2015)
  Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment
  Mol Psychiatry. 2015 Oct;20(10):1179-87
• Mentrup T, Häsler R, Fluhrer R, Saftig P, Schröder B (2015)
  A Cell-Based Assay Reveals Nuclear Translocation of Intracellular Domains Released by SPPL Proteases
  Traffic. 2015 Aug;16(8):871-92. doi: 10.1111/tra.12287. Epub 2015 May 6
• Michael Willem, Sabina Tahirovic, Marc Aurel Busche, Saak V. Ovsepian, Magda Chafai, Scherazad Kootar, Daniel Hornburg, Lewis D. B. Evans, Steven Moore, Anna Daria, Heike Hampel, Veronika Müller, Camilla Giudici, Brigitte Nuscher, Andrea Wenninger-Weinzierl, Elisabeth Kremmer, Michael T. Heneka, Dietmar R. Thal, Vilmantas Giedraitis, Lars Lannfelt, Ulrike Müller, Frederick J. Livesey, Felix Meissner, Jochen Herms, Arthur Konnerth, Hélène Marie, Christian Haass (2015)
  eta-Secretase processing of APP inhibits neuronal activity in the hippocampus
  Nature. 2015 Oct 15;526(7573):443-7
• Kuhn PH, Voss M, Haug-Kröper M, Schröder B, Schepers U, Bräse S, Haass C, Lichtenthaler SF, Fluhrer R (2015)
  Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways
  Mol Cell Proteomics. 2015 Jun;14(6):1584-98. doi: 10.1074/mcp.M115.048298. Epub 2015 Mar 31.
• Teresa Bachhuber, Natalie Katzmarski, Joanna F McCarter, Desiree Loreth, Sabina Tahirovic, Frits Kamp, Claudia Abou-Ajram, Brigitte Nuscher, Alberto Serrano-Pozo, Alexandra Müller, Marco Prinz, Harald Steiner, Bradley T Hyman, Christian Haass, Melanie Meyer-Luehmann (2015)
  Inhibition of amyloid-β plaque formation by α-synuclein
  Nat Med. 2015 Jul;21(7):802-7
• Fleck D, Voss M, Brankatschk B, Giudici C, Hampel H, Edbauer D, Steiner H, Kremmer E, Haug-Kröper M, Rossner MJ, Fluhrer R, Willem M, Haass C (2015)
  Proteolytic processing of neuregulin 1 type III by three intramembrane cleaving proteases
  J Biol Chem. 2016 Jan 1;291(1):318-33.
• Eva C Schulte, Brit Mollenhauer, Hyun Hor, Thomas Arzberger, Robert Perneczky, Alexander Kurz, Janine Diehl-Schmid, Michael Hüll, Peter Lichtner, Gertrud Eckstein, Alexander Zimprich, Dietrich Haubenberger, Walter Pirker, Thomas Brücke, Benjamin Bereznai, Maria J Molnar, Oswaldo Lorenzo-Betancor, Pau Pastor, Annette Peters, Christian Gieger, Xavier Estivill, Thomas Meitinger, Hans A Kretzschmar, Claudia Trenkwalder, Christian Haass, Juliane Winkelmann (2015)
  Rare variants in β-Amyloid precursor protein (APP) and Parkinson's disease
  Eur J Hum Genet. 2015 Oct;23(10):1328-33
• Jonathan Janssens, Stéphanie Philtjens, Gernot Kleinberger, Sara Van Mossevelde, Julie van der Zee, Rita Cacace, Sebastiaan Engelborghs, Anne Sieben, Julia Banzhaf-Strathmann, Lubina Dillen, Céline Merlin, Ivy Cuijt, Caroline Robberecht, Bettina Schmid, Patrick Santens, Adrian Ivanoiu, Mathieu Vandenbulcke, Rik Vandenberghe, Patrick Cras, Peter P. De Deyn, Jean-Jacques Martin, Stuart Maudsley, Christian Haass, Marc Cruts, Christine Van Broeckhoven (2015)
  Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains
  Acta Neuropathol Commun. 2015 Nov 10;3:68
• M Brendel, A Jaworska, J Herms, J Trambauer, C Rötzer, F-J Gildehaus, J Carlsen, P Cumming, J Bylund, T Luebbers, P Bartenstein, H Steiner, C Haass, K Baumann, A Rominger (2015)
  Monitoring of chronic γ-secretase modulator treatment by serial amyloid-PET
  Mol Psychiatry. 2015 Oct;20(10):1141
• Sandra Jäckel, Anna K. Summerer, Catherine M. Thömmes, Xia Pan, Aaron Voigt, Jörg B. Schulz, Tobias M. Rasse, Dorothee Dormann, Christian Haass, Philipp J. Kahle (2015)
  Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila
  Neurobiol Dis. 2015 Feb;74:76-88
• Frits Kamp, Edith Winkler, Johannes Trambauer, Amelie Ebke, Regina Fluhrer, Harald Steiner (2015)
  Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process
  Biophys J. 2015 Mar 10;108(5):1229-37.
• Barbara Solchenberger, Claire Russell, Elisabeth Kremmer, Christian Haass, Bettina Schmid (2015)
  Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology
  PLoS One. 2015 Mar 18;10(3):e0118956
• Voss M, Künzel U, Higel F, Kuhn PH, Colombo A, Haug-Kröper M, Klier B, Grammer G, Seidl A, Schröder B, Obst R, Steiner H, Lichtenthaler SF, Haass C, Fluhrer R (2014)
  Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation
  EMBO J. 2014 Dec 17;33(24):2890-905. doi: 10.15252/embj.201488375. Epub 2014 Oct 29.
• Schwenk BM, Lang CM, Hogl S, Tahirovic S, Orozco D, Rentzsch K, Lichtenthaler SF, Hoogenraad CC, Capell A, Haass C, Edbauer D (2014)
  The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes
  EMBO J. 2014 Jan 8. [Epub ahead of print]
• Fluhrer R (2014)
  Intramembrane cleaving proteases (I-CLiPs) as guardians of shuttling proteins
  Cell Cycle. 2014 Feb 4;13(5). [Epub ahead of print]
• Schneppenheim J, Hüttl S, Kruchen A, Fluhrer R, Müller I, Saftig P, Schneppenheim R, Martin CL, Schröder B (2014)
  Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells
  Biochem Biophys Res Commun. 2014 Aug 15;451(1):48-53. doi: 10.1016/j.bbrc.2014.07.051. Epub 2014 Jul 15.
• Klein P, Müller-Rischart AK, Motori E, Schönbauer C, Schnorrer F, Winklhofer KF, Klein R (2014)
  Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants
  EMBO J. 2014 Jan 28. [Epub ahead of print]
• Götzl JK, Mori K, Damme M, Fellerer K, Tahirovic S, Kleinberger G, Janssens J, van der Zee J, Lang CM, Kremmer E, Martin JJ, Engelborghs S, Kretzschmar HA, Arzberger T, Van Broeckhoven C, Haass C, Capell A (2014)
  Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis.
  Acta Neuropathol. 2014 Mar 12. [Epub ahead of print]
• Burbulla LF, Fitzgerald JC, Stegen K, Westermeier J, Thost AK, Kato H, Mokranjac D, Sauerwald J, Martins LM, Woitalla D, Rapaport D, Riess O, Proikas-Cezanne T, Rasse TM, Krüger R (2014)
  Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1
  Cell Death Dis. 2014 Apr 17;5(4):e1180.
• G. Kleinberger, Y. Yamanishi, M. Suarez-Calvet, E. Czirr, E. Lohmann, E. Cuyvers, H. Struyfs, N. Pettkus, F. Mazaheri, S. Tahirovic, A. Lleó, D. Alcolea, J. Fortea, M. Willem, S. Lammich, J. L. Molinuevo, R. Sanchez-Valle, A. Antonell, A. Ramirez, M. Heneka, K. Sleegers, J. van der Zee, J.-J. Martin, S. Engelborghs, A. Demirtas-Tatlidede, H. Zetterberg, C. Van Broeckhoven, H. Gurvit, T. Wyss-Coray, J. Hardy, M. Colonna, C. Haass (2014)
  TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
  Sci Transl Med 2 July 2014: Vol. 6, Issue 243, p. 243ra86
• Georg Sebastian Nübling, Johannes Levin, Benedikt Bader, Stefan Lorenzl, Andreas Hillmer, Tobias Högen, Frits Kamp, Armin Giese (2014)
  Modelling Ser129 phosphorylation inhibits membrane binding of pore-forming alpha-synuclein oligomers
• Schneppeneim J, Hüttl S, Mentrup T, Lüllmann-Rauch R, Rothaug M, Engelke M, Dittmann K, Dressel R, Araki M, Araki K, Wienands J, Fluhrer R, Saftig P, Schröder B (2014)
  The intramembrane proteases Signal-peptide-peptidase-like 2a and b (SPPL2a/b) have distinct functions in vivo
  Mol Cell Biol. 2014 Feb 3. [Epub ahead of print]
• Capell A, Fellerer K, Haass C (2014)
  Progranulin transcripts with short and long 5’-untranslated regions (UTR) are differentially expressed via post transcriptional and translational repression
  J Biol Chem. 2014 Jul 23. pii: jbc.M114.560128. [Epub ahead of print]
• McCarthy JM, Franke M, Resenberger UK, Waldron S, Simpson JC, Appelhans D, Rogers MS (2013)
  Anti-Prion Drug mPPIg5 Inhibits PrP(C) Conversion to PrP(Sc)
  PLoS One. 2013;8(1):e55282. doi: 10.1371/journal.pone.0055282. Epub 2013 Jan 28
• Reinhardt P, Schmid B, Burbulla LF, Schöndorf DC, Wagner L, Glatza M, Höing S, Hargus G, Heck SA, Dhingra A, Wu G, Müller S, Brockmann K, Kluba T, Maisel M, Krüger R, Berg D, Tsytsyura Y, Thiel CS, Psathaki OE, Klingauf J, Kuhlmann T, Klewin M, Müller H, Gasser T, Schöler HR, Sterneckert J (2013)
  Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression
  Cell Stem Cell. 2013 Mar 7;12(3):354-67.
• Mori K, Weng SM, Arzberger T, Rentzsch K, Kremmer E, Schmid B, Kretzschmar HA, Cruts M, Van Broeckhoven C, Haass C, Edbauer D (2013)
  The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS
  Science. 2013 Feb 7. [Epub ahead of print]
• Clemens-Grisham R, Kindt K, Finger-Baier K, Nicolson T (2013)
  Mutations in ap1b1 cause mistargeting of the Na+/K+-ATPase pump in sensory hair cells
  PLoS One. 2013 Apr 12;8(4):e60866. doi: 10.1371/journal.pone.0060866. Print 2013
• Schmid B, Haass C (2013)
  Genomic editing opens new avenues for zebrafish as a model for neurodegeneration
  J Neurochem. 2013 Nov;127(4):461-70. doi: 10.1111/jnc.12460. Epub 2013 Oct 21
• Julia Banzhaf-Strathmann, Rainer Claus, Oliver Mücke, Kristin Rentzsch, Julie van der Zee, Sebastiaan Engelborghs, Peter P De Deyn, Marc Cruts, Christine van Broeckhoven, Christoph Plass (2013)
  Promoter DNA methylation regulates progranulin expression and is altered in FTLD
  Acta Neuropathologica Communications 1 (1):16
• Boyer LA (2013)
  Getting to the heart of the matter: long non-coding RNAs in cardiac development and disease
  EMBO J. 2013 Jul 3;32(13):1805-16.
• Mori K, Lammich S, Mackenzie IR, Forne I, Zilow S, Kretzschmar H, Edbauer D, Janssens J, Kleinberger G, Cruts M, Herms J, Neumann M, Van Broeckhoven C, Arzberger T, Haass C (2013)
  hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations
  Acta Neuropathol. 2013 Mar;125(3):413-23. doi: 10.1007/s00401-013-1088-7. Epub 2013 Feb 5
• Fleck D, van Bebber F, Colombo A, Galante C, Rabe L, Hampel H, Novak B, Kremmer E, Tahirovic S, Edbauer D, Lichtenthaler SF, Schmid B, Willem M, Haass C (2013)
  Dual cleavage of neuregulin 1 Type III by BACE1 and ADAM17 Liberates Its EGF-Like Domain and Allows Paracrine Signaling
  J Neurosci. 2013 May 1;33(18):7856-69. doi: 10.1523/JNEUROSCI.3372-12.2013
• Poggi M, Kara I, Brunel JM, Landrier JF, Govers R, Bonardo B, Fluhrer R, Haass C, Alessi MC, Peiretti F (2013)
  Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling
  Biochim Biophys Acta. 2013 Mar;1833(3):602-12. doi: 10.1016/j.bbamcr.2012.11.009. Epub 2012 Nov 16.
• Rothhämel S, Haass C (2013)
  Real-Time Monitoring of Inclusion Formation in Living Zebrafish
• Zhang L, Karsten P, Hamm S, Pogson JH, Müller-Rischart AK, Exner N, Haass C, Whitworth AJ, Winklhofer KF, Schulz JB, Voigt A (2013)
  TRAP1 rescues PINK1 loss-of-function phenotypes
  Hum Mol Genet. 2013 Apr 7. [Epub ahead of print
• Panda SK, Wefers B, Ortiz O, Floss T, Schmid B, Haass C, Wurst W, Kühn R (2013)
  Highly Efficient Targeted Mutagenesis in Mice Using TALENs
  Genetics. 2013 Aug 26. [Epub ahead of print]
• Cheret C, Willem M, Fricker FR, Wende H, Wulf-Goldenberg A, Tahirovic S, Nave KA, Saftig P, Haass C, Garratt AN, Bennett DL, Birchmeier C (2013)
  Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles
  EMBO J. 2013 Jul 17;32(14):2015-28. doi: 10.1038/emboj.2013.146. Epub 2013 Jun 21
• Voss M, Schröder B, Fluhrer R (2013)
  Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases.
  Biochim Biophys Acta. 2013 Dec;1828(12):2828-39. doi: 10.1016/j.bbamem.2013.03.033.
• Prox J, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D´Hooge R, Stroobants S, Ahmed T, Balschun D, Willem M, Lammich S, Isbrandt D, Schweizer M, Horré K, De Strooper B, Saftig P (2013)
  Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions
  J Neurosci. 2013 Aug 7;33(32):12915-12928
• Hruscha A, Krawitz P, Rechenberg A, Heinrich V, Hecht J, Haass C, Schmid B (2013)
  Efficient CRISPR/Cas9 genome editing with low off target effects in zebrafish
  Development. 2013 Dec;140(24):4982-7. doi: 10.1242/dev.099085. Epub 2013 Nov 20
• Hogl S, van Bebber F, Dislich B, Kuhn PH, Haass C, Schmid B, Lichtenthaler SF (2013)
  Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains
  Proteomics. 2013 Mar 4. doi: 10.1002/pmic.201200582. [Epub ahead of print]
• Grau T, Burbulla LF, Engl G, Delettre C, Delprat B, Oexle K, Leo-Kottler B, Roscioli T, Krüger R, Rapaport D, Wissinger B, Schimpf-Linzenbold S (2013)
  A novel heterozygous OPA3 mutation located in the mitochondrial target sequence results in altered steady-state levels and fragmented mitochondrial network
  J Med Genet. 2013 Dec;50(12):848-58.
