Publications

Journal Article

• Winkler E, Kamp F, Scheuring J, Ebke A, Fukumori A, Steiner H (2012)
  Generation of Alzheimer disease-associated Aβ42/43 by γ-secretase can directly be inhibited by modulation of membrane thickness
  J. Biol. Chem. 2012 April 24 [First Published]
• Bentmann E, Neumann E, Tahirovic S, Rodde R, Dormann D, Haass C (2012)
  Requirements for Stress Granule Recruitment of Fused in Sarcoma (FUS) and TAR DNA Binding Protein of 43kDa (TDP-43)
  J. Biol. Chem. 2012 May 4. [First Published]
• Lang S, Benedix J, Fedeles SV, Schorr S, Schirra C, Schäuble N, Jalal C, Greiner M, Haßdenteufel S, Tatzelt J, Kreutzer B, Edelmann L, Krause E, Rettig J, Somlo S, Zimmermann R, Dudek J (2012)
  Differential effects of Sec61α-, Sec62- and Sec63-depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells
  J Cell Sci. 2012 Feb 28. [Epub ahead of print]
• Edbauer, Brooke H. Miller, Zane Zeier, Li Xi, Thomas A. Lanz, Shibing Deng, Julia Strathmann, David Willoughby, Paul J. Kenny, John D. Elsworth, Matthew S. Lawrence, Robert H. Roth, Dieter Edbauer, Robin J. Kleiman, and Claes Wahlestedt (2012)
  MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function
  Journal: PNAS February 6, 2012
• Butler EK, Voigt A, Lutz AK, Toegel JP, Gerhardt E, Karsten P, Falkenburger B, Reinartz A, Winklhofer KF, Schulz JB (2012)
  The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity
  PLoS Genet. 2012 Feb;8(2):e1002488
• Glas L, Kloos K, Giesert F, Roethig A, Di Benedetto B, Kühn R, Zang J, Hafen U, Zerle J, Hofmann A, Hrabé de Angelis M, Winklhofer KF, Hölter SM, Vogt Weisendorn DM, Wurst W (2012)
  Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb
  Exp Neurol. 2012 Jan 11
• Högen T, Levin J, Schmidt F, Caruana M, Vassallo N, Kretzschmar H, Bötzel K, Kamp F, Giese A (2012)
  Two Different Binding Modes of α-Synuclein to Lipid Vesicles Depending on its Aggregation State
  Biophys J. 2012 Apr 4;102(7):1646-55. Epub 2012 Apr 3
• Lang CM, Fellerer K, Schwenk BM, Kuhn PH, Kremmer E, Edbauer D, Capell A, Haass C (2012)
  Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration
  J Biol Chem. 2012 Apr 17. [Epub ahead of print]
• Kretner B, Fukumori A, Gutsmiedl A, Page RM, Luebbers T, Galley G, Baumann KH, Haass C, Steiner H (2011)
  Attenuated Aβ42 responses to low potency γ-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds
  J Biol Chem. 2011 Apr 29;286(17):15240-51. Epub 2011 Feb 25.
• Haass C, Hemmer B, Meyer B, Halle M, Förstl H (2011)
  Correspondence (reply): In Reply
  Dtsch Arztebl Int. 2011 Mar;108(9):146. Epub 2011 Mar 4.
• Augustin R, Lichtenthaler SF, Greeff M, Hansen J, Wurst W, Trümbach D (2011)
  Bioinformatics identification of modules of transcription factor binding sites in Alzheimer's disease-related genes by in silico promoter analysis and microarrays
  Int J Alzheimers Dis. 2011 Apr 26;2011:154325.
• Katsouri L, Parr C, Bogdanovic N, Willem M, Sastre M (2011)
  PPARγ Co-Activator-1α (PGC-1α) Reduces Amyloid-β Generation Through a PPARγ-Dependent Mechanism
  J Alzheimers Dis. 2011 Feb 25. [Epub ahead of print]
• Resenberger UK, Harmeier A, Woerner AC, Goodman JL, Müller V, Krishnan R, Vabulas RM, Kretzschmar HA, Lindquist S, Hartl FU, Multhaup G, Winklhofer KF, Tatzelt J (2011)
  The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication
  EMBO J. 2011 May 18;30(10):2057-70. Epub 2011 Mar 25. Comment in: EMBO J (2011) 30, 1882–1884
• Sakthivelu V, Seidel RP, Winklhofer KF, Tatzelt J (2011)
  Conserved stress-protective activity between prion protein and shadoo
  J Biol Chem. 2011 Mar 18;286(11):8901-8. Epub 2011 Jan 21.
• Capell A, Liebscher S, Fellerer K, Brouwers N, Willem M, Lammich S, Gijselinck I, Bittner T, Carlson AM, Sasse F, Kunze B, Steinmetz H, Jansen R, Dormann D, Sleegers K, Cruts M, Herms J, Van Broeckhoven C, Haass C. (2011)
  Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase
  J Neurosci. 2011 Feb 2;31(5):1885-1894.
• Velanac V, Unterbarnscheidt T, Hinrichs W, Gummert MN, Fischer TM, Rossner MJ, Trimarco A, Brivio V, Willem M, Taveggia C, Haass C, Möbius W, Nave KA, Schwab MH (2011)
  Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination
  Glia. 2011 Nov 2. doi: 10.1002/glia.21255. [Epub ahead of print]
• Lammich S, Kamp F, Wagner J, Nuscher B, Zilow S, Ludwig AK, Willem M, Haass C (2011)
  Translational repression of the Disintegrin and Metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5′-untranslated region
  J Biol Chem. 2011 Dec 30;286(52):45063-72. Epub2011 Nov 7.
