Review

• Haass C, Selkoe D (2022)
  If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline?
  PLoS Biol. 2022 Jul 21;20(7):e3001694.
• Lichtenthaler SF, Tschirner SK, Steiner H (2022)
  Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2
  Curr Opin Neurobiol. 2022 Feb;72:101-110
• Heger LM, Wise RM, Hees JT, Harbauer AB, Burbulla LF (2021)
  Mitochondrial Phenotypes in Parkinson's Diseases-A Focus on Human iPSC-Derived Dopaminergic Neurons
  Cells. 2021 Dec 7;10(12):3436.
• Trambauer J, Fukumori A, Steiner H (2020)
  Pathogenic Aβ generation in familial Alzheimer's disease: novel mechanistic insights and therapeutic implications
  Curr Opin Neurobiol. 2020 Apr;61:73-81
• Minakaki G, Krainc D, Burbulla LF (2020)
  The Convergence of Alpha-Synuclein, Mitochondrial, and Lysosomal Pathways in Vulnerability of Midbrain Dopaminergic Neurons in Parkinson's Disease
  Front Cell Dev Biol. 2020 Dec 14;8:580634.
• Fukumori A, Feilen LP, Steiner H (2020)
  Substrate recruitment by γ-secretase
  Semin Cell Dev Biol. 2020 Sep;105:54-63
• Burbulla LF, Krainc D (2019)
  The role of dopamine in the pathogenesis of GBA1-linked Parkinson's disease
  Neurobiol Dis. 2019 Dec;132:104545.
• Lichtenthaler, SF, Lemberg MK, Fluhrer R (2018)
  Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments
  EMBO J. 2018 Jul 5. pii: e99456. doi: 10.15252/embj.201899456. [Epub ahead of print]
• Fukumori A, Trambauer J, Steiner H (2018)
  Identifizierung von Substratbindestellen in der γ-Sekretase
  BIOspektrum 01/2018: 34-36
• Steiner H, Fukumori A, Tagami S, Okochi M (2018)
  Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase
  Cell Stress. 2018 Oct 28;2(11):292-310
• Langosch D, Steiner H (2017)
  Substrate processing in intramembrane proteolysis by γ-secretase - the role of protein dynamics
  Biol Chem. 2017 Apr 1;398(4):441-453
• Dieter Edbauer, Christian Haass (2016)
  An amyloid-like cascade hypothesis for C9orf72 ALS/FTD
  Curr Opin Neurobiol. 2016 Feb;36:99-106
• Marc Aurel Busche, Matthias Staufenbiel, Michael Willem, Christian Haass, Hans Förstl (2016)
  Mechanisms of Alzheimer's disease : Neuronal hyperactivity and hypoactivity as new therapeutic targets
  Nervenarzt. 2016 Jan 19
• Julia Götzl, Christina Lang, Christian Haass, Anja Capell (2016)
  Impaired protein degradation in FTLD and related disorders
  Ageing Res Rev. 2016 May 7. pii: S1568-1637(16)30065-4
• Stephanie Ghio, Frits Kamp, Ruben Cauchi, Armin Giese, Neville Vassallo (2016)
  Interaction of α-synuclein with biomembranes in Parkinson's disease -role of cardiolipin
• Langosch D, Scharnagl C, Steiner H, Lemberg MK (2015)
  Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics
  Trends Biochem Sci. 2015 Jun;40(6):318-27
• Voss M, Schröder B, Fluhrer R (2014)
  Intramembrane cleaving proteases (I-CLiPs) as guardians of shuttling proteins.
  Cell Cycle. 2014;13(5):695. doi: 10.4161/cc.28089. Epub 2014 Feb 4.
• Robert Vassar, Peer-Hendrik Kuhn, Christian Haass, Matthew E. Kennedy, Lawrence Rajendran, Philip C. Wong, Stefan F. Lichtenthaler (2014)
  Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects
  J Neurochem. 2014 Jul;130(1):4-28
• Kleinberger G, Capell A, Haass C, Van Broeckhoven C (2013)
  Mechanisms of granulin deficiency: lessons from cellular and animal models
  Mol Neurobiol. 2013 Feb;47(1):337-60. doi: 10.1007/s12035-012-8380-8. Epub 2012 Dec 13
• Bentmann E, Haass C, Dormann D (2013)
  Stress granules in neurodegeneration - lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma
  FEBS J. 2013 Apr 15. doi: 10.1111/febs.12287. [Epub ahead of print]
• Voss M, Schröder B, Fluhrer R (2013)
  Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases.
