Publications

Journal Article

• Schmidt FC, Fitz K, Feilen LP, Okochi M, Steiner H, Langosch D (2023)
  Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin
  J Biol Chem. 2023 Mar 20;299(5):104626.
• Dawkins E, Derks RJE, Schifferer M, Trambauer J, Winkler E, Simons M, Paquet D, Giera M, Kamp F, Steiner H (2023)
  Membrane lipid remodeling modulates γ-secretase processivity
  J Biol Chem. 2023 Apr;299(4):103027.
• Werner NT, Högel P, Güner G, Stelzer W, Wozny M, Aßfalg M, Lichtenthaler SF, Steiner H, Langosch D (2023)
  Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase
  Commun Biol. 2023 Feb 15;6(1):177
• Domenighetti C, ..., Burbulla LF, et al. (2022)
  Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study
  Mov Disord. 2022 Jan 8. doi: 10.1002/mds.28902. Online ahead of print.
• Morenas-Rodríguez E, Li Y, Nuscher B, Franzmeier N, Xiong C, Suárez-Calvet M, Fagan AM, Schultz S, Gordon BA, Benzinger TLS, Hassenstab J, McDade E, Feederle R, Karch CM, Schlepckow K, Morris JC, Kleinberger G, Nellgard B, Vöglein J, Blennow K, Zetterberg H, Ewers M, Jucker M, Levin J, Bateman RJ, Haass C, on behalf of the Dominantly Inherited Alzheimer Network (2022)
  Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer´s disease: a longitudinal observational study
  The Lancet Neurology Volume 21, Issue 4, April 2022, Pages 329-341
• Feilen LP, Chen SY, Fukumori A, Feederle R, Zacharias M, Steiner H (2022)
  Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis
  Elife. 2022 May 17;11:e76090.
• Domenighetti C, Sugier PE, Sreelatha AAK, Schulte C, Grover S, Mohamed O, Portugal B, May P, Bobbili DR, Radivojkov-Blagojevic M, Lichtner P, Singleton AB, Hernandez DG, Edsall C, Mellick GD, Zimprich A, Pirker W, Rogaeva E, Lang AE, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschländer AB, Hadjigeorgiou GM, Dardiotis E, Stefanis L, Simitsi AM, Valente EM, Petrucci S, Duga S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Matsuo H, Kawamura Y, Hattori N, Nishioka K, Chung SJ, Kim YJ, Kolber P, van de Warrenburg BP, Bloem BR, Aasly J, Toft M, Pihlstrøm L, Guedes LC, Ferreira JJ, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Diez-Fairen M, Wirdefeldt K, Pedersen NL, Ran C, Belin AC, Puschmann A, Hellberg C, Clarke CE, Morrison KE, Tan M, Krainc D, Burbulla LF, Farrer MJ, Krüger R, Gasser T, Sharma M, Elbaz A, Comprehensive Unbiaised Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (Courage-PD) consortium (2022)
  Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson's Disease
  J Parkinsons Dis. 2022;12(1):267-282.
• Anika Reifschneider, Sophie Robinson, Bettina van Lengerich, Johannes Gnörich, Todd Logan, Steffanie Heindl, Miriam A Vogt, Endy Weidinger, Lina Riedl, Karin Wind, Artem Zatcepin, Ida Pesämaa, Sophie Haberl, Brigitte Nuscher, Gernot Kleinberger, Julien Klimmt, Julia K Götzl, Arthur Liesz, Katharina Bürger, Matthias Brendel, Johannes Levin, Janine Diehl-Schmid, Jung Suh, Gilbert Di Paolo, Joseph W Lewcock, Kathryn M Monroe, Dominik Paquet, Anja Capell, Christian Haass (2022)
  Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency
  EMBO J. 2022 Jan 12; e109108
• Güner G, Aßfalg M, Zhao K, Dreyer T, Lahiri S, Lo Y, Slivinschi BI, Imhof A, Jocher G, Strohm L, Behrends C, Langosch D, Bronger H, Nimsky C, Bartsch JW, Riddell SR, Steiner H, Lichtenthaler SF (2022)
  Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ-secretase activity
  EMBO Mol Med. 2022 Oct 10;14(10):e16084
• Xianyuan Xiang, Karin Wind, Thomas Wiedemann, Tanja Blume, Yuan Shi, Nils Briel, Leonie Beyer, Gloria Biechele, Florian Eckenweber, Artem Zatcepin, Sven Lammich, Sara Ribicic, Sabina Tahirovic, Michael Willem, Maximilian Deussing, Carla Palleis, Boris-Stephan Rauchmann, Franz-Josef Gildehaus, Simon Lindner, Nicolai Franzmeier, Karlheinz Baumann, Axel Rominger, Peter Bartenstein, Sibylle Ziegler, Alexander Drzezga, Gesine Respondek, Katharina Buerger, Robert Perneczky, Johannes Levin, Günter U Höglinger, Jochen Herms, Christian Haass, Matthias Brendel (2021)
  Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases
  Sci Transl Med. 2021 Oct 13;13(615):eabe5640.
• Ariane Schumski, Almudena Ortega-Gómez, Kanin Wichapong, Carla Winter, Patricia Lemnitzer, Joana R Viola, Mayra Pinilla-Vera, Eduardo Folco, Victor Solis-Mezarino, Moritz Völker-Albert, Sanne L Maas, Chang Pan, Laura Perez Olivares, Janine Winter, Tilman Hackeng, Mikael C I Karlsson, Tanja Zeller, Axel Imhof, Rebecca M Baron, Gerry A F Nicolaes, Peter Libby, Lars Maegdefessel, Frits Kamp, Martin Benoit, Yvonne Döring, Oliver Soehnlein (2021)
  Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge-Mediated Monocyte Adhesion
  Circulation. 2021 Jan 19;143(3):254-266
• Colombo A, Sadler RK, Llovera G, Singh V, Roth S, Heindl S, Sebastian Monasor L, Verhoeven A, Peters F, Parhizkar S, Kamp F, Gomez de Aguero M, MacPherson AJ, Winkler E, Herms J, Benakis C, Dichgans M, Steiner H, Giera M, Haass C, Tahirovic S, Liesz A (2021)
  Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
  Elife. 2021 Apr 13;10:e59826
• Burbulla LF, Zheng J, Song P, Jiang W, Johnson ME, Brundin P, Krainc D (2021)
  Direct targeting of wild-type glucocerebrosidase by antipsychotic quetiapine improves pathogenic phenotypes in Parkinson's disease models
  JCI Insight. 2021 Oct 8;6(19):e148649.
• Earley AM, Burbulla LF, Krainc D, Awatramani R (2021)
  Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons
  Sci Rep. 2021 Nov 15;11(1):22257.
• Burbulla LF, Mc Donald JM, Valdez C, Gao F, Bigio EH, Krainc D (2021)
  Modeling Brain Pathology of Niemann-Pick Disease Type C Using Patient-Derived Neurons
  Mov Disord. 2021 Apr;36(4):1022-1027.
• Saretz S, Basset G, Useini L, Laube M, Pietzsch J, Draca D, Maksimovic-Ivanic D, Trambauer J, Steiner H, Hey-Hawkins E (2021)
  Modulation of γ-secretase activity by a carborane-based flurbiprofen analogue
  Molecules. 2021 May 11;26(10):2843
• Junker J, Kamp F, Winkler E, Steiner H, Bracher F, Müller C (2021)
  Effective sample preparation procedure for the analysis of free neutral steroids, free steroid acids and sterol sulfates in different tissues by GC-MS
  J Steroid Biochem Mol Biol. 2021 Jul;211:105880
• Yoshihiro Nihei, Kohji Mori, Georg Werner, Thomas Arzberger, Qihui Zhou, Barham Khosravi, Julia Japtok, Andreas Hermann, Andreas Sommacal, Markus Weber, German Consortium for Frontotemporal Lobar Degeneration, Bavarian Brain Banking Alliance, Frits Kamp, Brigitte Nuscher, Dieter Edbauer, Christian Haass (2020)
  Poly-glycine-alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3
  Acta Neuropathol 2020 Jan;139(1):99-118.
• Tasnim Chakroun, Valentin Evsyukov, Niko-Petteri Nykänen, Matthias Höllerhage, Andreas Schmidt, Frits Kamp, Viktoria C Ruf, Wolfgang Wurst, Thomas W Rösler, Günter U Höglinger (2020)
  Alpha-synuclein fragments trigger distinct aggregation pathways
  Cell Death Dis. 2020 Feb 3;11(2):84
• Godbe JM, Freeman R, Burbulla LF, Lewis J, Krainc D, Stupp SI (2020)
  Gelator length precisely tunes supramolecular hydrogel stiffness and neuronal phenotype in 3D culture
  ACS Biomater Sci Eng. 2020 Feb 10;6(2):1196-1207.