• Levin J, Högen T, Hillmer AS, Bader B, Schmidt F, Kamp F, Kretzschmar HA, Bötzel K, Giese A (2011)
  Generation of Ferric Iron Links Oxidative Stress to α-Synuclein Oligomer Formation
  J Park Dis. 2011 Oct 4. [Epub ahead of print]
• Moss ML, Powell G, Miller MA, Bin Q, Sang QX, De Strooper B, Tesseur I, Lichtenthaler SF, Taverna M, Zhong JL, Dingwall C, Ferdous T, Schlomann U, Zhou P, Griffith L, Lauffenberger D, Petrovich R, Bartsch JW (2011)
  ADAM9 inhibition increases membrane activity of ADAM10 and controls {alpha}secretase processing of amyloid precursor protein
  J Biol Chem. 2011 Sep 28. [Epub ahead of print]
• Fluhrer R, Martin L, Klier B, Haug-Kroeper M, Grammer G, Nuscher B, Haass C (2011)
  The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by Signal Peptide Peptidase-Like 2b (SPPL2b)
  J Biol Chem. 2012 Feb 10;287(7):5156-63. Epub 2011 Dec 22
• Fleck D, Garratt AN, Haass C, Willem M (2011)
  BACE1 Dependent Neuregulin Proteolysis
  Curr Alzheimer Res. 2011 May 23. [Epub ahead of print]
• Dormann D, Haass C (2011)
  TDP-43 and FUS: a nuclear affair
  Trends Neurosci. 2011 Jun 21. [Epub ahead of print]
• Hogl S, Kuhn PH, Colombo A, Lichtenthaler SF (2011)
  Determination of the Proteolytic Cleavage Sites of the Amyloid Precursor-Like Protein 2 by the Proteases ADAM10, BACE1 and γ-Secretase
  PLoS One. 2011;6(6):e21337. Epub 2011 Jun 17.
• Neumann M, Bentmann E, Dormann D, Jawaid A, DeJesus-Hernandez M, Ansorge O, Roeber S, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ang LC, Bilbao J, Rademakers R, Haass C, Mackenzie IRA (2011)
  FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations
  Brain. 2011 Sep;134(Pt 9):2595-609. Epub 2011 Aug 19.
• Mellios N, Sugihara H, Castro J, Banerjee A, Le C, Kumar A, Crawford B, Strathmann J, Tropea D, Levine SS, Edbauer D, Sur M (2011)
  miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity
  Nature Neuroscience 2011 Sep 4. [Epub ahead of print]
• Fluhrer R, Kamp F, Grammer G, Nuscher B, Steiner H, Beyer K, Haass C (2011)
  The Nicastrin ectodomain adopts a highly thermostable structure
  Biol Chem. 2011 Aug 18. [Epub ahead of print]
• Ebke A, Luebbers T, Fukumori A, Shirotani K, Haass C, Baumann KH, Steiner H (2011)
  Novel γ-secretase modulators directly target presenilin
  J Biol Chem. 2011 Oct 28;286(43):37181-6. Epub 2011 Sep 6.
• Zovoilis A, Agbemenyah HY, Agis-Balboa RC, Stilling RM, Edbauer D, Rao P, Farinelli L, Delalle I, Schmitt A, Falkai P, Bahari-Javan S, Burkhardt S, Sananbenesi F, Fischer A (2011)
  microRNA-34c is a novel target to treat dementias
  EMBO J. 2011 Sep 23. doi: 10.1038/emboj.2011.327. [Epub ahead of print]
• Rolyan H, Feike AC, Upadhaya AR, Waha A, Van Dooren T, Haass C, Birkenmeier G, Pietrzik CU, Van Leuven F, Thal DR (2011)
  Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease
  J Neural Transm. 2011 May;118(5):699-712. Epub 2011 Jan 6.
• Peterziel H, Sackmann T, Strelau J, Kuhn PH, Lichtenthaler SF, Marom K, Klar A, Unsicker K (2011)
  F-spondin regulates neuronal survival through activation of disabled-1 in the chicken ciliary ganglion
  Mol Cell Neurosci. 2010 Dec 9. [Epub ahead of print]
• Kuhn PH, Wang H, Dislich B, Colombo A, Zeitschel U, Ellwart JW, Kremmer E, Rossner S, Lichtenthaler SF (2010)
  ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons
  EMBO J. 2010 Sep 1;29(17):3020-32. Epub 2010 Jul 30.
• Bartels T, Ahlstrom LS, Leftin A, Kamp F, Haass C, Brown MF, Beyer K (2010)
  The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding
  Biophys J. 2010 Oct 6;99(7):2116-24.
• Chu NK, Olschewski D, Seidel R, Winklhofer KF, Tatzelt J, Engelhard M, Becker CF (2010)
  Protein immobilization on liposomes and lipid-coated nanoparticles by protein trans-splicing
  J Pept Sci. 2010 Oct;16(10):582-8.
• Schumacher MC, Resenberger U, Seidel RP, Becker CF, Winklhofer KF, Oesterhelt D, Tatzelt J, Engelhard M (2010)
  Synthesis of a GPI anchor module suitable for protein post-translational modification
  Biopolymers. 2010;94(4):457-64.
• Kamp F, Exner N, Lutz AK, Wender N, Hegermann J, Brunner B, Nuscher B, Bartels T, Giese A, Beyer K, Eimer S, Winklhofer KF, Haass C (2010)
  Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1
  EMBO J. 2010 Oct 20;29(20):3571-89. Epub 2010 Sep 14.
• Haass C, Mandelkow E (2010)
  Fyn-tau-amyloid: a toxic triad
  Cell. 2010 Aug 6;142(3):356-8.
