Ludwig-Maximilians-Universität, Chair of Metabolic Biochemistry

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Early changes in CSF sTREM2 in dominantly inherited Alzheimer’s disease occur after amyloid deposition and neuronal injury

Science Translational Medicine 14 Dec 2016: Vol. 8, Issue 369, pp. 369ra178 DOI: 10.1126/scitranslmed.aag1767

Authors/Editors: Marc Suárez-Calvet
Miguel Ángel Araque Caballero
Gernot Kleinberger
Randall J. Bateman
Anne M. Fagan
John C. Morris
Johannes Levin
Adrian Danek
Michael Ewers
Christian Haass
for the Dominantly Inherited Alzheimer Network
Publication Date: 2016
Type of Publication: Journal Article

Little is known about the role of microglia in Alzheimer’s disease (AD). TREM2 is a protein expressed by microglia. Mutations in TREM2 increase the risk for neurodegenerative diseases including AD. Suárez-Calvet and colleagues have measured the amount of a secreted form of TREM2 (sTREM2) as a surrogate marker for microglial activation. They measured sTREM2 in the cerebrospinal fluid (CSF) of a unique cohort of 127 subjects with autosomal dominant AD and 91 healthy siblings. CSF sTREM2 was abnormally increased 5 years before the expected onset of symptoms in the AD patients. This increase occurred after alterations in markers for brain amyloidosis and neuronal injury.


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