Ludwig-Maximilians-Universität, Chair of Metabolic Biochemistry

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Fyn-tau-amyloid: a toxic triad

Cell. 2010 Aug 6;142(3):356-8.

Authors/Editors: Haass C
Mandelkow E
Publication Date: 2010
Type of Publication: Journal Article

The axonal protein tau and amyloid beta-peptide (Abeta) are key players in the pathogenesis of Alzheimer's disease, and tau mediates Abeta toxicity, but it is not clear how. Ittner et al. (2010) now report an unexpected physiological function for tau in neuronal dendrites that may explain how tau mediates Abeta toxicity.

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