• Kai Schlepckow, Kathryn M. Monroe, Gernot Kleinberger, Ludovico Cantuti-Castelvetri, Samira Parhizkar, Dan Xia, Michael Willem, Georg Werner, Nadine Pettkus, Bettina Brunner, Alice Sülzen, Brigitte Nuscher, Heike Hampel, Xianyuan Xiang, Regina Feederle, Sabina Tahirovic, Joshua I. Park, Rachel Prorok, Cathal Mahon, Chun-Chi Liang, Ju Shi, Do Jin Kim, Hanna Sabelström, Fen Huang, Gilbert Di Paolo, Mikael Simons, Joseph W. Lewcock, Christian Haass (2020)
  Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region
  EMBO Mol Med. 2020 Apr 7;12(4):e11227.
• Georg S Nuebling, Eva Plesch, Viktoria C Ruf, Tobias Högen, Stefan Lorenzl, Frits Kamp, Armin Giese, Johannes Levin (2020)
  Binding of Metal-Ion-Induced Tau Oligomers to Lipid Surfaces Is Enhanced by GSK-3β-Mediated Phosphorylation
  ACS Chem Neurosci. 2020 Mar 18;11(6):880-887
• Kong L, Dawkins E, Campbell F, Winkler E, Derks RJE, Giera M, Kamp F, Steiner H, Kros A (2020)
  Photo-controlled delivery of very long chain fatty acids to cell membranes and modulation of membrane protein function
  Biochim Biophys Acta Biomembr. 2020 May 1;1862(5):183200
• Boussaad I, Obermaier CD, Hanss Z, Bobbili DR, Bolognin S, Glaab E, Wołyńska K, Weisschuh N, De Conti L, May C, Giesert F, Grossmann D, Lambert A, Kirchen S, Biryukov M, Burbulla LF, Massart F, Bohler J, Cruciani G, Schmid B, Kurz-Drexler A, May P, Duga S, Klein C, Schwamborn JC, Marcus K, Woitalla D, Vogt Weisenhorn DM, Wurst W, Barrale M, Krainc D, Gasser T, Wissinger B, Krüger R (2020)
  A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease
  Sci Transl Med. 2020 Sep 9;12(560):eaau3960
• Lüningschrör P, Werner G, Stroobants S, Kakuta S, Dombert B, Sinske D, Wanner R, Lüllmann-Rauch R, Wefers B, Wurst W, D'Hooge R, Uchiyama Y, Sendtner M, Haass C, Saftig P, Knöll B, Capell A, Damme M (2020)
  The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons
  Cell Rep. 2020 Mar 10;30(10):3506-3519.
• Trambauer J, Rodríguez Sarmiento RM, Fukumori A, Feederle R, Baumann K, Steiner H (2020)
  Aβ43-producing PS1 FAD mutants cause altered substrate interactions and respond to γ-secretase modulation
  EMBO Rep. 2020 Jan 7;21(1):e47996
• Angelique Camilleri, Stephanie Ghio, Mario Caruana, Daniel Weckbecker, Felix Schmidt, Frits Kamp, Andrei Leonov, Sergey Ryazanov, Christian Griesinger, Armin Giese, Ruben J Cauchi, Neville Vassallo (2020)
  Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin
  Biochim Biophys Acta Biomembr. 2020 Feb 1;1862(2):183064
• Steiner A, Schlepckow K, Brunner B, Steiner H, Haass C, Hagn F (2020)
  γ-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics
  EMBO J. 2020 Oct 15;39(20):e104247
• Graves SM, Xie Z, Stout KA, Zampese E, Burbulla LF, Shih JC, Kondapalli J, Patriarchi T, Tian L, Brichta L, Greengard P, Krainc D, Schumacker PT, Surmeier DJ (2020)
  Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain
  Nat Neurosci. 2020 Jan;23(1):15-20.
• Georg Werner, Markus Damme, Martin Schludi, Johannes Gnörich, Karin Wind, Katrin Fellerer, Benedikt Wefers, Wolfgang Wurst, Dieter Edbauer, Matthias Brendel, Christian Haass, Anja Capell (2020)
  Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice
  EMBO Rep. 2020 Oct 5;21(10):e50241.
• Michael Ewers, Nicolai Franzmeier, Marc Suárez-Calvet, Estrella Morenas-Rodriguez, Miguel Angel Araque Caballero, Gernot Kleinberger, Laura Piccio, Carlos Cruchaga, Yuetiva Deming, Martin Dichgans, John Q. Trojanowski, Leslie M. Shaw, Michael W. Weiner, Christian Haass, for the Alzheimer’s Disease Neuroimaging Initiative (2019)
  Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease
  Science Translational Medicine, 28 Aug 2019
• Iris Marti Fernandez, Caterina Macrini, Markus Krumbholz, Paul J Hensbergen, Agnes L Hipgrave Ederveen, Stephan Winklmeier, Atay Vural, Asli Kurne, Dieter Jenne, Frits Kamp, Lisa Ann Gerdes, Reinhard Hohlfeld, Manfred Wuhrer, Tania Kümpfel, Edgar Meinl (2019)
  The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients
  Front Immunol. 2019 Jun 11;10:1189
• Stephanie Ghio, Angelique Camilleri, Mario Caruana, Viktoria C Ruf, Felix Schmidt, Andrei Leonov, Sergey Ryazanov, Christian Griesinger, Ruben J Cauchi, Frits Kamp, Armin Giese, Neville Vassallo (2019)
  Cardiolipin Promotes Pore-Forming Activity of Alpha-Synuclein Oligomers in Mitochondrial Membranes
  ACS Chem Neurosci. 2019 Aug 21;10(8):3815-3829
• Viktoria C. Ruf, Georg S. Nübling, Sophia Willikens, Song Shi, Felix Schmidt, Johannes Levin, Kai Bötzel, Frits Kamp, Armin Giese (2019)
  Different effects of alpha-Synuclein mutants on lipid binding and aggregation detected by single molecule fluorescence spectroscopy and ThT fluorescence-based measurements
  ACS Chem Neurosci. 2019 Mar 20;10(3):1649-1659
• Carlos Silvestre-Roig, Quinte Braster, Kanin Wichapong, Ernest Y Lee, Jean Marie Teulon, Nihel Berrebeh, Janine Winter, José M Adrover, Giancarlo Santiago Santos, Alexander Froese, Patricia Lemnitzer, Almudena Ortega-Gómez, Raphael Chevre, Julian Marschner, Ariane Schumski, Carla Winter, Laura Perez-Olivares, Chang Pan, Nicole Paulin, Tom Schoufour, Helene Hartwig, Silvia González-Ramos, Frits Kamp, Remco T A Megens, Kerri A Mowen, Matthias Gunzer, Lars Maegdefessel, Tilman Hackeng, Esther Lutgens, Mat Daemen, Julia von Blume, Hans-Joachim Anders, Viacheslav O Nikolaev, Jean-Luc Pellequer, Christian Weber, Andrés Hidalgo, Gerry A F Nicolaes, Gerard C L Wong, Oliver Soehnlein (2019)
  Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death
  Nature. 2019 May;569(7755):236-240
• Götzl J, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, Colombo A, Deussing M, Wagner M, Winkelmann J, Diehl-Schmid J, Levin J, Fellerer K, Reifschneider A, Bultmann S, Bartenstein P, Rominger A, Tahirovic S, Smith ST, Madore C, Butovsky O, Capell A, Haass C (2019)
  Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism
  EMBO Mol Med. 2019 Jun;11(6):e9711.
• Berenguer-Escuder C, Grossmann D, Massart F, Antony P, Burbulla LF, Glaab E, Imhoff S, Trinh J, Seibler P, Grünewald A, Krüger R (2019)
  Variants in Miro1 Cause Alterations of ER-Mitochondria Contact Sites in Fibroblasts from Parkinson's Disease Patients
  J Clin Med. 2019 Dec 16;8(12):2226.
• Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Kai Schlepckow, Miguel Ángel Araque Caballero, Nicolai Franzmeier, Anja Capell, Katrin Fellerer, Brigitte Nuscher, Erden Eren, Johannes Levin, Yuetiva Deming, Laura Piccio, Celeste M. Karch, Carlos Cruchaga, Leslie M. Shaw, John Q. Trojanowski, Michael Weiner, Michael Ewers, Christian Haass, for the Alzheimer’s Disease Neuroimaging Initiative (2019)
  Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology
  Mol Neurodegener. 2019 Jan 10;14(1):1
• Torben Mentrup, Kosta Theodorou, Florencia Cabrera-Cabrera, Andreas O. Helbig, Kathrin Happ, Marion Gijbels, Ann-Christine Gradtke, Björn Rabe, Akio Fukumori, Harald Steiner, Andreas Tholey, Regina Fluhrer, Marjo Donners, Bernd Schröder (2019)
  Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis
  J Exp Med. 2019 Apr 1;216(4):807-830
• Burbulla LF, Jeon S, Zheng J, Song P, Silverman RB, Krainc D (2019)
  A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson's disease
  Sci Transl Med. 2019 Oct 16;11(514):eaau6870.