• McCarter JF, Liebscher S, Bachuber T, Abou-Ajram C, Hübener M, Hyman BT, Haass C, Meyer-Luehmann M (2013)
  Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer's disease.
  Acta Neuropathol. 2013 Aug;126(2):179-88. doi: 10.1007/s00401-013-1137-2. Epub 2013 Jun 18.
• Schneppeneim J, Dressel R, Hüttl S, Lüllmann-Rauch R, Engelke M, Dittmann K, Wienands J, Eskelinen EL, Hermans-Borgmeyer I, Fluhrer R, Saftig P, Schröder B (2013)
  The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain
  J Exp Med. 2013 Jan 14;210(1):41-58. doi: 10.1084/jem.20121069. Epub 2012 Dec 24.
• Zahn C, Kaup M, Fluhrer R, Fuchs H (2013)
  The transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2b
  FEBS J. 2013 Apr;280(7):1653-63. doi: 10.1111/febs.12176. Epub 2013 Mar 1.
• Klattenhoff CA, Surface LE, Bradley RK, Fields PA, Steinhauser ML, Ding H, Butty VL, Torrey L, Haas S, Abo R, Tabebordbar M, Lee RT, Burge CB, Boyer LA (2013)
  Braveheart, a long noncoding RNA required for cardiovascular lineage commitment
  Cell. 2013 Jan 31;152(3):570-83
• Müller-Rischart AK, Pilsl A, Beaudette P, Patra M, Hadian K, Funke M, Peis R, Schweimer C, Kuhn PH, Lichtenthaler SF, Motori E, Hrelia S, Wurst W, Trümbach D, Langer T, Krappmann D, Dittmar G, Winklhofer KF (2013)
  The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO
  Mol Cell. 2013 Mar 7;49(5):908-21. doi: 10.1016/j.molcel.2013.01.036. Epub 2013 Feb 28
• Schmid B, Hruscha A, Hogl S, Banzhaf-Strathmann J, van der Zee J, Teucke M, Eimer S, Hegermann J, Kittelmann M, Kremmer E, Cruts M, Solchenberger B, van Bebber F, Van Broeckhoven C, Edbauer D, Lichtenthaler SF, Haass C (2013)
  Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth
  Proc Natl Acad Sci U S A. 2013 Mar 1. [Epub ahead of print]
• van Bebber F, Hruscha A, Willem M, Schmid B, Haass C (2013)
  Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes
  J Neurochem. 2013 Feb 14. doi: 10.1111/jnc.12198. [Epub ahead of print]
• Bronckers AL, Gueneli N, Lüllmann-Rauch R, Schneppeneim J, Moraru AP, Himmerkus N, Bervoets TJ, Fluhrer R, Everts V, Saftig P, Schröder B (2013)
  The intramembrane protease SPPL2A is critical for tooth enamel formation
  J Bone Miner Res. 2013 Jul;28(7):1622-30. doi: 10.1002/jbmr.1895
• Mackenzie IR, Arzberger T, Kremmer E, Troost D, Lorenzl S, Mori K, Weng SM, Haass C, Kretzschmar HA, Edbauer D, Neumann M (2013)
  Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations
  Acta Neuropathol. 2013 Dec;126(6):859-79. doi: 10.1007/s00401-013-1181-y. Epub 2013 Oct 6.
• Dirndorfer D, Seidel RP, Nimrod G, Miesbauer M, Ben-Tal N, Engelhard M, Zimmermann R, Winklhofer KF (2013)
  The alpha-helical structure of prodomains promotes translocation of intrinsically disordered neuropeptide hormones into the endoplasmic reticulum
  J Biol Chem. 2013 Mar 26. [Epub ahead of print]
• Rominger A, Brendel M, Burgold S, Keppler K, Baumann K, Xiong G, Mille E, Gildehaus FJ, Carlsen J, Schlichtinger J, Niedermoser S, Wängler B, Cumming P, Steiner H, Herms J, Haass C, Bartenstein P (2013)
  Longitudinal assessment of cerebral β-amyloid deposition in mice overexpressing Swedish mutant β-amyloid precursor protein using 18F-florbetaben PET.
  J Nucl Med. 2013 Jul;54(7):1127-34. doi: 10.2967/jnumed.112.114660. Epub 2013 May 31.
• Brendel M, Delker A, Rötzer C, Böning G, Carlsen J, Cyran C, Mille E, Gildehaus FJ, Cumming P, Baumann K, Steiner H, Haass C, Herms J, Bartenstein P, Rominger A (2013)
  Impact of partial volume effect correction on cerebral β-amyloid imaging in APP-Swe mice using [(18)F]-florbetaben PET.
  Neuroimage. 2014 Jan 1;84:843-53. doi: 10.1016/j.neuroimage.2013.09.017. Epub 2013 Sep 20.
• Pfeiffer NV, Dirndorfer D, Resenberger UK, Restelli LM, Hemion C, Miesbauer M, Frank S, Neutzner A, Zimmermann R, Winklhofer KF (2013)
  Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria
  EMBO J. 2013 Mar 12. doi: 10.1038/emboj.2013.46. [Epub ahead of print]
• Kretner B, Kuhn PH, Pérez-Revuelta BI, Lichtenthaler SF, Haass C, Steiner H (2013)
  Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase
  J Neurochem. 2013 Apr;125(1):144-56. doi: 10.1111/jnc.12124. Epub 2013 Jan 15
• Mori K, Arzberger T, Grässer FA, Gijselinck I, Rentzsch K, Weng SM, Schludi HM, van der Zee J, Cruts M, Van Broeckhoven C, Kremmer E, Kretzschmar HA, Haass C, Edbauer D (2013)
  Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins.
  Acta Neuropathol. 2013 Dec;126(6):881-93. doi: 10.1007/s00401-013-1189-3. Epub 2013 Oct 17.
• Honarnejad K, Jung CK, Lammich S, Arzberger T, Kretzschmar H, Herms J (2013)
  Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease.
  J Cell Mol Med. 2013 Feb;17(2):293-302. doi: 10.1111/jcmm.12008. Epub 2013 Feb 5
• Liebscher S, Page RM, Käfer K, Winkler E, Quinn K, Goldbach E, Brigham EF, Quincy D, Basi GS, Schenk DB, Steiner H, Bonhoeffer T, Haass C, Meyer-Luehmann M, Hübener M (2013)
  Chronic γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures.
  Mol Psychiatry. 2013 Sep 24. doi: 10.1038/mp.2013.122. [Epub ahead of print]
• Zhu JY, Vereshchagina N, Sreekumar V, Burbulla LF, Costa AC, Daub KJ, Woitalla D, Martins LM, Krüger R, Rasse TM (2013)
  Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model
  PLoS One. 2013 Dec 30;8(12):e83714.
• Gutiérrez L, Müller J (2012)
  Histone H2A monoubiquitination and Polycomb repression: the missing pieces of the puzzle
  Fly (Austin). 2012 Jul-Sep;6(3):162-8
• Plucinska G, Paquet D, Hruscha A, Godinho L, Haass C, Schmid B, Misgeld T (2012)
  In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system
  J Neurosci. 2012 Nov 14;32(46):16203-12. doi: 10.1523/JNEUROSCI.1327-12.2012
• Gutiérrez L, Oktaba K, Gambetta MC, Ly-Hartig N, Müller J (2012)
  The role of the histone H2A ubiquitinase Sce in Polycomb repression
  Development. 2012 Jan;139(1):117-27.
• Glas L, Kloos K, Giesert F, Roethig A, Di Benedetto B, Kühn R, Zang J, Hafen U, Zerle J, Hofmann A, Hrabé de Angelis M, Winklhofer KF, Hölter SM, Vogt Weisendorn DM, Wurst W (2012)
  Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb
  Exp Neurol. 2012 Jan 11
• Yasmina Cuartero, Maravillas Mellado, Anja Capell, Manuel Álvarez-Dolado, Marcel Verges (2012)
  Retromer regulates postendocytic sorting of β-secretase in polarized Madin-Darby canine kidney cells
  Traffic. 2012 Oct;13(10):1393-410
• Burbulla LF, Krüger R (2012)
  The use of primary human fibroblasts for monitoring mitochondrial phenotypes in the field of Parkinson's disease
  J Vis Exp. 2012 Oct 3;(68):4228.
• Resenberger UK, Mueller V, Munter LM, Baier M, Multhaup G, Wilson MR, Winklhofer KF (2012)
  The heat shock response is modulated by and interferes with toxic effects of scrapie prion protein and amyloid β
  J Biol Chem. 2012 Dec 21;287(52):43765-76. doi: 10.1074/jbc.M112.389007. Epub 2012 Oct 31
• Dormann D, Madl T, Valori CF, Bentmann E, Kremmer E, Ansorge O, Mackenzie IR, Neumann M, Haass C (2012)
  Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS
  EMBO J. 2012 Sep 11. doi: 10.1038/emboj.2012.261. [Epub ahead of print]
• Lang CM, Fellerer K, Schwenk BM, Kuhn PH, Kremmer E, Edbauer D, Capell A, Haass C (2012)
  Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration
  J Biol Chem. 2012 Apr 17. [Epub ahead of print]
• Page RM, Münch A, Horn T, Kuhn PH, Colombo A, Reiner O, Boutros M, Steiner H, Lichtenthaler SF, Haass C (2012)
  Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments
  J Neurosci. 2012 Dec 12;32(50):18204-18214.
• Malnar M, Kosicek M, Lisica A, Posavec M, Krolo A, Njavro J, Omerbasic D, Hecimovic S (2012)
  Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1- deficient cells
  Biochim Biophys Acta. 2012 Apr 19;1822(8):1270-1283. [Epub ahead of print]
• Miller BH, Zeier Z, Xi L, Lanz TA, Deng S, Strathmann J, Willoughby D, Kenny PJ, Elsworth JD, Lawrence MS, Roth RH, Kleiman RJ, Wahlestedt C (2012)
  MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function
  Journal: PNAS February 6, 2012
• Wils H, Kleinberger G, Pereson S, Janssens J, Capell A, Van Dam D, Cuijt I, Joris G, De Deyn PP, Haass C, Van Broeckhoven C, Kumar-Singh S (2012)
  Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice
  J Pathol. 2012 Jun 25. doi: 10.1002/path.4043. [Epub ahead of print]
• Klionsky D, ..., Burbulla LF, et al. (2012)
  Guidelines for the use and interpretation of assays for monitoring autophagy
  Autophagy. 2012 Apr;8(4):445-544.
• Orozco D, Tahirovic S, Rentzsch K, Haass C, Edbauer D (2012)
  Loss of fused in sarcoma (FUS) promotes pathological Tau splicing
  EMBO Rep. 2012 Jun 19. doi: 10.1038/embor.2012.90. [Epub ahead of print]
• Leuner K, Schütt T, Kurz C, Eckert SH, Schiller C, Occhipinti A, Mai S, Jendrach M, Eckert GP, Kruse SE, Palmiter RD, Brandt U, Dröse S, Wittig I, Willem M, Haass C, Reichert AS, Müller WE (2012)
  Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation.
  Antioxid Redox Signal. 2012 Jun 15;16(12):1421-33. Epub 2012 Feb 28.
• Schmidt F, Levin J, Kamp F, Kretzschmar H, Giese A, Bötzel K (2012)
  Single-Channel Electrophysiology Reveals a Distinct and Uniform Pore Complex Formed by α-Synuclein Oligomers in Lipid Membranes
  PLoS One. 2012;7(8):e42545. Epub 2012 Aug 3.
• Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers U, Imhof A, Hoffmeister A, Haass C, Roßner S, Bräse S (2012)
  Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.
  EMBO J. 2012 Jun 22;31(14):3157-68. doi: 10.1038/emboj.2012.173.
• Fleck D, Garratt AN, Haass C, Willem M (2012)
  BACE1 dependent neuregulin processing: review.
  Curr Alzheimer Res. 2012 Feb;9(2):178-83
• Bentmann E, Neumann E, Tahirovic S, Rodde R, Dormann D, Haass C (2012)
  Requirements for Stress Granule Recruitment of Fused in Sarcoma (FUS) and TAR DNA Binding Protein of 43kDa (TDP-43)
  J. Biol. Chem. 2012 May 4. [First Published]
• Högen T, Levin J, Schmidt F, Caruana M, Vassallo N, Kretzschmar H, Bötzel K, Kamp F, Giese A (2012)
  Two Different Binding Modes of α-Synuclein to Lipid Vesicles Depending on its Aggregation State
  Biophys J. 2012 Apr 4;102(7):1646-55. Epub 2012 Apr 3
• Caruana M, Neuner J, Högen T, Schmid F, Kamp F, Scerri C, Giese A, Vassallo N (2012)
  Polyphenolic compounds are novel protective agents against lipid membrane damage by α-synuclein aggregates in vitro
  Biochim Biophys Acta. 2012 May 23;1818(11):2502-2510. [Epub ahead of print]
• Winkler E, Kamp F, Scheuring J, Ebke A, Steiner H (2012)
  Generation of Alzheimer disease-associated Aβ42/43 by γ-secretase can directly be inhibited by modulation of membrane thickness
  J. Biol. Chem. 287, 21326-34.
• Voss M, Kuhn PH, Künzel U, Klier B, Haug-Kröper M, Kremmer E, Lichtenthaler SF, Steiner H, Schröder B, Fluhrer R (2012)
  Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3)
  J Biol Chem. 2012 Dec 21;287(52):43401-9. doi: 10.1074/jbc.M112.371369. Epub 2012 Nov 6.
• Lang S, Benedix J, Fedeles SV, Schorr S, Schirra C, Schäuble N, Jalal C, Greiner M, Haßdenteufel S, Kreutzer B, Edelmann L, Krause E, Rettig J, Somlo S, Zimmermann R, Dudek J (2012)
  Different effects of Sec61α-, Sec62- and Sec63-depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells
  J Cell Sci. 2012 Apr 15;125(Pt 8):1958-69
• Cuartero Y, Mellado M, Capell A, Alvarez-Dolado M, Verges M (2012)
  Retromer regulates postendocytic sorting of ß-secretase in polarized Madin-Darby canine kidney cells
  Traffic. 2012 Jul 3;9999(999A). doi: 10.1111/j.1600-0854.2012.01392.x. [Epub ahead of print]
• Butler EK, Voigt A, Lutz AK, Toegel JP, Gerhardt E, Karsten P, Falkenburger B, Reinartz A, Winklhofer KF, Schulz JB (2012)
  The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity
  PLoS Genet. 2012 Feb;8(2):e1002488
• Ebke A, Luebbers T, Shirotani K, Haass C, Baumann KH, Steiner H (2011)
  Novel γ-secretase modulators directly target presenilin
  J Biol Chem. 2011 Oct 28;286(43):37181-6. Epub 2011 Sep 6.
