Publications

Journal Article

• Marvin Reich, Matthew J Simon, Beate Polke, Iñaki Paris, Georg Werner, Christian Schrader, Lena Spieth, Sonnet S Davis, Sophie Robinson, Gabrielly Lunkes de Melo, Lennart Schlaphoff, Katrin Buschmann, Stefan Berghoff, Todd Logan, Brigitte Nuscher , Lis de Weerd, Dieter Edbauer, Mikael Simons, Jung H Suh, Thomas Sandmann, Mihalis S Kariolis, Sarah L DeVos, Joseph W Lewcock, Dominik Paquet , Anja Capell , Gilbert Di Paolo, Christian Haass (2024)
  Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration
  Sci Transl Med. 2024 Jun 5;16(750):eadj7308.
• Anika Reifschneider, Sophie Robinson, Bettina van Lengerich, Johannes Gnörich, Todd Logan, Steffanie Heindl, Miriam A Vogt, Endy Weidinger, Lina Riedl, Karin Wind, Artem Zatcepin, Ida Pesämaa, Sophie Haberl, Brigitte Nuscher, Gernot Kleinberger, Julien Klimmt, Julia K Götzl, Arthur Liesz, Katharina Bürger, Matthias Brendel, Johannes Levin, Janine Diehl-Schmid, Jung Suh, Gilbert Di Paolo, Joseph W Lewcock, Kathryn M Monroe, Dominik Paquet, Anja Capell, Christian Haass (2022)
  Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency
  EMBO J. 2022 Jan 12; e109108
• Morenas-Rodríguez E, Li Y, Nuscher B, Franzmeier N, Xiong C, Suárez-Calvet M, Fagan AM, Schultz S, Gordon BA, Benzinger TLS, Hassenstab J, McDade E, Feederle R, Karch CM, Schlepckow K, Morris JC, Kleinberger G, Nellgard B, Vöglein J, Blennow K, Zetterberg H, Ewers M, Jucker M, Levin J, Bateman RJ, Haass C, on behalf of the Dominantly Inherited Alzheimer Network (2022)
  Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer´s disease: a longitudinal observational study
  The Lancet Neurology Volume 21, Issue 4, April 2022, Pages 329-341
• Colombo A, Sadler RK, Llovera G, Singh V, Roth S, Heindl S, Sebastian Monasor L, Verhoeven A, Peters F, Parhizkar S, Kamp F, Gomez de Aguero M, MacPherson AJ, Winkler E, Herms J, Benakis C, Dichgans M, Steiner H, Giera M, Haass C, Tahirovic S, Liesz A (2021)
  Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
  Elife. 2021 Apr 13;10:e59826
• Xianyuan Xiang, Karin Wind, Thomas Wiedemann, Tanja Blume, Yuan Shi, Nils Briel, Leonie Beyer, Gloria Biechele, Florian Eckenweber, Artem Zatcepin, Sven Lammich, Sara Ribicic, Sabina Tahirovic, Michael Willem, Maximilian Deussing, Carla Palleis, Boris-Stephan Rauchmann, Franz-Josef Gildehaus, Simon Lindner, Nicolai Franzmeier, Karlheinz Baumann, Axel Rominger, Peter Bartenstein, Sibylle Ziegler, Alexander Drzezga, Gesine Respondek, Katharina Buerger, Robert Perneczky, Johannes Levin, Günter U Höglinger, Jochen Herms, Christian Haass, Matthias Brendel (2021)
  Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases
  Sci Transl Med. 2021 Oct 13;13(615):eabe5640.
• Kai Schlepckow, Kathryn M. Monroe, Gernot Kleinberger, Ludovico Cantuti-Castelvetri, Samira Parhizkar, Dan Xia, Michael Willem, Georg Werner, Nadine Pettkus, Bettina Brunner, Alice Sülzen, Brigitte Nuscher, Heike Hampel, Xianyuan Xiang, Regina Feederle, Sabina Tahirovic, Joshua I. Park, Rachel Prorok, Cathal Mahon, Chun-Chi Liang, Ju Shi, Do Jin Kim, Hanna Sabelström, Fen Huang, Gilbert Di Paolo, Mikael Simons, Joseph W. Lewcock, Christian Haass (2020)
  Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region
  EMBO Mol Med. 2020 Apr 7;12(4):e11227.
• Georg Werner, Markus Damme, Martin Schludi, Johannes Gnörich, Karin Wind, Katrin Fellerer, Benedikt Wefers, Wolfgang Wurst, Dieter Edbauer, Matthias Brendel, Christian Haass, Anja Capell (2020)
  Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice
  EMBO Rep. 2020 Oct 5;21(10):e50241.
• Yoshihiro Nihei, Kohji Mori, Georg Werner, Thomas Arzberger, Qihui Zhou, Barham Khosravi, Julia Japtok, Andreas Hermann, Andreas Sommacal, Markus Weber, German Consortium for Frontotemporal Lobar Degeneration, Bavarian Brain Banking Alliance, Frits Kamp, Brigitte Nuscher, Dieter Edbauer, Christian Haass (2020)
  Poly-glycine-alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3
  Acta Neuropathol 2020 Jan;139(1):99-118.
• Lüningschrör P, Werner G, Stroobants S, Kakuta S, Dombert B, Sinske D, Wanner R, Lüllmann-Rauch R, Wefers B, Wurst W, D'Hooge R, Uchiyama Y, Sendtner M, Haass C, Saftig P, Knöll B, Capell A, Damme M (2020)
  The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons
  Cell Rep. 2020 Mar 10;30(10):3506-3519.
• Steiner A, Schlepckow K, Brunner B, Steiner H, Haass C, Hagn F (2020)
  γ-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics
  EMBO J. 2020 Oct 15;39(20):e104247
• Vöglein J, Paumier K, Jucker M, Preische O, McDade E, Hassenstab J, Benzinger TL, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal J, Salloway S, Xiong C, Karch CM, Cairns N, Mori H, Schofield PR, Masters CL, Goate A, Buckles V, Fox N, Rossor M, Chrem P, Allegri R, Ringman JM, Höglinger G, Steiner H, Dieterich M, Haass C, Laske C, Morris JC, Bateman RJ, Danek A, Levin J, Dominantly Inherited Alzheimer Network (2019)
  Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease
  Brain 2019 May 1;142(5):1429-1440
• Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Kai Schlepckow, Miguel Ángel Araque Caballero, Nicolai Franzmeier, Anja Capell, Katrin Fellerer, Brigitte Nuscher, Erden Eren, Johannes Levin, Yuetiva Deming, Laura Piccio, Celeste M. Karch, Carlos Cruchaga, Leslie M. Shaw, John Q. Trojanowski, Michael Weiner, Michael Ewers, Christian Haass, for the Alzheimer’s Disease Neuroimaging Initiative (2019)
  Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology
  Mol Neurodegener. 2019 Jan 10;14(1):1
• Vöglein J, Willem M, Trambauer J, Schönecker S, Dieterich M, Biskup S, Giudici C, Utz K, Oberstein T, Brendel M, Rominger A, Danek A, Steiner H, Haass C, Levin J (2019)
  Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-β processing effects
  Neurobiol Aging. 2019 Dec;84:241.e5-241.e11
• Michael Ewers, Nicolai Franzmeier, Marc Suárez-Calvet, Estrella Morenas-Rodriguez, Miguel Angel Araque Caballero, Gernot Kleinberger, Laura Piccio, Carlos Cruchaga, Yuetiva Deming, Martin Dichgans, John Q. Trojanowski, Leslie M. Shaw, Michael W. Weiner, Christian Haass, for the Alzheimer’s Disease Neuroimaging Initiative (2019)
  Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease
  Science Translational Medicine, 28 Aug 2019
• Samira Parhizkar, Thomas Arzberger, Matthias Brendel, Gernot Kleinberger, Maximilian Deussing, Carola Focke, Brigitte Nuscher, Monica Xiong, Alireza Ghasemigharagoz, Natalie Katzmarski, Susanne Krasemann, Stefan F. Lichtenthaler, Stephan A. Müller, Alessio Colombo, Laura Sebastian Monasor, Sabina Tahirovic, Jochen Herms, Michael Willem, Nadine Pettkus, Oleg Butovsky, Peter Bartenstein, Dieter Edbauer, Axel Rominger, Ali Ertürk, Stefan A. Grathwohl, Jonas J. Neher, David M. Holtzman, Melanie Meyer-Luehmann, Christian Haass (2019)
  Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
  Nat Neurosci. 2019 Feb;22(2):191-204
• Götzl J, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, Colombo A, Deussing M, Wagner M, Winkelmann J, Diehl-Schmid J, Levin J, Fellerer K, Reifschneider A, Bultmann S, Bartenstein P, Rominger A, Tahirovic S, Smith ST, Madore C, Butovsky O, Capell A, Haass C (2019)
  Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism
  EMBO Mol Med. 2019 Jun;11(6):e9711.
• Marc Suárez-Calvet, Anja Capell, Miguel Ángel Araque Caballero, Estrella Morenas-Rodríguez, Katrin Fellerer, Nicolai Franzmeier, Gernot Kleinberger, Erden Eren, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Katrina Paumier, Randall J Bateman, Anne M Fagan, John C Morris, Johannes Levin, Adrian Danek, Mathias Jucker, Colin L Masters, Martin N Rossor, John M Ringman, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers , Christian Haass, for the Dominantly Inherited Alzheimer Network, & for the Alzheimer's Disease Neuroimaging Initiative (2018)
  CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline
  EMBO Mol Med. 2018 Dec;10(12). pii: e9712.
• Julia K. Götzl, Alessio-Vittorio Colombo, Katrin Fellerer, Anika Reifschneider, Georg Werner, Sabina Tahirovic, Christian Haass, Anja Capell (2018)
  Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice
  Mol Neurodegener. 2018 Sep 4;13(1):48
• Matthias Brendel, Anna Jaworska, Felix Overhoff, Tanja Blume, Federico Probst, Franz-Josef Gildehaus, Peter Bartenstein, Christian Haass, Bernd Bohrmann, Jochen Herms, Michael Willem, Axel Rominger (2018)
  Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation
  Theranostics. 2018 Sep 9;8(18):4957-4968
• Cornelis Blauwendraat, Carlo Wilke, Javier Simón-Sánchez, Iris E. Jansen, Anika Reifschneider, Anja Capell, Christian Haass, Melissa Castillo-Lizardo, Saskia Biskup, Walter Maetzler, Patrizia Rizzu, Peter Heutink, Matthis Synofzik (2018)
  The wide genetic landscape of clinical frontotemporal dementia: systematic combined sequencing of 121 consecutive subjects
  Genet Med. 2018 Feb;20(2):240-249
• Kai Schlepckow, Gernot Kleinberger, Akio Fukumori, Regina Feederle, Stefan F. Lichtenthaler, Harald Steiner, Christian Haass (2017)
  An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function
  EMBO Mol Med. 2017 Oct;9(10):1356-1365
• Yu Ohki, Andrea Wenninger-Weinzierl, Alexander Hruscha, Kazuhide Asakawa, Koichi Kawakami, Christian Haass, Dieter Edbauer, Bettina Schmid (2017)
  Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration
  Mol Neurodegener. 2017 Jan 14;12(1):6. doi: 10.1186/s13024-016-0146-8.