• Alkmini A Papadopoulou, Stephan A Müller, Torben Mentrup, Merav D Shmueli, Johannes Niemeyer, Martina Haug-Kröper, Julia von Blume, Artur Mayerhofer, Regina Feederle, Bernd Schröder, Stefan F Lichtenthaler, Regina Fluhrer (2019)
  Signal Peptide Peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins
  EMBO Rep. 2019 May;20(5). pii: e48133
• Junker J, Chong I, Kamp F, Steiner H, Giera M, Müller C, Bracher F (2019)
  Comparison of strategies for the determination of sterol sulfates via GC-MS leading to a novel deconjugation-derivatization protocol
  Molecules. 2019 Jun 26;24(13):2353
• Vöglein J, Willem M, Trambauer J, Schönecker S, Dieterich M, Biskup S, Giudici C, Utz K, Oberstein T, Brendel M, Rominger A, Danek A, Steiner H, Haass C, Levin J (2019)
  Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-β processing effects
  Neurobiol Aging. 2019 Dec;84:241.e5-241.e11
• Zheng J, Jeon S, Jiang W, Burbulla LF, Ysselstein D, Oevel K, Krainc D, Silverman RB (2019)
  Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase
  J Med Chem. 2019 Feb 14;62(3):1218-1230.
• Vöglein J, Paumier K, Jucker M, Preische O, McDade E, Hassenstab J, Benzinger TL, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal J, Salloway S, Xiong C, Karch CM, Cairns N, Mori H, Schofield PR, Masters CL, Goate A, Buckles V, Fox N, Rossor M, Chrem P, Allegri R, Ringman JM, Höglinger G, Steiner H, Dieterich M, Haass C, Laske C, Morris JC, Bateman RJ, Danek A, Levin J, Dominantly Inherited Alzheimer Network (2019)
  Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease
  Brain 2019 May 1;142(5):1429-1440
• Johannes Niemeyer, Torben Mentrup, Ronny Heidasch, Stephan A Müller, Uddipta Biswas, Rieke Meyer, Alkmini A Papadopoulou, Verena Dederer, Martina Haug-Kröper, Vivian Adamski, Renate Lüllmann-Rauch, Martin Bergmann, Artur Mayerhofer, Paul Saftig, Gunther Wennemuth, Rolf Jessberger, Regina Fluhrer, Stefan F Lichtenthaler, Marius K Lemberg, Bernd Schröder (2019)
  The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban
  EMBO Rep. 2019 Feb 7
• Samira Parhizkar, Thomas Arzberger, Matthias Brendel, Gernot Kleinberger, Maximilian Deussing, Carola Focke, Brigitte Nuscher, Monica Xiong, Alireza Ghasemigharagoz, Natalie Katzmarski, Susanne Krasemann, Stefan F. Lichtenthaler, Stephan A. Müller, Alessio Colombo, Laura Sebastian Monasor, Sabina Tahirovic, Jochen Herms, Michael Willem, Nadine Pettkus, Oleg Butovsky, Peter Bartenstein, Dieter Edbauer, Axel Rominger, Ali Ertürk, Stefan A. Grathwohl, Jonas J. Neher, David M. Holtzman, Melanie Meyer-Luehmann, Christian Haass (2019)
  Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
  Nat Neurosci. 2019 Feb;22(2):191-204
• Tretter JY, Schorpp K, Luxenburger E, Trambauer J, Steiner H, Hadian K, Gires O, Niessing D (2018)
  A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor
  J Biol Chem. 2018 Jun 8;293(23):8994-9005
• Kim MJ, Jeon S, Burbulla LF, Krainc D (2018)
  Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function
  Hum Mol Genet. 2018 Jun 1;27(11):1972-1988.
• Frits Kamp, Holger A. Scheidt, Edith Winkler, Gabriele Basset, Hannes Heinel, James M. Hutchison, Loren M. LaPointe, Charles R. Sanders, Harald Steiner, Daniel Huster (2018)
  Bexarotene binds to the amyloid precursor protein transmembrane domain, alters its α-helical conformation, and inhibits γ-secretase nonselectively in liposomes
  ACS Chem Neurosci. 2018 Jul 18;9(7):1702-1713.
• Seibler P, Burbulla LF, Dulovic M, Zittel S, Heine J, Schmidt T, Rudolph F, Westenberger A, Rakovic A, Münchau A, Krainc D, Klein C (2018)
  Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells
  Brain. 2018 Oct 1;141(10):3052-3064.
• Julia K. Götzl, Alessio-Vittorio Colombo, Katrin Fellerer, Anika Reifschneider, Georg Werner, Sabina Tahirovic, Christian Haass, Anja Capell (2018)
  Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice
  Mol Neurodegener. 2018 Sep 4;13(1):48
• Melania Spadaro, Stephan Winklmeier, Eduardo Beltrán, Caterina Macrini, Romana Höftberger, Elisabeth Schuh, Franziska S. Thaler, Lisa Ann Gerdes, Sarah Laurent, Ramona Gerhards, Simone Brändle, Klaus Dornmair, Constanze Breithaupt, Markus Krumbholz, Markus Moser, Gurumoorthy Krishnamoorthy, Frits Kamp, Dieter Jenne, Reinhard Hohlfeld, Tania Kümpfel, Hans Lassmann, Naoto Kawakami, Edgar Meinl (2018)
  Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein
  Ann Neurol. 2018 Aug;84(2):315-328.
• Cornelis Blauwendraat, Carlo Wilke, Javier Simón-Sánchez, Iris E. Jansen, Anika Reifschneider, Anja Capell, Christian Haass, Melissa Castillo-Lizardo, Saskia Biskup, Walter Maetzler, Patrizia Rizzu, Peter Heutink, Matthis Synofzik (2018)
  The wide genetic landscape of clinical frontotemporal dementia: systematic combined sequencing of 121 consecutive subjects
  Genet Med. 2018 Feb;20(2):240-249
• Marc Suárez-Calvet, Anja Capell, Miguel Ángel Araque Caballero, Estrella Morenas-Rodríguez, Katrin Fellerer, Nicolai Franzmeier, Gernot Kleinberger, Erden Eren, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Katrina Paumier, Randall J Bateman, Anne M Fagan, John C Morris, Johannes Levin, Adrian Danek, Mathias Jucker, Colin L Masters, Martin N Rossor, John M Ringman, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers , Christian Haass, for the Dominantly Inherited Alzheimer Network, & for the Alzheimer's Disease Neuroimaging Initiative (2018)
  CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline
  EMBO Mol Med. 2018 Dec;10(12). pii: e9712.
• Alexander Götz, Nadine Mylonas, Philipp Högel, Mara Silber, Hannes Heinel, Simon Menig, Alexander Vogel, Hannes Feyrer, Daniel Huster, Burkhard Luy, Dieter Langosch, Christina Scharnagl, Claudia Muhle-Goll, Frits Kamp, Harald Steiner (2018)
  Modulating hinge flexibility in the APP transmembrane domain alters γ-secretase
  Biophys J. 2019 Jun 4;116(11):2103-2120
• Karim S. Echtay, Martin Bienengraeber, Peter Mayinger, Simone Heimpel, Doerthe Druhmann, Karina Frischmuth, Frits Kamp, Shu-Gui Huang (2018)
  Uncoupling proteins: Martin Klingenberg's contributions for 40 years
  Arch Biochem Biophys. 2018 Nov 1;657:41-55
• Matthias Brendel, Anna Jaworska, Felix Overhoff, Tanja Blume, Federico Probst, Franz-Josef Gildehaus, Peter Bartenstein, Christian Haass, Bernd Bohrmann, Jochen Herms, Michael Willem, Axel Rominger (2018)
  Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation
  Theranostics. 2018 Sep 9;8(18):4957-4968
• Gernot Kleinberger, Matthias Brendel, Eva Mracsko, Benedikt Wefers, Linda Groeneweg, Xianyuan Xiang, Carola Focke, Maximilian Deußing, Marc Suárez-Calvet, Fargol Mazaheri, Samira Parhizkar, Nadine Pettkus, Wolfgang Wurst, Regina Feederle, Peter Bartenstein, Thomas Mueggler, Thomas Arzberger, Irene Knuesel, Axel Rominger, Christian Haass (2017)
  The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion and glucose metabolism
  EMBO J. 2017 Jul 3;36(13):1837-1853
• Yu Ohki, Andrea Wenninger-Weinzierl, Alexander Hruscha, Kazuhide Asakawa, Koichi Kawakami, Christian Haass, Dieter Edbauer, Bettina Schmid (2017)
  Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration
  Mol Neurodegener. 2017 Jan 14;12(1):6. doi: 10.1186/s13024-016-0146-8.
