Ludwig-Maximilians-Universität, Chair of Metabolic Biochemistry

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Intramembrane proteolysis by signal peptidepeptidases - a comparative discussion of GxGD-type aspartyl proteases

J Biol Chem. 2009 May 22;284(21):13975-9. Epub 2009 Feb 3.

Authors/Editors: Fluhrer R
Steiner H
Haass C
Publication Date: 2009
Type of Publication: Review

Intramembrane-cleaving proteases are required for reverse signaling and membrane protein degradation. A major class of these proteases is represented by the GXGD-type aspartyl proteases. GXGD describes a novel signature sequence that distinguishes these proteases from conventional aspartyl proteases. Members of the family of the GXGD-type aspartyl proteases are the Alzheimer disease-related γ-secretase, the signal peptide peptidases and their homologs, and the bacterial type IV prepilin peptidases. We will describe the major biochemical and functional properties of the signal peptide peptidases and their relatives. We then compare these properties with those of γ-secretase and discuss common mechanisms but also point out a number of substantial differences.

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