• Gernot Kleinberger, Matthias Brendel, Eva Mracsko, Benedikt Wefers, Linda Groeneweg, Xianyuan Xiang, Carola Focke, Maximilian Deußing, Marc Suárez-Calvet, Fargol Mazaheri, Samira Parhizkar, Nadine Pettkus, Wolfgang Wurst, Regina Feederle, Peter Bartenstein, Thomas Mueggler, Thomas Arzberger, Irene Knuesel, Axel Rominger, Christian Haass (2017)
  The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion and glucose metabolism
  EMBO J. 2017 Jul 3;36(13):1837-1853
• Fargol Mazaheri, Nicolas Snaidero, Gernot Kleinberger, Charlotte Madore, Anna Daria, Georg Werner, Susanne Krasemann, Anja Capell, Dietrich Trümbach, Wolfgang Wurst, Bettina Brunner, Sebastian Bultmann, Sabina Tahirovic, Martin Kerschensteiner, Thomas Misgeld, Oleg Butovsky, Christian Haass (2017)
  TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury
  EMBO Rep. 2017 Jul;18(7):1186-1198
• Felix Overhoff, Matthias Brendel, Anna Jaworska, Viktoria Korzhova, Andreas Delker, Federico Probst, Carola Focke, Franz-Josef Gildehaus, Janette Carlsen, Karlheinz Baumann, Christian Haass, Peter Bartenstein, Jochen Herms, Axel Rominger (2016)
  Automated Spatial Brain Normalization and Hindbrain White Matter Reference Tissue Give Improved [(18)F]-Florbetaben PET Quantitation in Alzheimer's Model Mice
  Front Neurosci. 2016 Feb 29;10:45
• Kaichuan Zhu, Xianyuan Xiang, Severin Filser, Petar Marinkovic, Mario M. Dorostkar, Sophie Crux, Ulf Neumann, Derya R. Shimshek, Gerhard Rammes, Christian Haass, Stefan F. Lichtenthaler, Jenny M. Gunnersen, Jochen Herms (2016)
  Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6
  Biol Psychiatry. 2016 Dec 26. pii: S0006-3223(16)33157-2. doi: 10.1016/j.biopsych.2016.12.023.
• Juan Domingo Gispert, Marc Suárez-Calvet, Gemma C. Monte, Alan Tucholka, Carles Falcon, Santiago Rojas, Lorena Rami, Raquel Sanchez-Valle, Albert Lladó, Gernot Kleinberger, Christian Haass, José Luis Molinuevo (2016)
  Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease
  Alzheimers Dement. 2016 Jul 13. pii: S1552-5260(16)30026-7.
• Rashi Halder, Magali Hennion, Ramon O Vidal, Orr Shomroni, Raza-Ur Rahman, Ashish Rajput, Tonatiuh Pena Centeno, Frauke van Bebber, Vincenzo Capece, Julio C Garcia Vizcaino, Anna-Lena Schuetz, Susanne Burkhardt, Eva Benito, Magdalena Navarro Sala, Sanaz Bahari Javan, Christian Haass, Bettina Schmid, Andre Fischer, Stefan Bonn (2016)
  DNA methylation changes in plasticity genes accompany the formation and maintenance of memory
  Nat Neurosci. 2016 Jan;19(1):102-10
• Marc Suárez-Calvet, Miguel Ángel Araque Caballero, Gernot Kleinberger, Randall J. Bateman, Anne M. Fagan, John C. Morris, Johannes Levin, Adrian Danek, Michael Ewers, Christian Haass, for the Dominantly Inherited Alzheimer Network (2016)
  Early changes in CSF sTREM2 in dominantly inherited Alzheimer’s disease occur after amyloid deposition and neuronal injury
  Science Translational Medicine 14 Dec 2016: Vol. 8, Issue 369, pp. 369ra178 DOI: 10.1126/scitranslmed.aag1767
• Benedikt Kretner, Johannes Trambauer, Janina Mielke, Peer-Hendrik Kuhn, Elisabeth Kremmer, Armin Giese, Stefan Lichtenthaler, Christian Haass, Thomas Arzberger, Harald Steiner (2016)
  Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer’s disease
  EMBO Mol Med. 2016 May 2;8(5):458-65
• Matthias Brendel, Federico Probst, Anna Jaworska, Felix Overhoff, Viktoria Korzhova, Nathalie L. Albert, Roswitha Beck, Simon Lindner, Franz-Josef Gildehaus, Karlheinz Baumann, Peter Bartenstein, Gernot Kleinberger, Christian Haass, Jochen Herms, Axel Rominger (2016)
  Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple-Tracer PET Study
  J Nucl Med. 2016 Jun;57(6):954-60
• Marc Suárez-Calvet, Manuela Neumann, Thomas Arzberger, Claudia Abou-Ajram, Eva Funk, Hannelore Hartmann, Dieter Edbauer, Elisabeth Kremmer, Christoph Göbl, Moritz Resch, Benjamin Bourgeois, Tobias Madl, Stefan Reber, Daniel Jutzi, Marc-David Ruepp, Ian R. A. Mackenzie, Olaf Ansorge, Dorothee Dormann, Christian Haass (2016)
  Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS
  Acta Neuropathol. 2016 Apr;131(4):587-604
• Kohji Mori, Yoshihiro Nihei, Thomas Arzberger, Qihui Zhou, Ian R Mackenzie, Andreas Hermann, Frank Hanisch, German Consortium for Frontotemporal Lobar Degeneration, Bavarian Brain Banking Alliance, Frits Kamp, Brigitte Nuscher, Denise Orozco, Dieter Edbauer, Christian Haass (2016)
  Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition
  EMBO Reports, published online 26.07.2016
• Gernot Kleinberger, Anja Capell, Nathalie Brouwers, Katrin Fellerer, Kristel Sleegers, Marc Cruts, Christina Van Broeckhoven, Christian Haass (2016)
  Reduced secretion and altered proteolytic processing caused by missense mutations in progranulin
  Neurobiol Aging. 2016 Mar;39:220.e17-26
• Matthias Brendel, Anna Jaworska, Federico Probst, Felix Overhoff, Viktoria Korzhova, Simon Lindner, Janette Carlsen, Peter Bartenstein, Ryuichi Harada, Yukitsuka Kudo, Christian Haass, Fred van Leuven, Nobuyuki Okamura, Jochen Herms, Axel Rominger (2016)
  Small-Animal PET Imaging of Tau Pathology with 18F-THK5117 in 2 Transgenic Mouse Models
  J Nucl Med. 2016 May;57(5):792-8
• Saoussen Ben Halima, Sabyashachi Mishra, K. Muruga Poopathi Raja, Michael Willem, Antonio Baici, Kai Simons, Oliver Brüstle, Philipp Koch, Christian Haass, Amedeo Caflisch, Lawrence Rajendran (2016)
  Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein
  Cell Rep. 2016 Mar 8;14(9):2127-41
• Marc Suárez-Calvet, Gernot Kleinberger, Miguel Ángel Araque Caballero, Matthias Brendel, Axel Rominger, Daniel Alcolea, Juan Fortea, Alberto Lleó, Rafael Blesa, Juan Domingo Gispert, Raquel Sánchez-Valle, Anna Antonell, Lorena Rami, José L. Molinuevo, Frederic Brosseron, Andreas Traschütz, Michael T. Heneka, Hanne Struyfs, Sebastiaan Engelborghs, Kristel Sleegers, Christine Van Broeckhoven, Henrik Zetterberg, Bengt Nellgard, Kaj Blennow, Alexander Crispin, Michael Ewers, Christian Haass (2016)
  sTREM2 cerebrospinal fluid levels are a potent biomarker for microglia activity in early-stage Alzheimer’s disease and associate with neuronal injury markers
  EMBO Mol Med. 2016 May 2;8(5):466-76
• Juan Domingo Gispert, Gemma C. Monté, Marc Suárez-Calvet, Carles Falcon, Alan Tucholka, Santiago Rojas, Lorena Rami, Raquel Sánchez-Valle, Albert Lladó, Gernot Kleinberger, Christian Haass, José Luis Molinuevo (2016)
  The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2
  Alzheimers Dement (Amst). 2016 Dec 22;6:50-59
• Xianyuan Xiang, Georg Werner, Bernd Bohrmann, Arthur Liesz, Fargol Mazaheri, Anja Capell, Regina Feederle, Irene Knuesel, Gernot Kleinberger, Christian Haass (2016)
  TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
  EMBO Molecular Medicine (2016) e201606370, Published online 08.07.2016
• Anna Daria, Alessio Colombo, Gemma llovera, Heike Hampel, Michael Willem, Arthur Liesz, Christian Haass, Sabina Tahirovic (2016)
  Young microglia restore amyloid plaque clearance of aged microglia
  EMBO J. 2016 Dec 21. pii: e201694591. doi: 10.15252/embj.201694591. [Epub ahead of print]
• M Brendel, A Jaworska, J Herms, J Trambauer, C Rötzer, F-J Gildehaus, J Carlsen, P Cumming, J Bylund, T Luebbers, P Bartenstein, H Steiner, C Haass, K Baumann, A Rominger (2015)
  Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment
  Mol Psychiatry. 2015 Oct;20(10):1179-87
• Matthias Brendel, Anna Jaworska, Eric Grießinger, Christina Rötzer, Steffen Burgold, Franz-Josef Gildehaus, Janette Carlsen, Paul Cumming, Karlheinz Baumann, Christian Haass, Harald Steiner, Peter Bartenstein, Jochen Herms, Axel Rominger (2015)
  Cross-sectional comparison of small animal [18F]-florbetaben amyloid-PET between transgenic AD mouse models
  PLoS One. 2015 Feb 23;10(2):e0116678
• Michael Willem, Sabina Tahirovic, Marc Aurel Busche, Saak V. Ovsepian, Magda Chafai, Scherazad Kootar, Daniel Hornburg, Lewis D. B. Evans, Steven Moore, Anna Daria, Heike Hampel, Veronika Müller, Camilla Giudici, Brigitte Nuscher, Andrea Wenninger-Weinzierl, Elisabeth Kremmer, Michael T. Heneka, Dietmar R. Thal, Vilmantas Giedraitis, Lars Lannfelt, Ulrike Müller, Frederick J. Livesey, Felix Meissner, Jochen Herms, Arthur Konnerth, Hélène Marie, Christian Haass (2015)
  eta-Secretase processing of APP inhibits neuronal activity in the hippocampus
  Nature. 2015 Oct 15;526(7573):443-7
• Barbara Solchenberger, Claire Russell, Elisabeth Kremmer, Christian Haass, Bettina Schmid (2015)
  Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology
  PLoS One. 2015 Mar 18;10(3):e0118956
• Teresa Bachhuber, Natalie Katzmarski, Joanna F McCarter, Desiree Loreth, Sabina Tahirovic, Frits Kamp, Claudia Abou-Ajram, Brigitte Nuscher, Alberto Serrano-Pozo, Alexandra Müller, Marco Prinz, Harald Steiner, Bradley T Hyman, Christian Haass, Melanie Meyer-Luehmann (2015)
  Inhibition of amyloid-β plaque formation by α-synuclein
  Nat Med. 2015 Jul;21(7):802-7
• Jonathan Janssens, Stéphanie Philtjens, Gernot Kleinberger, Sara Van Mossevelde, Julie van der Zee, Rita Cacace, Sebastiaan Engelborghs, Anne Sieben, Julia Banzhaf-Strathmann, Lubina Dillen, Céline Merlin, Ivy Cuijt, Caroline Robberecht, Bettina Schmid, Patrick Santens, Adrian Ivanoiu, Mathieu Vandenbulcke, Rik Vandenberghe, Patrick Cras, Peter P. De Deyn, Jean-Jacques Martin, Stuart Maudsley, Christian Haass, Marc Cruts, Christine Van Broeckhoven (2015)
  Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains
  Acta Neuropathol Commun. 2015 Nov 10;3:68
• M Brendel, A Jaworska, J Herms, J Trambauer, C Rötzer, F-J Gildehaus, J Carlsen, P Cumming, J Bylund, T Luebbers, P Bartenstein, H Steiner, C Haass, K Baumann, A Rominger (2015)
  Monitoring of chronic γ-secretase modulator treatment by serial amyloid-PET
  Mol Psychiatry. 2015 Oct;20(10):1141
• Sandra Jäckel, Anna K. Summerer, Catherine M. Thömmes, Xia Pan, Aaron Voigt, Jörg B. Schulz, Tobias M. Rasse, Dorothee Dormann, Christian Haass, Philipp J. Kahle (2015)
  Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila
  Neurobiol Dis. 2015 Feb;74:76-88
• Fleck D, Voss M, Brankatschk B, Giudici C, Hampel H, Edbauer D, Steiner H, Kremmer E, Haug-Kröper M, Rossner MJ, Fluhrer R, Willem M, Haass C (2015)
  Proteolytic processing of neuregulin 1 type III by three intramembrane cleaving proteases
  J Biol Chem. 2016 Jan 1;291(1):318-33.
