Ludwig-Maximilians-Universität, Chair of Metabolic Biochemistry

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Alpha-synuclein immunoreactive Lewy bodies and Lewy neurites in Parkinson's disease are detectable by an advanced silver-staining technique

Acta Neuropathol 98(5): 461-4

Authors/Editors: Sandmann-Keil D
Braak H
Okochi M
Haass C
Braak E
Publication Date: 1999
Type of Publication: Journal Article
Immunostaining with anti-alpha-synuclein is used to detect Lewy bodies and Lewy neurites in cases of Parkinson's disease and related disorders. To prove that the result of a modern silver method is equivalent to that achieved with immunoreactions for alpha-synuclein, individual sections were successively processed using both methods. The silver-stained sections showed all of the immunoreactive Lewy bodies, and thin Lewy neurites were detected equally well by both techniques. The present study, therefore, points to the capabilities of a modern silver-staining method which is less time consuming and less expensive than immunocytochemical techniques.

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