• Jules F, Sauvageau E, Dumaresq-Doiron K, Mazzaferri J, Haug-Kröper M, Fluhrer R, Costantino S, Lefrancois S (2017)
  CLN5 is cleaved by members of the SPP/SPPL family to produce a mature soluble protein
  Exp Cell Res. 2017 Aug 1;357(1):40-50
• Kai Schlepckow, Gernot Kleinberger, Akio Fukumori, Regina Feederle, Stefan F. Lichtenthaler, Harald Steiner, Christian Haass (2017)
  An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function
  EMBO Mol Med. 2017 Oct;9(10):1356-1365
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  Latest emerging functions of SPP/SPPL intramembrane proteases
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  TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury
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• Mentrup T, Loock AC, Fluhrer R, Schröder B (2017)
  Signal peptide peptidase and SPP-like proteases - Possible therapeutic targets?
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  Analyzing amyloid-β peptide modulation profiles and binding sites of γ-secretase modulators
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  Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease
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• Felix Overhoff, Matthias Brendel, Anna Jaworska, Viktoria Korzhova, Andreas Delker, Federico Probst, Carola Focke, Franz-Josef Gildehaus, Janette Carlsen, Karlheinz Baumann, Christian Haass, Peter Bartenstein, Jochen Herms, Axel Rominger (2016)
  Automated Spatial Brain Normalization and Hindbrain White Matter Reference Tissue Give Improved [(18)F]-Florbetaben PET Quantitation in Alzheimer's Model Mice
  Front Neurosci. 2016 Feb 29;10:45
• Juan Domingo Gispert, Marc Suárez-Calvet, Gemma C. Monte, Alan Tucholka, Carles Falcon, Santiago Rojas, Lorena Rami, Raquel Sanchez-Valle, Albert Lladó, Gernot Kleinberger, Christian Haass, José Luis Molinuevo (2016)
  Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease
  Alzheimers Dement. 2016 Jul 13. pii: S1552-5260(16)30026-7.
• Kaichuan Zhu, Xianyuan Xiang, Severin Filser, Petar Marinkovic, Mario M. Dorostkar, Sophie Crux, Ulf Neumann, Derya R. Shimshek, Gerhard Rammes, Christian Haass, Stefan F. Lichtenthaler, Jenny M. Gunnersen, Jochen Herms (2016)
  Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6
  Biol Psychiatry. 2016 Dec 26. pii: S0006-3223(16)33157-2. doi: 10.1016/j.biopsych.2016.12.023.
• Hsieh CH, Shaltouki A, Gonzalez AE, Bettencourt da Cruz A, Burbulla LF, St Lawrence E, Schüle B, Krainc D, Palmer TD, Wang X (2016)
  Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease
  Cell Stem Cell. 2016 Dec 1;19(6):709-724.
• Xianyuan Xiang, Georg Werner, Bernd Bohrmann, Arthur Liesz, Fargol Mazaheri, Anja Capell, Regina Feederle, Irene Knuesel, Gernot Kleinberger, Christian Haass (2016)
  TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
  EMBO Molecular Medicine (2016) e201606370, Published online 08.07.2016
• Benedikt Kretner, Johannes Trambauer, Janina Mielke, Peer-Hendrik Kuhn, Elisabeth Kremmer, Armin Giese, Stefan Lichtenthaler, Christian Haass, Thomas Arzberger, Harald Steiner (2016)
  Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer’s disease
  EMBO Mol Med. 2016 May 2;8(5):458-65
• Juan Domingo Gispert, Gemma C. Monté, Marc Suárez-Calvet, Carles Falcon, Alan Tucholka, Santiago Rojas, Lorena Rami, Raquel Sánchez-Valle, Albert Lladó, Gernot Kleinberger, Christian Haass, José Luis Molinuevo (2016)
  The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2
  Alzheimers Dement (Amst). 2016 Dec 22;6:50-59
• Susann Hüttl, Felix Helfrich, Torben Mentrup, Sebastian Held, Harald Steiner, Paul Saftig, Regina Fluhrer, Bernd Schröder (2016)
  Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74
  Biochem J. 2016 May 15;473(10):1405-22.
• Rashi Halder, Magali Hennion, Ramon O Vidal, Orr Shomroni, Raza-Ur Rahman, Ashish Rajput, Tonatiuh Pena Centeno, Frauke van Bebber, Vincenzo Capece, Julio C Garcia Vizcaino, Anna-Lena Schuetz, Susanne Burkhardt, Eva Benito, Magdalena Navarro Sala, Sanaz Bahari Javan, Christian Haass, Bettina Schmid, Andre Fischer, Stefan Bonn (2016)
  DNA methylation changes in plasticity genes accompany the formation and maintenance of memory
  Nat Neurosci. 2016 Jan;19(1):102-10
• Gernot Kleinberger, Anja Capell, Nathalie Brouwers, Katrin Fellerer, Kristel Sleegers, Marc Cruts, Christina Van Broeckhoven, Christian Haass (2016)
  Reduced secretion and altered proteolytic processing caused by missense mutations in progranulin
  Neurobiol Aging. 2016 Mar;39:220.e17-26
• Matthias Brendel, Federico Probst, Anna Jaworska, Felix Overhoff, Viktoria Korzhova, Nathalie L. Albert, Roswitha Beck, Simon Lindner, Franz-Josef Gildehaus, Karlheinz Baumann, Peter Bartenstein, Gernot Kleinberger, Christian Haass, Jochen Herms, Axel Rominger (2016)
  Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple-Tracer PET Study
  J Nucl Med. 2016 Jun;57(6):954-60
• Saoussen Ben Halima, Sabyashachi Mishra, K. Muruga Poopathi Raja, Michael Willem, Antonio Baici, Kai Simons, Oliver Brüstle, Philipp Koch, Christian Haass, Amedeo Caflisch, Lawrence Rajendran (2016)
  Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein
  Cell Rep. 2016 Mar 8;14(9):2127-41
• Marc Suárez-Calvet, Miguel Ángel Araque Caballero, Gernot Kleinberger, Randall J. Bateman, Anne M. Fagan, John C. Morris, Johannes Levin, Adrian Danek, Michael Ewers, Christian Haass, for the Dominantly Inherited Alzheimer Network (2016)
  Early changes in CSF sTREM2 in dominantly inherited Alzheimer’s disease occur after amyloid deposition and neuronal injury
  Science Translational Medicine 14 Dec 2016: Vol. 8, Issue 369, pp. 369ra178 DOI: 10.1126/scitranslmed.aag1767
• Marc Suárez-Calvet, Manuela Neumann, Thomas Arzberger, Claudia Abou-Ajram, Eva Funk, Hannelore Hartmann, Dieter Edbauer, Elisabeth Kremmer, Christoph Göbl, Moritz Resch, Benjamin Bourgeois, Tobias Madl, Stefan Reber, Daniel Jutzi, Marc-David Ruepp, Ian R. A. Mackenzie, Olaf Ansorge, Dorothee Dormann, Christian Haass (2016)
  Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS
  Acta Neuropathol. 2016 Apr;131(4):587-604
• Kohji Mori, Yoshihiro Nihei, Thomas Arzberger, Qihui Zhou, Ian R Mackenzie, Andreas Hermann, Frank Hanisch, German Consortium for Frontotemporal Lobar Degeneration, Bavarian Brain Banking Alliance, Frits Kamp, Brigitte Nuscher, Denise Orozco, Dieter Edbauer, Christian Haass (2016)
  Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition
  EMBO Reports, published online 26.07.2016
• Matthias Brendel, Anna Jaworska, Federico Probst, Felix Overhoff, Viktoria Korzhova, Simon Lindner, Janette Carlsen, Peter Bartenstein, Ryuichi Harada, Yukitsuka Kudo, Christian Haass, Fred van Leuven, Nobuyuki Okamura, Jochen Herms, Axel Rominger (2016)
  Small-Animal PET Imaging of Tau Pathology with 18F-THK5117 in 2 Transgenic Mouse Models
  J Nucl Med. 2016 May;57(5):792-8
• Anna Daria, Alessio Colombo, Gemma llovera, Heike Hampel, Michael Willem, Arthur Liesz, Christian Haass, Sabina Tahirovic (2016)
  Young microglia restore amyloid plaque clearance of aged microglia
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• Mazzulli JR, Burbulla LF, Krainc D, Ischiropoulos H (2016)
  Detection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence
  Anal Chem. 2016 Feb 16;88(4):2399-405.
• Mazzulli JR, Zunke F, Tsunemi T, Toker NJ, Jeon S, Burbulla LF, Patnaik S, Sidransky E, Marugan JJ, Sue CM, Krainc D (2016)
  Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons
  J Neurosci. 2016 Jul 20;36(29):7693-706.