• Eva C Schulte, Brit Mollenhauer, Hyun Hor, Thomas Arzberger, Robert Perneczky, Alexander Kurz, Janine Diehl-Schmid, Michael Hüll, Peter Lichtner, Gertrud Eckstein, Alexander Zimprich, Dietrich Haubenberger, Walter Pirker, Thomas Brücke, Benjamin Bereznai, Maria J Molnar, Oswaldo Lorenzo-Betancor, Pau Pastor, Annette Peters, Christian Gieger, Xavier Estivill, Thomas Meitinger, Hans A Kretzschmar, Claudia Trenkwalder, Christian Haass, Juliane Winkelmann (2015)
  Rare variants in β-Amyloid precursor protein (APP) and Parkinson's disease
  Eur J Hum Genet. 2015 Oct;23(10):1328-33
• Kuhn PH, Voss M, Haug-Kröper M, Schröder B, Schepers U, Bräse S, Haass C, Lichtenthaler SF, Fluhrer R (2015)
  Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways
  Mol Cell Proteomics. 2015 Jun;14(6):1584-98. doi: 10.1074/mcp.M115.048298. Epub 2015 Mar 31.
• Götzl JK, Mori K, Damme M, Fellerer K, Tahirovic S, Kleinberger G, Janssens J, van der Zee J, Lang CM, Kremmer E, Martin JJ, Engelborghs S, Kretzschmar HA, Arzberger T, Van Broeckhoven C, Haass C, Capell A (2014)
  Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis.
  Acta Neuropathol. 2014 Mar 12. [Epub ahead of print]
• Capell A, Fellerer K, Haass C (2014)
  Progranulin transcripts with short and long 5’-untranslated regions (UTR) are differentially expressed via post transcriptional and translational repression
  J Biol Chem. 2014 Jul 23. pii: jbc.M114.560128. [Epub ahead of print]
• Voss M, Künzel U, Higel F, Kuhn PH, Colombo A, Haug-Kröper M, Klier B, Grammer G, Seidl A, Schröder B, Obst R, Steiner H, Lichtenthaler SF, Haass C, Fluhrer R (2014)
  Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation
  EMBO J. 2014 Dec 17;33(24):2890-905. doi: 10.15252/embj.201488375. Epub 2014 Oct 29.
• Schwenk BM, Lang CM, Hogl S, Tahirovic S, Orozco D, Rentzsch K, Lichtenthaler SF, Hoogenraad CC, Capell A, Haass C, Edbauer D (2014)
  The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes
  EMBO J. 2014 Jan 8. [Epub ahead of print]
• G. Kleinberger, Y. Yamanishi, M. Suarez-Calvet, E. Czirr, E. Lohmann, E. Cuyvers, H. Struyfs, N. Pettkus, F. Mazaheri, S. Tahirovic, A. Lleó, D. Alcolea, J. Fortea, M. Willem, S. Lammich, J. L. Molinuevo, R. Sanchez-Valle, A. Antonell, A. Ramirez, M. Heneka, K. Sleegers, J. van der Zee, J.-J. Martin, S. Engelborghs, A. Demirtas-Tatlidede, H. Zetterberg, C. Van Broeckhoven, H. Gurvit, T. Wyss-Coray, J. Hardy, M. Colonna, C. Haass (2014)
  TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
  Sci Transl Med 2 July 2014: Vol. 6, Issue 243, p. 243ra86
• Cheret C, Willem M, Fricker FR, Wende H, Wulf-Goldenberg A, Tahirovic S, Nave KA, Saftig P, Haass C, Garratt AN, Bennett DL, Birchmeier C (2013)
  Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles
  EMBO J. 2013 Jul 17;32(14):2015-28. doi: 10.1038/emboj.2013.146. Epub 2013 Jun 21
• Mori K, Arzberger T, Grässer FA, Gijselinck I, Rentzsch K, Weng SM, Schludi HM, van der Zee J, Cruts M, Van Broeckhoven C, Kremmer E, Kretzschmar HA, Haass C, Edbauer D (2013)
  Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins.
  Acta Neuropathol. 2013 Dec;126(6):881-93. doi: 10.1007/s00401-013-1189-3. Epub 2013 Oct 17.
• Liebscher S, Page RM, Käfer K, Winkler E, Quinn K, Goldbach E, Brigham EF, Quincy D, Basi GS, Schenk DB, Steiner H, Bonhoeffer T, Haass C, Meyer-Luehmann M, Hübener M (2013)
  Chronic γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures.
  Mol Psychiatry. 2013 Sep 24. doi: 10.1038/mp.2013.122. [Epub ahead of print]
• McCarter JF, Liebscher S, Bachuber T, Abou-Ajram C, Hübener M, Hyman BT, Haass C, Meyer-Luehmann M (2013)
  Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer's disease.
  Acta Neuropathol. 2013 Aug;126(2):179-88. doi: 10.1007/s00401-013-1137-2. Epub 2013 Jun 18.
• Mackenzie IR, Arzberger T, Kremmer E, Troost D, Lorenzl S, Mori K, Weng SM, Haass C, Kretzschmar HA, Edbauer D, Neumann M (2013)
  Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations
  Acta Neuropathol. 2013 Dec;126(6):859-79. doi: 10.1007/s00401-013-1181-y. Epub 2013 Oct 6.
• Fleck D, van Bebber F, Colombo A, Galante C, Rabe L, Hampel H, Novak B, Kremmer E, Tahirovic S, Edbauer D, Lichtenthaler SF, Schmid B, Willem M, Haass C (2013)
  Dual cleavage of neuregulin 1 Type III by BACE1 and ADAM17 Liberates Its EGF-Like Domain and Allows Paracrine Signaling
  J Neurosci. 2013 May 1;33(18):7856-69. doi: 10.1523/JNEUROSCI.3372-12.2013
• Hruscha A, Krawitz P, Rechenberg A, Heinrich V, Hecht J, Haass C, Schmid B (2013)
  Efficient CRISPR/Cas9 genome editing with low off target effects in zebrafish
  Development. 2013 Dec;140(24):4982-7. doi: 10.1242/dev.099085. Epub 2013 Nov 20
• Schmid B, Haass C (2013)
  Genomic editing opens new avenues for zebrafish as a model for neurodegeneration
  J Neurochem. 2013 Nov;127(4):461-70. doi: 10.1111/jnc.12460. Epub 2013 Oct 21
• Panda SK, Wefers B, Ortiz O, Floss T, Schmid B, Haass C, Wurst W, Kühn R (2013)
  Highly Efficient Targeted Mutagenesis in Mice Using TALENs
  Genetics. 2013 Aug 26. [Epub ahead of print]
• Mori K, Lammich S, Mackenzie IR, Forne I, Zilow S, Kretzschmar H, Edbauer D, Janssens J, Kleinberger G, Cruts M, Herms J, Neumann M, Van Broeckhoven C, Arzberger T, Haass C (2013)
  hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations
  Acta Neuropathol. 2013 Mar;125(3):413-23. doi: 10.1007/s00401-013-1088-7. Epub 2013 Feb 5
• Brendel M, Delker A, Rötzer C, Böning G, Carlsen J, Cyran C, Mille E, Gildehaus FJ, Cumming P, Baumann K, Steiner H, Haass C, Herms J, Bartenstein P, Rominger A (2013)
  Impact of partial volume effect correction on cerebral β-amyloid imaging in APP-Swe mice using [(18)F]-florbetaben PET.
  Neuroimage. 2014 Jan 1;84:843-53. doi: 10.1016/j.neuroimage.2013.09.017. Epub 2013 Sep 20.
• Kretner B, Kuhn PH, Pérez-Revuelta BI, Lichtenthaler SF, Haass C, Steiner H (2013)
  Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase
  J Neurochem. 2013 Apr;125(1):144-56. doi: 10.1111/jnc.12124. Epub 2013 Jan 15
• Hogl S, van Bebber F, Dislich B, Kuhn PH, Haass C, Schmid B, Lichtenthaler SF (2013)
  Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains
  Proteomics. 2013 Mar 4. doi: 10.1002/pmic.201200582. [Epub ahead of print]
• Rominger A, Brendel M, Burgold S, Keppler K, Baumann K, Xiong G, Mille E, Gildehaus FJ, Carlsen J, Schlichtinger J, Niedermoser S, Wängler B, Cumming P, Steiner H, Herms J, Haass C, Bartenstein P (2013)
  Longitudinal assessment of cerebral β-amyloid deposition in mice overexpressing Swedish mutant β-amyloid precursor protein using 18F-florbetaben PET.
  J Nucl Med. 2013 Jul;54(7):1127-34. doi: 10.2967/jnumed.112.114660. Epub 2013 May 31.
• Schmid B, Hruscha A, Hogl S, Banzhaf-Strathmann J, van der Zee J, Teucke M, Eimer S, Hegermann J, Kittelmann M, Kremmer E, Cruts M, Solchenberger B, van Bebber F, Van Broeckhoven C, Edbauer D, Lichtenthaler SF, Haass C (2013)
  Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth
  Proc Natl Acad Sci U S A. 2013 Mar 1. [Epub ahead of print]
• van Bebber F, Hruscha A, Willem M, Schmid B, Haass C (2013)
  Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes
  J Neurochem. 2013 Feb 14. doi: 10.1111/jnc.12198. [Epub ahead of print]
• Poggi M, Kara I, Brunel JM, Landrier JF, Govers R, Bonardo B, Fluhrer R, Haass C, Alessi MC, Peiretti F (2013)
  Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling
  Biochim Biophys Acta. 2013 Mar;1833(3):602-12. doi: 10.1016/j.bbamcr.2012.11.009. Epub 2012 Nov 16.
