Intramembrane proteolysis by presenilins
Nat Rev Mol Cell Biol 1(3): 217-24
|Type of Publication:||Review|
Many neurodegenerative diseases involve the deposition of insoluble amyloid molecules. In Alzheimer's disease, for example, the amyloid β-peptide (Aβ) is the main component of the characteristic senile plaques. Proteolytic enzymes called secretases are involved in generating Aβ, and one of these may have been identified as presenilin--a discovery that paves the way for a more complete understanding of presenilin structure and function.