• Marc Suárez-Calvet, Gernot Kleinberger, Miguel Ángel Araque Caballero, Matthias Brendel, Axel Rominger, Daniel Alcolea, Juan Fortea, Alberto Lleó, Rafael Blesa, Juan Domingo Gispert, Raquel Sánchez-Valle, Anna Antonell, Lorena Rami, José L. Molinuevo, Frederic Brosseron, Andreas Traschütz, Michael T. Heneka, Hanne Struyfs, Sebastiaan Engelborghs, Kristel Sleegers, Christine Van Broeckhoven, Henrik Zetterberg, Bengt Nellgard, Kaj Blennow, Alexander Crispin, Michael Ewers, Christian Haass (2016)
  sTREM2 cerebrospinal fluid levels are a potent biomarker for microglia activity in early-stage Alzheimer’s disease and associate with neuronal injury markers
  EMBO Mol Med. 2016 May 2;8(5):466-76
• Burbulla LF, Beaumont KG, Mrksich M, Krainc D (2016)
  Micropatterning Facilitates the Long-Term Growth and Analysis of iPSC-Derived Individual Human Neurons and Neuronal Networks
  Adv Healthc Mater. 2016 Aug;5(15):1894-903.
• Matthias Brendel, Anna Jaworska, Eric Grießinger, Christina Rötzer, Steffen Burgold, Franz-Josef Gildehaus, Janette Carlsen, Paul Cumming, Karlheinz Baumann, Christian Haass, Harald Steiner, Peter Bartenstein, Jochen Herms, Axel Rominger (2015)
  Cross-sectional comparison of small animal [18F]-florbetaben amyloid-PET between transgenic AD mouse models
  PLoS One. 2015 Feb 23;10(2):e0116678
• Kuhn PH, Voss M, Haug-Kröper M, Schröder B, Schepers U, Bräse S, Haass C, Lichtenthaler SF, Fluhrer R (2015)
  Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways
  Mol Cell Proteomics. 2015 Jun;14(6):1584-98. doi: 10.1074/mcp.M115.048298. Epub 2015 Mar 31.
• Frits Kamp, Edith Winkler, Johannes Trambauer, Amelie Ebke, Regina Fluhrer, Harald Steiner (2015)
  Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process
  Biophys J. 2015 Mar 10;108(5):1229-37.
• Mentrup T, Häsler R, Fluhrer R, Saftig P, Schröder B (2015)
  A Cell-Based Assay Reveals Nuclear Translocation of Intracellular Domains Released by SPPL Proteases
  Traffic. 2015 Aug;16(8):871-92. doi: 10.1111/tra.12287. Epub 2015 May 6
• Fleck D, Voss M, Brankatschk B, Giudici C, Hampel H, Edbauer D, Steiner H, Kremmer E, Haug-Kröper M, Rossner MJ, Fluhrer R, Willem M, Haass C (2015)
  Proteolytic processing of neuregulin 1 type III by three intramembrane cleaving proteases
  J Biol Chem. 2016 Jan 1;291(1):318-33.
• Sandra Jäckel, Anna K. Summerer, Catherine M. Thömmes, Xia Pan, Aaron Voigt, Jörg B. Schulz, Tobias M. Rasse, Dorothee Dormann, Christian Haass, Philipp J. Kahle (2015)
  Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila
  Neurobiol Dis. 2015 Feb;74:76-88
• M Brendel, A Jaworska, J Herms, J Trambauer, C Rötzer, F-J Gildehaus, J Carlsen, P Cumming, J Bylund, T Luebbers, P Bartenstein, H Steiner, C Haass, K Baumann, A Rominger (2015)
  Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment
  Mol Psychiatry. 2015 Oct;20(10):1179-87
• Barbara Solchenberger, Claire Russell, Elisabeth Kremmer, Christian Haass, Bettina Schmid (2015)
  Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology
  PLoS One. 2015 Mar 18;10(3):e0118956
• Teresa Bachhuber, Natalie Katzmarski, Joanna F McCarter, Desiree Loreth, Sabina Tahirovic, Frits Kamp, Claudia Abou-Ajram, Brigitte Nuscher, Alberto Serrano-Pozo, Alexandra Müller, Marco Prinz, Harald Steiner, Bradley T Hyman, Christian Haass, Melanie Meyer-Luehmann (2015)
  Inhibition of amyloid-β plaque formation by α-synuclein
  Nat Med. 2015 Jul;21(7):802-7
• Michael Willem, Sabina Tahirovic, Marc Aurel Busche, Saak V. Ovsepian, Magda Chafai, Scherazad Kootar, Daniel Hornburg, Lewis D. B. Evans, Steven Moore, Anna Daria, Heike Hampel, Veronika Müller, Camilla Giudici, Brigitte Nuscher, Andrea Wenninger-Weinzierl, Elisabeth Kremmer, Michael T. Heneka, Dietmar R. Thal, Vilmantas Giedraitis, Lars Lannfelt, Ulrike Müller, Frederick J. Livesey, Felix Meissner, Jochen Herms, Arthur Konnerth, Hélène Marie, Christian Haass (2015)
  eta-Secretase processing of APP inhibits neuronal activity in the hippocampus
  Nature. 2015 Oct 15;526(7573):443-7
• Eva C Schulte, Brit Mollenhauer, Hyun Hor, Thomas Arzberger, Robert Perneczky, Alexander Kurz, Janine Diehl-Schmid, Michael Hüll, Peter Lichtner, Gertrud Eckstein, Alexander Zimprich, Dietrich Haubenberger, Walter Pirker, Thomas Brücke, Benjamin Bereznai, Maria J Molnar, Oswaldo Lorenzo-Betancor, Pau Pastor, Annette Peters, Christian Gieger, Xavier Estivill, Thomas Meitinger, Hans A Kretzschmar, Claudia Trenkwalder, Christian Haass, Juliane Winkelmann (2015)
  Rare variants in β-Amyloid precursor protein (APP) and Parkinson's disease
  Eur J Hum Genet. 2015 Oct;23(10):1328-33
• M Brendel, A Jaworska, J Herms, J Trambauer, C Rötzer, F-J Gildehaus, J Carlsen, P Cumming, J Bylund, T Luebbers, P Bartenstein, H Steiner, C Haass, K Baumann, A Rominger (2015)
  Monitoring of chronic γ-secretase modulator treatment by serial amyloid-PET
  Mol Psychiatry. 2015 Oct;20(10):1141
• Jonathan Janssens, Stéphanie Philtjens, Gernot Kleinberger, Sara Van Mossevelde, Julie van der Zee, Rita Cacace, Sebastiaan Engelborghs, Anne Sieben, Julia Banzhaf-Strathmann, Lubina Dillen, Céline Merlin, Ivy Cuijt, Caroline Robberecht, Bettina Schmid, Patrick Santens, Adrian Ivanoiu, Mathieu Vandenbulcke, Rik Vandenberghe, Patrick Cras, Peter P. De Deyn, Jean-Jacques Martin, Stuart Maudsley, Christian Haass, Marc Cruts, Christine Van Broeckhoven (2015)
  Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains
  Acta Neuropathol Commun. 2015 Nov 10;3:68
• Götzl JK, Mori K, Damme M, Fellerer K, Tahirovic S, Kleinberger G, Janssens J, van der Zee J, Lang CM, Kremmer E, Martin JJ, Engelborghs S, Kretzschmar HA, Arzberger T, Van Broeckhoven C, Haass C, Capell A (2014)
  Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis.