• Rothhämel S, Haass C (2013)
  Real-Time Monitoring of Inclusion Formation in Living Zebrafish
• Mori K, Weng SM, Arzberger T, Rentzsch K, Kremmer E, Schmid B, Kretzschmar HA, Cruts M, Van Broeckhoven C, Haass C, Edbauer D (2013)
  The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS
  Science. 2013 Feb 7. [Epub ahead of print]
• Zhang L, Karsten P, Hamm S, Pogson JH, Müller-Rischart AK, Exner N, Haass C, Whitworth AJ, Winklhofer KF, Schulz JB, Voigt A (2013)
  TRAP1 rescues PINK1 loss-of-function phenotypes
  Hum Mol Genet. 2013 Apr 7. [Epub ahead of print
• Dormann D, Madl T, Valori CF, Bentmann E, Kremmer E, Ansorge O, Mackenzie IR, Neumann M, Haass C (2012)
  Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS
  EMBO J. 2012 Sep 11. doi: 10.1038/emboj.2012.261. [Epub ahead of print]
• Fleck D, Garratt AN, Haass C, Willem M (2012)
  BACE1 dependent neuregulin processing: review.
  Curr Alzheimer Res. 2012 Feb;9(2):178-83
• Wils H, Kleinberger G, Pereson S, Janssens J, Capell A, Van Dam D, Cuijt I, Joris G, De Deyn PP, Haass C, Van Broeckhoven C, Kumar-Singh S (2012)
  Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice
  J Pathol. 2012 Jun 25. doi: 10.1002/path.4043. [Epub ahead of print]
• Plucinska G, Paquet D, Hruscha A, Godinho L, Haass C, Schmid B, Misgeld T (2012)
  In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system
  J Neurosci. 2012 Nov 14;32(46):16203-12. doi: 10.1523/JNEUROSCI.1327-12.2012
• Orozco D, Tahirovic S, Rentzsch K, Haass C, Edbauer D (2012)
  Loss of fused in sarcoma (FUS) promotes pathological Tau splicing
  EMBO Rep. 2012 Jun 19. doi: 10.1038/embor.2012.90. [Epub ahead of print]
• Page RM, Münch A, Horn T, Kuhn PH, Colombo A, Reiner O, Boutros M, Steiner H, Lichtenthaler SF, Haass C (2012)
  Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments
  J Neurosci. 2012 Dec 12;32(50):18204-18214.
• Lang CM, Fellerer K, Schwenk BM, Kuhn PH, Kremmer E, Edbauer D, Capell A, Haass C (2012)
  Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration
  J Biol Chem. 2012 Apr 17. [Epub ahead of print]
• Leuner K, Schütt T, Kurz C, Eckert SH, Schiller C, Occhipinti A, Mai S, Jendrach M, Eckert GP, Kruse SE, Palmiter RD, Brandt U, Dröse S, Wittig I, Willem M, Haass C, Reichert AS, Müller WE (2012)
  Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation.
  Antioxid Redox Signal. 2012 Jun 15;16(12):1421-33. Epub 2012 Feb 28.
• Bentmann E, Neumann E, Tahirovic S, Rodde R, Dormann D, Haass C (2012)
  Requirements for Stress Granule Recruitment of Fused in Sarcoma (FUS) and TAR DNA Binding Protein of 43kDa (TDP-43)
  J. Biol. Chem. 2012 May 4. [First Published]
• Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers U, Imhof A, Hoffmeister A, Haass C, Roßner S, Bräse S (2012)
  Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.
  EMBO J. 2012 Jun 22;31(14):3157-68. doi: 10.1038/emboj.2012.173.
• Rolyan H, Feike AC, Upadhaya AR, Waha A, Van Dooren T, Haass C, Birkenmeier G, Pietrzik CU, Van Leuven F, Thal DR (2011)
  Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease
  J Neural Transm. 2011 May;118(5):699-712. Epub 2011 Jan 6.
• Kretner B, Gutsmiedl A, Page RM, Luebbers T, Galley G, Baumann KH, Haass C, Steiner H (2011)
  Attenuated Aβ42 responses to low potency γ-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds
  J Biol Chem. 2011 Apr 29;286(17):15240-51. Epub 2011 Feb 25.
• Fleck D, Garratt AN, Haass C, Willem M (2011)
  BACE1 Dependent Neuregulin Proteolysis
  Curr Alzheimer Res. 2011 May 23. [Epub ahead of print]
• Velanac V, Unterbarnscheidt T, Hinrichs W, Gummert MN, Fischer TM, Rossner MJ, Trimarco A, Brivio V, Willem M, Taveggia C, Haass C, Möbius W, Nave KA, Schwab MH (2011)
  Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination
  Glia. 2011 Nov 2. doi: 10.1002/glia.21255. [Epub ahead of print]
• Haass C, Hemmer B, Meyer B, Halle M, Förstl H (2011)
  Correspondence (reply): In Reply
  Dtsch Arztebl Int. 2011 Mar;108(9):146. Epub 2011 Mar 4.
• Neumann M, Bentmann E, Dormann D, Jawaid A, DeJesus-Hernandez M, Ansorge O, Roeber S, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ang LC, Bilbao J, Rademakers R, Haass C, Mackenzie IRA (2011)
  FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations
  Brain. 2011 Sep;134(Pt 9):2595-609. Epub 2011 Aug 19.
• Ebke A, Luebbers T, Shirotani K, Haass C, Baumann KH, Steiner H (2011)
  Novel γ-secretase modulators directly target presenilin
  J Biol Chem. 2011 Oct 28;286(43):37181-6. Epub 2011 Sep 6.
• Capell A, Liebscher S, Fellerer K, Brouwers N, Willem M, Lammich S, Gijselinck I, Bittner T, Carlson AM, Sasse F, Kunze B, Steinmetz H, Jansen R, Dormann D, Sleegers K, Cruts M, Herms J, Van Broeckhoven C, Haass C. (2011)
  Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase
  J Neurosci. 2011 Feb 2;31(5):1885-1894.
• Dormann D, Haass C (2011)
  TDP-43 and FUS: a nuclear affair
  Trends Neurosci. 2011 Jun 21. [Epub ahead of print]
• Fluhrer R, Kamp F, Nuscher B, Steiner H, Beyer K, Haass C (2011)
  The nicastrin ectodomain adopts a highly thermostable structure
  Biol Chem. 2011 Aug 18. [Epub ahead of print]
• Fluhrer R, Martin L, Haug-Kroeper M, Nuscher B, Haass C (2011)
  The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by Signal Peptide Peptidase-Like 2b (SPPL2b)
  J Biol Chem. 2012 Feb 10;287(7):5156-63. Epub 2011 Dec 22
• Lammich S, Kamp F, Wagner J, Nuscher B, Zilow S, Ludwig AK, Willem M, Haass C (2011)
  Translational repression of the Disintegrin and Metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5′-untranslated region
  J Biol Chem. 2011 Dec 30;286(52):45063-72. Epub2011 Nov 7.
• Mitterreiter S, Page RM, Kamp F, Hopson J, Ha HR, Hamid R, Herms J, Mayer TU, Nelson DJ, Steiner H, Stahl T, Zeitschel U, Roßner S, Haass C (2010)
  Bepridil and Amiodarone Simultaneously Target the Alzheimer’s Disease β- and γ-Secretase via Distinct Mechanisms
  J. Neurosci. 2010 Apr 20. [Epub ahead of print]
• Fluhrer R, Steiner H, Haass C (2010)
  Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of γ-secretase-mediated intramembrane proteolysis
  J. Neurosci. 2010 Apr 20. [Epub ahead of print]
• Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IR, Capell A, Schmid B, Neumann M, Haass C (2010)
  ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
  EMBO J. 2010 Aug 18;29(16):2841-57. Epub 2010 Jul 6.
• Lammich S, Buell D, Zilow S, Ludwig AK, Nuscher B, Prinzen C, Fahrenholz F, Haass C (2010)
  Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region
  J Biol Chem. 2010 Mar 26. [Epub ahead of print]
• Haass C, Mandelkow E (2010)
  Fyn-tau-amyloid: a toxic triad
  Cell. 2010 Aug 6;142(3):356-8.
• Kamp F, Exner N, Lutz AK, Wender N, Hegermann J, Brunner B, Nuscher B, Bartels T, Giese A, Beyer K, Eimer S, Winklhofer KF, Haass C (2010)
  Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1
  EMBO J. 2010 Oct 20;29(20):3571-89. Epub 2010 Sep 14.
• van Bebber F, Paquet D, Hruscha A, Schmid B, Haass C (2010)
  Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in Zebrafish
  Neurobiol Dis. 2010 Sep;39(3):265-71. Epub 2010 Apr 8.
• Fuhrmann M, Bittner T, Jung CK, Burgold S, Page RM, Mitteregger G, Haass C, LaFerla FM, Kretzschmar H, Herms J (2010)
  Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease
  Nat Neurosci. 2010 Apr;13(4):411-3. Epub 2010 Mar 21.
• Fett ME, Pilsl A, Paquet D, van Bebber F, Haass C, Schmid B, Winklhofer KF (2010)
  Parkin is protective against proteotoxic stress in a transgenic zebrafish model
  PLoS One. 2010 Jul 30;5(7):e11783.
• Bartels T, Ahlstrom LS, Leftin A, Kamp F, Haass C, Brown MF, Beyer K (2010)
  The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding
  Biophys J. 2010 Oct 6;99(7):2116-24.
• Dettmer U, Kuhn PH, Krueger M, Kremmer E, Haass C, Haffner C (2010)
  The transmembrane protein 147 (TMEM147) is a novel component of the nicalin-nomo protein complex
  J Biol Chem. 2010 Jun 10. [Epub ahead of print]
• Fluhrer R, Steiner H, Haass C (2010)
  Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of γ-secretase-mediated intramembrane proteolysis
  J Neurosci. 2010 Jun 9;30(23):7853-62.
• Paquet D, Schmid B, Haass C (2010)
  Transgenic Zebrafish as a Novel Animal Model to Study Tauopathies and Other Neurodegenerative Disorders in vivo
  Neurodegener Dis. 2010 Feb 18;7(1-3):99-102. [Epub ahead of print]
• Page RM, Gutsmiedl A, Haass C, Steiner H (2010)
  β-Amyloid precursor protein mutants respond to γ-secretase modulators
  J Biol Chem. 2010 Jun 4;285(23):17798-810. Epub 2010 Mar 26.
• Paquet D, Haass C (2009)
  Alzheimerforschung in transgenen Zebrafischen
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• Haass C (2009)
  Alzheimer - Mechanismen und therapeutische Ansätze. Warum wir im Alter dement werden
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• Paquet D, Bhat R, Sydow A, Mandelkow EM, Berg S, Hellberg S, Fälting J, Distel M, Köster RW, Schmid B, Haass C (2009)
  A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation
  J Clin Invest. 2009 May;119(5):1382-95. doi: 10.1172/JCI37537. Epub 2009 Apr 13.
• Itoh N, Okochi M, Tagami S, Nishitomi K, Nakayama T, Yanagida K, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, Takemoto H, Minagawa K, Katoh T, Willem M, Haass C, Morihara T, Tanaka T, Kudo T, Hasegawa H, Nishimura M, Sakaguchi G, Kato A, Takeda M (2009)
  Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor
  Neurodegener Dis. 2009;6(5-6):230-9. Epub 2009 Sep 9.
• Willem M, Lammich S, Haass C (2009)
  Function, regulation and therapeutic properties of beta-secretase (BACE1)
  Semin Cell Dev Biol. 2009 Apr;20(2):175-82. Epub 2009 Jan 20.
