Ludwig-Maximilians-Universität, Chair of Metabolic Biochemistry

Breadcrumb Navigation


The “Hartwig Piepenbrock-DZNE Prize” is awarded every two years by the Company Piepenbrock and the German Center for Neurodegenerative Diseases (DZNE) for outstanding research on neurodegenerative diseases. This year it goes to the Alzheimer's researcher Christian Haass in Munich. more

Nature Neuroscience: Coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated with late-onset Alzheimer’s disease (AD). We demonstrate that amyloid plaque seeding is increased in the absence of functional Trem2. Increased seeding is accompanied by decreased microglial clustering around newly seeded plaques and reduced plaque-associated apolipoprotein E (ApoE). Reduced ApoE deposition in plaques is also observed in brains of AD patients carrying TREM2 coding variants. more