MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function
Journal: PNAS February 6, 2012
|Type of Publication:||Journal Article|
We discovered that a microRNA (miR-132) that is reduced in brains of patients with Alzheimer's disease (Cogswell JP et al, J. Alzheimers. Dis. 2008) is also downregulated in schizophrenia patients. Several target genes of miR-132 (including DNMT3A, GATA2, and DPYSL3) exhibited altered expression either during normal neurodevelopment or in tissue from adult schizophrenic subjects.
Interestingly, we had previously shown, that inhibiting miR-132 impairs ocular dominance plasticity, a classical learning paradigm (Mellios et al, Nat Neuroscience 2011).
This may also contribute to the detrimental effect of miR-132 dysregulation in cognitive disorders, such as Alzheimer’s disease and schizophrenia.