• Katsouri L, Parr C, Bogdanovic N, Willem M, Sastre M (2011)
  PPARγ Co-Activator-1α (PGC-1α) Reduces Amyloid-β Generation Through a PPARγ-Dependent Mechanism
  J Alzheimers Dis. 2011 Feb 25. [Epub ahead of print]
• Kretner B, Gutsmiedl A, Page RM, Luebbers T, Galley G, Baumann KH, Haass C, Steiner H (2011)
  Attenuated Aβ42 responses to low potency γ-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds
  J Biol Chem. 2011 Apr 29;286(17):15240-51. Epub 2011 Feb 25.
• Resenberger UK, Harmeier A, Woerner AC, Goodman JL, Müller V, Krishnan R, Vabulas RM, Kretzschmar HA, Lindquist S, Hartl FU, Multhaup G, Winklhofer KF (2011)
  The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication
  EMBO J. 2011 May 18;30(10):2057-70. Epub 2011 Mar 25. Comment in: EMBO J (2011) 30, 1882–1884
• Hogl S, Kuhn PH, Colombo A, Lichtenthaler SF (2011)
  Determination of the Proteolytic Cleavage Sites of the Amyloid Precursor-Like Protein 2 by the Proteases ADAM10, BACE1 and γ-Secretase
  PLoS One. 2011;6(6):e21337. Epub 2011 Jun 17.
• Augustin R, Greeff M, Hansen J, Wurst W, Trümbach D (2011)
  Bioinformatics identification of modules of transcription factor binding sites in Alzheimer's disease-related genes by in silico promoter analysis and microarrays
  Int J Alzheimers Dis. 2011 Apr 26;2011:154325.
• Rolyan H, Feike AC, Upadhaya AR, Waha A, Van Dooren T, Haass C, Birkenmeier G, Pietrzik CU, Van Leuven F, Thal DR (2011)
  Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease
  J Neural Transm. 2011 May;118(5):699-712. Epub 2011 Jan 6.
• Fluhrer R, Kamp F, Nuscher B, Steiner H, Beyer K, Haass C (2011)
  The nicastrin ectodomain adopts a highly thermostable structure
  Biol Chem. 2011 Aug 18. [Epub ahead of print]
• Sakthivelu V, Seidel RP, Winklhofer KF (2011)
  Conserved stress-protective activity between prion protein and shadoo
  J Biol Chem. 2011 Mar 18;286(11):8901-8. Epub 2011 Jan 21.
• Capell A, Liebscher S, Fellerer K, Brouwers N, Willem M, Lammich S, Gijselinck I, Bittner T, Carlson AM, Sasse F, Kunze B, Steinmetz H, Jansen R, Dormann D, Sleegers K, Cruts M, Herms J, Van Broeckhoven C, Haass C. (2011)
  Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase
  J Neurosci. 2011 Feb 2;31(5):1885-1894.
• Velanac V, Unterbarnscheidt T, Hinrichs W, Gummert MN, Fischer TM, Rossner MJ, Trimarco A, Brivio V, Willem M, Taveggia C, Haass C, Möbius W, Nave KA, Schwab MH (2011)
  Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination
  Glia. 2011 Nov 2. doi: 10.1002/glia.21255. [Epub ahead of print]
• Lammich S, Kamp F, Wagner J, Nuscher B, Zilow S, Ludwig AK, Willem M, Haass C (2011)
  Translational repression of the Disintegrin and Metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5′-untranslated region
  J Biol Chem. 2011 Dec 30;286(52):45063-72. Epub2011 Nov 7.
• Levin J, Högen T, Hillmer AS, Bader B, Schmidt F, Kamp F, Kretzschmar HA, Bötzel K, Giese A (2011)
  Generation of Ferric Iron Links Oxidative Stress to α-Synuclein Oligomer Formation
  J Park Dis. 2011 Oct 4. [Epub ahead of print]
• Haass C, Hemmer B, Meyer B, Halle M, Förstl H (2011)
  Correspondence (reply): In Reply
  Dtsch Arztebl Int. 2011 Mar;108(9):146. Epub 2011 Mar 4.
• Fluhrer R, Martin L, Haug-Kroeper M, Nuscher B, Haass C (2011)
  The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by Signal Peptide Peptidase-Like 2b (SPPL2b)
  J Biol Chem. 2012 Feb 10;287(7):5156-63. Epub 2011 Dec 22
• Fleck D, Garratt AN, Haass C, Willem M (2011)
  BACE1 Dependent Neuregulin Proteolysis
  Curr Alzheimer Res. 2011 May 23. [Epub ahead of print]
• Dormann D, Haass C (2011)
  TDP-43 and FUS: a nuclear affair
  Trends Neurosci. 2011 Jun 21. [Epub ahead of print]
• Neumann M, Bentmann E, Dormann D, Jawaid A, DeJesus-Hernandez M, Ansorge O, Roeber S, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ang LC, Bilbao J, Rademakers R, Haass C, Mackenzie IRA (2011)
  FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations
  Brain. 2011 Sep;134(Pt 9):2595-609. Epub 2011 Aug 19.
• Mellios N, Sugihara H, Castro J, Banerjee A, Le C, Kumar A, Crawford B, Strathmann J, Tropea D, Levine SS, Sur M (2011)
  miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity
  Nature Neuroscience 2011 Sep 4. [Epub ahead of print]
• Peterziel H, Sackmann T, Strelau J, Kuhn PH, Marom K, Klar A, Unsicker K (2011)
  F-spondin regulates neuronal survival through activation of disabled-1 in the chicken ciliary ganglion
  Mol Cell Neurosci. 2010 Dec 9. [Epub ahead of print]
• Zovoilis A, Agbemenyah HY, Agis-Balboa RC, Stilling RM, Rao P, Farinelli L, Delalle I, Schmitt A, Falkai P, Bahari-Javan S, Burkhardt S, Sananbenesi F, Fischer A (2011)
  microRNA-34c is a novel target to treat dementias
  EMBO J. 2011 Sep 23. doi: 10.1038/emboj.2011.327. [Epub ahead of print]
• Moss ML, Powell G, Miller MA, Bin Q, Sang QX, De Strooper B, Tesseur I, Taverna M, Zhong JL, Dingwall C, Ferdous T, Schlomann U, Zhou P, Griffith L, Lauffenberger D, Petrovich R, Bartsch JW (2011)
  ADAM9 inhibition increases membrane activity of ADAM10 and controls {alpha}secretase processing of amyloid precursor protein
  J Biol Chem. 2011 Sep 28. [Epub ahead of print]
• Ullrich S, Münch A, Neumann S, Kremmer E (2010)
  The Novel Membrane Protein TMEM59 Modulates Complex Glycosylation, Cell Surface Expression and Secretion of the Amyloid Precursor Protein
  J Biol Chem. 2010 Apr 28. [Epub ahead of print]
• Burbulla LF, Schelling C, Kato H, Rapaport D, Woitalla D, Schiesling C, Schulte C, Sharma M, Illig T, Bauer P, Jung S, Nordheim A, Schöls L, Riess O, Krüger R (2010)
  Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis
  Hum Mol Genet. 2010 Nov 15;19(22):4437-52.
• Kuhn PH, Wang H, Dislich B, Colombo A, Zeitschel U, Ellwart JW, Kremmer E, Rossner S (2010)
  ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons
  EMBO J. 2010 Sep 1;29(17):3020-32. Epub 2010 Jul 30.
• de Ayala Alonso AG, Oktaba K, Ly-Hartig N, McGinty RK, Fraterman S, Wilm M, Muir TW, Müller J (2010)
  Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
  Nature. 2010 May 13;465(7295):243-7.
• Höttecke N, Liebeck M, Baumann K, Schubenel R, Winkler E, Steiner H, Schmidt B (2010)
  Inhibition of γ-secretase by the CK1 inhibitor IC261 does not depend on CK1δ
  Bioorg Med Chem Lett. 2010 Mar 4. [Epub ahead of print]
• Chu NK, Olschewski D, Seidel R, Winklhofer KF, Engelhard M, Becker CF (2010)
  Protein immobilization on liposomes and lipid-coated nanoparticles by protein trans-splicing
  J Pept Sci. 2010 Oct;16(10):582-8.
• Krebiehl G, Ruckerbauer S, Burbulla LF, Kieper N, Maurer B, Waak J, Wolburg H, Gizatullina Z, Gellerich FN, Woitalla D, Riess O, Kahle PJ, Proikas-Cezanne T, Krüger R (2010)
  Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1
  PLoS One. 2010 Feb 23;5(2):e9367.
• Haass C, Mandelkow E (2010)
  Fyn-tau-amyloid: a toxic triad
  Cell. 2010 Aug 6;142(3):356-8.
• Irrcher I, Aleyasin H, Seifert EL, Hewitt SJ, Chhabra S, Phillips M, Lutz AK, Rousseaux MW, Bevilacqua L, Jahani-Asl A, Callaghan S, MacLaurin JG, Winklhofer KF, Rizzu P, Rippstein P, Kim RH, Chen CX, Fon EA, Slack RS, Harper ME, McBride HM, Mak TW, Park DS (2010)
  Loss of the Parkinson's Disease-linked gene DJ-1 perturbs mitochondrial dynamics
  Hum Mol Genet. 2010 Oct 1;19(19):3734-46. Epub 2010 Jul 16.
• Bouman L, Schlierf A, Lutz AK, Shan J, Kast J, Galehdar Z, Palmisano V, Patenge N, Berg D, Gasser T, Augustin R, Trümbach D, Irrcher I, Park DS, Wurst W, Kilberg MS, Winklhofer KF (2010)
  Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress
  Cell Death Differ. 2011 May;18(5):769-82. Epub 2010 Nov 26.
• Dislich B, Than ME (2010)
  Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33
  Biochem J. 2010 Dec 15;433(1):75-83.
• Karpuj MV, Gelibter-Niv S, Tiran A, Rambold A, Nunziante M, Schatzl HM (2010)
  Conditional modulation of membrane protein expression in cultured cells mediated by prion protein recognition of short phosphorothioate oligodeoxynucleotides
  J Biol Chem. 2011 Mar 4;286(9):6911-7. Epub 2010 Dec 14.
• Malnar M, Kosicek M, Mitterreiter S, Omerbasic D, Goate A, Hecimovic S (2010)
  Niemann Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface its increased processing through the beta-secretase pathway
  Biochim Biophys Acta. 2010 May 18. [Epub ahead of print]
• Irrcher I, Aleyasin H, Seifert EL, Hewitt SJ, Chhabra S, Phillips M, Lutz AK, Rousseaux MW, Bevilacqua L, Jahani-Asl A, Callaghan S, MacLaurin JG, Winklhofer KF, Rizzu P, Rippstein P, Kim RH, Chen CX, Fon EA, Slack RS, Harper ME, McBride HM, Mak TW, Park DS (2010)
  Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics
  Hum Mol Genet. 2010 Oct 1;19(19):3734-46. Epub 2010 Jul 16.
• Neilson JR, Foster KA, Wang CF, Seeburg DP, Batterton MN, Tada T, Dolan BM, Sharp PA, Sheng M (2010)
  Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132
  Neuron. 2010 Feb 11;65(3):373-84.
• Paquet D, Schmid B, Haass C (2010)
  Transgenic Zebrafish as a Novel Animal Model to Study Tauopathies and Other Neurodegenerative Disorders in vivo
  Neurodegener Dis. 2010 Feb 18;7(1-3):99-102. [Epub ahead of print]
• van Bebber F, Paquet D, Hruscha A, Schmid B, Haass C (2010)
  Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in Zebrafish
  Neurobiol Dis. 2010 Sep;39(3):265-71. Epub 2010 Apr 8.
• Fuhrmann M, Bittner T, Jung CK, Burgold S, Page RM, Mitteregger G, Haass C, LaFerla FM, Kretzschmar H, Herms J (2010)
  Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease
  Nat Neurosci. 2010 Apr;13(4):411-3. Epub 2010 Mar 21.
• Page RM, Gutsmiedl A, Haass C, Steiner H (2010)
  β-Amyloid precursor protein mutants respond to γ-secretase modulators
  J Biol Chem. 2010 Jun 4;285(23):17798-810. Epub 2010 Mar 26.
• Lammich S, Buell D, Zilow S, Ludwig AK, Nuscher B, Prinzen C, Fahrenholz F, Haass C (2010)
  Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region
  J Biol Chem. 2010 Mar 26. [Epub ahead of print]
• Foster KA, McLaughlin N, Phillips M, Bolton A, Constantine-Paton M, Sheng M (2010)
  Distinct roles of NR2A and NR2B cytoplasmic tails in long-term potentiation
  J Neurosci. 2010 Feb 17;30(7):2676-85.
• Mitterreiter S, Page RM, Kamp F, Hopson J, Ha HR, Hamid R, Herms J, Mayer TU, Nelson DJ, Steiner H, Stahl T, Zeitschel U, Roßner S, Haass C (2010)
  Bepridil and Amiodarone Simultaneously Target the Alzheimer’s Disease β- and γ-Secretase via Distinct Mechanisms
  J. Neurosci. 2010 Apr 20. [Epub ahead of print]
• Fluhrer R, Steiner H, Haass C (2010)
  Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of γ-secretase-mediated intramembrane proteolysis
  J. Neurosci. 2010 Apr 20. [Epub ahead of print]
• Dettmer U, Kuhn PH, Krueger M, Kremmer E, Haass C, Haffner C (2010)
  The transmembrane protein 147 (TMEM147) is a novel component of the nicalin-nomo protein complex
  J Biol Chem. 2010 Jun 10. [Epub ahead of print]
• Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IR, Capell A, Schmid B, Neumann M, Haass C (2010)
  ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
  EMBO J. 2010 Aug 18;29(16):2841-57. Epub 2010 Jul 6.
• Schumacher MC, Resenberger U, Seidel RP, Becker CF, Winklhofer KF, Oesterhelt D, Engelhard M (2010)
  Synthesis of a GPI anchor module suitable for protein post-translational modification
  Biopolymers. 2010;94(4):457-64.
• Fluhrer R, Steiner H, Haass C (2010)
  Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of γ-secretase-mediated intramembrane proteolysis
  J Neurosci. 2010 Jun 9;30(23):7853-62.
• Bartels T, Ahlstrom LS, Leftin A, Kamp F, Haass C, Brown MF, Beyer K (2010)
  The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding
  Biophys J. 2010 Oct 6;99(7):2116-24.
• Kamp F, Exner N, Lutz AK, Wender N, Hegermann J, Brunner B, Nuscher B, Bartels T, Giese A, Beyer K, Eimer S, Winklhofer KF, Haass C (2010)
  Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1
  EMBO J. 2010 Oct 20;29(20):3571-89. Epub 2010 Sep 14.
