Ludwig-Maximilians-Universität, Chair of Metabolic Biochemistry

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The cell biology of Alzheimer's disease: uncovering the secrets of secretases

Curr Opin Neurobiol 11(5): 585-90

Authors/Editors: Walter J
Kaether C
Steiner H
Haass C
Publication Date: 2001
Type of Publication: Review

Progress has been made in characterizing the secretases involved in endoproteolytic processing of the β-amyloid precursor protein - the precursor of the amyloid β-peptide (Aβ), which is the main constituent of amyloid plaques that form in the brains of patients with Alzheimer's disease. It is now thought that Aβ is pivotal in the pathogenesis of Alzheimer's disease, and that reducing brain Aβ levels may help to treat or prevent the disease. Two essential factors for the proteolytic generation of Aβ have been identified, β-secretase and the presenilins, which might aid the design of drugs against this disease.

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