Ludwig-Maximilians-Universität, Chair of Metabolic Biochemistry

Breadcrumb Navigation


Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

Nat Neurosci. 2020 Jan;23(1):15-20.

Authors/Editors: Graves SM
Xie Z
Stout KA
Zampese E
Burbulla LF
Shih JC
Kondapalli J
Patriarchi T
Tian L
Brichta L
Greengard P
Krainc D
Schumacker PT
Surmeier DJ
Publication Date: 2020
Type of Publication: Journal Article

Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA), thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H2O2). We show that MAO metabolism of DA does not increase cytosolic H2O2 but leads to mitochondrial electron transport chain (ETC) activity. This is dependent upon MAO anchoring to the outer mitochondrial membrane and shuttling electrons through the intermembrane space to support the bioenergetic demands of phasic DA release.

Related Links