• Fett ME, Pilsl A, Paquet D, van Bebber F, Haass C, Schmid B, Winklhofer KF (2010)
  Parkin is protective against proteotoxic stress in a transgenic zebrafish model
  PLoS One. 2010 Jul 30;5(7):e11783.
• Winklhofer KF, Haass C (2009)
  Mitochondrial dysfunction in Parkinson's disease
  Biochim Biophys Acta. 2010 Jan;1802(1):29-44. Epub 2009 Sep 3.
• Lutz AK, Exner N, Schlehe JS, Kloos K, Laemmermann K, Brunner B, Kurz-Drexler A, Vogel F, Reichert AS, Bouman L, Vogt-Weisenhorn D, Wurst W, Haass C, Winklhofer KF (2009)
  Loss of parkin or PINK1 function increases DRP1-dependent mitochondrial fragmentation
  J Biol Chem. 2009 Aug 21;284(34):22938-51. Epub 2009 Jun 22.
• Spires-Jones TL, Mielke ML, Rozkalne A, Meyer-Luehmann M, de Calignon A, Bacskai BJ, Schenk D, Hyman BT (2009)
  Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease
  Neurobiol Dis. 2009 Feb;33(2):213-20. Epub 2008 Nov 6.
• Paquet D, Bhat R, Sydow A, Mandelkow EM, Berg S, Hellberg S, Fälting J, Distel M, Köster RW, Schmid B, Haass C (2009)
  A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation
  J Clin Invest. 2009 May;119(5):1382-95. doi: 10.1172/JCI37537. Epub 2009 Apr 13.
• Itoh N, Okochi M, Tagami S, Nishitomi K, Nakayama T, Yanagida K, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, Takemoto H, Minagawa K, Katoh T, Willem M, Haass C, Morihara T, Tanaka T, Kudo T, Hasegawa H, Nishimura M, Sakaguchi G, Kato A, Takeda M (2009)
  Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor
  Neurodegener Dis. 2009;6(5-6):230-9. Epub 2009 Sep 9.
• Pérez-Revuelta BI, Lammich S, Yamasaki A, Haass C, Steiner H (2009)
  Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage
  J Neurochem. 2010 Feb;112(4):940-50. Epub 2009 Dec 15.
• Haass C (2009)
  Alzheimer - Mechanismen und therapeutische Ansätze. Warum wir im Alter dement werden
  Biologie in unserer Zeit, Vol. 39, Iss. 2, Pg. 92-100
• Meyer-Luehmann M, Mielke M, Spires-Jones TL, Stoothoff W, Jones P, Bacskai BJ, Hyman BT (2009)
  A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice
  J Neurosci. 2009 Oct 7;29(40):12636-40.
• Leuchtenberger S, Maler J, Czirr E, Ness J, Esselmann H, Pietrzik CU, Wiltfang J, Weggen S (2009)
  Nonsteroidal anti-inflammatory drugs and ectodomain shedding of the amyloid precursor protein
  Neurodegener Dis. 2009;6(1-2):1-8. Epub 2008 Mar 18.
• Gannagé M, Albrecht R, Dengjel J, Torossi T, Rämer PC, Lee M, Strowig T, Arrey F, Conenello G, Pypaert M, Andersen J, García-Sastre A, Münz C (2009)
  Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes
  Cell Host Microbe. 2009 Oct 22;6(4):367-80.
• Fournier M, Vitte J, Garrigue J, Langui D, Dullin JP, Saurini F, Hanoun N, Perez-Diaz F, Cornilleau F, Joubert C, Ardila-Osorio H, Traver S, Duchateau R, Goujet-Zalc C, Paleologou K, Lashuel HA, Haass C, Duyckaerts C, Cohen-Salmon C, Kahle PJ, Hamon M, Brice A, Corti O (2009)
  Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy
  PLoS One. 2009 Aug 14;4(8):e6629.
• Bittner T, Fuhrmann M, Burgold S, Jung CK, Volbracht C, Steiner H, Mitteregger G, Kretzschmar HA, Haass C, Herms J (2009)
  γ-Secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway
  J Neurosci. 2009 Aug 19;29(33):10405-9.
• Paquet D, Haass C (2009)
  Alzheimerforschung in transgenen Zebrafischen
  BioSpektrum Special: Bio-Imaging
• (2009)
  The Prion Protein: Friend and Foe
  Curr Issues Mol Biol. 2009 Sep 18;12(2):49-50. [Epub ahead of print]
• Miesbauer M, Rambold AS, Winklhofer KF (2009)
  Targeting of the Prion Protein to the Cytosol: Mechanisms and Consequences
  Curr Issues Mol Biol. 2009 Sep 18;12(2):109-118. [Epub ahead of print]
• Schaefer K, Brosamle C (2009)
  Zwilling-A and -B, two related myelin proteins of teleosts, which originate from a single, bicistronic transcript
  Mol Biol Evol
• Brösamle C (2009)
  The myelin proteolipid DMalpha in fishes
  Neuron Glia Biol. 2009 Jun 10:1-4.
• Fassler M, Zocher M, Klare S, de la Fuente AG, Scheuermann J, Capell A, Haass C, Valkova C, Veerappan A, Schneider D, Kaether C (2009)
  Masking of Transmembrane-Based Retention Signals Controls ER Export of gamma-Secretase
  Traffic. 2010 Feb;11(2):250-8. Epub 2009 Nov 5.
• Koffie RM, Hashimoto T, Adams KW, Mielke ML, Garcia-Alloza M, Micheva KD, Smith SJ, Kim ML, Lee VM, Hyman BT, Spires-Jones TL (2009)
  Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
  Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):4012-7. Epub 2009 Feb 19.
• Miesbauer M, Pfeiffer NV, Rambold AS, Müller V, Kiachopoulos S, Winklhofer KF (2009)
  Alpha-helical domains promote translocation of intrinsically disordered polypeptides into the endoplasmic reticulum
  J Biol Chem. 2009 Sep 4;284(36):24384-93. Epub 2009 Jun 26.
• Dormann D, Capell A, Carlson AM, Shankaran SS, Rodde R, Neumann M, Kremmer E, Matsuwaki T, Yamanouchi K, Nishihara M, Haass C (2009)
  Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin
  J Neurochem. 2009 Aug;110(3):1082-94. Epub 2009 Jun 9.
• Willem M, Lammich S, Haass C (2009)
  Function, regulation and therapeutic properties of beta-secretase (BACE1)
  Semin Cell Dev Biol. 2009 Apr;20(2):175-82. Epub 2009 Jan 20.
• Hobson S, Dümpelfeld B, Luebbers T, Baumann K, Haass C, Hopf C, Steiner H (2009)
  Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human γ-secretase
  Biochemistry 2009 Jan 21.
• Cheng D, Batterton MN, Wang CF, Duong DM, Yaffe MB, Peng J, Sheng M (2009)
  Identification and characterization of neuronal mitogen-activated protein kinase substrates using a specific phosphomotif antibody
  Mol Cell Proteomics. 2009 Apr;8(4):681-95. Epub 2008 Dec 3.
• Münz C (2008)
  Localization and MHC class II presentation of antigens targeted for macroautophagy
  Methods Mol Biol. 2008;445:213-25.
• Brosamle C, Halpern ME (2008)
  Nogo-Nogo receptor signalling in PNS axon outgrowth and pathfinding
  Mol Cell Neurosci
• Martin L, Fluhrer R, Reiss K, Kremmer E, Saftig P, Haass C (2008)
  Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b
  J Biol Chem 283(3): 1644-52
• Dejaegere T, Serneels L, Schafer MK, Van Biervliet J, Horre K, Depboylu C, Alvarez-Fischer D, Herreman A, Willem M, Haass C, Hoglinger GU, D'Hooge R, De Strooper B (2008)
  Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment
  Proc Natl Acad Sci U S A 105(28): 9775-80
• Rambold AS, Miesbauer M, Olschewski D, Seidel R, Riemer C, Smale L, Brumm L, Levy M, Gazit E, Oesterhelt D, Baier M, Becker CF, Engelhard M, Winklhofer KF (2008)
  Green tea extracts interfere with the stress-protective activity of PrP and the formation of PrP
  J Neurochem 107(1): 218-29
• Martin L, Fluhrer R, Haass C (2008)
  Substrate requirements for SPPL2b dependent regulated intramembrane proteolysis
  J Biol Chem
• Page RM, Baumann K, Tomioka M, Perez-Revuelta BI, Jacobsen H, Flohr A, Luebbers T, Ozmen L, Steiner H, Haass C (2008)
  Generation of Aβ38 and Aβ42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and γ-secretase modulation
  J Biol Chem 283(2): 677-83
• Schlehe JS, Lutz AK, Pilsl A, Lammermann K, Grgur K, Henn IH, Winklhofer KF (2008)
  Aberrant folding of pathogenic Parkin mutants: aggregation versus degradation
  J Biol Chem 283(20): 13771-9
• St George-Hyslop P, Haass C (2008)
  Regulatory RNA goes awry in Alzheimer's disease
  Nat Med 14(7): 711-2
• Shankaran SS, Capell A, Hruscha AT, Fellerer K, Neumann M, Schmid B, Haass C (2008)
  Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion
  J Biol Chem 283(3): 1744-53
• Fluhrer R, Martin L, Grammer G, Haug-Kroper M, Klier B, Winkler E, Kremmer E, Condron MM, Teplow DB, Steiner H, Haass C (2008)
  Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation
  J Biol Chem 283(44): 30121-8
• Spires-Jones TL, Prada C, Garcia-Alloza M, de Calignon A, Rozkalne A, Koenigsknecht-Talboo J, Holtzman DM, Bacskai BJ, Hyman BT (2008)
  Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease
  Nature. 2008 Feb 7;451(7179):720-4.
• O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Hebert SS, De Strooper B, Haass C, Bennett DA, Vassar R (2008)
  Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis
  Neuron 60(6): 988-1009
• Koenigsknecht-Talboo J, Meyer-Luehmann M, Parsadanian M, Garcia-Alloza M, Finn MB, Hyman BT, Bacskai BJ, Holtzman DM (2008)
  Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice
  J Neurosci. 2008 Dec 24;28(52):14156-64.
• Heiseke A, Schöbel S, Vorberg I, Groschup MH, Kretzschmar H, Schätzl HM, Nunziante M (2008)
  The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding
  Traffic. 2008 Jul;9(7):1116-29. Epub 2008 Apr 18.
• Steiner H, Winkler E, Haass C (2008)
  Chemical cross-linking provides a model of the γ-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1
  J Biol Chem 283(50): 34677-86
• Simard JR, Kamp F, Hamilton JA (2008)
  Measuring the adsorption of Fatty acids to phospholipid vesicles by multiple fluorescence probes
  Biophys J. 2008 Jun;94(11):4493-503. Epub 2008 Feb 22.
• Chiesa C, Osborn JF, Haass C, Natale F, Spinelli M, Scapillati E, Spinelli A, Pacifico L (2008)
  Ghrelin, leptin, IGF-1, IGFBP-3, and insulin concentrations at birth: is there a relationship with fetal growth and neonatal anthropometry?
  Clin Chem 54(3): 550-8
• Busche MA, Eichhoff G, Adelsberger H, Abramowski D, Wiederhold KH, Haass C, Staufenbiel M, Konnerth A, Garaschuk O (2008)
  Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease
  Science 321(5896): 1686-9
• Schobel S, Neumann S, Hertweck M, Dislich B, Kuhn PH, Kremmer E, Seed B, Baumeister R, Haass C (2008)
  A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein
  J Biol Chem 283(21): 14257-68
• Tamguney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Rubinstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz J, Epstein CJ, Cruz TD, Kuziel WA, Maeda N, Sap J, Ashe KH, Carlson GA, Tesseur I, Wyss-Coray T, Mucke L, Weisgraber KH, Mahley RW, Cohen FE, Prusiner SB (2008)
  Genes contributing to prion pathogenesis
  J Gen Virol 89(Pt 7): 1777-88
• Wegmann S, Miesbauer M, Winklhofer KF, Muller DJ (2008)
  Observing fibrillar assemblies on scrapie-infected cells
  Pflugers Arch 456(1): 83-93
• Rambold AS, Muller V, Ron U, Ben-Tal N, Winklhofer KF (2008)
  Stress-protective signalling of prion protein is corrupted by scrapie prions
  EMBO J 27(14): 1974-84
• Jones PB, Rozkalne A, Meyer-Luehmann M, Spires-Jones TL, Makarova A, Kumar AT, Berezovska O, Bacskai BB, Hyman BT (2008)
  Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy
  J Biomed Opt. 2008 Jan-Feb;13(1):014008.
• Thal DR, Larionov S, Abramowski D, Wiederhold KH, Van Dooren T, Yamaguchi H, Haass C, Van Leuven F, Staufenbiel M, Capetillo-Zarate E (2007)
  Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice
  Neurobiol Aging 28(8): 1221-30
• Lünemann JD, Schmidt J, Barthel K, Wrede A, Dalakas MC, Münz C (2007)
  Beta-amyloid is a substrate of autophagy in sporadic inclusion body myositis
  Ann Neurol. 2007 May;61(5):476-83.
• Tada T, Simonetta A, Batterton M, Kinoshita M, Sheng M (2007)
  Role of Septin cytoskeleton in spine morphogenesis and dendrite development in neurons
  Curr Biol. 2007 Oct 23;17(20):1752-8. Epub 2007 Oct 11.
• Bolmont T, Clavaguera F, Herzig MC, Radde R, Staufenbiel M, Lewis J, Hutton M, Tolnay M, Jucker M (2007)
  Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice
  Am J Pathol. 2007 Dec;171(6):2012-20. Epub 2007 Nov 30.
• Spires-Jones TL, Osetek JD, Jones PB, Stern EA, Bacskai BJ, Hyman BT (2007)
  Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model
  Am J Pathol. 2007 Oct;171(4):1304-11. Epub 2007 Aug 23.
• Münz C (2007)
  Immune surveillance via self digestion
  Autophagy. 2007 Mar-Apr;3(2):133-5. Epub 2007 Apr 9.
• Pypaert M, Münz C (2007)
  Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes
  Immunity. 2007 Jan;26(1):79-92. Epub 2006 Dec 21.