• Bouman L, Schlierf A, Lutz AK, Shan J, Deinlein A, Kast J, Galehdar Z, Palmisano V, Patenge N, Berg D, Gasser T, Augustin R, Trümbach D, Irrcher I, Park DS, Wurst W, Kilberg MS, Tatzelt J, Winklhofer KF (2010)
  Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress
  Cell Death Differ. 2011 May;18(5):769-82. Epub 2010 Nov 26.
• Dislich B, Than ME, Lichtenthaler SF (2010)
  Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33
  Biochem J. 2010 Dec 15;433(1):75-83.
• Fett ME, Pilsl A, Paquet D, van Bebber F, Haass C, Tatzelt J, Schmid B, Winklhofer KF (2010)
  Parkin is protective against proteotoxic stress in a transgenic zebrafish model
  PLoS One. 2010 Jul 30;5(7):e11783.
• Karpuj MV, Gelibter-Niv S, Tiran A, Rambold A, Tatzelt J, Nunziante M, Schatzl HM (2010)
  Conditional modulation of membrane protein expression in cultured cells mediated by prion protein recognition of short phosphorothioate oligodeoxynucleotides
  J Biol Chem. 2011 Mar 4;286(9):6911-7. Epub 2010 Dec 14.
• Irrcher I, Aleyasin H, Seifert EL, Hewitt SJ, Chhabra S, Phillips M, Lutz AK, Rousseaux MW, Bevilacqua L, Jahani-Asl A, Callaghan S, MacLaurin JG, Winklhofer KF, Rizzu P, Rippstein P, Kim RH, Chen CX, Fon EA, Slack RS, Harper ME, McBride HM, Mak TW, Park DS (2010)
  Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics
  Hum Mol Genet. 2010 Oct 1;19(19):3734-46. Epub 2010 Jul 16.
• Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IR, Capell A, Schmid B, Neumann M, Haass C (2010)
  ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
  EMBO J. 2010 Aug 18;29(16):2841-57. Epub 2010 Jul 6.
• Paquet D, Schmid B, Haass C (2010)
  Transgenic Zebrafish as a Novel Animal Model to Study Tauopathies and Other Neurodegenerative Disorders in vivo
  Neurodegener Dis. 2010 Feb 18;7(1-3):99-102. [Epub ahead of print]
• Höttecke N, Liebeck M, Baumann K, Schubenel R, Winkler E, Steiner H, Schmidt B (2010)
  Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta
  Bioorg Med Chem Lett. 2010 Mar 4. [Epub ahead of print]
• Fuhrmann M, Bittner T, Jung CK, Burgold S, Page RM, Mitteregger G, Haass C, LaFerla FM, Kretzschmar H, Herms J (2010)
  Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease
  Nat Neurosci. 2010 Apr;13(4):411-3. Epub 2010 Mar 21.
• Page RM, Gutsmiedl A, Fukumori A, Winkler E, Haass C, Steiner H (2010)
  Beta-amyloid precursor protein mutants respond to gamma-secretase modulators
  J Biol Chem. 2010 Jun 4;285(23):17798-810. Epub 2010 Mar 26.
• Lammich S, Buell D, Ludwig AK, Nuscher B, Lichtenthaler SF, Prinzen C, Fahrenholz F, Haass C (2010)
  Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region
  J Biol Chem. 2010 Mar 26. [Epub ahead of print]
• van Bebber F, Paquet D, Hruscha A, Schmid B, Haass C (2010)
  Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in Zebrafish
  Neurobiol Dis. 2010 Sep;39(3):265-71. Epub 2010 Apr 8.
• Mitterreiter S, Page RM, Kamp F, Hopson J, Winkler E, Ha HR, Hamid R, Herms J, Mayer TU, Nelson DJ, Steiner H, Stahl T, Zeitschel U, Roßner S, Haass C, Lichtenthaler SF (2010)
  Bepridil and Amiodarone Simultaneously Target the Alzheimer’s Disease β- and γ-Secretase via Distinct Mechanisms
  J. Neurosci. 2010 Apr 20. [Epub ahead of print]
• Fukumori A, Fluhrer R, Steiner H, Haass C (2010)
  Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of γ-secretase-mediated intramembrane proteolysis
  J. Neurosci. 2010 Apr 20. [Epub ahead of print]
• Ullrich S, Münch A, Neumann S, Kremmer E, Tatzelt J, Lichtenthaler SF (2010)
  The Novel Membrane Protein TMEM59 Modulates Complex Glycosylation, Cell Surface Expression and Secretion of the Amyloid Precursor Protein
  J Biol Chem. 2010 Apr 28. [Epub ahead of print]
• Foster KA, McLaughlin N, Edbauer D, Phillips M, Bolton A, Constantine-Paton M, Sheng M (2010)
  Distinct roles of NR2A and NR2B cytoplasmic tails in long-term potentiation
  J Neurosci. 2010 Feb 17;30(7):2676-85.
• Malnar M, Kosicek M, Mitterreiter S, Omerbasic D, Lichtenthaler SF, Goate A, Hecimovic S (2010)
  Niemann Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface its increased processing through the beta-secretase pathway
  Biochim Biophys Acta. 2010 May 18. [Epub ahead of print]
• Fukumori A, Fluhrer R, Steiner H, Haass C (2010)
  Three-Amino Acid Spacing of Presenilin Endoproteolysis Suggests a General Stepwise Cleavage of {gamma}-Secretase-Mediated Intramembrane Proteolysis
  J Neurosci. 2010 Jun 9;30(23):7853-62.
• Edbauer D, Neilson JR, Foster KA, Wang CF, Seeburg DP, Batterton MN, Tada T, Dolan BM, Sharp PA, Sheng M (2010)
  Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132
  Neuron. 2010 Feb 11;65(3):373-84.
