Ludwig-Maximilians-Universität, Chair of Metabolic Biochemistry

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DNA methylation changes in plasticity genes accompany the formation and maintenance of memory

Nat Neurosci. 2016 Jan;19(1):102-10

Authors/Editors: Rashi Halder
Magali Hennion
Ramon O Vidal
Orr Shomroni
Raza-Ur Rahman
Ashish Rajput
Tonatiuh Pena Centeno
Frauke van Bebber
Vincenzo Capece
Julio C Garcia Vizcaino
Anna-Lena Schuetz
Susanne Burkhardt
Eva Benito
Magdalena Navarro Sala
Sanaz Bahari Javan
Christian Haass
Bettina Schmid
Andre Fischer
Stefan Bonn
Publication Date: 2016
Type of Publication: Journal Article

The ability to form memories is a prerequisite for an organism's behavioral adaptation to environmental changes. At the molecular level, the acquisition and maintenance of memory requires changes in chromatin modifications. In an effort to unravel the epigenetic network underlying both short- and long-term memory, we examined chromatin modification changes in two distinct mouse brain regions, two cell types and three time points before and after contextual learning. We found that histone modifications predominantly changed during memory acquisition and correlated surprisingly little with changes in gene expression. Although long-lasting changes were almost exclusive to neurons, learning-related histone modification and DNA methylation changes also occurred in non-neuronal cell types, suggesting a functional role for non-neuronal cells in epigenetic learning. Finally, our data provide evidence for a molecular framework of memory acquisition and maintenance, wherein DNA methylation could alter the expression and splicing of genes involved in functional plasticity and synaptic wiring.

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