• Hamid R, Kilger E, Willem M, Vassallo N, Kostka M, Bornhovd C, Reichert AS, Kretzschmar HA, Haass C, Herms J (2007)
  Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content
  J Neurochem 102(4): 1264-75
• Kuhn PH, Marjaux E, Imhof A, De Strooper B, Haass C (2007)
  Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase
  J Biol Chem 282(16): 11982-95
• Freichel C, Neumann M, Ballard T, Muller V, Woolley M, Ozmen L, Borroni E, Kretzschmar HA, Haass C, Spooren W, Kahle PJ (2007)
  Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice
  Neurobiol Aging 28(9): 1421-35
• Exner N, Treske B, Paquet D, Holmstrom K, Schiesling C, Gispert S, Carballo-Carbajal I, Berg D, Hoepken HH, Gasser T, Kruger R, Winklhofer KF, Vogel F, Reichert AS, Auburger G, Kahle PJ, Schmid B, Haass C (2007)
  Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin
  J Neurosci 27(45): 12413-8
• Henn IH, Bouman L, Schlehe JS, Schramm JE, Wegener E, Nakaso K, Culmsee C, Berninger B, Krappmann D, Winklhofer KF (2007)
  Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling
  J Neurosci 27(8): 1868-78
• Olschewski D, Seidel R, Miesbauer M, Rambold AS, Oesterhelt D, Winklhofer KF, Engelhard M, Becker CF (2007)
  Semisynthetic murine prion protein equipped with a GPI anchor mimic incorporates into cellular membranes
  Chem Biol 14(9): 994-1006
• Barazza A, Gotz M, Cadamuro SA, Goettig P, Willem M, Steuber H, Kohler T, Jestel A, Reinemer P, Renner C, Bode W, Moroder L (2007)
  Macrocyclic statine-based inhibitors of BACE-1
  Chembiochem 8(17): 2078-91
• Steiner H (2007)
  Sheddases and intramembrane-cleaving proteases: RIPpers of the membrane. Symposium on regulated intramembrane proteolysis
  EMBO Rep 8(6): 537-41
• Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, Steiner H, Haass C, Wolfe MS (2007)
  Active γ-secretase complexes contain only one of each component
  J Biol Chem 282(47): 33985-93
• Prager K, Wang-Eckhardt L, Fluhrer R, Killick R, Barth E, Hampel H, Haass C, Walter J (2007)
  A structural switch of presenilin 1 by glycogen synthase kinase 3beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling
  J Biol Chem 282(19): 14083-93
• Narlawar R, Perez Revuelta BI, Baumann K, Schubenel R, Haass C, Steiner H, Schmidt B (2007)
  N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated γ-secretase
  Bioorg Med Chem Lett 17(1): 176-82
• Gorner K, Holtorf E, Waak J, Pham TT, Vogt-Weisenhorn DM, Wurst W, Haass C, Kahle PJ (2007)
  Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1
  J Biol Chem 282(18): 13680-91
• Kaether C, Scheuermann J, Fassler M, Zilow S, Shirotani K, Valkova C, Novak B, Kacmar S, Steiner H, Haass C (2007)
  Endoplasmic reticulum retention of the γ-secretase complex component Pen2 by Rer1
  EMBO Rep 8(8): 743-8
• Haffner C, Dettmer U, Weiler T, Haass C (2007)
  The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex
  J Biol Chem 282(14): 10632-8
• Shirotani K, Tomioka M, Kremmer E, Haass C, Steiner H (2007)
  Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different γ-secretase complexes
  Neurobiol Dis 27(1): 102-7
• Schiffer NW, Broadley SA, Hirschberger T, Tavan P, Kretzschmar HA, Giese A, Haass C, Hartl FU, Schmid B (2007)
  Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model
  J Biol Chem 282(12): 9195-203
• Bohm C, Seibel NM, Henkel B, Steiner H, Haass C, Hampe W (2006)
  SorLA signaling by regulated intramembrane proteolysis
  J Biol Chem 281(21): 14547-53
• Hirschberger T, Stork M, Schropp B, Winklhofer KF, Tavan P (2006)
  Structural instability of the prion protein upon M205S/R mutations revealed by molecular dynamics simulations
  Biophys J 90(11): 3908-18
• Miesbauer M, Bamme T, Riemer C, Oidtmann B, Winklhofer KF, Baier M (2006)
  Prion protein-related proteins from zebrafish are complex glycosylated and contain a glycosylphosphatidylinositol anchor
  Biochem Biophys Res Commun 341(1): 218-24
• Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M (2006)
  Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct
  Biochemistry 45(15): 4907-14
• Anders L, Mertins P, Lammich S, Murgia M, Hartmann D, Saftig P, Haass C, Ullrich A (2006)
  Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity
  Mol Cell Biol 26(10): 3917-34
• Kaether C, Schmitt S, Willem M, Haass C (2006)
  Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface
  Traffic 7(4): 408-15
• Narlawar R, Perez Revuelta BI, Haass C, Steiner H, Schmidt B, Baumann K (2006)
  Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer γ-secretase modulators
  J Med Chem 49(26): 7588-91
• Goldsbury C, Mocanu MM, Thies E, Kaether C, Haass C, Keller P, Biernat J, Mandelkow E, Mandelkow EM (2006)
  Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides
  Traffic 7(7): 873-88
• Schöbel S, Neumann S, Seed B (2006)
  Expression cloning screen for modifiers of amyloid precursor protein shedding
  Int J Dev Neurosci. 2006 Apr-May;24(2-3):141-8. Epub 2006 Jan 30.
• Fluhrer R, Grammer G, Israel L, Condron MM, Haffner C, Friedmann E, Bohland C, Imhof A, Martoglio B, Teplow DB, Haass C (2006)
  A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b
  Nat Cell Biol 8(8): 894-6
• Capetillo-Zarate E, Staufenbiel M, Abramowski D, Haass C, Escher A, Stadelmann C, Yamaguchi H, Wiestler OD, Thal DR (2006)
  Selective vulnerability of different types of commissural neurons for amyloid beta-protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology
  Brain 129(Pt 11): 2992-3005
• Naus S, Reipschläger S, Wildeboer D, Mitterreiter S, Guan Z, Moss ML, Bartsch JW (2006)
  Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8
  Biol Chem. 2006 Mar;387(3):337-46.
• Avila J, Nitsch RM, Haass C, De Strooper B (2006)
  European Alzheimer disease funding
  Nat Med 12(7): 776-7
• Kamp F, Hamilton JA (2006)
  How fatty acids of different chain length enter and leave cells by free diffusion
  Prostaglandins Leukot Essent Fatty Acids. 2006 Sep;75(3):149-59. Epub 2006 Jul 7.
• Kamp F, Beyer K (2006)
  Binding of alpha-synuclein affects the lipid packing in bilayers of small vesicles
  J Biol Chem. 2006 Apr 7;281(14):9251-9. Epub 2006 Feb 1.
• Wild-Bode C, Fellerer K, Kugler J, Haass C, Capell A (2006)
  A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration
  J Biol Chem 281(33): 23824-9
• Rambold AS, Miesbauer M, Rapaport D, Bartke T, Baier M, Winklhofer KF (2006)
  Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP
  Mol Biol Cell 17(8): 3356-68
• Winklhofer KF (2006)
  [Inactivation of parkin in Parkinson disease]
  Pharm Unserer Zeit 35(3): 186-7
• Guo C, Willem M, Raivich G, Emerson M, Neyses L, Mayer U (2006)
  Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy
  Human Molecular Genetics 15(6): 989-998
• meyer-luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret JM, Paganetti P, Walsh DM, Mathews PM, Ghiso J, Staufenbiel M, Walker LC, Jucker M (2006)
  Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host
  Science. 2006 Sep 22;313(5794):1781-4.
• Garcia-Alloza M, Dodwell SA, Meyer-Luehmann M, Hyman BT, Bacskai BJ (2006)
  Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model
  J Neuropathol Exp Neurol. 2006 Nov;65(11):1082-9.
• Schöbel S, Neumann S, Seed B (2006)
  Expression cloning screen for modifiers of amyloid precursor protein shedding
  Int J Dev Neurosci. 2006 Apr-May;24(2-3):141-8. Epub 2006 Jan 30.
• von Arnim CA, Spoelgen R, Peltan ID, Deng M, Courchesne S, Koker M, Matsui T, Kowa H, Irizarry MC, Hyman BT (2006)
  GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing
  J Neurosci. 2006 Sep 27;26(39):9913-22.
• Friedmann E, Hauben E, Maylandt K, Schleeger S, Vreugde S, Kuhn PH, Stauffer D, Rovelli G, Martoglio B (2006)
  SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production
  Nat Cell Biol. 2006 Aug;8(8):843-8. Epub 2006 Jul 9.
• Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H (2006)
  The GxGD motif of presenilin contributes to catalytic function and substrate identification of γ-secretase
  J Neurosci 26(14): 3821-8
• Steiner H, Than M, Bode W, Haass C (2006)
  Pore-forming scissors? A first structural glimpse of γ-secretase
  Trends Biochem Sci 31(9): 491-3
• Radde R, Bolmont T, Kaeser SA, Coomaraswamy J, Lindau D, Stoltze L, Calhoun ME, Jaggi F, Wolburg H, Gengler S, Haass C, Ghetti B, Czech C, Holscher C, Mathews PM, Jucker M (2006)
  Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
  EMBO Rep 7(9): 940-6
• Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, DeStrooper B, Saftig P, Birchmeier C, Haass C (2006)
  Control of peripheral nerve myelination by the beta-secretase BACE1
  Science 314(5799): 664-6
• Neumann S, Schobel S, Jager S, Trautwein A, Haass C, Pietrzik CU (2006)
  Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein
  J Biol Chem 281(11): 7583-94
• Okochi M, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M (2006)
  Secretion of the Notch-1 Aβ-like peptide during Notch signaling
  J Biol Chem 281(12): 7890-8
• Wingert RA, Galloway JL, Barut B, Foott H, Fraenkel P, Axe JL, Weber GJ, Dooley K, Davidson AJ, Paw BH, Shaw GC, Kingsley P, Palis J, Schubert H, Chen O, Kaplan J, Zon LI (2005)
  Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis
  Nature 436(7053): 1035-39
• Paludan C, Landthaler M, Vockerodt M, Kube D, Tuschl T, Münz C (2005)
  Endogenous MHC class II processing of a viral nuclear antigen after autophagy
  Science. 2005 Jan 28;307(5709):593-6. Epub 2004 Dec 9.
• Prokop S, Haass C, Steiner H (2005)
  Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments
  J Neurochem 94(1): 57-62
• Uelhoff A, Aguzzi A, Winklhofer KF, Haass C (2005)
  A pathogenic PrP mutation and doppel interfere with polarized sorting of the prion protein
  J Biol Chem 280(7): 5137-40
• Thal DR, Capetillo-Zarate E, Schultz C, Rub U, Saido TC, Yamaguchi H, Haass C, Griffin WS, Del Tredici K, Braak H, Ghebremedhin E (2005)
  Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner
  Acta Neuropathol 110(5): 459-71
• Straub T, Neumann MF, Prestel M, Kremmer E, Kaether C, Haass C, Becker PB (2005)
  Stable chromosomal association of MSL2 defines a dosage-compensated nuclear compartment
  Chromosoma 114(5): 352-64
• Stefanova N, Reindl M, Neumann M, Haass C, Poewe W, Kahle PJ, Wenning GK (2005)
  Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy
  Am J Pathol 166(3): 869-76
• Syková E, Vorísek I, Antonova T, Mazel T, Meyer-Luehmann M, Jucker M, Hájek M, Ort M, Bures J (2005)
  Changes in extracellular space size and geometry in APP23 transgenic mice: a model of Alzheimer's disease
  Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):479-84. Epub 2005 Jan 3.
• Krawitz P, Haffner C, Fluhrer R, Steiner H, Schmid B, Haass C (2005)
  Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3
  J Biol Chem 280(47): 39515-23
• Giese A, Bader B, Bieschke J, Schaffar G, Odoy S, Kahle PJ, Haass C, Kretzschmar H (2005)
  Single particle detection and characterization of synuclein co-aggregation
  Biochem Biophys Res Commun 333(4): 1202-10
• Capell A, Beher D, Prokop S, Steiner H, Kaether C, Shearman MS, Haass C (2005)
  γ-Secretase complex assembly within the early secretory pathway
  J Biol Chem 280(8): 6471-8
• Dumpitak C, Beekes M, Weinmann N, Metzger S, Winklhofer KF, Riesner D (2005)
  The polysaccharide scaffold of PrP 27-30 is a common compound of natural prions and consists of alpha-linked polyglucose
  Biol Chem 386(11): 1149-55
• Bertsch U, Winklhofer KF, Hirschberger T, Bieschke J, Weber P, Hartl FU, Tavan P, Kretzschmar HA, Giese A (2005)
  Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets
  J Virol 79(12): 7785-91
• Barazza A, Renner C, Willem M, Moroder L (2005)
  Cyclic phenylstatine-based tetrapeptides as inhibitors of beta-secretase
  Biopolymers 80(4): 554-554
• Yamamoto A, Friedlein A, Imai Y, Takahashi R, Kahle PJ, Haass C (2005)
  Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity
  J Biol Chem 280(5): 3390-9
• Wahle T, Prager K, Raffler N, Haass C, Famulok M, Walter J (2005)
  GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network
  Mol Cell Neurosci 29(3): 453-61
• Gamse JT, Kuan YS, Macurak M, Brosamle C, Thisse B, Thisse C, Halpern ME (2005)
  Directional asymmetry of the zebrafish epithalamus guides dorsoventral innervation of the midbrain target
  Development 132(21): 4869-81
• Spires TL, Meyer-Luehmann M, Stern EA, McLean PJ, Skoch J, Nguyen PT, Bacskai BJ, Hyman BT (2005)
  Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy
  J Neurosci. 2005 Aug 3;25(31):7278-87.
• Halfter W, Willem M, Mayer U (2005)
  Basement membrane-dependent survival of retinal ganglion cells
  Invest Ophthalmol Vis Sci 46(3): 1000-9
• Henn IH, Gostner JM, Lackner P, Winklhofer KF (2005)
  Pathogenic mutations inactivate parkin by distinct mechanisms
  J Neurochem 92(1): 114-22
• Andersson CX, Fernandez-Rodriguez J, Laos S, Baeckstrom D, Haass C, Hansson GC (2005)
  Shedding and gamma-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43
  Biochem J 387(Pt 2): 377-84
• Yamazaki S, Münz C (2005)
  Autophagy links innate with adaptive immunity
  Cell Tech. 2005, May; 24(6): 577-580
• Kiachopoulos S, Bracher A, Winklhofer KF (2005)
  Pathogenic mutations located in the hydrophobic core of the prion protein interfere with folding and attachment of the glycosylphosphatidylinositol anchor
  J Biol Chem 280(10): 9320-9
• Ferlazzo G, Pack M, Thomas D, Paludan C, Strowig T, Bougras G, Muller WA, Moretta L, Münz C (2004)
  Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs
  Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16606-11. Epub 2004 Nov 9.
• Edbauer D, Kaether C, Steiner H, Haass C (2004)
  Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1
  J Biol Chem 279(36): 37311-5
• Peters N, Opherk C, Zacherle S, Capell A, Gempel P, Dichgans M (2004)
  CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk
  Exp Cell Res. 2004 Oct 1;299(2):454-64.