• Kuhn PH, Abou-Ajram C, Lichtenthaler SF, Krueger M, Kremmer E, Haass C, Haffner C (2010)
  The transmembrane protein 147 (TMEM147) is a novel component of the nicalin-nomo protein complex
  J Biol Chem. 2010 Jun 10. [Epub ahead of print]
• Itoh N, Okochi M, Tagami S, Nishitomi K, Nakayama T, Yanagida K, Fukumori A, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, Takemoto H, Minagawa K, Katoh T, Willem M, Haass C, Morihara T, Tanaka T, Kudo T, Hasegawa H, Nishimura M, Sakaguchi G, Kato A, Takeda M (2009)
  Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor
  Neurodegener Dis. 2009;6(5-6):230-9. Epub 2009 Sep 9.
• Tatzelt J (2009)
  The Prion Protein: Friend and Foe
  Curr Issues Mol Biol. 2009 Sep 18;12(2):49-50. [Epub ahead of print]
• Miesbauer M, Rambold AS, Winklhofer KF, Tatzelt J (2009)
  Targeting of the Prion Protein to the Cytosol: Mechanisms and Consequences
  Curr Issues Mol Biol. 2009 Sep 18;12(2):109-118. [Epub ahead of print]
• Bittner T, Fuhrmann M, Burgold S, Jung CK, Volbracht C, Steiner H, Mitteregger G, Kretzschmar HA, Haass C, Herms J (2009)
  Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway
  J Neurosci. 2009 Aug 19;29(33):10405-9.
• Paquet D, Haass C (2009)
  Alzheimerforschung in transgenen Zebrafischen
  BioSpektrum Special: Bio-Imaging
• Fassler M, Zocher M, Klare S, de la Fuente AG, Scheuermann J, Capell A, Haass C, Valkova C, Veerappan A, Schneider D, Kaether C (2009)
  Masking of Transmembrane-Based Retention Signals Controls ER Export of gamma-Secretase
  Traffic. 2010 Feb;11(2):250-8. Epub 2009 Nov 5.
• Fukumori A, Lammich S, Yamasaki A, Haass C, Steiner H (2009)
  Requirement for Small Side Chain Residues within the GxGD-Motif of Presenilin for gamma-Secretase Substrate Cleavage
  J Neurochem. 2010 Feb;112(4):940-50. Epub 2009 Dec 15.
• Winklhofer KF, Haass C (2009)
  Mitochondrial dysfunction in Parkinson's disease
  Biochim Biophys Acta. 2010 Jan;1802(1):29-44. Epub 2009 Sep 3.
• Meyer-Luehmann M, Mielke M, Spires-Jones TL, Stoothoff W, Jones P, Bacskai BJ, Hyman BT (2009)
  A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice
  J Neurosci. 2009 Oct 7;29(40):12636-40.
• Leuchtenberger S, Maler J, Czirr E, Ness J, Lichtenthaler SF, Esselmann H, Pietrzik CU, Wiltfang J, Weggen S (2009)
  Nonsteroidal anti-inflammatory drugs and ectodomain shedding of the amyloid precursor protein
  Neurodegener Dis. 2009;6(1-2):1-8. Epub 2008 Mar 18.
• Gannagé M, Dormann D, Albrecht R, Dengjel J, Torossi T, Rämer PC, Lee M, Strowig T, Arrey F, Conenello G, Pypaert M, Andersen J, García-Sastre A, Münz C (2009)
  Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes
  Cell Host Microbe. 2009 Oct 22;6(4):367-80.
• Spires-Jones TL, Mielke ML, Rozkalne A, Meyer-Luehmann M, de Calignon A, Bacskai BJ, Schenk D, Hyman BT (2009)
  Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease
  Neurobiol Dis. 2009 Feb;33(2):213-20. Epub 2008 Nov 6.
• Fournier M, Vitte J, Garrigue J, Langui D, Dullin JP, Saurini F, Hanoun N, Perez-Diaz F, Cornilleau F, Joubert C, Ardila-Osorio H, Traver S, Duchateau R, Goujet-Zalc C, Paleologou K, Lashuel HA, Haass C, Duyckaerts C, Cohen-Salmon C, Kahle PJ, Hamon M, Brice A, Corti O (2009)
  Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy
  PLoS One. 2009 Aug 14;4(8):e6629.
• Willem M, Lammich S, Haass C (2009)
  Function, regulation and therapeutic properties of beta-secretase (BACE1)
  Semin Cell Dev Biol. 2009 Apr;20(2):175-82. Epub 2009 Jan 20.
• Paquet D, Bhat R, Sydow A, Mandelkow EM, Berg S, Hellberg S, Fälting J, Distel M, Köster RW, Schmid B, Haass C (2009)
  A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation
  J Clin Invest. 2009 May;119(5):1382-95. doi: 10.1172/JCI37537. Epub 2009 Apr 13.
• Schaefer K, Brosamle C (2009)
  Zwilling-A and -B, two related myelin proteins of teleosts, which originate from a single, bicistronic transcript
  Mol Biol Evol
• Winkler E, Hobson S, Fukumori A, Dümpelfeld B, Luebbers T, Baumann K, Haass C, Hopf C, Steiner H (2009)
  Purification, Pharmacological Modulation, and Biochemical Characterization of Interactors of Endogenous Human γ-Secretase
  Biochemistry 2009 Jan 21.
• Brösamle C (2009)
  The myelin proteolipid DMalpha in fishes
  Neuron Glia Biol. 2009 Jun 10:1-4.
• Dormann D, Capell A, Carlson AM, Shankaran SS, Rodde R, Neumann M, Kremmer E, Matsuwaki T, Yamanouchi K, Nishihara M, Haass C (2009)
  Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin
  J Neurochem. 2009 Aug;110(3):1082-94. Epub 2009 Jun 9.