  Biochim Biophys Acta. 2013 Dec;1828(12):2828-39. doi: 10.1016/j.bbamem.2013.03.033.
• Dormann D, Haass C (2013)
  Fused in sarcoma (FUS): An oncogene goes awry in neurodegeneration
  Mol Cell Neurosci. 2013 Apr 2. pii: S1044-7431(13)00048-1. doi: 10.1016/j.mcn.2013.03.006. [Epub ahead of print]
• Exner N, Lutz AK, Haass C, Winkelhofer KF (2012)
  Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences
  EMBO J. 2012 Jun 26;31(14):3038-62. doi: 10.1038/emboj.2012.170.
• Resenberger UK, Winklhofer KF (2012)
  Cellular Prion Protein Mediates Toxic Signaling of Amyloid Beta
  Neurodegener Dis, 10, 298-300
• (2012)
  Cell biology: Sheddase gets guidance
  Science 2012 Jan 13;335(6065):179-80.
• Burbulla LF, Krüger R (2011)
  Converging environmental and genetic pathways in the pathogenesis of Parkinson's disease
  J Neurol Sci. 2011 Jul 15;306(1-2):1-8.
• Resenberger UK, Winklhofer KF (2011)
  Neuroprotective and Neurotoxic Signaling by the Prion Protein
  Topics in Current Chemistry, 2011, Volume 305/2011, 101-119, DOI: 10.1007/128_2011_160
• (2011)
  Alpha-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potential
  J Neurochem. 2011 Jan;116(1):10-21. doi: 10.1111/j.1471-4159.2010.07081.x. Epub 2010 Dec 2.
• Pilsl A, Winklhofer KF (2011)
  Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson's disease
  Acta Neuropathol. 2011 Nov 6. [Epub ahead of print]
• (2011)
  ADAM10: potential ‘molecular scissors’ for the treatment of Alzheimer’s disease
  Future Neurology, January 2011, Vol. 6, No. 1, Pages 1-4 , DOI 10.2217/fnl.10.75
• Haass C, Steiner H (2011)
  Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing
  J Neurochem. 2011 Jun;117(5):779-96. doi: 10.1111/j.1471-4159.2011.07248.x. Epub 2011 Apr 14.
• (2011)
  Alpha-Secretase Cleavage of the Amyloid Precursor Protein: Proteolysis Regulated by Signaling Pathways and Protein Trafficking
  Curr Alzheimer Res. 2011 May 23. [Epub ahead of print]
• Winklhofer KF, Haass C (2010)
  Mitochondrial dysfunction in Parkinson's disease
  Biochim Biophys Acta. 2010 Jan;1802(1):29-44. Epub 2009 Sep 3.
• Burbulla LF, Krebiehl G, Krüger R (2010)
  Balance is the challenge--the impact of mitochondrial dynamics in Parkinson's disease
  Eur J Clin Invest. 2010 Nov;40(11):1048-60.
• Förstl H, Haass C, Hemmer B, Meyer B, Halle M. (2010)
  Boxing-acute complications and late sequelae: from concussion to dementia
  Dtsch Arztebl Int. 2010 Nov;107(47):835-9. Epub 2010 Nov 26.
• Fluhrer R, Steiner H, Haass C (2009)
  Intramembrane proteolysis by signal peptidepeptidases - a comparative discussion of GxGD-type aspartyl proteases
  J Biol Chem. 2009 May 22;284(21):13975-9. Epub 2009 Feb 3.
• Steiner H, Fluhrer R, Haass C (2008)
  Intramembrane proteolysis by γ-secretase
  J Biol Chem 283(44): 29627-31
• Steiner H (2008)
  The catalytic core of γ-secretase: presenilin revisited
  Curr Alzheimer Res 5(2): 147-57
• Winklhofer KF, Haass C (2008)
  The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases
  EMBO J 27(2): 336-49
• Fluhrer R, Haass C (2007)
  Signal peptide peptidases and gamma-secretase: cousins of the same protease family?