• Lutz AK, Exner N, Schlehe JS, Kloos K, Laemmermann K, Brunner B, Kurz-Drexler A, Vogel F, Reichert AS, Bouman L, Vogt-Weisenhorn D, Wurst W, Haass C, Winklhofer KF (2009)
  Loss of parkin or PINK1 function increases DRP1-dependent mitochondrial fragmentation
  J Biol Chem. 2009 Aug 21;284(34):22938-51. Epub 2009 Jun 22.
• Fassler M, Zocher M, Klare S, de la Fuente AG, Scheuermann J, Capell A, Haass C, Valkova C, Veerappan A, Schneider D, Kaether C (2009)
  Masking of Transmembrane-Based Retention Signals Controls ER Export of gamma-Secretase
  Traffic. 2010 Feb;11(2):250-8. Epub 2009 Nov 5.
• Winklhofer KF, Haass C (2009)
  Mitochondrial dysfunction in Parkinson's disease
  Biochim Biophys Acta. 2010 Jan;1802(1):29-44. Epub 2009 Sep 3.
• Fournier M, Vitte J, Garrigue J, Langui D, Dullin JP, Saurini F, Hanoun N, Perez-Diaz F, Cornilleau F, Joubert C, Ardila-Osorio H, Traver S, Duchateau R, Goujet-Zalc C, Paleologou K, Lashuel HA, Haass C, Duyckaerts C, Cohen-Salmon C, Kahle PJ, Hamon M, Brice A, Corti O (2009)
  Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy
  PLoS One. 2009 Aug 14;4(8):e6629.
• Dormann D, Capell A, Carlson AM, Shankaran SS, Rodde R, Neumann M, Kremmer E, Matsuwaki T, Yamanouchi K, Nishihara M, Haass C (2009)
  Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin
  J Neurochem. 2009 Aug;110(3):1082-94. Epub 2009 Jun 9.
• Hobson S, Dümpelfeld B, Luebbers T, Baumann K, Haass C, Hopf C, Steiner H (2009)
  Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human γ-secretase
  Biochemistry 2009 Jan 21.
• Pérez-Revuelta BI, Lammich S, Yamasaki A, Haass C, Steiner H (2009)
  Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage
  J Neurochem. 2010 Feb;112(4):940-50. Epub 2009 Dec 15.
• Bittner T, Fuhrmann M, Burgold S, Jung CK, Volbracht C, Steiner H, Mitteregger G, Kretzschmar HA, Haass C, Herms J (2009)
  γ-Secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway
  J Neurosci. 2009 Aug 19;29(33):10405-9.
• Schobel S, Neumann S, Hertweck M, Dislich B, Kuhn PH, Kremmer E, Seed B, Baumeister R, Haass C (2008)
  A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein
  J Biol Chem 283(21): 14257-68
• Steiner H, Winkler E, Haass C (2008)
  Chemical cross-linking provides a model of the γ-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1
  J Biol Chem 283(50): 34677-86
• Busche MA, Eichhoff G, Adelsberger H, Abramowski D, Wiederhold KH, Haass C, Staufenbiel M, Konnerth A, Garaschuk O (2008)
  Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease
  Science 321(5896): 1686-9
• Dejaegere T, Serneels L, Schafer MK, Van Biervliet J, Horre K, Depboylu C, Alvarez-Fischer D, Herreman A, Willem M, Haass C, Hoglinger GU, D'Hooge R, De Strooper B (2008)
  Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment
  Proc Natl Acad Sci U S A 105(28): 9775-80
• Page RM, Baumann K, Tomioka M, Perez-Revuelta BI, Jacobsen H, Flohr A, Luebbers T, Ozmen L, Steiner H, Haass C (2008)
  Generation of Aβ38 and Aβ42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and γ-secretase modulation
  J Biol Chem 283(2): 677-83
• Chiesa C, Osborn JF, Haass C, Natale F, Spinelli M, Scapillati E, Spinelli A, Pacifico L (2008)
  Ghrelin, leptin, IGF-1, IGFBP-3, and insulin concentrations at birth: is there a relationship with fetal growth and neonatal anthropometry?
  Clin Chem 54(3): 550-8
• Fluhrer R, Martin L, Grammer G, Haug-Kroper M, Klier B, Winkler E, Kremmer E, Condron MM, Teplow DB, Steiner H, Haass C (2008)
  Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation
  J Biol Chem 283(44): 30121-8
• Shankaran SS, Capell A, Hruscha AT, Fellerer K, Neumann M, Schmid B, Haass C (2008)
  Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion
  J Biol Chem 283(3): 1744-53
• O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Hebert SS, De Strooper B, Haass C, Bennett DA, Vassar R (2008)
  Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis
  Neuron 60(6): 988-1009
• Martin L, Fluhrer R, Reiss K, Kremmer E, Saftig P, Haass C (2008)
  Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b
  J Biol Chem 283(3): 1644-52
• St George-Hyslop P, Haass C (2008)
  Regulatory RNA goes awry in Alzheimer's disease
  Nat Med 14(7): 711-2
• Martin L, Fluhrer R, Haass C (2008)
  Substrate requirements for SPPL2b dependent regulated intramembrane proteolysis
  J Biol Chem
• Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, Steiner H, Haass C, Wolfe MS (2007)
  Active γ-secretase complexes contain only one of each component
  J Biol Chem 282(47): 33985-93
• Freichel C, Neumann M, Ballard T, Muller V, Woolley M, Ozmen L, Borroni E, Kretzschmar HA, Haass C, Spooren W, Kahle PJ (2007)
  Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice
  Neurobiol Aging 28(9): 1421-35
• Hamid R, Kilger E, Willem M, Vassallo N, Kostka M, Bornhovd C, Reichert AS, Kretzschmar HA, Haass C, Herms J (2007)
  Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content
  J Neurochem 102(4): 1264-75
• Prager K, Wang-Eckhardt L, Fluhrer R, Killick R, Barth E, Hampel H, Haass C, Walter J (2007)
  A structural switch of presenilin 1 by glycogen synthase kinase 3beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling
  J Biol Chem 282(19): 14083-93
• Kaether C, Scheuermann J, Fassler M, Zilow S, Shirotani K, Valkova C, Novak B, Kacmar S, Steiner H, Haass C (2007)
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• Schiffer NW, Broadley SA, Hirschberger T, Tavan P, Kretzschmar HA, Giese A, Haass C, Hartl FU, Schmid B (2007)
  Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model
  J Biol Chem 282(12): 9195-203
• Exner N, Treske B, Paquet D, Holmstrom K, Schiesling C, Gispert S, Carballo-Carbajal I, Berg D, Hoepken HH, Gasser T, Kruger R, Winklhofer KF, Vogel F, Reichert AS, Auburger G, Kahle PJ, Schmid B, Haass C (2007)
  Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin
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• Narlawar R, Perez Revuelta BI, Baumann K, Schubenel R, Haass C, Steiner H, Schmidt B (2007)
  N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated γ-secretase
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• Thal DR, Larionov S, Abramowski D, Wiederhold KH, Van Dooren T, Yamaguchi H, Haass C, Van Leuven F, Staufenbiel M, Capetillo-Zarate E (2007)
  Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice
  Neurobiol Aging 28(8): 1221-30
• Shirotani K, Tomioka M, Kremmer E, Haass C, Steiner H (2007)
  Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different γ-secretase complexes
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• Kuhn PH, Marjaux E, Imhof A, De Strooper B, Haass C (2007)
  Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase
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• Gorner K, Holtorf E, Waak J, Pham TT, Vogt-Weisenhorn DM, Wurst W, Haass C, Kahle PJ (2007)
  Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1
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• Haffner C, Dettmer U, Weiler T, Haass C (2007)
  The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex
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• Wild-Bode C, Fellerer K, Kugler J, Haass C, Capell A (2006)
  A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration
  J Biol Chem 281(33): 23824-9
• Radde R, Bolmont T, Kaeser SA, Coomaraswamy J, Lindau D, Stoltze L, Calhoun ME, Jaggi F, Wolburg H, Gengler S, Haass C, Ghetti B, Czech C, Holscher C, Mathews PM, Jucker M (2006)
  Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology
  EMBO Rep 7(9): 940-6
• Fluhrer R, Grammer G, Israel L, Condron MM, Haffner C, Friedmann E, Bohland C, Imhof A, Martoglio B, Teplow DB, Haass C (2006)
  A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b
  Nat Cell Biol 8(8): 894-6
• Neumann S, Schobel S, Jager S, Trautwein A, Haass C, Pietrzik CU (2006)
  Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein
  J Biol Chem 281(11): 7583-94
• Kaether C, Schmitt S, Willem M, Haass C (2006)
  Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface
  Traffic 7(4): 408-15
• Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, DeStrooper B, Saftig P, Birchmeier C, Haass C (2006)
  Control of peripheral nerve myelination by the beta-secretase BACE1
  Science 314(5799): 664-6
• Avila J, Nitsch RM, Haass C, De Strooper B (2006)
  European Alzheimer disease funding
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• Anders L, Mertins P, Lammich S, Murgia M, Hartmann D, Saftig P, Haass C, Ullrich A (2006)
  Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity
  Mol Cell Biol 26(10): 3917-34
• Goldsbury C, Mocanu MM, Thies E, Kaether C, Haass C, Keller P, Biernat J, Mandelkow E, Mandelkow EM (2006)
  Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides
  Traffic 7(7): 873-88
• Steiner H, Than M, Bode W, Haass C (2006)
  Pore-forming scissors? A first structural glimpse of γ-secretase
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• Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M (2006)
  Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct
  Biochemistry 45(15): 4907-14
• Narlawar R, Perez Revuelta BI, Haass C, Steiner H, Schmidt B, Baumann K (2006)
  Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer γ-secretase modulators
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• Okochi M, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M (2006)
  Secretion of the Notch-1 Aβ-like peptide during Notch signaling
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• Capetillo-Zarate E, Staufenbiel M, Abramowski D, Haass C, Escher A, Stadelmann C, Yamaguchi H, Wiestler OD, Thal DR (2006)
  Selective vulnerability of different types of commissural neurons for amyloid beta-protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology
  Brain 129(Pt 11): 2992-3005
• Bohm C, Seibel NM, Henkel B, Steiner H, Haass C, Hampe W (2006)
  SorLA signaling by regulated intramembrane proteolysis
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• Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H (2006)
  The GxGD motif of presenilin contributes to catalytic function and substrate identification of γ-secretase
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• Uelhoff A, Aguzzi A, Winklhofer KF, Haass C (2005)
  A pathogenic PrP mutation and doppel interfere with polarized sorting of the prion protein
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• Thal DR, Capetillo-Zarate E, Schultz C, Rub U, Saido TC, Yamaguchi H, Haass C, Griffin WS, Del Tredici K, Braak H, Ghebremedhin E (2005)
  Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner
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• Krawitz P, Haffner C, Fluhrer R, Steiner H, Schmid B, Haass C (2005)
  Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3
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• Wahle T, Prager K, Raffler N, Haass C, Famulok M, Walter J (2005)
  GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network
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• Prokop S, Haass C, Steiner H (2005)
  Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments
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• Stefanova N, Reindl M, Neumann M, Haass C, Poewe W, Kahle PJ, Wenning GK (2005)
  Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy
  Am J Pathol 166(3): 869-76
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  Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity
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• Andersson CX, Fernandez-Rodriguez J, Laos S, Baeckstrom D, Haass C, Hansson GC (2005)
  Shedding and gamma-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43
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• Giese A, Bader B, Bieschke J, Schaffar G, Odoy S, Kahle PJ, Haass C, Kretzschmar H (2005)
  Single particle detection and characterization of synuclein co-aggregation
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• Straub T, Neumann MF, Prestel M, Kremmer E, Kaether C, Haass C, Becker PB (2005)
  Stable chromosomal association of MSL2 defines a dosage-compensated nuclear compartment
  Chromosoma 114(5): 352-64
• Capell A, Beher D, Prokop S, Steiner H, Kaether C, Shearman MS, Haass C (2005)
  γ-Secretase complex assembly within the early secretory pathway
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• Nuscher B, Kamp F, Mehnert T, Odoy S, Haass C, Kahle PJ, Beyer K (2004)
  Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study
  J Biol Chem 279(21): 21966-75
• Keil U, Bonert A, Marques CA, Scherping I, Weyermann J, Strosznajder JB, Muller-Spahn F, Haass C, Czech C, Pradier L, Muller WE, Eckert A (2004)
  Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis
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• Willem M, Dewachter I, Smyth N, Van Dooren T, Borghgraef P, Haass C, Van Leuven F (2004)
  beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice
  Am J Pathol 165(5): 1621-31
• Edbauer D, Kaether C, Steiner H, Haass C (2004)
  Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1
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• Gorner K, Holtorf E, Odoy S, Nuscher B, Yamamoto A, Regula JT, Beyer K, Haass C, Kahle PJ (2004)
  Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1
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• Westmeyer GG, Willem M, Lurman G, Multhaup G, Assfalg-Machleidt I, Reiss K, Saftig P, Haass C (2004)
  Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme
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• Lammich S, Schobel S, Zimmer AK, Haass C (2004)
  Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region
  EMBO Rep 5(6): 620-5
• Schmechel A, Strauss M, Schlicksupp A, Pipkorn R, Haass C, Bayer TA, Multhaup G (2004)
  Human BACE forms dimers and colocalizes with APP
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• Shirotani K, Edbauer D, Prokop S, Haass C, Steiner H (2004)
  Identification of distinct γ-secretase complexes with different APH-1 variants
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• Shirotani K, Edbauer D, Kostka M, Steiner H, Haass C (2004)
  Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1
  J Neurochem 89(6): 1520-7
• Haffner C, Frauli M, Topp S, Irmler M, Hofmann K, Regula JT, Bally-Cuif L, Haass C (2004)
  Nicalin and its binding partner Nomo are novel Nodal signaling antagonists
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• Neumann M, Muller V, Gorner K, Kretzschmar HA, Haass C, Kahle PJ (2004)
  Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease
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• Fluhrer R, Friedlein A, Haass C, Walter J (2004)
  Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis
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• Neumann M, Muller V, Kretzschmar HA, Haass C, Kahle PJ (2004)
  Regional distribution of proteinase K-resistant alpha-synuclein correlates with Lewy body disease stage
  J Neuropathol Exp Neurol 63(12): 1225-35
• Prokop S, Shirotani K, Edbauer D, Haass C, Steiner H (2004)
  Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the γ-secretase complex
  J Biol Chem 279(22): 23255-61
• Kaether C, Capell A, Edbauer D, Winkler E, Novak B, Steiner H, Haass C (2004)
  The presenilin C-terminus is required for ER-retention, nicastrin-binding and γ-secretase activity
  EMBO J 23(24): 4738-48
• Ehehalt R, Keller P, Haass C, Thiele C, Simons K (2003)
  Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts
  J Cell Biol 160(1): 113-23
• Fluhrer R, Multhaup G, Schlicksupp A, Okochi M, Takeda M, Lammich S, Willem M, Westmeyer G, Bode W, Walter J, Haass C (2003)
  Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation
  J Biol Chem 278(8): 5531-8
• Marques CA, Keil U, Bonert A, Steiner B, Haass C, Muller WE, Eckert A (2003)
  Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway
  J Biol Chem 278(30): 28294-302
• Capell A, Kaether C, Edbauer D, Shirotani K, Merkl S, Steiner H, Haass C (2003)
  Nicastrin interacts with γ-secretase complex components via the N-terminal part of its transmembrane domain
  J Biol Chem 278(52): 52519-23
• Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo EH, Haass C, Takio K, Morishima-Kawashima M, Ishiura S, Ihara Y (2003)
  Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein
  J Biol Chem 278(27): 24294-301
• Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C (2003)
  Reconstitution of γ-secretase activity
  Nat Cell Biol 5(5): 486-8
• Dominguez DI, Westmeyer GG, Reiss K, Haass C, Saftig P, De Strooper B, Seed B (2003)
  The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1
  J Biol Chem 278(49): 48713-9
• Shirotani K, Edbauer D, Capell A, Schmitz J, Steiner H, Haass C (2003)
  γ-Secretase activity is associated with a conformational change of nicastrin
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• Fluhrer R, Capell A, Westmeyer G, Willem M, Hartung B, Condron MM, Teplow DB, Haass C, Walter J (2002)
  A non-amyloidogenic function of BACE-2 in the secretory pathway
  J Neurochem 81(5): 1011-20
• Capell A, Meyn L, Fluhrer R, Teplow DB, Walter J, Haass C (2002)
  Apical sorting of beta-secretase limits amyloid beta-peptide production
  J Biol Chem 277(7): 5637-43
• Geling A, Steiner H, Willem M, Bally-Cuif L, Haass C (2002)
  A γ-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish
  EMBO Rep 3(7): 688-94
• Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Spooren W, Fuss B, Mallon B, Macklin WB, Fujiwara H, Hasegawa M, Iwatsubo T, Kretzschmar HA, Haass C (2002)
  Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes
  EMBO Rep 3(6): 583-8
• Edbauer D, Willem M, Lammich S, Steiner H, Haass C (2002)
  Insulin-degrading enzyme rapidly removes the β-amyloid precursor protein intracellular domain (AICD)
  J Biol Chem 277(16): 13389-93
• Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Muller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C (2002)
  Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies
  J Clin Invest 110(10): 1429-39
• Haass C (2002)
  New hope for Alzheimer disease vaccine
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• Steiner H, Winkler E, Edbauer D, Prokop S, Basset G, Yamasaki A, Kostka M, Haass C (2002)
  PEN-2 is an integral component of the γ-secretase complex required for coordinated expression of presenilin and nicastrin
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• Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C (2002)
  Presenilin-1 affects trafficking and processing of βAPP and is targeted in a complex with nicastrin to the plasma membrane
  J Cell Biol 158(3): 551-61
• Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, Capell A, Kaether C, Zheng H, Ghetti B, Haass C, Steiner H (2002)
  Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ 42 production
  Proc Natl Acad Sci U S A 99(12): 8025-30
• Edbauer D, Winkler E, Haass C, Steiner H (2002)
  Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation
  Proc Natl Acad Sci U S A 99(13): 8666-71
• Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, Edbauer D, Walter J, Steiner H, Haass C (2002)
  Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Aβ-like peptide
  J Biol Chem 277(47): 44754-9
• Okochi M, Steiner H, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C (2002)
  Presenilins mediate a dual intramembranous γ-secretase cleavage of Notch-1
  EMBO J 21(20): 5408-16
• Leutz S, Steiner B, Marques CA, Haass C, Muller WE, Eckert A (2002)
  Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death
  J Mol Neurosci 18(3): 189-201
• Thal DR, Ghebremedhin E, Haass C, Schultz C (2002)
  UV light-induced autofluorescence of full-length Abeta-protein deposits in the human brain
  Clin Neuropathol 21(1): 35-40
• Yamazaki T, Chang TY, Haass C, Ihara Y (2001)
  Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells
  J Biol Chem 276(6): 4454-60
• Steiner H, Revesz T, Neumann M, Romig H, Grim MG, Pesold B, Kretzschmar HA, Hardy J, Holton JL, Baumeister R, Houlden H, Haass C (2001)
  A pathogenic presenilin-1 deletion causes abberrant Aβ 42 production in the absence of congophilic amyloid plaques
  J Biol Chem 276(10): 7233-9
• Eckert A, Steiner B, Marques C, Leutz S, Romig H, Haass C, Muller WE (2001)
  Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation
  J Neurosci Res 64(2): 183-92
• Steiner H, Winkler E, Shearman MS, Prywes R, Haass C (2001)
  Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins
  Neurobiol Dis 8(4): 717-22
• Haass C, Kahle PJ (2001)
  Neuroscience. Parkin and its substrates
  Science 293(5528): 224-5
• Walter J, Fluhrer R, Hartung B, Willem M, Kaether C, Capell A, Lammich S, Multhaup G, Haass C (2001)
  Phosphorylation regulates intracellular trafficking of beta-secretase
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• Sastre M, Steiner H, Fuchs K, Capell A, Multhaup G, Condron MM, Teplow DB, Haass C (2001)
  Presenilin-dependent γ-secretase processing of β-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch
  EMBO Rep 2(9): 835-41
• Haass C, Steiner H (2001)
  Protofibrils, the unifying toxic molecule of neurodegenerative disorders?
  Nat Neurosci 4(9): 859-60
• Kahle PJ, Neumann M, Ozmen L, Muller V, Odoy S, Okamoto N, Jacobsen H, Iwatsubo T, Trojanowski JQ, Takahashi H, Wakabayashi K, Bogdanovic N, Riederer P, Kretzschmar HA, Haass C (2001)
  Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model
  Am J Pathol 159(6): 2215-25
• Rathke-Hartlieb S, Kahle PJ, Neumann M, Ozmen L, Haid S, Okochi M, Haass C, Schulz JB (2001)
  Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice
  J Neurochem 77(4): 1181-4
• Kahle PJ, Haass C (2001)
  The emerging utility of animal models of chronic neurodegenerative diseases
  Expert Opin Ther Targets 5(1): 125-32
• Okochi M, Eimer S, Bottcher A, Baumeister R, Romig H, Walter J, Capell A, Steiner H, Haass C (2000)
  A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases Aβ42 generation in human cells
  J Biol Chem 275(52): 40925-32
• Hayashi H, Mizuno T, Michikawa M, Haass C, Yanagisawa K (2000)
  Amyloid precursor protein in unique cholesterol-rich microdomains different from caveolae-like domains
  Biochim Biophys Acta 1483(1): 81-90
• Mathews PM, Cataldo AM, Kao BH, Rudnicki AG, Qin X, Yang JL, Jiang Y, Picciano M, Hulette C, Lippa CF, Bird TD, Nochlin D, Walter J, Haass C, Levesque L, Fraser PE, Andreadis A, Nixon RA (2000)
  Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease
  Mol Med 6(10): 878-91
• Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle PJ, Haass C (2000)
  Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein
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• Steiner H, Kostka M, Romig H, Basset G, Pesold B, Hardy J, Capell A, Meyn L, Grim ML, Baumeister R, Fechteler K, Haass C (2000)
  Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases
  Nat Cell Biol 2(11): 848-51
• Wirths O, Weickert S, Majtenyi K, Havas L, Kahle PJ, Okochi M, Haass C, Multhaup G, Beyreuther K, Bayer TA (2000)
  Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques
  Neuroreport 11(17): 3737-41
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  Maturation and pro-peptide cleavage of β-secretase
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• Yu G, Chen F, Nishimura M, Steiner H, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Holmes E, Zhang DM, Milman P, Fraser P, Haass C, St George-Hyslop P (2000)
  Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes
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  Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes
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• Haass C, Kahle PJ (2000)
  Parkinson's pathology in a fly
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  Phosphorylation of the beta-amyloid precursor protein at the cell surface by ectocasein kinases 1 and 2
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  Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch
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  Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain
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• Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, Tomita T, Iwatsubo T, Baumeister R, Haass C (1999)
  A loss of function mutation of presenilin-2 interferes with amyloid β-peptide production and notch signaling
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  Alpha-synuclein immunoreactive Lewy bodies and Lewy neurites in Parkinson's disease are detectable by an advanced silver-staining technique
  Acta Neuropathol 98(5): 461-4
• Steiner H, Romig H, Pesold B, Philipp U, Baader M, Citron M, Loetscher H, Jacobsen H, Haass C (1999)
  Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis
  Biochemistry 38(44): 14600-5
• Diehlmann A, Ida N, Weggen S, Grunberg J, Haass C, Masters CL, Bayer TA, Beyreuther K (1999)
  Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies
  J Neurosci Res 56(4): 405-19
• Steiner H, Pesold B, Haass C (1999)
  An in vivo assay for the identification of target proteases which cleave membrane-associated substrates
  FEBS Lett 463(3): 245-9
• Haass C (1999)
  Apoptosis. Dead end for neurodegeneration?