• Koffie RM, Meyer-Luehmann M, Hashimoto T, Adams KW, Mielke ML, Garcia-Alloza M, Micheva KD, Smith SJ, Kim ML, Lee VM, Hyman BT, Spires-Jones TL (2009)
  Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
  Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):4012-7. Epub 2009 Feb 19.
• Haass C (2009)
  Alzheimer - Mechanismen und therapeutische Ansätze. Warum wir im Alter dement werden
  Biologie in unserer Zeit, Vol. 39, Iss. 2, Pg. 92-100
• Lutz AK, Exner N, Schlehe JS, Kloos K, Laemmermann K, Brunner B, Kurz-Drexler A, Vogel F, Reichert AS, Bouman L, Vogt-Weisenhorn D, Wurst W, Tatzelt J, Haass C, Winklhofer KF (2009)
  Loss of parkin or PINK1 function increases DRP1-dependent mitochondrial fragmentation
  J Biol Chem. 2009 Aug 21;284(34):22938-51. Epub 2009 Jun 22.
• Miesbauer M, Pfeiffer NV, Rambold AS, Müller V, Kiachopoulos S, Winklhofer KF, Tatzelt J (2009)
  Alpha-helical domains promote translocation of intrinsically disordered polypeptides into the endoplasmic reticulum
  J Biol Chem. 2009 Sep 4;284(36):24384-93. Epub 2009 Jun 26.
• Edbauer D, Cheng D, Batterton MN, Wang CF, Duong DM, Yaffe MB, Peng J, Sheng M (2009)
  Identification and characterization of neuronal mitogen-activated protein kinase substrates using a specific phosphomotif antibody
  Mol Cell Proteomics. 2009 Apr;8(4):681-95. Epub 2008 Dec 3.
• Schmid D, Münz C (2008)
  Localization and MHC class II presentation of antigens targeted for macroautophagy
  Methods Mol Biol. 2008;445:213-25.
• Simard JR, Kamp F, Hamilton JA (2008)
  Measuring the adsorption of Fatty acids to phospholipid vesicles by multiple fluorescence probes
  Biophys J. 2008 Jun;94(11):4493-503. Epub 2008 Feb 22.
• Heiseke A, Schöbel S, Lichtenthaler SF, Vorberg I, Groschup MH, Kretzschmar H, Schätzl HM, Nunziante M (2008)
  The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding
  Traffic. 2008 Jul;9(7):1116-29. Epub 2008 Apr 18.
• Martin L, Fluhrer R, Haass C (2008)
  Substrate requirements for SPPL2b dependent regulated intramembrane proteolysis
  J Biol Chem
• Dejaegere T, Serneels L, Schafer MK, Van Biervliet J, Horre K, Depboylu C, Alvarez-Fischer D, Herreman A, Willem M, Haass C, Hoglinger GU, D'Hooge R, De Strooper B (2008)
  Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment
  Proc Natl Acad Sci U S A 105(28): 9775-80
• Chiesa C, Osborn JF, Haass C, Natale F, Spinelli M, Scapillati E, Spinelli A, Pacifico L (2008)
  Ghrelin, leptin, IGF-1, IGFBP-3, and insulin concentrations at birth: is there a relationship with fetal growth and neonatal anthropometry?
  Clin Chem 54(3): 550-8
• Rambold AS, Miesbauer M, Olschewski D, Seidel R, Riemer C, Smale L, Brumm L, Levy M, Gazit E, Oesterhelt D, Baier M, Becker CF, Engelhard M, Winklhofer KF, Tatzelt J (2008)
  Green tea extracts interfere with the stress-protective activity of PrP and the formation of PrP
  J Neurochem 107(1): 218-29
• Fluhrer R, Fukumori A, Martin L, Grammer G, Haug-Kroper M, Klier B, Winkler E, Kremmer E, Condron MM, Teplow DB, Steiner H, Haass C (2008)
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• Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, Tomita T, Iwatsubo T, Baumeister R, Haass C (1999)
  A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling
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• Sandmann-Keil D, Braak H, Okochi M, Haass C, Braak E (1999)
  Alpha-synuclein immunoreactive Lewy bodies and Lewy neurites in Parkinson's disease are detectable by an advanced silver-staining technique
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• Steiner H, Romig H, Grim MG, Philipp U, Pesold B, Citron M, Baumeister R, Haass C (1999)
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• Mizuno T, Nakata M, Naiki H, Michikawa M, Wang R, Haass C, Yanagisawa K (1999)
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• Flugel A, Willem M, Berkowicz T, Wekerle H (1999)
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  Genes Funct 1(2): 149-59
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• Schatzl HM, Laszlo L, Holtzman DM, Tatzelt J, DeArmond SJ, Weiner RI, Mobley WC, Prusiner SB (1997)
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Book chapter / Editorial material

• Tatzelt J (2011)
  Neuroprotective and Neurotoxic Signaling by the Prion Protein
  Top Curr Chem. 2011;305:101-19.
• Tatzelt J (ed.) (2011)
  Prion Proteins
  Top Curr Chem. 2011;305:ix-x. No abstract available.
• St George-Hyslop P, Haass C (2008)
  Regulatory RNA goes awry in Alzheimer's disease
  Nat Med. 2008 Jul;14(7):711-2.
• Haass C, Multhaup G (2006)
  Six years of collaborative Alzheimer's disease research in Germany
  Neurodegenerative Dis 2006;3:193-196
• Haass C (2006)
  European Alzheimer disease funding
  Nat Med. 2006 Jul;12(7):776-7.