• Neumann M, Muller V, Gorner K, Kretzschmar HA, Haass C, Kahle PJ (2004)
  Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease
  Acta Neuropathol 107(6): 489-96
• Holscher C, Meilinger T, Vrachliotis G, Brosamle M, Knauff M (2004)
  Finding the way inside: Linking architectural design analysis and cognitive processes
  Spatial Cognition Iv, Reasoning, Action, Interaction 3343: 1-23
• Leffers KW, Schell J, Jansen K, Lucassen R, Kaimann T, Nagel-Steger L, Riesner D (2004)
  The structural transition of the prion protein into its pathogenic conformation is induced by unmasking hydrophobic sites
  J Mol Biol 344(3): 839-53
• Haffner C, Frauli M, Topp S, Irmler M, Hofmann K, Regula JT, Bally-Cuif L, Haass C (2004)
  Nicalin and its binding partner Nomo are novel Nodal signaling antagonists
  EMBO J 23(15): 3041-50
• Gorner K, Holtorf E, Odoy S, Nuscher B, Yamamoto A, Regula JT, Beyer K, Haass C, Kahle PJ (2004)
  Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1
  J Biol Chem 279(8): 6943-51
• Fluhrer R, Friedlein A, Haass C, Walter J (2004)
  Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis
  J Biol Chem 279(3): 1585-93
• Westmeyer GG, Willem M, Lurman G, Multhaup G, Assfalg-Machleidt I, Reiss K, Saftig P, Haass C (2004)
  Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme
  J Biol Chem 279(51): 53205-12
• Heske J, Heller U, Winklhofer KF (2004)
  The C-terminal globular domain of the prion protein is necessary and sufficient for import into the endoplasmic reticulum
  J Biol Chem 279(7): 5435-43
• Kiachopoulos S, Heske J, Winklhofer KF (2004)
  Misfolding of the prion protein at the plasma membrane induces endocytosis, intracellular retention and degradation
  Traffic 5(6): 426-36
• Shirotani K, Edbauer D, Kostka M, Steiner H, Haass C (2004)
  Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1
  J Neurochem 89(6): 1520-7
• Nuscher B, Kamp F, Mehnert T, Odoy S, Haass C, Kahle PJ, Beyer K (2004)
  Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study
  J Biol Chem 279(21): 21966-75
• Mueggler T, Rausch M, Staufenbiel M, Jucker M, Rudin M (2004)
  Restricted diffusion in the brain of transgenic mice with cerebral amyloidosis
  Eur J Neurosci. 2004 Aug;20(3):811-7.
• Neumann M, Muller V, Kretzschmar HA, Haass C, Kahle PJ (2004)
  Regional distribution of proteinase K-resistant alpha-synuclein correlates with Lewy body disease stage
  J Neuropathol Exp Neurol 63(12): 1225-35
• Shirotani K, Edbauer D, Prokop S, Haass C, Steiner H (2004)
  Identification of distinct γ-secretase complexes with different APH-1 variants
  J Biol Chem 279(40): 41340-5
• Lammich S, Schobel S, Zimmer AK, Haass C (2004)
  Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region
  EMBO Rep 5(6): 620-5
• Keil U, Bonert A, Marques CA, Scherping I, Weyermann J, Strosznajder JB, Muller-Spahn F, Haass C, Czech C, Pradier L, Muller WE, Eckert A (2004)
  Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis
  J Biol Chem 279(48): 50310-20
• Kaether C, Capell A, Edbauer D, Winkler E, Novak B, Steiner H, Haass C (2004)
  The presenilin C-terminus is required for ER-retention, nicastrin-binding and γ-secretase activity
  EMBO J 23(24): 4738-48
• Willem M, Dewachter I, Smyth N, Van Dooren T, Borghgraef P, Haass C, Van Leuven F (2004)
  beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice
  Am J Pathol 165(5): 1621-31
• Prokop S, Shirotani K, Edbauer D, Haass C, Steiner H (2004)
  Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the γ-secretase complex
  J Biol Chem 279(22): 23255-61
• Schmechel A, Strauss M, Schlicksupp A, Pipkorn R, Haass C, Bayer TA, Multhaup G (2004)
  Human BACE forms dimers and colocalizes with APP
  J Biol Chem 279(38): 39710-7
• Nawrotzki R, Willem M, Miosge N, Brinkmeier H, Mayer U (2003)
  Defective integrin switch and matrix composition at alpha 7-deficient myotendinous junctions precede the onset of muscular dystrophy in mice
  Hum Mol Genet 12(5): 483-95
• Ehehalt R, Keller P, Haass C, Thiele C, Simons K (2003)
  Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts
  J Cell Biol 160(1): 113-23
• Fluhrer R, Multhaup G, Schlicksupp A, Okochi M, Takeda M, Lammich S, Willem M, Westmeyer G, Bode W, Walter J, Haass C (2003)
  Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation
  J Biol Chem 278(8): 5531-8
• Winklhofer KF, Heller U, Reintjes A (2003)
  Inhibition of complex glycosylation increases the formation of PrPsc
  Traffic 4(5): 313-22
• Capell A, Kaether C, Edbauer D, Shirotani K, Merkl S, Steiner H, Haass C (2003)
  Nicastrin interacts with γ-secretase complex components via the N-terminal part of its transmembrane domain
  J Biol Chem 278(52): 52519-23
• Brychzy A, Rein T, Winklhofer KF, Hartl FU, Young JC, Obermann WM (2003)
  Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system
  EMBO J 22(14): 3613-23
• Shirotani K, Edbauer D, Capell A, Schmitz J, Steiner H, Haass C (2003)
  γ-Secretase activity is associated with a conformational change of nicastrin
  J Biol Chem 278(19): 16474-7
• Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo EH, Haass C, Takio K, Morishima-Kawashima M, Ishiura S, Ihara Y (2003)
  Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein
  J Biol Chem 278(27): 24294-301
• Marques CA, Keil U, Bonert A, Steiner B, Haass C, Muller WE, Eckert A (2003)
  Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway
  J Biol Chem 278(30): 28294-302
• Dominguez DI, Westmeyer GG, Reiss K, Haass C, Saftig P, De Strooper B, Seed B (2003)
  The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1
  J Biol Chem 278(49): 48713-9
• Kamp F, Kizilbash N, Corkey BE, Berggren PO, Hamilton JA (2003)
  Sulfonylureas rapidly cross phospholipid bilayer membranes by a free-diffusion mechanism
  Diabetes. 2003 Oct;52(10):2526-31.
• Kamp F, Guo W, Souto R, Pilch PF, Corkey BE, Hamilton JA (2003)
  Rapid flip-flop of oleic acid across the plasma membrane of adipocytes
  J Biol Chem. 2003 Mar 7;278(10):7988-95. Epub 2002 Dec 23.
• Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C (2003)
  Reconstitution of γ-secretase activity
  Nat Cell Biol 5(5): 486-8
• Winklhofer KF, Heske J, Heller U, Reintjes A, Muranyi W, Moarefi I (2003)
  Determinants of the in vivo folding of the prion protein. A bipartite function of helix 1 in folding and aggregation
  J Biol Chem 278(17): 14961-70
• Heller U, Winklhofer KF, Heske J, Reintjes A (2003)
  Post-translational import of the prion protein into the endoplasmic reticulum interferes with cell viability: a critical role for the putative transmembrane domain
  J Biol Chem 278(38): 36139-47
• Oertle T, van der Haar ME, Bandtlow CE, Robeva A, Burfeind P, Buss A, Huber AB, Simonen M, Schnell L, Brosamle C, Kaupmann K, Vallon R, Schwab ME (2003)
  Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions
  J Neurosci 23(13): 5393-406
• Winklhofer KF, Henn IH, Kay-Jackson PC, Heller U (2003)
  Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones
  J Biol Chem 278(47): 47199-208
• Porter JD, Merriam AP, Khanna S, Andrade FH, Richmonds CR, Leahy P, Cheng G, Karathanasis P, Zhou X, Kusner LL, Adams ME, Willem M, Mayer U, Kaminski HJ (2003)
  Constitutive properties, not molecular adaptations, mediate extraocular muscle sparing in dystrophic mdx mice
  FASEB J 17(8): 893-5
• Stalder M, Herzig MC, Kaeser SA, Kohler E, Pfeifer M, Boncristiano S, Mathews PM, Mercken M, Abramowski D, Staufenbiel M, Jucker M (2003)
  Extracellular amyloid formation and associated pathology in neural grafts
  Nat Neurosci. 2003 Apr;6(4):370-7.
• Kramer C, Mayr T, Nowak M, Schumacher J, Runke G, Bauer H, Wagner DS, Imai Y, Talbot WS, Mullins MC, Hammerschmidt M (2002)
  Maternally supplied Smad5 is required for ventral specification in zebrafish embryos prior to zygotic Bmp signaling
  Dev Biol 250(2): 263-79
• Geling A, Steiner H, Willem M, Bally-Cuif L, Haass C (2002)
  A γ-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish
  EMBO Rep 3(7): 688-94
• Halfter W, Dong S, Yip YP, Willem M, Mayer U (2002)
  A critical function of the pial basement membrane in cortical histogenesis
  J Neurosci 22(14): 6029-40
• Meyer-Luehmann M, Thompson JF, Berridge KC, Aldridge JW (2002)
  Substantia nigra pars reticulata neurons code initiation of a serial pattern: implications for natural action sequences and sequential disorders
  Eur J Neurosci. 2002 Oct;16(8):1599-608.
• Brosamle C, Halpern ME (2002)
  Characterization of myelination in the developing zebrafish
  Glia 39(1): 47-57
• Capell A, Meyn L, Fluhrer R, Teplow DB, Walter J, Haass C (2002)
  Apical sorting of beta-secretase limits amyloid beta-peptide production
  J Biol Chem 277(7): 5637-43
• Huber AB, Weinmann O, Brosamle C, Oertle T, Schwab ME (2002)
  Patterns of Nogo mRNA and protein expression in the developing and adult rat and after CNS lesions
  J Neurosci 22(9): 3553-67
• Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Muller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C (2002)
  Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies
  J Clin Invest 110(10): 1429-39
• Porter JD, Merriam AP, Khanna S, Kaminski HJ, Richmonds CR, Leahy P, Cheng G, Zhou X, Kushner LL, Andrade FH, Karathanasis P, Adams ME, Willem M, Mayer U (2002)
  Constitutive properties, not cellular/molecular adaptations, mediate extraocular muscle sparing in MDX mice
  Journal of the Neurological Sciences 199: S47-S47
• Willem M, Miosge N, Halfter W, Smyth N, Jannetti I, Burghart E, Timpl R, Mayer U (2002)
  Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development
  Development 129(11): 2711-22
• Leutz S, Steiner B, Marques CA, Haass C, Muller WE, Eckert A (2002)
  Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death
  J Mol Neurosci 18(3): 189-201
• Willot V, Mathieu J, Lu Y, Sidi S, Yan YL, Postlethwait JH, Mullins M, Rosa F, Peyrieras N (2002)
  Cooperative action of ADMP- and BMP-mediated pathways in regulating cell fates in the zebrafish gastrula
  Dev Biol 241(1): 59-78
• Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C (2002)
  Presenilin-1 affects trafficking and processing of βAPP and is targeted in a complex with nicastrin to the plasma membrane
  J Cell Biol 158(3): 551-61
• Haass C (2002)
  New hope for Alzheimer disease vaccine
  Nat Med 8(11): 1195-6
• Thal DR, Ghebremedhin E, Haass C, Schultz C (2002)
  UV light-induced autofluorescence of full-length Abeta-protein deposits in the human brain
  Clin Neuropathol 21(1): 35-40
• Fluhrer R, Capell A, Westmeyer G, Willem M, Hartung B, Condron MM, Teplow DB, Haass C, Walter J (2002)
  A non-amyloidogenic function of BACE-2 in the secretory pathway
  J Neurochem 81(5): 1011-20
• Edbauer D, Winkler E, Haass C, Steiner H (2002)
  Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation
  Proc Natl Acad Sci U S A 99(13): 8666-71
• Edbauer D, Willem M, Lammich S, Steiner H, Haass C (2002)
  Insulin-degrading enzyme rapidly removes the β-amyloid precursor protein intracellular domain (AICD)
  J Biol Chem 277(16): 13389-93
• Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, Capell A, Kaether C, Zheng H, Ghetti B, Haass C, Steiner H (2002)
  Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ 42 production
  Proc Natl Acad Sci U S A 99(12): 8025-30
• Steiner H, Winkler E, Edbauer D, Prokop S, Basset G, Yamasaki A, Kostka M, Haass C (2002)
  PEN-2 is an integral component of the γ-secretase complex required for coordinated expression of presenilin and nicastrin
  J Biol Chem 277(42): 39062-5
• Okochi M, Steiner H, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C (2002)
  Presenilins mediate a dual intramembranous γ-secretase cleavage of Notch-1
  EMBO J 21(20): 5408-16
• Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Spooren W, Fuss B, Mallon B, Macklin WB, Fujiwara H, Hasegawa M, Iwatsubo T, Kretzschmar HA, Haass C (2002)
  Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes
  EMBO Rep 3(6): 583-8
• Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, Edbauer D, Walter J, Steiner H, Haass C (2002)
  Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Aβ-like peptide
  J Biol Chem 277(47): 44754-9
• Barbero P, Zulley S, Buell E, Pfeffer SR (2001)
  TIP47 is not a component of lipid droplets
  J Biol Chem. 2001 Jun 29;276(26):24348-51. Epub 2001 Apr 19.
• Yamazaki T, Chang TY, Haass C, Ihara Y (2001)
  Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells
  J Biol Chem 276(6): 4454-60
• Haass C, Steiner H (2001)
  Protofibrils, the unifying toxic molecule of neurodegenerative disorders?
  Nat Neurosci 4(9): 859-60
• Winklhofer KF, Reintjes A, Hoener MC, Voellmy R (2001)
  Geldanamycin restores a defective heat shock response in vivo
  J Biol Chem 276(48): 45160-7
• Walter J, Fluhrer R, Hartung B, Willem M, Kaether C, Capell A, Lammich S, Multhaup G, Haass C (2001)
  Phosphorylation regulates intracellular trafficking of beta-secretase
  J Biol Chem 276(18): 14634-41
• Steiner H, Winkler E, Shearman MS, Prywes R, Haass C (2001)
  Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins
  Neurobiol Dis 8(4): 717-22
• Steiner H, Revesz T, Neumann M, Romig H, Grim MG, Pesold B, Kretzschmar HA, Hardy J, Holton JL, Baumeister R, Houlden H, Haass C (2001)
  A pathogenic presenilin-1 deletion causes abberrant Aβ 42 production in the absence of congophilic amyloid plaques
  J Biol Chem 276(10): 7233-9
• Sastre M, Steiner H, Fuchs K, Capell A, Multhaup G, Condron MM, Teplow DB, Haass C (2001)
  Presenilin-dependent γ-secretase processing of β-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch
  EMBO Rep 2(9): 835-41
• Rathke-Hartlieb S, Kahle PJ, Neumann M, Ozmen L, Haid S, Okochi M, Haass C, Schulz JB (2001)
  Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice
  J Neurochem 77(4): 1181-4
• Kahle PJ, Neumann M, Ozmen L, Muller V, Odoy S, Okamoto N, Jacobsen H, Iwatsubo T, Trojanowski JQ, Takahashi H, Wakabayashi K, Bogdanovic N, Riederer P, Kretzschmar HA, Haass C (2001)
  Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model
  Am J Pathol 159(6): 2215-25
• Kahle PJ, Haass C (2001)
  The emerging utility of animal models of chronic neurodegenerative diseases
  Expert Opin Ther Targets 5(1): 125-32
• Winklhofer KF, Hartl FU (2001)
  A sensitive filter retention assay for the detection of PrP(Sc) and the screening of anti-prion compounds
  FEBS Lett 503(1): 41-5
• Haass C, Kahle PJ (2001)
  Neuroscience. Parkin and its substrates
  Science 293(5528): 224-5
• Eckert A, Steiner B, Marques C, Leutz S, Romig H, Haass C, Muller WE (2001)
  Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation
  J Neurosci Res 64(2): 183-92
• Gilch S, Winklhofer KF, Groschup MH, Nunziante M, Lucassen R, Spielhaupter C, Muranyi W, Riesner D, Schatzl HM (2001)
  Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease
  EMBO J 20(15): 3957-66
• Kojro E, Gimpl G, Lammich S, Marz W, Fahrenholz F (2001)
  Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10
  Proc Natl Acad Sci U S A. 2001 May 8;98(10):5815-20. Epub 2001 Apr 17.
