Ludwig-Maximilians-Universität, Chair of Metabolic Biochemistry

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Intramembrane proteolysis by presenilins

Nat Rev Mol Cell Biol 1(3): 217-24

Authors/Editors: Steiner H
Haass C
Publication Date: 2000
Type of Publication: Review

Many neurodegenerative diseases involve the deposition of insoluble amyloid molecules. In Alzheimer's disease, for example, the amyloid β-peptide (Aβ) is the main component of the characteristic senile plaques. Proteolytic enzymes called secretases are involved in generating Aβ, and one of these may have been identified as presenilin--a discovery that paves the way for a more complete understanding of presenilin structure and function.

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