• Steiner H (2006)
  The players on the gamma-secretase team - The author's perspective
  Nature Medicine 12(7): 767-767
• Lichtenthaler SF, Haass C (2004)
  Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model
  J Clin Invest. 2004 May;113(10):1384-7.Click here to read
• Kaether C, Haass C (2004)
  A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation
  J Cell Biol. 2004 Dec 6;167(5):809-12.

Dissertations

• Johanna Scheuermann (2010)
  Untersuchung der Transportregulation des γ-Sekretase-Komplexes anhand seiner Untereinheit Pen2
  LMU München, Medical Faculty; 2010-04-08
• Lucas Martin (2010)
  Regulierte Intramembranproteolyse des Bri2-Proteins
  LMU München, Faculty of Chemistry and Pharmacy; 2010-06-22
• Karin Schaefer (2010)
  Characterization of two novel myelin proteins
  LMU München, Faculty of Chemistry and Pharmacy; 2010-03-25
• Katharina Schranner (2009)
  Analyse der BACE-1-Regulation in der Alzheimer-Krankheit und im Down-Syndrom
  LMU München, Medical Faculty; 2009-07-21
• Dominik Paquet (2009)
  Ein transgenes Zebrafischmodell zur Erforschung neurodegenerativer Erkrankungen am Beispiel der Tauopathien
  LMU München, Faculty of Chemistry and Pharmacy; 2009-08-05
• Peter Krawitz (2009)
  Funktionelle Analyse der Signalpeptidpeptidase Familie im Zebrafisch
  LMU München, Medical Faculty; 2009-03-17
• Peer-Hendrik Kuhn (2009)
  Regulierte Intramembranproteolyse des Interleukin-1 Rezeptors II durch α-, β- und γ-Sekretase
  LMU München, Medical Faculty; 2010-01-25
• Margit Miesbauer (2009)
  Translokation des Prion-Proteins ins endoplasmatische Retikulum: die Rolle intrinsischer und zellulärer Faktoren
  LMU München, Faculty of Chemistry and Pharmacy; 2009-07-16
• Stefan Mitterreiter (2008)
  Duale Modulation der proteolytischen Spaltung des Amyloid-Vorläufer-Proteins durch den Wirkstoff Bepridil
  LMU München, Faculty of Chemistry and Pharmacy; 2008-11-07
• Julia Schlehe (2008)
  Folding, function and subcellular localization of parkin
  LMU München, Faculty of Chemistry and Pharmacy; 2008-11-26
• Stephanie Neumann (2008)
  Die Bedeutung der Endozytose für die proteolytische Spaltung des Amyloid Precursor Proteins
  LMU München, Faculty of Biology; 2009-02-13
• Blanca Isabel Pérez Revuelta (2008)
  Functional characterization of the N-terminal glycine of the GxGD aspartyl protease active site motif in presenilin 1
  LMU München, Faculty of Chemistry and Pharmacy; 2009-03-09
• Angelika Rambold (2008)
  Funktionelle Charakterisierung des Prion-Proteins: physiologische Aktivität und pathophysiologische Alteration
  LMU München, Faculty of Biology; 2008-10-22
• Sylvia Fischer (2008)
  Analyse des neuen Proteins TMEM59 und seiner Funktion in dem Transport und der Prozessierung des Amyloid-Vorläufer-Proteins
  LMU München, Faculty of Biology; 2008-10-22
• Tim Bartels (2008)
  Domain formation in phospholipid membranes and the toxicity of alpha-synuclein
  TUM München, Faculty of Chemistry; 2008-08-13
• Iris Henn (2007)
  Die Rolle von Parkin bei der Parkinson-Erkrankung: Physiologische Funktion und Mechanismen der Inaktivierung
  LMU München, Faculty of Chemistry and Pharmacy; 2008-10-22
• Susanne Schöbel (2007)
  Analyse eines neuen Sorting Nexins und seiner Funktion in der ßAPP-Prozessierung
  LMU München, Faculty of Biology; 2008-10-22
• Aya Yamasaki-Meythaler (2006)
  Functional Characterization of the Presenilin Homologue SPE-4
  LMU München, Faculty of Chemistry and Pharmacy; 2008-10-22
• Karin Görner (2006)
  Strukturelle und funktionelle Untersuchungen des PARK7 Parkinsongenprodukts DJ-1
  LMU München, Faculty of Chemistry and Pharmacy; 2008-10-22
• Tobias Möhlmann (2006)
  Auswirkungen von artifiziellen und familiären Presenilin-1 Mutationen auf die Endoproteolyse des beta-Amyloid-Vorläuferproteins und des Zelloberflächenrezeptors Notch
  LMU München, Medical Faculty;
• Stefan Prokop (2006)
  Funktionelle Charakterisierung der gamma-Sekretasekomponente PEN-2
  LMU München, Medical Faculty; 2008-10-22
• Gwenaelle Fillon (2006)
  Establishment of primary culture models of multiple system atrophy based on expression of alpha-synuclein in oligodentrocytes
  LMU München, Medical Faculty;
• Gil Westmeyer (2006)
  Identification of a BACE dimer and characterization of its biochemical and enzymatic properties
  LMU München, Medical Faculty; 2008-10-22
• Sophia Kiachopoulos (2005)
  Biogenese des Prion-Proteins: Regulation und Fehlregulation bei Prion-Erkrankungen
  LMU München, Faculty of Biology; 2005-12-02
• Wolfdieter Springer (2005)
  Caenorhabditis elegans as an Experimental Model Organism to Study Parkinson's Disease-Related Genes: Functional Analysis of Parkin and alpha-Synuclein
  LMU München, Faculty of Chemistry and Pharmacy; 2005-07-07
• Armgard Uelhoff (2005)
  Polarisierter Transport des Prion-Proteins
  LMU München, Faculty of Medicine; 2005-07-19
• Anja Capell (2005)
  Funktionelle Charakterisierung von BACE, einer für die Alzheimer Krankheit relevanten Protease
  HU Berlin, Faculty of Mathematics and Natural Sciences I, 2005-08-10
• Stefan Eimer (2003)
  Analysis and suppression of mutant sel-12 in Caenorhabditis elegans
  LMU München, Faculty of Chemistry and Pharmacy; 2003-06-02
• Regina Fluhrer (2003)
  Zwei neuartige Aspartylproteasen BACE-1 und BACE-2: Charakterisierung und Vergleich der katalytischen Spezifitäten bei der Proteolyse des Alzheimer beta-Amyloid Vorläufer Proteins
  LMU München, Faculty of Chemistry and Pharmacy; 2003-10-21
• Luca Kulic (2003)
  Differenzielle Effekte von Presenilin-Mutationen auf die Generierung des Amyloid-ß-Peptids (Aß) und die Endoproteolyse des Notch-Rezeptors
  LMU München, Faculty of Medicine; 2003-07-31
• Bernhard Steinbauer (2001)
  Dynamics and structure of lamellar lipid mixtures as a function of hydration. A NMR study.