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• Voss M, Künzel U, Higel F, Kuhn PH, Colombo A, Haug-Kröper M, Klier B, Grammer G, Seidl A, Schröder B, Obst R, Steiner H, Lichtenthaler SF, Haass C, Fluhrer R (2014)
  Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation
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• Schwenk BM, Lang CM, Hogl S, Tahirovic S, Orozco D, Rentzsch K, Lichtenthaler SF, Hoogenraad CC, Capell A, Haass C, Edbauer D (2014)
  The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes
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• Schneppeneim J, Hüttl S, Mentrup T, Lüllmann-Rauch R, Rothaug M, Engelke M, Dittmann K, Dressel R, Araki M, Araki K, Wienands J, Fluhrer R, Saftig P, Schröder B (2014)
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  TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
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  Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1
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  Anti-Prion Drug mPPIg5 Inhibits PrP(C) Conversion to PrP(Sc)
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• Mackenzie IR, Arzberger T, Kremmer E, Troost D, Lorenzl S, Mori K, Weng SM, Haass C, Kretzschmar HA, Edbauer D, Neumann M (2013)
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• Reinhardt P, Schmid B, Burbulla LF, Schöndorf DC, Wagner L, Glatza M, Höing S, Hargus G, Heck SA, Dhingra A, Wu G, Müller S, Brockmann K, Kluba T, Maisel M, Krüger R, Berg D, Tsytsyura Y, Thiel CS, Psathaki OE, Klingauf J, Kuhlmann T, Klewin M, Müller H, Gasser T, Schöler HR, Sterneckert J (2013)
  Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression
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• Cheret C, Willem M, Fricker FR, Wende H, Wulf-Goldenberg A, Tahirovic S, Nave KA, Saftig P, Haass C, Garratt AN, Bennett DL, Birchmeier C (2013)
  Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles
  EMBO J. 2013 Jul 17;32(14):2015-28. doi: 10.1038/emboj.2013.146. Epub 2013 Jun 21
• Julia Banzhaf-Strathmann, Rainer Claus, Oliver Mücke, Kristin Rentzsch, Julie van der Zee, Sebastiaan Engelborghs, Peter P De Deyn, Marc Cruts, Christine van Broeckhoven, Christoph Plass (2013)
  Promoter DNA methylation regulates progranulin expression and is altered in FTLD
  Acta Neuropathologica Communications 1 (1):16
• Prox J, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D´Hooge R, Stroobants S, Ahmed T, Balschun D, Willem M, Lammich S, Isbrandt D, Schweizer M, Horré K, De Strooper B, Saftig P (2013)
  Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions
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• Panda SK, Wefers B, Ortiz O, Floss T, Schmid B, Haass C, Wurst W, Kühn R (2013)
  Highly Efficient Targeted Mutagenesis in Mice Using TALENs
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• Haass C, Capell A, Citron M, Teplow DB, Selkoe DJ (1995)
  The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein
  J Biol Chem 270(11): 6186-92
• Wieland J, Nitsche AM, Strayle J, Steiner H, Rudolph HK (1995)
  The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane
  EMBO J 14(16): 3870-82
• Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ (1995)
  ß-Secretase cleavage of ß-Amyloid precursor protein with the Swedish mutation occurs within the secretory pathway after the trans-Golgi network
  Nat. Med. 1; 1291-6
• Lemere CA, Munger JS, Shi GP, Natkin L, Haass C, Chapman HA, Selkoe DJ (1995)
  The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study
  Am J Pathol 146(4): 848-60
• Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ (1995)
  The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway
  Nat Med 1(12): 1291-6
• Haass C, Koo EH, Teplow DB, Selkoe DJ (1994)
  Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells
  Proc Natl Acad Sci U S A 91(4): 1564-8
• Hamilton JA, Civelek VN, Kamp F, Tornheim K, Corkey BE (1994)
  Changes in internal pH caused by movement of fatty acids into and out of clonal pancreatic beta-cells (HIT)
  J Biol Chem. 1994 Aug 19;269(33):20852-6.
• Juretić D, Hendler RW, Kamp F, Caughey WS, Zasloff M, Westerhoff HV (1994)
  Magainin oligomers reversibly dissipate delta microH+ in cytochrome oxidase liposomes
  Biochemistry. 1994 Apr 19;33(15):4562-70.
• Haass C, Hung AY, Selkoe DJ, Teplow DB (1994)
  Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor
  J Biol Chem 269(26): 17741-8
• Lo AC, Haass C, Wagner SL, Teplow DB, Sisodia SS (1994)
  Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells
  J Biol Chem 269(49): 30966-73
• Skatchkov S, Brosamle C, Vyklicky L, Kuffler DP, Orkand RK (1994)
  NMDA receptors on adult frog spinal motoneurons in culture
  Neurosci Lett 176(2): 251-4
• Citron M, Haass C, Selkoe DJ (1993)
  Production of amyloid-beta-peptide by cultured cells: no evidence for internal initiation of translation at Met596
  Neurobiol Aging 14(6): 571-3
• Kamp F, Hamilton JA, Westerhoff HV (1993)
  Movement of fatty acids, fatty acid analogues, and bile acids across phospholipid bilayers
  Biochemistry. 1993 Oct 19;32(41):11074-86.
• Fechteler K, Langenbach P, Doerfler W (1993)
  Fractionated nuclear extracts from hamster cells catalyze cell-free recombination at selective sequences between adenovirus DNA and a hamster preinsertion site
  Proc Natl Acad Sci U S A 90(15): 7356-60
• Hung AY, Haass C, Nitsch RM, Qiu WQ, Citron M, Wurtman RJ, Growdon JH, Selkoe DJ (1993)
  Activation of protein kinase C inhibits cellular production of the amyloid beta-protein
  J Biol Chem 268(31): 22959-62
• Haass C, Hung AY, Schlossmacher MG, Oltersdorf T, Teplow DB, Selkoe DJ (1993)
  Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules
  Ann N Y Acad Sci 695: 109-16
• Haass C, Hung AY, Schlossmacher MG, Teplow DB, Selkoe DJ (1993)
  beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms
  J Biol Chem 268(5): 3021-4
• Kamp F, Hamilton JA. (1992)
  pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acids
  Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11367-70.
• Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ (1992)
  Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments
  Nature 357(6378): 500-3
• Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB, et al. (1992)
  Amyloid beta-peptide is produced by cultured cells during normal metabolism
  Nature 359(6393): 322-5
• Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ (1992)
  Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production
  Nature 360(6405): 672-4
• Scholz B, Fechteler K, Jessberger R, Doerfler W (1992)
  Recombination between adenovirus type 12 DNA and a hamster preinsertion sequence in a cell-free system. Patch homologies and fractionation of nuclear extracts
  J Mol Biol 226(1): 117-26
• Frentzel S, Troxell M, Haass C, Pesold-Hurt B, Glatzer KH, Kloetzel PM (1992)
  Molecular characterization of the genomic regions of the Drosophila alpha-type subunit proteasome genes PROS-Dm28.1 and PROS-Dm35
  Eur J Biochem 205(3): 1043-51
• Schlossmacher MG, Ostaszewski BL, Hecker LI, Celi A, Haass C, Chin D, Lieberburg I, Furie BC, Furie B, Selkoe DJ (1992)
  Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes
  Neurobiol Aging 13(3): 421-34
• Hung AY, Koo EH, Haass C, Selkoe DJ (1992)
  Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage
  Proc Natl Acad Sci U S A 89(20): 9439-43
• Haass C, Hung AY, Selkoe DJ (1991)
  Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion
  J Neurosci 11(12): 3783-93
• Kloetzel PM, Frentzel S, Gernold M, Haass C, Klein U, Pesold-Hurt B, Seelig A (1991)
  The proteasome of Drosophila and features of the evolutionarily conserved PROS-gene family
  Biomed Biochim Acta 50(4-6): 451-7
• Haass C, Pesold-Hurt B, Kloetzel PM (1990)
  The Drosophila PROS-29 gene is a new member of the PROS-gene family
  Nucleic Acids Res 18(13): 4018
• Haass C, Pesold-Hurt B, Multhaup G, Beyreuther K, Kloetzel PM (1990)
  The Drosophila PROS-28.1 gene is a member of the proteasome gene family
  Gene 90(2): 235-41
• Haass C, Klein U, Kloetzel PM (1990)
  Developmental expression of Drosophila melanogaster small heat-shock proteins
  J Cell Sci 96 ( Pt 3): 413-8
• Haass C, Kloetzel PM (1990)
  Molecular analysis of alpha ecdysone induced 16S complexes in Drosophila Schneider's S3 cells
  Biochem Biophys Res Commun 168(1): 314-9
• Haass C, Pesold-Hurt B, Multhaup G, Beyreuther K, Kloetzel PM (1989)
  The PROS-35 gene encodes the 35 kd protein subunit of Drosophila melanogaster proteasome
  EMBO J 8(8): 2373-9
• Haass C, Kloetzel PM (1989)
  The Drosophila proteasome undergoes changes in its subunit pattern during development
  Exp Cell Res 180(1): 243-52
• Kamp F, Astumian RD, Westerhoff HV. (1988)
  Coupling of vectorial proton flow to a biochemical reaction by local electric interactions
  Proc Natl Acad Sci U S A. 1988 Jun;85(11):3792-6.
• Falkenburg PE, Haass C, Kloetzel PM, Niedel B, Kopp F, Kuehn L, Dahlmann B (1988)
  Drosophila small cytoplasmic 19S ribonucleoprotein is homologous to the rat multicatalytic proteinase
  Nature 331(6152): 190-2
• Tsaktanis T, Kremling H, Pavsic M, von Stackelberg R, Mack B, Steiner H, Vielmuth F, Spindler V, Huang Z, Jakubowski J, Stoecklein NH, Luxenburger E, Lauber K, Lenarcic B, Gires O
  Cleavage and cell adhesion properties of human epithelial cell adhesion molecule (HEPCAM)
  J Biol Chem. 2015 Oct 2;290(40):24574-91.
• Dönem Avci, Shai Fuchs, Bianca Schrul, Michal Breker, Idan Frumkin, Chia-yi Chen, Martin L. Biniossek, Elisabeth Kremmer, Oliver Schilling, Harald Steiner, Maya Schuldiner, Marius K. Lemberg
  The yeast ER-intramembrane protease Ypf1 refines nutrient sensing by regulating transporter abundance
  Mol Cell. 2014 Dec 4;56(5):630-40.