  Nature 399(6733): 204-5, 207
• Haass C (1999)
  Biology of Alzheimer's disease
  Eur Arch Psychiatry Clin Neurosci 249(6): 265
• Mizuno T, Nakata M, Naiki H, Michikawa M, Wang R, Haass C, Yanagisawa K (1999)
  Cholesterol-dependent generation of a seeding amyloid beta-protein in cell culture
  J Biol Chem 274(21): 15110-4
• Lammich S, Kojro E, Postina R, Gilbert S, Pfeiffer R, Jasionowski M, Haass C, Fahrenholz F (1999)
  Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease
  Proc Natl Acad Sci U S A 96(7): 3922-7
• Thal DR, Sassin I, Schultz C, Haass C, Braak E, Braak H (1999)
  Fleecy amyloid deposits in the internal layers of the human entorhinal cortex are comprised of N-terminal truncated fragments of Abeta
  J Neuropathol Exp Neurol 58(2): 210-6
• Guenette SY, Chen J, Ferland A, Haass C, Capell A, Tanzi RE (1999)
  hFE65L influences amyloid precursor protein maturation and secretion
  J Neurochem 73(3): 985-93
• Walter J, Schindzielorz A, Grunberg J, Haass C (1999)
  Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis
  Proc Natl Acad Sci U S A 96(4): 1391-6
• Haass C, Mandelkow E (1999)
  Proteolysis by presenilins and the renaissance of tau
  Trends Cell Biol 9(6): 241-4
• Steiner H, Romig H, Grim MG, Philipp U, Pesold B, Citron M, Baumeister R, Haass C (1999)
  The biological and pathological function of the presenilin-1 Δexon 9 mutation is independent of its defect to undergo proteolytic processing
  J Biol Chem 274(12): 7615-8
• Leimer U, Lun K, Romig H, Walter J, Grunberg J, Brand M, Haass C (1999)
  Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis
  Biochemistry 38(41): 13602-9
• Grunberg J, Walter J, Loetscher H, Deuschle U, Jacobsen H, Haass C (1998)
  Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family
  Biochemistry 37(8): 2263-70
• Haass C, Selkoe DJ (1998)
  Alzheimer's disease. A technical KO of amyloid-beta peptide
  Nature 391(6665): 339-40
• Brockhaus M, Grunberg J, Rohrig S, Loetscher H, Wittenburg N, Baumeister R, Jacobsen H, Haass C (1998)
  Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling
  Neuroreport 9(7): 1481-6
• Mizuno T, Haass C, Michikawa M, Yanagisawa K (1998)
  Cholesterol-dependent generation of a unique amyloid beta-protein from apically missorted amyloid precursor protein in MDCK cells
  Biochim Biophys Acta 1373(1): 119-30
• Steiner H, Capell A, Pesold B, Citron M, Kloetzel PM, Selkoe DJ, Romig H, Mendla K, Haass C (1998)
  Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation
  J Biol Chem 273(48): 32322-31
• Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grunberg J, Ueyama Y, Haass C, Ihara Y (1998)
  Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain
  J Neurochem 71(1): 313-22
• Walter J, Grunberg J, Schindzielorz A, Haass C (1998)
  Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms
  Biochemistry 37(17): 5961-7
• Capell A, Grunberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C (1998)
  The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex
  J Biol Chem 273(6): 3205-11
• Grunberg J, Walter J, Eckman C, Capell A, Schindzielorz A, Younkin S, Mehta N, Hardy J, Haass C (1998)
  Truncated presenilin 2 derived from differentially spliced mRNA does not affect the ratio of amyloid beta-peptide 1-42/1-40
  Neuroreport 9(14): 3293-9
• Capell A, Saffrich R, Olivo JC, Meyn L, Walter J, Grunberg J, Mathews P, Nixon R, Dotti C, Haass C (1997)
  Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation
  J Neurochem 69(6): 2432-40
• Walter J, Capell A, Hung AY, Langen H, Schnolzer M, Thinakaran G, Sisodia SS, Selkoe DJ, Haass C (1997)
  Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations
  J Biol Chem 272(3): 1896-903
• Xia W, Zhang J, Kholodenko D, Citron M, Podlisny MB, Teplow DB, Haass C, Seubert P, Koo EH, Selkoe DJ (1997)
  Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins
  J Biol Chem 272(12): 7977-82
• Kim SH, Kim YK, Jeong SJ, Haass C, Kim YH, Suh YH (1997)
  Enhanced release of secreted form of Alzheimer's amyloid precursor protein from PC12 cells by nicotine
  Mol Pharmacol 52(3): 430-6
• Baumeister R, Leimer U, Zweckbronner I, Jakubek C, Grunberg J, Haass C (1997)
  Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing
  Genes Funct 1(2): 149-59
• Wild-Bode C, Yamazaki T, Capell A, Leimer U, Steiner H, Ihara Y, Haass C (1997)
  Intracellular generation and accumulation of amyloid β-peptide terminating at amino acid 42
  J Biol Chem 272(26): 16085-8
• Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ (1997)
  Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue
  Neurobiol Dis 3(4): 325-37
• Loetscher H, Deuschle U, Brockhaus M, Reinhardt D, Nelboeck P, Mous J, Grunberg J, Haass C, Jacobsen H (1997)
  Presenilins are processed by caspase-type proteases
  J Biol Chem 272(33): 20655-9
• Walter J, Grunberg J, Capell A, Pesold B, Schindzielorz A, Citron M, Mendla K, George-Hyslop PS, Multhaup G, Selkoe DJ, Haass C (1997)
  Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C
  Proc Natl Acad Sci U S A 94(10): 5349-54
• Yamazaki T, Haass C, Saido TC, Omura S, Ihara Y (1997)
  Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition
  Biochemistry 36(27): 8377-83
• Tomita T, Maruyama K, Saido TC, Kume H, Shinozaki K, Tokuhiro S, Capell A, Walter J, Grunberg J, Haass C, Iwatsubo T, Obata K (1997)
  The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue
  Proc Natl Acad Sci U S A 94(5): 2025-30
• Qiu WQ, Borth W, Ye Z, Haass C, Teplow DB, Selkoe DJ (1996)
  Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex
  J Biol Chem 271(14): 8443-51
• Citron M, Diehl TS, Capell A, Haass C, Teplow DB, Selkoe DJ (1996)
  Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF
  Neuron 17(1): 171-9
• Capell A, Teplow DB, Citron M, Selkoe DJ, Haass C (1996)
  Substitution of phenylalanine by proline at position 19 of amyloid-ß peptide results in the inhibition of protein kinase C mediated decrease of amyloidogenic processing
  Amyloid 3; 150-155
• Walter J, Capell A, Grunberg J, Pesold B, Schindzielorz A, Prior R, Podlisny MB, Fraser P, Hyslop PS, Selkoe DJ, Haass C (1996)
  The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum
  Mol Med 2(6): 673-91
• Munger JS, Haass C, Lemere CA, Shi GP, Wong WS, Teplow DB, Selkoe DJ, Chapman HA (1995)
  Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S
  Biochem J 311 ( Pt 1): 299-305
• Haass C, Koo EH, Capell A, Teplow DB, Selkoe DJ (1995)
  Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals
  J Cell Biol 128(4): 537-47
• Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ (1995)
  ß-Secretase cleavage of ß-Amyloid precursor protein with the Swedish mutation occurs within the secretory pathway after the trans-Golgi network
  Nat. Med. 1; 1291-6
• Lemere CA, Munger JS, Shi GP, Natkin L, Haass C, Chapman HA, Selkoe DJ (1995)
  The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study
  Am J Pathol 146(4): 848-60
• Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ (1995)
  The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway
  Nat Med 1(12): 1291-6
• Haass C, Capell A, Citron M, Teplow DB, Selkoe DJ (1995)
  The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein
  J Biol Chem 270(11): 6186-92
• Lo AC, Haass C, Wagner SL, Teplow DB, Sisodia SS (1994)
  Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells
  J Biol Chem 269(49): 30966-73
• Haass C, Hung AY, Selkoe DJ, Teplow DB (1994)
  Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor
  J Biol Chem 269(26): 17741-8
• Haass C, Koo EH, Teplow DB, Selkoe DJ (1994)
  Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells
  Proc Natl Acad Sci U S A 91(4): 1564-8
• Hung AY, Haass C, Nitsch RM, Qiu WQ, Citron M, Wurtman RJ, Growdon JH, Selkoe DJ (1993)
  Activation of protein kinase C inhibits cellular production of the amyloid beta-protein
  J Biol Chem 268(31): 22959-62
• Haass C, Hung AY, Schlossmacher MG, Teplow DB, Selkoe DJ (1993)
  beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms
  J Biol Chem 268(5): 3021-4
• Haass C, Hung AY, Schlossmacher MG, Oltersdorf T, Teplow DB, Selkoe DJ (1993)
  Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules
  Ann N Y Acad Sci 695: 109-16
• Citron M, Haass C, Selkoe DJ (1993)
  Production of amyloid-beta-peptide by cultured cells: no evidence for internal initiation of translation at Met596
  Neurobiol Aging 14(6): 571-3
• Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB, et al. (1992)
  Amyloid beta-peptide is produced by cultured cells during normal metabolism
  Nature 359(6393): 322-5
• Schlossmacher MG, Ostaszewski BL, Hecker LI, Celi A, Haass C, Chin D, Lieberburg I, Furie BC, Furie B, Selkoe DJ (1992)
  Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes
  Neurobiol Aging 13(3): 421-34
• Hung AY, Koo EH, Haass C, Selkoe DJ (1992)
  Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage
  Proc Natl Acad Sci U S A 89(20): 9439-43
• Frentzel S, Troxell M, Haass C, Pesold-Hurt B, Glatzer KH, Kloetzel PM (1992)
  Molecular characterization of the genomic regions of the Drosophila alpha-type subunit proteasome genes PROS-Dm28.1 and PROS-Dm35
  Eur J Biochem 205(3): 1043-51
• Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ (1992)
  Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production
  Nature 360(6405): 672-4
• Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ (1992)
  Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments
  Nature 357(6378): 500-3
• Haass C, Hung AY, Selkoe DJ (1991)
  Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion
  J Neurosci 11(12): 3783-93
• Kloetzel PM, Frentzel S, Gernold M, Haass C, Klein U, Pesold-Hurt B, Seelig A (1991)
  The proteasome of Drosophila and features of the evolutionarily conserved PROS-gene family
  Biomed Biochim Acta 50(4-6): 451-7
• Haass C, Klein U, Kloetzel PM (1990)
  Developmental expression of Drosophila melanogaster small heat-shock proteins
  J Cell Sci 96 ( Pt 3): 413-8
• Haass C, Kloetzel PM (1990)
  Molecular analysis of alpha ecdysone induced 16S complexes in Drosophila Schneider's S3 cells
  Biochem Biophys Res Commun 168(1): 314-9
• Haass C, Pesold-Hurt B, Multhaup G, Beyreuther K, Kloetzel PM (1990)
  The Drosophila PROS-28.1 gene is a member of the proteasome gene family
  Gene 90(2): 235-41
• Haass C, Pesold-Hurt B, Kloetzel PM (1990)
  The Drosophila PROS-29 gene is a new member of the PROS-gene family
  Nucleic Acids Res 18(13): 4018
• Haass C, Kloetzel PM (1989)
  The Drosophila proteasome undergoes changes in its subunit pattern during development
  Exp Cell Res 180(1): 243-52
• Haass C, Pesold-Hurt B, Multhaup G, Beyreuther K, Kloetzel PM (1989)
  The PROS-35 gene encodes the 35 kd protein subunit of Drosophila melanogaster proteasome
  EMBO J 8(8): 2373-9
• Falkenburg PE, Haass C, Kloetzel PM, Niedel B, Kopp F, Kuehn L, Dahlmann B (1988)
  Drosophila small cytoplasmic 19S ribonucleoprotein is homologous to the rat multicatalytic proteinase
  Nature 331(6152): 190-2

Review

• Haass C, Selkoe D (2022)
  If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline?