  Neurodegener Dis 4(2-3): 112-6
• Münz C (2007)
  Innate and adaptive immunity through autophagy
  Immunity. 2007 Jul;27(1):11-21.
• Haass C, Selkoe DJ (2007)
  Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
  Nat Rev Mol Cell Biol 8(2): 101-12
• Schatzl HM (2007)
  Molecular basis of cerebral neurodegeneration in prion diseases
  FEBS J 274(3): 606-11
• Winklhofer KF (2007)
  The parkin protein as a therapeutic target in Parkinson's disease
  Expert Opin Ther Targets 11(12): 1543-52
• Münz C (2006)
  Immune surveillance of intracellular pathogens via autophagy
  Cell Death Differ. 2005 Nov;12 Suppl 2:1519-27.
• Kaether C, Haass C, Steiner H (2006)
  Assembly, trafficking and function of γ-secretase
  Neurodegener Dis 3(4-5): 275-83
• (2006)
  Ectodomain shedding of the amyloid precursor protein: cellular control mechanisms and novel modifiers
  Neurodegener Dis. 2006;3(4-5):262-9.
• Rossner S, Sastre M, Bourne K (2006)
  Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease
  Prog Neurobiol. 2006 Jun;79(2):95-111. Epub 2006 Aug 14.
• Dengjel J, Schoor O, Stevanovic S, Münz C (2006)
  Autophagy in innate and adaptive immunity against intracellular pathogens
  J Mol Med (Berl). 2006 Mar;84(3):194-202. Epub 2006 Jan 28.
• Haffner C, Haass C (2006)
  Cellular functions of gamma-secretase-related proteins
  Neurodegener Dis 3(4-5): 284-9
• Winklhofer KF (2006)
  The role of chaperones in Parkinson's disease and prion diseases
  Handb Exp Pharmacol(172): 221-58
• Haass C (2004)
  Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model
  J Clin Invest 113(10): 1384-7
• Kahle PJ, Haass C (2004)
  How does parkin ligate ubiquitin to Parkinson's disease?
  EMBO Rep 5(7): 681-5
• Haffner C, Haass C (2004)
  The biochemical and genetic odyssey to the function of a nicastrin-like protein
  Neurodegener Dis 1(4-5): 192-5
• Haass C (2004)
  Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation
  EMBO J 23(3): 483-8
• Kaether C, Haass C (2004)
  A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation
  J Cell Biol 167(5): 809-12
• Steiner H (2004)
  Uncovering γ-secretase
  Curr Alzheimer Res 1(3): 175-81
• Winklhofer KF (2004)
  Folding and misfolding of the prion protein in the secretory pathway
  Amyloid 11(3): 162-72
• Aguzzi A, Haass C (2003)
  Games played by rogue proteins in prion disorders and Alzheimer's disease
  Science 302(5646): 814-8
• Haass C, Steiner H (2002)
  Alzheimer disease γ-secretase: a complex story of GxGD-type presenilin proteases
  Trends Cell Biol 12(12): 556-62
• Kahle PJ, Haass C, Kretzschmar HA, Neumann M (2002)
  Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases
  J Neurochem 82(3): 449-57
• Wolfe MS, Haass C (2001)
  The Role of presenilins in gamma-secretase activity
  J Biol Chem 276(8): 5413-6
• Walter J, Kaether C, Steiner H, Haass C (2001)
  The cell biology of Alzheimer's disease: uncovering the secrets of secretases
  Curr Opin Neurobiol 11(5): 585-90
• Steiner H, Haass C (2001)
  Nuclear signaling: a common function of presenilin substrates?
  J Mol Neurosci 17(2): 193-8
• Haass C (2000)
  Presenilin proteins and their function during embryonic development and Alzheimer's disease
  Ernst Schering Res Found Workshop(29): 57-64
• Steiner H, Haass C (2000)
  Intramembrane proteolysis by presenilins
  Nat Rev Mol Cell Biol 1(3): 217-24
• Kahle PJ, Neumann M, Ozmen L, Haass C (2000)
  Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein
  Ann N Y Acad Sci 920: 33-41
• Kahle PJ, Leimer U, Haass C (2000)
  Does failure of parkin-mediated ubiquitination cause juvenile parkinsonism?