• Matthias Hachmeister, Karolina D. Bobowski, Sebastian Hogl, Bastian Dislich, Carola Eggert, Brigitte Mack, Heidi Kremling, Sannia Sarrach, Fabian Coscia, Wolfgang Zimmermann, Harald Steiner, Stefan F. Lichtenthaler, Oliver Gires
  Regulated intramembrane proteolysis and degradation of murine epithelial cell adhesion molecule mEpCAM
  PLoS One. 2013 Aug 29;8(8):e71836
• Winkler E, Julius A, Steiner H, Langosch D
  Homodimerization protects the amyloid precursor protein C99 fragment from cleavage by γ-secretase
  Biochemistry. 2015 Oct 13;54(40):6149-52.
• Harald Steiner
  Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping
  EMBO J. 2016 May 23. pii: e201694151. [Epub ahead of print]

Book chapter / Editorial material

• Steiner H (2020)
  Understanding intramembrane proteolysis by γ-secretase
  Semin Cell Dev Biol. 2020 Sep;105:1-2
• Regina Fluhrer (2018)
  A Unique Family of Intramembrane Proteases
  E-book
• Burbulla LF, Krüger R (2012)
  Loss of mortalin function in PD – supporting the mitochondrial pathway of neurodegeneration.
  IN: Wadhwa R., Kaul S. C. (Eds.), Mortalin Biology – Stress, Life and Death; Springer Press New York. pp 159-177. Book Chapter
• (2011)
  Neuroprotective and Neurotoxic Signaling by the Prion Protein
  Top Curr Chem. 2011;305:101-19.
• (2011)
  Prion Proteins
  Top Curr Chem. 2011;305:ix-x. No abstract available.
• St George-Hyslop P, Haass C (2008)
  Regulatory RNA goes awry in Alzheimer's disease
  Nat Med. 2008 Jul;14(7):711-2.
• Steiner H (2006)
  The players on the gamma-secretase team - The author's perspective
  Nature Medicine 12(7): 767-767
• Haass C, Multhaup G (2006)
  Six years of collaborative Alzheimer's disease research in Germany
  Neurodegenerative Dis 2006;3:193-196
• Haass C (2006)
  European Alzheimer disease funding
  Nat Med. 2006 Jul;12(7):776-7.
• Haass C (2004)
  Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model
  J Clin Invest. 2004 May;113(10):1384-7.Click here to read
• Kaether C, Haass C (2004)
  A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation
  J Cell Biol. 2004 Dec 6;167(5):809-12.

Review

• Haass C, Selkoe D (2022)
  If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline?
  PLoS Biol. 2022 Jul 21;20(7):e3001694.
• Lichtenthaler SF, Tschirner SK, Steiner H (2022)
  Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2
  Curr Opin Neurobiol. 2022 Feb;72:101-110
• Heger LM, Wise RM, Hees JT, Harbauer AB, Burbulla LF (2021)
  Mitochondrial Phenotypes in Parkinson's Diseases-A Focus on Human iPSC-Derived Dopaminergic Neurons
  Cells. 2021 Dec 7;10(12):3436.
• Trambauer J, Fukumori A, Steiner H (2020)
  Pathogenic Aβ generation in familial Alzheimer's disease: novel mechanistic insights and therapeutic implications
  Curr Opin Neurobiol. 2020 Apr;61:73-81
• Minakaki G, Krainc D, Burbulla LF (2020)
  The Convergence of Alpha-Synuclein, Mitochondrial, and Lysosomal Pathways in Vulnerability of Midbrain Dopaminergic Neurons in Parkinson's Disease
  Front Cell Dev Biol. 2020 Dec 14;8:580634.
• Fukumori A, Feilen LP, Steiner H (2020)
  Substrate recruitment by γ-secretase
  Semin Cell Dev Biol. 2020 Sep;105:54-63
• Burbulla LF, Krainc D (2019)
  The role of dopamine in the pathogenesis of GBA1-linked Parkinson's disease
  Neurobiol Dis. 2019 Dec;132:104545.
• Lichtenthaler, SF, Lemberg MK, Fluhrer R (2018)
  Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments
  EMBO J. 2018 Jul 5. pii: e99456. doi: 10.15252/embj.201899456. [Epub ahead of print]
• Fukumori A, Trambauer J, Steiner H (2018)
  Identifizierung von Substratbindestellen in der γ-Sekretase
  BIOspektrum 01/2018: 34-36
• Steiner H, Fukumori A, Tagami S, Okochi M (2018)
  Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase
  Cell Stress. 2018 Oct 28;2(11):292-310
• Langosch D, Steiner H (2017)
  Substrate processing in intramembrane proteolysis by γ-secretase - the role of protein dynamics
  Biol Chem. 2017 Apr 1;398(4):441-453
• Dieter Edbauer, Christian Haass (2016)
  An amyloid-like cascade hypothesis for C9orf72 ALS/FTD
  Curr Opin Neurobiol. 2016 Feb;36:99-106
• Marc Aurel Busche, Matthias Staufenbiel, Michael Willem, Christian Haass, Hans Förstl (2016)
  Mechanisms of Alzheimer's disease : Neuronal hyperactivity and hypoactivity as new therapeutic targets
  Nervenarzt. 2016 Jan 19
• Julia Götzl, Christina Lang, Christian Haass, Anja Capell (2016)
  Impaired protein degradation in FTLD and related disorders
  Ageing Res Rev. 2016 May 7. pii: S1568-1637(16)30065-4
• Stephanie Ghio, Frits Kamp, Ruben Cauchi, Armin Giese, Neville Vassallo (2016)
  Interaction of α-synuclein with biomembranes in Parkinson's disease -role of cardiolipin
• Langosch D, Scharnagl C, Steiner H, Lemberg MK (2015)
  Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics
  Trends Biochem Sci. 2015 Jun;40(6):318-27
• Voss M, Schröder B, Fluhrer R (2014)
  Intramembrane cleaving proteases (I-CLiPs) as guardians of shuttling proteins.
  Cell Cycle. 2014;13(5):695. doi: 10.4161/cc.28089. Epub 2014 Feb 4.
• Robert Vassar, Peer-Hendrik Kuhn, Christian Haass, Matthew E. Kennedy, Lawrence Rajendran, Philip C. Wong, Stefan F. Lichtenthaler (2014)
  Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects
  J Neurochem. 2014 Jul;130(1):4-28
• Kleinberger G, Capell A, Haass C, Van Broeckhoven C (2013)
  Mechanisms of granulin deficiency: lessons from cellular and animal models
  Mol Neurobiol. 2013 Feb;47(1):337-60. doi: 10.1007/s12035-012-8380-8. Epub 2012 Dec 13
• Bentmann E, Haass C, Dormann D (2013)
  Stress granules in neurodegeneration - lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma
  FEBS J. 2013 Apr 15. doi: 10.1111/febs.12287. [Epub ahead of print]
• Voss M, Schröder B, Fluhrer R (2013)
  Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases.
  Biochim Biophys Acta. 2013 Dec;1828(12):2828-39. doi: 10.1016/j.bbamem.2013.03.033.
• Dormann D, Haass C (2013)
  Fused in sarcoma (FUS): An oncogene goes awry in neurodegeneration
  Mol Cell Neurosci. 2013 Apr 2. pii: S1044-7431(13)00048-1. doi: 10.1016/j.mcn.2013.03.006. [Epub ahead of print]
• Exner N, Lutz AK, Haass C, Winkelhofer KF (2012)
  Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences
  EMBO J. 2012 Jun 26;31(14):3038-62. doi: 10.1038/emboj.2012.170.
• Resenberger UK, Winklhofer KF (2012)
  Cellular Prion Protein Mediates Toxic Signaling of Amyloid Beta
  Neurodegener Dis, 10, 298-300
• (2012)
  Cell biology: Sheddase gets guidance
  Science 2012 Jan 13;335(6065):179-80.
• Burbulla LF, Krüger R (2011)
  Converging environmental and genetic pathways in the pathogenesis of Parkinson's disease
  J Neurol Sci. 2011 Jul 15;306(1-2):1-8.
• Resenberger UK, Winklhofer KF (2011)
  Neuroprotective and Neurotoxic Signaling by the Prion Protein
  Topics in Current Chemistry, 2011, Volume 305/2011, 101-119, DOI: 10.1007/128_2011_160
• (2011)
  Alpha-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potential
  J Neurochem. 2011 Jan;116(1):10-21. doi: 10.1111/j.1471-4159.2010.07081.x. Epub 2010 Dec 2.
• Pilsl A, Winklhofer KF (2011)
  Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson's disease
  Acta Neuropathol. 2011 Nov 6. [Epub ahead of print]
• (2011)
  ADAM10: potential ‘molecular scissors’ for the treatment of Alzheimer’s disease
  Future Neurology, January 2011, Vol. 6, No. 1, Pages 1-4 , DOI 10.2217/fnl.10.75
• Haass C, Steiner H (2011)
  Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing
  J Neurochem. 2011 Jun;117(5):779-96. doi: 10.1111/j.1471-4159.2011.07248.x. Epub 2011 Apr 14.