• Meins M, Piosik P, Schaeren-Wiemers N, Franzoni S, Troncoso E, Kiss JZ, Brosamle C, Schwab ME, Molnar Z, Monard D (2001)
  Progressive neuronal and motor dysfunction in mice overexpressing the serine protease inhibitor protease nexin-1 in postmitotic neurons
  J Neurosci 21(22): 8830-41
• Flugel A, Berkowicz T, Ritter T, Labeur M, Jenne DE, Li Z, Ellwart JW, Willem M, Lassmann H, Wekerle H (2001)
  Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis
  Immunity 14(5): 547-60
• Hamilton JA, Johnson RA, Corkey B, Kamp F (2001)
  Fatty acid transport: the diffusion mechanism in model and biological membranes
  J Mol Neurosci. 2001 Apr-Jun;16(2-3):99-108; discussion 151-7.
• Fouad K, Pedersen V, Schwab ME, Brosamle C (2001)
  Cervical sprouting of corticospinal fibers after thoracic spinal cord injury accompanies shifts in evoked motor responses
  Curr Biol 11(22): 1766-70
• Yu G, Chen F, Nishimura M, Steiner H, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Holmes E, Zhang DM, Milman P, Fraser PE, Haass C, George-Hyslop PS (2000)
  Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes
  J Biol Chem 275(35): 27348-53
• Kelsh RN, Eisen JS (2000)
  Genetic analysis of melanophore development in zebrafish embryos
  Dev Biol 225(2): 277-93
• Flugel A, Schwaiger FW, Neumann H, Medana I, Willem M, Wekerle H, Kreutzberg GW, Graeber MB (2000)
  Neuronal FasL induces cell death of encephalitogenic T lymphocytes
  Brain Pathol 10(3): 353-64
• Huber AB, Ehrengruber MU, Schwab ME, Brosamle C (2000)
  Adenoviral gene transfer to the injured spinal cord of the adult rat
  Eur J Neurosci 12(9): 3437-42
• Werner A, Willem M, Jones LL, Kreutzberg GW, Mayer U, Raivich G (2000)
  Impaired axonal regeneration in alpha7 integrin-deficient mice
  J Neurosci 20(5): 1822-30
• Furthauer M, Connors SA, Trout J, Thisse B, Thisse C, Mullins MC (2000)
  Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation
  Development 127(5): 957-67
• Fahrenholz F, Gilbert S, Kojro E, Lammich S, Postina R (2000)
  Alpha-secretase activity of the disintegrin metalloprotease ADAM 10. Influences of domain structure
  Ann N Y Acad Sci. 2000;920:215-22.
• Capell A, Steiner H, Romig H, Keck S, Baader M, Grim MG, Baumeister R, Haass C (2000)
  Presenilin-1 differentially facilitates endoproteolysis of the β-amyloid precursor protein and Notch
  Nat Cell Biol 2(4): 205-11
• Okochi M, Eimer S, Bottcher A, Baumeister R, Romig H, Walter J, Capell A, Steiner H, Haass C (2000)
  A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases Aβ42 generation in human cells
  J Biol Chem 275(52): 40925-32
• Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Schindzielorz A, Okochi M, Leimer U, van Der Putten H, Probst A, Kremmer E, Kretzschmar HA, Haass C (2000)
  Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain
  J Neurosci 20(17): 6365-73
• Capell A, Steiner H, Willem M, Kaiser H, Meyer C, Walter J, Lammich S, Multhaup G, Haass C (2000)
  Maturation and pro-peptide cleavage of β-secretase
  J Biol Chem 275(40): 30849-54
• Brosamle C, Schwab ME (2000)
  Ipsilateral, ventral corticospinal tract of the adult rat: ultrastructure, myelination and synaptic connections
  J Neurocytol 29(7): 499-507
• Winklhofer KF (2000)
  Cationic lipopolyamines induce degradation of PrPSc in scrapie-infected mouse neuroblastoma cells
  Biol Chem 381(5-6): 463-9
• Winklhofer KF, Albrecht I, Wegner M, Heilbronn R (2000)
  Human cytomegalovirus immediate-early gene 2 expression leads to JCV replication in nonpermissive cells via transcriptional activation of JCV T antigen
  Virology 275(2): 323-34
• Brosamle C, Huber AB, Fiedler M, Skerra A, Schwab ME (2000)
  Regeneration of lesioned corticospinal tract fibers in the adult rat induced by a recombinant, humanized IN-1 antibody fragment
  J Neurosci 20(21): 8061-8
• Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle PJ, Haass C (2000)
  Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein
  J Biol Chem 275(1): 390-7
• Wirths O, Weickert S, Majtenyi K, Havas L, Kahle PJ, Okochi M, Haass C, Multhaup G, Beyreuther K, Bayer TA (2000)
  Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques
  Neuroreport 11(17): 3737-41
• Walter J, Schindzielorz A, Hartung B, Haass C (2000)
  Phosphorylation of the beta-amyloid precursor protein at the cell surface by ectocasein kinases 1 and 2
  J Biol Chem 275(31): 23523-9
• Steiner H, Kostka M, Romig H, Basset G, Pesold B, Hardy J, Capell A, Meyn L, Grim ML, Baumeister R, Fechteler K, Haass C (2000)
  Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases
  Nat Cell Biol 2(11): 848-51
• Hayashi H, Mizuno T, Michikawa M, Haass C, Yanagisawa K (2000)
  Amyloid precursor protein in unique cholesterol-rich microdomains different from caveolae-like domains
  Biochim Biophys Acta 1483(1): 81-90
• Mathews PM, Cataldo AM, Kao BH, Rudnicki AG, Qin X, Yang JL, Jiang Y, Picciano M, Hulette C, Lippa CF, Bird TD, Nochlin D, Walter J, Haass C, Levesque L, Fraser PE, Andreadis A, Nixon RA (2000)
  Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease
  Mol Med 6(10): 878-91
• Kulic L, Walter J, Multhaup G, Teplow DB, Baumeister R, Romig H, Capell A, Steiner H, Haass C (2000)
  Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch
  Proc Natl Acad Sci U S A 97(11): 5913-8
• Yu G, Chen F, Nishimura M, Steiner H, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Holmes E, Zhang DM, Milman P, Fraser P, Haass C, St George-Hyslop P (2000)
  Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes
  Acta Neurol Scand Suppl 176: 6-11
• Haass C, Kahle PJ (2000)
  Parkinson's pathology in a fly
  Nature 404(6776): 341, 343
• Steiner H, Romig H, Pesold B, Philipp U, Baader M, Citron M, Loetscher H, Jacobsen H, Haass C (1999)
  Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis
  Biochemistry 38(44): 14600-5
• Steiner H, Romig H, Grim MG, Philipp U, Pesold B, Citron M, Baumeister R, Haass C (1999)
  The biological and pathological function of the presenilin-1 Δexon 9 mutation is independent of its defect to undergo proteolytic processing
  J Biol Chem 274(12): 7615-8
• Sandmann-Keil D, Braak H, Okochi M, Haass C, Braak E (1999)
  Alpha-synuclein immunoreactive Lewy bodies and Lewy neurites in Parkinson's disease are detectable by an advanced silver-staining technique
  Acta Neuropathol 98(5): 461-4
• Mizuno T, Nakata M, Naiki H, Michikawa M, Wang R, Haass C, Yanagisawa K (1999)
  Cholesterol-dependent generation of a seeding amyloid beta-protein in cell culture
  J Biol Chem 274(21): 15110-4
• Walter J, Schindzielorz A, Grunberg J, Haass C (1999)
  Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis
  Proc Natl Acad Sci U S A 96(4): 1391-6
• Lammich S, Kojro E, Postina R, Gilbert S, Pfeiffer R, Jasionowski M, Haass C, Fahrenholz F (1999)
  Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease
  Proc Natl Acad Sci U S A 96(7): 3922-7
• Haass C, Mandelkow E (1999)
  Proteolysis by presenilins and the renaissance of tau
  Trends Cell Biol 9(6): 241-4
• Haass C (1999)
  Apoptosis. Dead end for neurodegeneration?
  Nature 399(6733): 204-5, 207
• Haass C (1999)
  Biology of Alzheimer's disease
  Eur Arch Psychiatry Clin Neurosci 249(6): 265
• Guenette SY, Chen J, Ferland A, Haass C, Capell A, Tanzi RE (1999)
  hFE65L influences amyloid precursor protein maturation and secretion
  J Neurochem 73(3): 985-93
• Thal DR, Sassin I, Schultz C, Haass C, Braak E, Braak H (1999)
  Fleecy amyloid deposits in the internal layers of the human entorhinal cortex are comprised of N-terminal truncated fragments of Abeta
  J Neuropathol Exp Neurol 58(2): 210-6
• Groth DF, Torchia M, Prusiner SB, DeArmond SJ (1999)
  Kinetics of prion protein accumulation in the CNS of mice with experimental scrapie
  J Neuropathol Exp Neurol 58(12): 1244-9
• Huber AB, Brosamle C, Mechler H, Huber G (1999)
  Metalloprotease MP100: a synaptic protease in rat brain
  Brain Res 837(1-2): 193-202
• Steiner H, Pesold B, Haass C (1999)
  An in vivo assay for the identification of target proteases which cleave membrane-associated substrates
  FEBS Lett 463(3): 245-9
• Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, Tomita T, Iwatsubo T, Baumeister R, Haass C (1999)
  A loss of function mutation of presenilin-2 interferes with amyloid β-peptide production and notch signaling
  J Biol Chem 274(40): 28669-73
• Hamilton JA, Kamp F (1999)
  How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids?
  Diabetes. 1999 Dec;48(12):2255-69.
• Leimer U, Lun K, Romig H, Walter J, Grunberg J, Brand M, Haass C (1999)
  Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis
  Biochemistry 38(41): 13602-9
• Flugel A, Willem M, Berkowicz T, Wekerle H (1999)
  Gene transfer into CD4+ T lymphocytes: green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses
  Nat Med 5(7): 843-7
• Diehlmann A, Ida N, Weggen S, Grunberg J, Haass C, Masters CL, Bayer TA, Beyreuther K (1999)
  Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies
  J Neurosci Res 56(4): 405-19
• Miosge N, Klenczar C, Herken R, Willem M, Mayer U (1999)
  Organization of the myotendinous junction is dependent on the presence of alpha7beta1 integrin
  Lab Invest 79(12): 1591-9
• Capell A, Grunberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C (1998)
  The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex
  J Biol Chem 273(6): 3205-11
• Nguyen VH, Trout J, Connors SA, Ekker M, Mullins MC (1998)
  Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genes
  Dev Biol 199(1): 93-110
• Kamp F, Donoso P, Hidalgo C (1998)
  Changes in luminal pH caused by calcium release in sarcoplasmic reticulum vesicles
  Biophys J. 1998 Jan;74(1):290-6.
• Brosamle C, Schwab ME (1998)
  Detailed anatomy and ultrastructure of IN-1 facilitated regenerated corticospinal nerve fibers in the rat spinal cord.