  Trends Biochem Sci 25(11): 524-7
• Haass C, Baumeister R (1999)
  The biological and pathological function of presenilin proteins--simple cell systems and a worm in Alzheimer's disease research
  Eur Arch Psychiatry Clin Neurosci 249 Suppl 3: 23-7
• Steiner H, Capell A, Leimer U, Haass C (1999)
  Genes and mechanisms involved in β-amyloid generation and Alzheimer's disease
  Eur Arch Psychiatry Clin Neurosci 249(6): 266-70
• Haass C, De Strooper B (1999)
  The presenilins in Alzheimer's disease--proteolysis holds the key
  Science 286(5441): 916-9
• Steiner H, Capell A, Haass C (1999)
  Proteolytic processing and degradation of Alzheimer's disease relevant proteins
  Biochem Soc Trans 27(2): 234-42
• Haass C, Baumeister R (1998)
  What do we learn from a few familial Alzheimer's disease cases?
  J Neural Transm Suppl 54: 137-45
• Haass C, Grunberg J, Capell A, Wild-Bode C, Leimer U, Walter J, Yamazaki T, Ihara I, Zweckbronner I, Jakubek C, Baumeister R (1998)
  Proteolytic processing of Alzheimer's disease associated proteins
  J Neural Transm Suppl 53: 159-67
• Voellmy R, Welch WJ (1998)
  Abnormalities in stress proteins in prion diseases
  Cell Mol Neurobiol 18(6): 721-9
• Tatagiba M, Brosamle C, Schwab ME (1997)
  Regeneration of injured axons in the adult mammalian central nervous system
  Neurosurgery 40(3): 541-6; discussion 546-7
• Haass C (1997)
  Presenilins: genes for life and death
  Neuron 18(5): 687-90
• Schwab ME, Brosamle C (1997)
  Regeneration of lesioned corticospinal tract fibers in the adult rat spinal cord under experimental conditions
  Spinal Cord 35(7): 469-73
• Selkoe DJ, Yamazaki T, Citron M, Podlisny MB, Koo EH, Teplow DB, Haass C (1996)
  The role of APP processing and trafficking pathways in the formation of amyloid beta-protein
  Ann N Y Acad Sci 777: 57-64
• Haass C (1996)
  The molecular significance of amyloid beta-peptide for Alzheimer's disease
  Eur Arch Psychiatry Clin Neurosci 246(3): 118-23
• Haass C (1996)
  Presenile because of presenilin: the presenilin genes and early onset Alzheimer's disease
  Curr Opin Neurol 9(4): 254-9
• Fechteler K, Huppertz S, Wilgenbus P, Doerfler W (1995)
  The mechanism of adenovirus DNA integration: studies in a cell-free system
  Curr Top Microbiol Immunol 199 ( Pt 2): 109-37
• Haass C, Selkoe DJ (1993)
  Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide
  Cell 75(6): 1039-42
• Bettina Schmid, Christian Haass
  Genomic editing opens new avenues for zebrafish as a model for neurodegeneration
  J Neurochem. 2013 Nov;127(4):461-70
• Bradley T. Hyman, John H. Growdon, Mark W. Albers, Randy L. Buckner, Jasmeer Chhatwal, Maria Teresa Gomez-Isla, Christian Haass, Eloise Hudry, Clifford R. Jack Jr., Keith A. Johnson, Zaven S. Khachaturian, Doo Yeon Kim, Joseph B. Martin, Roger M. Nitsch, Bruce R. Rosen, Dennis J. Selkoe, Reisa A. Sperling, Peter St. George-Hyslop, Rudolph E. Tanzi, Liang Yap, Anne B. Young, Creighton H. Phelps, Patricia G. McCaffrey
  Massachusetts Alzheimer's Disease Research Center: progress and challenges
  Alzheimers Dement. 2015 Oct;11(10):1241-5
• Kaj Blennow, Henrik Zetterberg, Christian Haass, Thomas Finucane
  Semagacestat's fall: where next for AD therapies?
  Nat Med. 2013 Oct;19(10):1214-5.