• (2011)
  Alpha-Secretase Cleavage of the Amyloid Precursor Protein: Proteolysis Regulated by Signaling Pathways and Protein Trafficking
  Curr Alzheimer Res. 2011 May 23. [Epub ahead of print]
• Winklhofer KF, Haass C (2010)
  Mitochondrial dysfunction in Parkinson's disease
  Biochim Biophys Acta. 2010 Jan;1802(1):29-44. Epub 2009 Sep 3.
• Burbulla LF, Krebiehl G, Krüger R (2010)
  Balance is the challenge--the impact of mitochondrial dynamics in Parkinson's disease
  Eur J Clin Invest. 2010 Nov;40(11):1048-60.
• Förstl H, Haass C, Hemmer B, Meyer B, Halle M. (2010)
  Boxing-acute complications and late sequelae: from concussion to dementia
  Dtsch Arztebl Int. 2010 Nov;107(47):835-9. Epub 2010 Nov 26.
• Fluhrer R, Steiner H, Haass C (2009)
  Intramembrane proteolysis by signal peptidepeptidases - a comparative discussion of GxGD-type aspartyl proteases
  J Biol Chem. 2009 May 22;284(21):13975-9. Epub 2009 Feb 3.
• Steiner H, Fluhrer R, Haass C (2008)
  Intramembrane proteolysis by γ-secretase
  J Biol Chem 283(44): 29627-31
• Steiner H (2008)
  The catalytic core of γ-secretase: presenilin revisited
  Curr Alzheimer Res 5(2): 147-57
• Winklhofer KF, Haass C (2008)
  The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases
  EMBO J 27(2): 336-49
• Fluhrer R, Haass C (2007)
  Signal peptide peptidases and gamma-secretase: cousins of the same protease family?
  Neurodegener Dis 4(2-3): 112-6
• Münz C (2007)
  Innate and adaptive immunity through autophagy
  Immunity. 2007 Jul;27(1):11-21.
• Haass C, Selkoe DJ (2007)
  Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
  Nat Rev Mol Cell Biol 8(2): 101-12
• Schatzl HM (2007)
  Molecular basis of cerebral neurodegeneration in prion diseases
  FEBS J 274(3): 606-11
• Winklhofer KF (2007)
  The parkin protein as a therapeutic target in Parkinson's disease
  Expert Opin Ther Targets 11(12): 1543-52
• Münz C (2006)
  Immune surveillance of intracellular pathogens via autophagy
  Cell Death Differ. 2005 Nov;12 Suppl 2:1519-27.
• Kaether C, Haass C, Steiner H (2006)
  Assembly, trafficking and function of γ-secretase
  Neurodegener Dis 3(4-5): 275-83
• (2006)
  Ectodomain shedding of the amyloid precursor protein: cellular control mechanisms and novel modifiers
  Neurodegener Dis. 2006;3(4-5):262-9.
• Rossner S, Sastre M, Bourne K (2006)
  Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease
  Prog Neurobiol. 2006 Jun;79(2):95-111. Epub 2006 Aug 14.
• Dengjel J, Schoor O, Stevanovic S, Münz C (2006)
  Autophagy in innate and adaptive immunity against intracellular pathogens
  J Mol Med (Berl). 2006 Mar;84(3):194-202. Epub 2006 Jan 28.
• Haffner C, Haass C (2006)
  Cellular functions of gamma-secretase-related proteins
  Neurodegener Dis 3(4-5): 284-9
• Winklhofer KF (2006)
  The role of chaperones in Parkinson's disease and prion diseases
  Handb Exp Pharmacol(172): 221-58
• Haass C (2004)
  Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model
  J Clin Invest 113(10): 1384-7
• Kahle PJ, Haass C (2004)
  How does parkin ligate ubiquitin to Parkinson's disease?
  EMBO Rep 5(7): 681-5
• Haffner C, Haass C (2004)
  The biochemical and genetic odyssey to the function of a nicastrin-like protein
  Neurodegener Dis 1(4-5): 192-5
• Haass C (2004)
  Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation
  EMBO J 23(3): 483-8
• Kaether C, Haass C (2004)
  A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation
  J Cell Biol 167(5): 809-12
• Steiner H (2004)
  Uncovering γ-secretase
  Curr Alzheimer Res 1(3): 175-81
• Winklhofer KF (2004)
  Folding and misfolding of the prion protein in the secretory pathway
  Amyloid 11(3): 162-72
• Aguzzi A, Haass C (2003)
  Games played by rogue proteins in prion disorders and Alzheimer's disease
  Science 302(5646): 814-8
• Haass C, Steiner H (2002)
  Alzheimer disease γ-secretase: a complex story of GxGD-type presenilin proteases
  Trends Cell Biol 12(12): 556-62
• Kahle PJ, Haass C, Kretzschmar HA, Neumann M (2002)
  Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases
  J Neurochem 82(3): 449-57
• Wolfe MS, Haass C (2001)
  The Role of presenilins in gamma-secretase activity
  J Biol Chem 276(8): 5413-6
• Walter J, Kaether C, Steiner H, Haass C (2001)
  The cell biology of Alzheimer's disease: uncovering the secrets of secretases
  Curr Opin Neurobiol 11(5): 585-90
• Steiner H, Haass C (2001)
  Nuclear signaling: a common function of presenilin substrates?
  J Mol Neurosci 17(2): 193-8
• Haass C (2000)
  Presenilin proteins and their function during embryonic development and Alzheimer's disease
  Ernst Schering Res Found Workshop(29): 57-64
• Steiner H, Haass C (2000)
  Intramembrane proteolysis by presenilins
  Nat Rev Mol Cell Biol 1(3): 217-24
• Kahle PJ, Neumann M, Ozmen L, Haass C (2000)
  Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein
  Ann N Y Acad Sci 920: 33-41
• Kahle PJ, Leimer U, Haass C (2000)
  Does failure of parkin-mediated ubiquitination cause juvenile parkinsonism?
  Trends Biochem Sci 25(11): 524-7
• Haass C, Baumeister R (1999)
  The biological and pathological function of presenilin proteins--simple cell systems and a worm in Alzheimer's disease research
  Eur Arch Psychiatry Clin Neurosci 249 Suppl 3: 23-7
• Steiner H, Capell A, Leimer U, Haass C (1999)
  Genes and mechanisms involved in β-amyloid generation and Alzheimer's disease
  Eur Arch Psychiatry Clin Neurosci 249(6): 266-70
• Haass C, De Strooper B (1999)
  The presenilins in Alzheimer's disease--proteolysis holds the key
  Science 286(5441): 916-9
• Steiner H, Capell A, Haass C (1999)
  Proteolytic processing and degradation of Alzheimer's disease relevant proteins
  Biochem Soc Trans 27(2): 234-42
• Haass C, Baumeister R (1998)
  What do we learn from a few familial Alzheimer's disease cases?
  J Neural Transm Suppl 54: 137-45
• Haass C, Grunberg J, Capell A, Wild-Bode C, Leimer U, Walter J, Yamazaki T, Ihara I, Zweckbronner I, Jakubek C, Baumeister R (1998)
  Proteolytic processing of Alzheimer's disease associated proteins
  J Neural Transm Suppl 53: 159-67
• Voellmy R, Welch WJ (1998)
  Abnormalities in stress proteins in prion diseases
  Cell Mol Neurobiol 18(6): 721-9
• Tatagiba M, Brosamle C, Schwab ME (1997)
  Regeneration of injured axons in the adult mammalian central nervous system
  Neurosurgery 40(3): 541-6; discussion 546-7
• Haass C (1997)
  Presenilins: genes for life and death
  Neuron 18(5): 687-90
• Schwab ME, Brosamle C (1997)
  Regeneration of lesioned corticospinal tract fibers in the adult rat spinal cord under experimental conditions
  Spinal Cord 35(7): 469-73
• Selkoe DJ, Yamazaki T, Citron M, Podlisny MB, Koo EH, Teplow DB, Haass C (1996)
  The role of APP processing and trafficking pathways in the formation of amyloid beta-protein
  Ann N Y Acad Sci 777: 57-64
• Haass C (1996)
  The molecular significance of amyloid beta-peptide for Alzheimer's disease
  Eur Arch Psychiatry Clin Neurosci 246(3): 118-23
• Haass C (1996)
  Presenile because of presenilin: the presenilin genes and early onset Alzheimer's disease
  Curr Opin Neurol 9(4): 254-9
• Fechteler K, Huppertz S, Wilgenbus P, Doerfler W (1995)
  The mechanism of adenovirus DNA integration: studies in a cell-free system
  Curr Top Microbiol Immunol 199 ( Pt 2): 109-37
• Haass C, Selkoe DJ (1993)
  Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide
  Cell 75(6): 1039-42
• Bettina Schmid, Christian Haass
  Genomic editing opens new avenues for zebrafish as a model for neurodegeneration
  J Neurochem. 2013 Nov;127(4):461-70
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