  PLoS Biol. 2022 Jul 21;20(7):e3001694.
• Dieter Edbauer, Christian Haass (2016)
  An amyloid-like cascade hypothesis for C9orf72 ALS/FTD
  Curr Opin Neurobiol. 2016 Feb;36:99-106
• Julia Götzl, Christina Lang, Christian Haass, Anja Capell (2016)
  Impaired protein degradation in FTLD and related disorders
  Ageing Res Rev. 2016 May 7. pii: S1568-1637(16)30065-4
• Marc Aurel Busche, Matthias Staufenbiel, Michael Willem, Christian Haass, Hans Förstl (2016)
  Mechanisms of Alzheimer's disease : Neuronal hyperactivity and hypoactivity as new therapeutic targets
  Nervenarzt. 2016 Jan 19
• Robert Vassar, Peer-Hendrik Kuhn, Christian Haass, Matthew E. Kennedy, Lawrence Rajendran, Philip C. Wong, Stefan F. Lichtenthaler (2014)
  Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects
  J Neurochem. 2014 Jul;130(1):4-28
• Dormann D, Haass C (2013)
  Fused in sarcoma (FUS): An oncogene goes awry in neurodegeneration
  Mol Cell Neurosci. 2013 Apr 2. pii: S1044-7431(13)00048-1. doi: 10.1016/j.mcn.2013.03.006. [Epub ahead of print]
• Kleinberger G, Capell A, Haass C, Van Broeckhoven C (2013)
  Mechanisms of granulin deficiency: lessons from cellular and animal models
  Mol Neurobiol. 2013 Feb;47(1):337-60. doi: 10.1007/s12035-012-8380-8. Epub 2012 Dec 13
• Bentmann E, Haass C, Dormann D (2013)
  Stress granules in neurodegeneration - lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma
  FEBS J. 2013 Apr 15. doi: 10.1111/febs.12287. [Epub ahead of print]
• Exner N, Lutz AK, Haass C, Winkelhofer KF (2012)
  Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences
  EMBO J. 2012 Jun 26;31(14):3038-62. doi: 10.1038/emboj.2012.170.
• Haass C, Steiner H (2011)
  Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing
  J Neurochem. 2011 Jun;117(5):779-96. doi: 10.1111/j.1471-4159.2011.07248.x. Epub 2011 Apr 14.
• Förstl H, Haass C, Hemmer B, Meyer B, Halle M. (2010)
  Boxing-acute complications and late sequelae: from concussion to dementia
  Dtsch Arztebl Int. 2010 Nov;107(47):835-9. Epub 2010 Nov 26.
• Winklhofer KF, Haass C (2010)
  Mitochondrial dysfunction in Parkinson's disease
  Biochim Biophys Acta. 2010 Jan;1802(1):29-44. Epub 2009 Sep 3.
• Fluhrer R, Steiner H, Haass C (2009)
  Intramembrane proteolysis by signal peptidepeptidases - a comparative discussion of GxGD-type aspartyl proteases
  J Biol Chem. 2009 May 22;284(21):13975-9. Epub 2009 Feb 3.
• Steiner H, Fluhrer R, Haass C (2008)
  Intramembrane proteolysis by γ-secretase
  J Biol Chem 283(44): 29627-31
• Winklhofer KF, Haass C (2008)
  The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases
  EMBO J 27(2): 336-49
• Fluhrer R, Haass C (2007)
  Signal peptide peptidases and gamma-secretase: cousins of the same protease family?
  Neurodegener Dis 4(2-3): 112-6
• Haass C, Selkoe DJ (2007)
  Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
  Nat Rev Mol Cell Biol 8(2): 101-12
• Kaether C, Haass C, Steiner H (2006)
  Assembly, trafficking and function of γ-secretase
  Neurodegener Dis 3(4-5): 275-83
• Haffner C, Haass C (2006)
  Cellular functions of gamma-secretase-related proteins
  Neurodegener Dis 3(4-5): 284-9
• Kaether C, Haass C (2004)
  A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation
  J Cell Biol 167(5): 809-12
• Haass C (2004)
  Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model
  J Clin Invest 113(10): 1384-7
• Kahle PJ, Haass C (2004)
  How does parkin ligate ubiquitin to Parkinson's disease?
  EMBO Rep 5(7): 681-5
• Haass C (2004)
  Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation
  EMBO J 23(3): 483-8
• Haffner C, Haass C (2004)
  The biochemical and genetic odyssey to the function of a nicastrin-like protein
  Neurodegener Dis 1(4-5): 192-5
• Aguzzi A, Haass C (2003)
  Games played by rogue proteins in prion disorders and Alzheimer's disease
  Science 302(5646): 814-8
• Haass C, Steiner H (2002)
  Alzheimer disease γ-secretase: a complex story of GxGD-type presenilin proteases
  Trends Cell Biol 12(12): 556-62
• Kahle PJ, Haass C, Kretzschmar HA, Neumann M (2002)
  Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases
  J Neurochem 82(3): 449-57
• Steiner H, Haass C (2001)
  Nuclear signaling: a common function of presenilin substrates?
  J Mol Neurosci 17(2): 193-8
• Walter J, Kaether C, Steiner H, Haass C (2001)
  The cell biology of Alzheimer's disease: uncovering the secrets of secretases
  Curr Opin Neurobiol 11(5): 585-90
• Wolfe MS, Haass C (2001)
  The Role of presenilins in gamma-secretase activity
  J Biol Chem 276(8): 5413-6
• Kahle PJ, Leimer U, Haass C (2000)
  Does failure of parkin-mediated ubiquitination cause juvenile parkinsonism?
  Trends Biochem Sci 25(11): 524-7
• Steiner H, Haass C (2000)
  Intramembrane proteolysis by presenilins
  Nat Rev Mol Cell Biol 1(3): 217-24
• Kahle PJ, Neumann M, Ozmen L, Haass C (2000)
  Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein
  Ann N Y Acad Sci 920: 33-41
• Haass C (2000)
  Presenilin proteins and their function during embryonic development and Alzheimer's disease
  Ernst Schering Res Found Workshop(29): 57-64
• Steiner H, Capell A, Leimer U, Haass C (1999)
  Genes and mechanisms involved in β-amyloid generation and Alzheimer's disease
  Eur Arch Psychiatry Clin Neurosci 249(6): 266-70
• Steiner H, Capell A, Haass C (1999)
  Proteolytic processing and degradation of Alzheimer's disease relevant proteins
  Biochem Soc Trans 27(2): 234-42
• Haass C, Baumeister R (1999)
  The biological and pathological function of presenilin proteins--simple cell systems and a worm in Alzheimer's disease research
  Eur Arch Psychiatry Clin Neurosci 249 Suppl 3: 23-7
• Haass C, De Strooper B (1999)
  The presenilins in Alzheimer's disease--proteolysis holds the key
  Science 286(5441): 916-9
• Haass C, Grunberg J, Capell A, Wild-Bode C, Leimer U, Walter J, Yamazaki T, Ihara I, Zweckbronner I, Jakubek C, Baumeister R (1998)
  Proteolytic processing of Alzheimer's disease associated proteins
  J Neural Transm Suppl 53: 159-67
• Haass C, Baumeister R (1998)
  What do we learn from a few familial Alzheimer's disease cases?
  J Neural Transm Suppl 54: 137-45
• Haass C (1997)
  Presenilins: genes for life and death
  Neuron 18(5): 687-90
• Haass C (1996)
  Presenile because of presenilin: the presenilin genes and early onset Alzheimer's disease
  Curr Opin Neurol 9(4): 254-9
• Haass C (1996)
  The molecular significance of amyloid beta-peptide for Alzheimer's disease
  Eur Arch Psychiatry Clin Neurosci 246(3): 118-23
• Selkoe DJ, Yamazaki T, Citron M, Podlisny MB, Koo EH, Teplow DB, Haass C (1996)
  The role of APP processing and trafficking pathways in the formation of amyloid beta-protein
  Ann N Y Acad Sci 777: 57-64
• Haass C, Selkoe DJ (1993)
  Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide
  Cell 75(6): 1039-42
• Bettina Schmid, Christian Haass
  Genomic editing opens new avenues for zebrafish as a model for neurodegeneration
  J Neurochem. 2013 Nov;127(4):461-70
• Bradley T. Hyman, John H. Growdon, Mark W. Albers, Randy L. Buckner, Jasmeer Chhatwal, Maria Teresa Gomez-Isla, Christian Haass, Eloise Hudry, Clifford R. Jack Jr., Keith A. Johnson, Zaven S. Khachaturian, Doo Yeon Kim, Joseph B. Martin, Roger M. Nitsch, Bruce R. Rosen, Dennis J. Selkoe, Reisa A. Sperling, Peter St. George-Hyslop, Rudolph E. Tanzi, Liang Yap, Anne B. Young, Creighton H. Phelps, Patricia G. McCaffrey
  Massachusetts Alzheimer's Disease Research Center: progress and challenges
  Alzheimers Dement. 2015 Oct;11(10):1241-5
• Kaj Blennow, Henrik Zetterberg, Christian Haass, Thomas Finucane
  Semagacestat's fall: where next for AD therapies?
  Nat Med. 2013 Oct;19(10):1214-5.

Book chapter / Editorial material

• St George-Hyslop P, Haass C (2008)
  Regulatory RNA goes awry in Alzheimer's disease
  Nat Med. 2008 Jul;14(7):711-2.
• Haass C (2006)
  European Alzheimer disease funding
  Nat Med. 2006 Jul;12(7):776-7.
• Haass C, Multhaup G (2006)
  Six years of collaborative Alzheimer's disease research in Germany
  Neurodegenerative Dis 2006;3:193-196
• Kaether C, Haass C (2004)
  A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation
  J Cell Biol. 2004 Dec 6;167(5):809-12.
• Haass C (2004)
  Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model
  J Clin Invest. 2004 May;113(10):1384-7.Click here to read