  TU Munich, Faculty of Physics, 2001-11-29

Review

• Resenberger UK, Winklhofer KF, Tatzelt J (2012)
  Cellular Prion Protein Mediates Toxic Signaling of Amyloid Beta
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• Lichtenthaler (2012)
  Cell biology: Sheddase gets guidance
  Science 2012 Jan 13;335(6065):179-80.
• Pilsl A, Winklhofer KF (2011)
  Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson's disease
  Acta Neuropathol. 2011 Nov 6. [Epub ahead of print]
• Resenberger UK, Winklhofer KF, Tatzelt J (2011)
  Neuroprotective and Neurotoxic Signaling by the Prion Protein
  Topics in Current Chemistry, 2011, Volume 305/2011, 101-119, DOI: 10.1007/128_2011_160
• Lichtenthaler SF., Haass C, Steiner H (2011)
  Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing
  J Neurochem. 2011 Jun;117(5):779-96. doi: 10.1111/j.1471-4159.2011.07248.x. Epub 2011 Apr 14.
• Lichtenthaler SF. (2011)
  Alpha-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potential
  J Neurochem. 2011 Jan;116(1):10-21. doi: 10.1111/j.1471-4159.2010.07081.x. Epub 2010 Dec 2.
• Lichtenthaler SF. (2011)
  ADAM10: potential ‘molecular scissors’ for the treatment of Alzheimer’s disease
  Future Neurology, January 2011, Vol. 6, No. 1, Pages 1-4 , DOI 10.2217/fnl.10.75
• Lichtenthaler SF. (2011)
  Alpha-Secretase Cleavage of the Amyloid Precursor Protein: Proteolysis Regulated by Signaling Pathways and Protein Trafficking
  Curr Alzheimer Res. 2011 May 23. [Epub ahead of print]
• Winklhofer KF, Haass C (2010)
  Mitochondrial dysfunction in Parkinson's disease
  Biochim Biophys Acta. 2010 Jan;1802(1):29-44. Epub 2009 Sep 3.
• Förstl H, Haass C, Hemmer B, Meyer B, Halle M. (2010)
  Boxing-acute complications and late sequelae: from concussion to dementia
  Dtsch Arztebl Int. 2010 Nov;107(47):835-9. Epub 2010 Nov 26.
• Fluhrer R, Steiner H, Haass C (2009)
  Intramembrane proteolysis by signal peptidepeptidases - a comparative discussion of GxGD-type aspartyl proteases
  J Biol Chem. 2009 May 22;284(21):13975-9. Epub 2009 Feb 3.
• Steiner H (2008)
  The catalytic core of gamma-secretase: presenilin revisited
  Curr Alzheimer Res 5(2): 147-57
• Steiner H, Fluhrer R, Haass C (2008)
  Intramembrane proteolysis by gamma-secretase
  J Biol Chem 283(44): 29627-31
• Winklhofer KF, Tatzelt J, Haass C (2008)
  The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases
  EMBO J 27(2): 336-49
• Haass C, Selkoe DJ (2007)
  Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
  Nat Rev Mol Cell Biol 8(2): 101-12
• Fluhrer R, Haass C (2007)
  Signal peptide peptidases and gamma-secretase: cousins of the same protease family?
  Neurodegener Dis 4(2-3): 112-6
• Schmid D, Münz C (2007)
  Innate and adaptive immunity through autophagy
  Immunity. 2007 Jul;27(1):11-21.
• Tatzelt J, Schatzl HM (2007)
  Molecular basis of cerebral neurodegeneration in prion diseases
  FEBS J 274(3): 606-11
• Winklhofer KF (2007)
  The parkin protein as a therapeutic target in Parkinson's disease
  Expert Opin Ther Targets 11(12): 1543-52
• Schmid D, Münz C (2006)
  Immune surveillance of intracellular pathogens via autophagy
  Cell Death Differ. 2005 Nov;12 Suppl 2:1519-27.
• Winklhofer KF, Tatzelt J (2006)
  The role of chaperones in Parkinson's disease and prion diseases
  Handb Exp Pharmacol(172): 221-58
• Kaether C, Haass C, Steiner H (2006)
  Assembly, trafficking and function of gamma-secretase
  Neurodegener Dis 3(4-5): 275-83
• Haffner C, Haass C (2006)
  Cellular functions of gamma-secretase-related proteins
  Neurodegener Dis 3(4-5): 284-9
• Lichtenthaler SF. (2006)
  Ectodomain shedding of the amyloid precursor protein: cellular control mechanisms and novel modifiers
  Neurodegener Dis. 2006;3(4-5):262-9.