  European Journal of Neuroscience 10: 61-61
• Steiner H, Capell A, Pesold B, Citron M, Kloetzel PM, Selkoe DJ, Romig H, Mendla K, Haass C (1998)
  Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation
  J Biol Chem 273(48): 32322-31
• Haass C, Selkoe DJ (1998)
  Alzheimer's disease. A technical KO of amyloid-beta peptide
  Nature 391(6665): 339-40
• Walter J, Grunberg J, Schindzielorz A, Haass C (1998)
  Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms
  Biochemistry 37(17): 5961-7
• von Meyenburg J, Brosamle C, Metz GA, Schwab ME (1998)
  Regeneration and sprouting of chronically injured corticospinal tract fibers in adult rats promoted by NT-3 and the mAb IN-1, which neutralizes myelin-associated neurite growth inhibitors
  Exp Neurol 154(2): 583-94
• Grunberg J, Walter J, Eckman C, Capell A, Schindzielorz A, Younkin S, Mehta N, Hardy J, Haass C (1998)
  Truncated presenilin 2 derived from differentially spliced mRNA does not affect the ratio of amyloid beta-peptide 1-42/1-40
  Neuroreport 9(14): 3293-9
• Grunberg J, Walter J, Loetscher H, Deuschle U, Jacobsen H, Haass C (1998)
  Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family
  Biochemistry 37(8): 2263-70
• Brockhaus M, Grunberg J, Rohrig S, Loetscher H, Wittenburg N, Baumeister R, Jacobsen H, Haass C (1998)
  Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling
  Neuroreport 9(7): 1481-6
• Brosamle C (1998)
  The making, changing, and breaking of contacts
  Trends Neurosci 21(3): 91-4
• Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grunberg J, Ueyama Y, Haass C, Ihara Y (1998)
  Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain
  J Neurochem 71(1): 313-22
• Mizuno T, Haass C, Michikawa M, Yanagisawa K (1998)
  Cholesterol-dependent generation of a unique amyloid beta-protein from apically missorted amyloid precursor protein in MDCK cells
  Biochim Biophys Acta 1373(1): 119-30
• Schatzl HM, Laszlo L, Holtzman DM, DeArmond SJ, Weiner RI, Mobley WC, Prusiner SB (1997)
  A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis
  J Virol 71(11): 8821-31
• Baumeister R, Leimer U, Zweckbronner I, Jakubek C, Grunberg J, Haass C (1997)
  Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing
  Genes Funct 1(2): 149-59
• Walter J, Grunberg J, Capell A, Pesold B, Schindzielorz A, Citron M, Mendla K, George-Hyslop PS, Multhaup G, Selkoe DJ, Haass C (1997)
  Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C
  Proc Natl Acad Sci U S A 94(10): 5349-54
• Yamazaki T, Haass C, Saido TC, Omura S, Ihara Y (1997)
  Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition
  Biochemistry 36(27): 8377-83
• Xia W, Zhang J, Kholodenko D, Citron M, Podlisny MB, Teplow DB, Haass C, Seubert P, Koo EH, Selkoe DJ (1997)
  Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins
  J Biol Chem 272(12): 7977-82
• Wild-Bode C, Yamazaki T, Capell A, Leimer U, Steiner H, Ihara Y, Haass C (1997)
  Intracellular generation and accumulation of amyloid β-peptide terminating at amino acid 42
  J Biol Chem 272(26): 16085-8
• Loetscher H, Deuschle U, Brockhaus M, Reinhardt D, Nelboeck P, Mous J, Grunberg J, Haass C, Jacobsen H (1997)
  Presenilins are processed by caspase-type proteases
  J Biol Chem 272(33): 20655-9
• Walter J, Capell A, Hung AY, Langen H, Schnolzer M, Thinakaran G, Sisodia SS, Selkoe DJ, Haass C (1997)
  Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations
  J Biol Chem 272(3): 1896-903
• Capell A, Saffrich R, Olivo JC, Meyn L, Walter J, Grunberg J, Mathews P, Nixon R, Dotti C, Haass C (1997)
  Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation
  J Neurochem 69(6): 2432-40
• Brosamle C, Schwab ME (1997)
  Cells of origin, course, and termination patterns of the ventral, uncrossed component of the mature rat corticospinal tract
  J Comp Neurol 386(2): 293-303
• Blochberger TC, Cooper C, Peretz D, Griffith OH, Baldwin MA, Prusiner SB (1997)
  Prion protein expression in Chinese hamster ovary cells using a glutamine synthetase selection and amplification system
  Protein Eng 10(12): 1465-73
• Scott MR, Groth D, Torchia M, Tremblay P, DeArmond SJ, Prusiner SB (1997)
  Propagation of prion strains through specific conformers of the prion protein
  J Virol 71(12): 9032-44
• Tomita T, Maruyama K, Saido TC, Kume H, Shinozaki K, Tokuhiro S, Capell A, Walter J, Grunberg J, Haass C, Iwatsubo T, Obata K (1997)
  The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue
  Proc Natl Acad Sci U S A 94(5): 2025-30
• Herzog A, Brosamle C (1997)
  'Semifree-floating' treatment: a simple and fast method to process consecutive sections for immunohistochemistry and neuronal tracing
  J Neurosci Methods 72(1): 57-63
• Kim SH, Kim YK, Jeong SJ, Haass C, Kim YH, Suh YH (1997)
  Enhanced release of secreted form of Alzheimer's amyloid precursor protein from PC12 cells by nicotine
  Mol Pharmacol 52(3): 430-6
• Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ (1997)
  Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue
  Neurobiol Dis 3(4): 325-37
• Walter J, Capell A, Grunberg J, Pesold B, Schindzielorz A, Prior R, Podlisny MB, Fraser P, Hyslop PS, Selkoe DJ, Haass C (1996)
  The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum
  Mol Med 2(6): 673-91
• Citron M, Diehl TS, Capell A, Haass C, Teplow DB, Selkoe DJ (1996)
  Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF
  Neuron 17(1): 171-9
• Bergmann A, Stein D, Geisler R, Hagenmaier S, Fernandez N, Schnell B, Nusslein-Volhard C (1996)
  A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila
  Mech Dev 60(1): 109-23
• Court DA, Nargang FE, Steiner H, Hodges RS, Neupert W, Lill R (1996)
  Role of the intermembrane-space domain of the preprotein receptor Tom22 in protein import into mitochondria
  Mol Cell Biol 16(8): 4035-42
• Brosamle C, Kuffler DP (1996)
  Rapid dispersal of clustered postsynaptic nuclei following dissociation of skeletal muscle fibers
  J Exp Biol 199(Pt 11): 2359-67
• Steiner H, Kispal G, Zollner A, Haid A, Neupert W, Lill R (1996)
  Heme binding to a conserved Cys-Pro-Val motif is crucial for the catalytic function of mitochondrial heme lyases
  J Biol Chem 271(51): 32605-11
• Prusiner SB, Welch WJ (1996)
  Chemical chaperones interfere with the formation of scrapie prion protein
  EMBO J 15(23): 6363-73
• Capell A, Teplow DB, Citron M, Selkoe DJ, Haass C (1996)
  Substitution of phenylalanine by proline at position 19 of amyloid-ß peptide results in the inhibition of protein kinase C mediated decrease of amyloidogenic processing
  Amyloid 3; 150-155
• Kamp F, Zhang F, Hamilton JA. (1996)
  Dissociation of long and very long chain fatty acids from phospholipid bilayers
  Biochemistry. 1996 Dec 17;35(50):16055-60.
• Maeda N, Pekny M, Yang SL, Betsholtz C, Eliasson C, Cayetano J, Camerino AP, DeArmond SJ, Prusiner SB (1996)
  Scrapie in mice deficient in apolipoprotein E or glial fibrillary acidic protein
  Neurology 47(2): 449-53
• Qiu WQ, Borth W, Ye Z, Haass C, Teplow DB, Selkoe DJ (1996)
  Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex
  J Biol Chem 271(14): 8443-51
• Kispal G, Steiner H, Court DA, Rolinski B, Lill R (1996)
  Mitochondrial and cytosolic branched-chain amino acid transaminases from yeast, homologs of the myc oncogene-regulated Eca39 protein
  J Biol Chem 271(40): 24458-64
• Brosamle C, Schwab ME (1996)
  Axonal regeneration in the mammalian CNS
  Seminars in the Neurosciences 8(2): 107-113
• Steiner H, Zollner A, Haid A, Neupert W, Lill R (1995)
  Biogenesis of mitochondrial heme lyases in yeast. Import and folding in the intermembrane space
  J Biol Chem 270(39): 22842-9
• Haass C, Koo EH, Capell A, Teplow DB, Selkoe DJ (1995)
  Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals
  J Cell Biol 128(4): 537-47
• Munger JS, Haass C, Lemere CA, Shi GP, Wong WS, Teplow DB, Selkoe DJ, Chapman HA (1995)
  Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S
  Biochem J 311 ( Pt 1): 299-305
• Wieland J, Nitsche AM, Strayle J, Steiner H, Rudolph HK (1995)
  The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane
  EMBO J 14(16): 3870-82
• Kamp F, Zakim D, Zhang F, Noy N, Hamilton JA (1995)
  Fatty acid flip-flop in phospholipid bilayers is extremely fast
  Biochemistry. 1995 Sep 19;34(37):11928-37.
• Zuo J, Voellmy R, Scott M, Hartl U, Prusiner SB, Welch WJ (1995)
  Scrapie prions selectively modify the stress response in neuroblastoma cells
  Proc Natl Acad Sci U S A 92(7): 2944-8
• Haass C, Capell A, Citron M, Teplow DB, Selkoe DJ (1995)
  The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein
  J Biol Chem 270(11): 6186-92
• Lemere CA, Munger JS, Shi GP, Natkin L, Haass C, Chapman HA, Selkoe DJ (1995)
  The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study
  Am J Pathol 146(4): 848-60
• Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ (1995)
  ß-Secretase cleavage of ß-Amyloid precursor protein with the Swedish mutation occurs within the secretory pathway after the trans-Golgi network
  Nat. Med. 1; 1291-6
• Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ (1995)
  The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway
  Nat Med 1(12): 1291-6
• Haass C, Koo EH, Teplow DB, Selkoe DJ (1994)
  Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells
  Proc Natl Acad Sci U S A 91(4): 1564-8
• Haass C, Hung AY, Selkoe DJ, Teplow DB (1994)
  Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor
  J Biol Chem 269(26): 17741-8
• Juretić D, Hendler RW, Kamp F, Caughey WS, Zasloff M, Westerhoff HV (1994)
  Magainin oligomers reversibly dissipate delta microH+ in cytochrome oxidase liposomes
  Biochemistry. 1994 Apr 19;33(15):4562-70.
• Lo AC, Haass C, Wagner SL, Teplow DB, Sisodia SS (1994)
  Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells
  J Biol Chem 269(49): 30966-73
• Skatchkov S, Brosamle C, Vyklicky L, Kuffler DP, Orkand RK (1994)
  NMDA receptors on adult frog spinal motoneurons in culture
  Neurosci Lett 176(2): 251-4
• Hamilton JA, Civelek VN, Kamp F, Tornheim K, Corkey BE (1994)
  Changes in internal pH caused by movement of fatty acids into and out of clonal pancreatic beta-cells (HIT)
  J Biol Chem. 1994 Aug 19;269(33):20852-6.
• Kamp F, Hamilton JA, Westerhoff HV (1993)
  Movement of fatty acids, fatty acid analogues, and bile acids across phospholipid bilayers
  Biochemistry. 1993 Oct 19;32(41):11074-86.
• Haass C, Hung AY, Schlossmacher MG, Oltersdorf T, Teplow DB, Selkoe DJ (1993)
  Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules
  Ann N Y Acad Sci 695: 109-16
• Fechteler K, Langenbach P, Doerfler W (1993)
  Fractionated nuclear extracts from hamster cells catalyze cell-free recombination at selective sequences between adenovirus DNA and a hamster preinsertion site
  Proc Natl Acad Sci U S A 90(15): 7356-60
• Hung AY, Haass C, Nitsch RM, Qiu WQ, Citron M, Wurtman RJ, Growdon JH, Selkoe DJ (1993)
  Activation of protein kinase C inhibits cellular production of the amyloid beta-protein
  J Biol Chem 268(31): 22959-62
• Haass C, Hung AY, Schlossmacher MG, Teplow DB, Selkoe DJ (1993)
  beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms
  J Biol Chem 268(5): 3021-4
• Citron M, Haass C, Selkoe DJ (1993)
  Production of amyloid-beta-peptide by cultured cells: no evidence for internal initiation of translation at Met596
  Neurobiol Aging 14(6): 571-3
• Kamp F, Hamilton JA. (1992)
  pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acids
  Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11367-70.
• Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB, et al. (1992)
  Amyloid beta-peptide is produced by cultured cells during normal metabolism
  Nature 359(6393): 322-5
• Schlossmacher MG, Ostaszewski BL, Hecker LI, Celi A, Haass C, Chin D, Lieberburg I, Furie BC, Furie B, Selkoe DJ (1992)
  Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes
  Neurobiol Aging 13(3): 421-34
• Scholz B, Fechteler K, Jessberger R, Doerfler W (1992)
  Recombination between adenovirus type 12 DNA and a hamster preinsertion sequence in a cell-free system. Patch homologies and fractionation of nuclear extracts
  J Mol Biol 226(1): 117-26
• Hung AY, Koo EH, Haass C, Selkoe DJ (1992)
  Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage
  Proc Natl Acad Sci U S A 89(20): 9439-43
• Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ (1992)
  Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments
  Nature 357(6378): 500-3
• Frentzel S, Troxell M, Haass C, Pesold-Hurt B, Glatzer KH, Kloetzel PM (1992)
  Molecular characterization of the genomic regions of the Drosophila alpha-type subunit proteasome genes PROS-Dm28.1 and PROS-Dm35
  Eur J Biochem 205(3): 1043-51
• Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ (1992)
  Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production
  Nature 360(6405): 672-4
• Haass C, Hung AY, Selkoe DJ (1991)
  Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion
  J Neurosci 11(12): 3783-93
• Kloetzel PM, Frentzel S, Gernold M, Haass C, Klein U, Pesold-Hurt B, Seelig A (1991)
  The proteasome of Drosophila and features of the evolutionarily conserved PROS-gene family
  Biomed Biochim Acta 50(4-6): 451-7
• Haass C, Klein U, Kloetzel PM (1990)
  Developmental expression of Drosophila melanogaster small heat-shock proteins
  J Cell Sci 96 ( Pt 3): 413-8
• Haass C, Pesold-Hurt B, Kloetzel PM (1990)
  The Drosophila PROS-29 gene is a new member of the PROS-gene family
  Nucleic Acids Res 18(13): 4018
• Haass C, Kloetzel PM (1990)
  Molecular analysis of alpha ecdysone induced 16S complexes in Drosophila Schneider's S3 cells
  Biochem Biophys Res Commun 168(1): 314-9
• Haass C, Pesold-Hurt B, Multhaup G, Beyreuther K, Kloetzel PM (1990)
  The Drosophila PROS-28.1 gene is a member of the proteasome gene family
  Gene 90(2): 235-41
• Haass C, Kloetzel PM (1989)
  The Drosophila proteasome undergoes changes in its subunit pattern during development
  Exp Cell Res 180(1): 243-52
• Haass C, Pesold-Hurt B, Multhaup G, Beyreuther K, Kloetzel PM (1989)
  The PROS-35 gene encodes the 35 kd protein subunit of Drosophila melanogaster proteasome
  EMBO J 8(8): 2373-9
• Kamp F, Astumian RD, Westerhoff HV. (1988)
  Coupling of vectorial proton flow to a biochemical reaction by local electric interactions
  Proc Natl Acad Sci U S A. 1988 Jun;85(11):3792-6.
• Falkenburg PE, Haass C, Kloetzel PM, Niedel B, Kopp F, Kuehn L, Dahlmann B (1988)
  Drosophila small cytoplasmic 19S ribonucleoprotein is homologous to the rat multicatalytic proteinase
  Nature 331(6152): 190-2
• Tsaktanis T, Kremling H, Pavsic M, von Stackelberg R, Mack B, Steiner H, Vielmuth F, Spindler V, Huang Z, Jakubowski J, Stoecklein NH, Luxenburger E, Lauber K, Lenarcic B, Gires O
  Cleavage and cell adhesion properties of human epithelial cell adhesion molecule (HEPCAM)
  J Biol Chem. 2015 Oct 2;290(40):24574-91.
• Winkler E, Julius A, Steiner H, Langosch D
  Homodimerization protects the amyloid precursor protein C99 fragment from cleavage by γ-secretase
  Biochemistry. 2015 Oct 13;54(40):6149-52.
• Matthias Hachmeister, Karolina D. Bobowski, Sebastian Hogl, Bastian Dislich, Carola Eggert, Brigitte Mack, Heidi Kremling, Sannia Sarrach, Fabian Coscia, Wolfgang Zimmermann, Harald Steiner, Stefan F. Lichtenthaler, Oliver Gires
  Regulated intramembrane proteolysis and degradation of murine epithelial cell adhesion molecule mEpCAM
  PLoS One. 2013 Aug 29;8(8):e71836
• Harald Steiner
  Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping
  EMBO J. 2016 May 23. pii: e201694151. [Epub ahead of print]
• Dönem Avci, Shai Fuchs, Bianca Schrul, Michal Breker, Idan Frumkin, Chia-yi Chen, Martin L. Biniossek, Elisabeth Kremmer, Oliver Schilling, Harald Steiner, Maya Schuldiner, Marius K. Lemberg
  The yeast ER-intramembrane protease Ypf1 refines nutrient sensing by regulating transporter abundance
  Mol Cell. 2014 Dec 4;56(5):630-40.