• Rossner S, Sastre M, Bourne K, Lichtenthaler SF (2006)
  Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease
  Prog Neurobiol. 2006 Jun;79(2):95-111. Epub 2006 Aug 14.
• Schmid D, Dengjel J, Schoor O, Stevanovic S, Münz C (2006)
  Autophagy in innate and adaptive immunity against intracellular pathogens
  J Mol Med (Berl). 2006 Mar;84(3):194-202. Epub 2006 Jan 28.
• Haass C (2004)
  Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation
  EMBO J 23(3): 483-8
• Lichtenthaler SF, Haass C (2004)
  Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model
  J Clin Invest 113(10): 1384-7
• Kahle PJ, Haass C (2004)
  How does parkin ligate ubiquitin to Parkinson's disease?
  EMBO Rep 5(7): 681-5
• Kaether C, Haass C (2004)
  A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation
  J Cell Biol 167(5): 809-12
• Haffner C, Haass C (2004)
  The biochemical and genetic odyssey to the function of a nicastrin-like protein
  Neurodegener Dis 1(4-5): 192-5
• Tatzelt J, Winklhofer KF (2004)
  Folding and misfolding of the prion protein in the secretory pathway
  Amyloid 11(3): 162-72
• Steiner H (2004)
  Uncovering gamma-secretase
  Curr Alzheimer Res 1(3): 175-81
• Aguzzi A, Haass C (2003)
  Games played by rogue proteins in prion disorders and Alzheimer's disease
  Science 302(5646): 814-8
• Haass C, Steiner H (2002)
  Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases
  Trends Cell Biol 12(12): 556-62
• Kahle PJ, Haass C, Kretzschmar HA, Neumann M (2002)
  Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases
  J Neurochem 82(3): 449-57
• Wolfe MS, Haass C (2001)
  The Role of presenilins in gamma-secretase activity
  J Biol Chem 276(8): 5413-6
• Walter J, Kaether C, Steiner H, Haass C (2001)
  The cell biology of Alzheimer's disease: uncovering the secrets of secretases
  Curr Opin Neurobiol 11(5): 585-90
• Steiner H, Haass C (2001)
  Nuclear signaling: a common function of presenilin substrates?
  J Mol Neurosci 17(2): 193-8
• Haass C (2000)
  Presenilin proteins and their function during embryonic development and Alzheimer's disease
  Ernst Schering Res Found Workshop(29): 57-64
• Kahle PJ, Leimer U, Haass C (2000)
  Does failure of parkin-mediated ubiquitination cause juvenile parkinsonism?
  Trends Biochem Sci 25(11): 524-7
• Steiner H, Haass C (2000)
  Intramembrane proteolysis by presenilins
  Nat Rev Mol Cell Biol 1(3): 217-24
• Kahle PJ, Neumann M, Ozmen L, Haass C (2000)
  Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein
  Ann N Y Acad Sci 920: 33-41
• Haass C, Baumeister R (1999)
  The biological and pathological function of presenilin proteins--simple cell systems and a worm in Alzheimer's disease research
  Eur Arch Psychiatry Clin Neurosci 249 Suppl 3: 23-7
• Haass C, De Strooper B (1999)
  The presenilins in Alzheimer's disease--proteolysis holds the key
  Science 286(5441): 916-9
• Steiner H, Capell A, Leimer U, Haass C (1999)
  Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease
  Eur Arch Psychiatry Clin Neurosci 249(6): 266-70
• Steiner H, Capell A, Haass C (1999)
  Proteolytic processing and degradation of Alzheimer's disease relevant proteins
  Biochem Soc Trans 27(2): 234-42
• Haass C, Grunberg J, Capell A, Wild-Bode C, Leimer U, Walter J, Yamazaki T, Ihara I, Zweckbronner I, Jakubek C, Baumeister R (1998)
  Proteolytic processing of Alzheimer's disease associated proteins
  J Neural Transm Suppl 53: 159-67
• Haass C, Baumeister R (1998)
  What do we learn from a few familial Alzheimer's disease cases?
  J Neural Transm Suppl 54: 137-45
• Tatzelt J, Voellmy R, Welch WJ (1998)
  Abnormalities in stress proteins in prion diseases
  Cell Mol Neurobiol 18(6): 721-9
• Schwab ME, Brosamle C (1997)
  Regeneration of lesioned corticospinal tract fibers in the adult rat spinal cord under experimental conditions
  Spinal Cord 35(7): 469-73
• Tatagiba M, Brosamle C, Schwab ME (1997)
  Regeneration of injured axons in the adult mammalian central nervous system
  Neurosurgery 40(3): 541-6; discussion 546-7
• Haass C (1997)
  Presenilins: genes for life and death
  Neuron 18(5): 687-90
• Haass C (1996)
  Presenile because of presenilin: the presenilin genes and early onset Alzheimer's disease
  Curr Opin Neurol 9(4): 254-9
• Selkoe DJ, Yamazaki T, Citron M, Podlisny MB, Koo EH, Teplow DB, Haass C (1996)
  The role of APP processing and trafficking pathways in the formation of amyloid beta-protein
  Ann N Y Acad Sci 777: 57-64
• Haass C (1996)
  The molecular significance of amyloid beta-peptide for Alzheimer's disease
  Eur Arch Psychiatry Clin Neurosci 246(3): 118-23
• Fechteler K, Tatzelt J, Huppertz S, Wilgenbus P, Doerfler W (1995)
  The mechanism of adenovirus DNA integration: studies in a cell-free system
  Curr Top Microbiol Immunol 199 ( Pt 2): 109-37
• Haass C, Selkoe DJ (1993)
  Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide
  Cell 75(6): 1039-42