Top Curr Chem. 2011;305:ix-x. No abstract available.
|Type of Publication:||Book chapter / Editorial material|
In addition, a wide spectrum of methodological approaches are described, ranging from in silico, chemical, and in vitro approaches to animal models, to illustrate the elaborate and extensive technology established in the prion field, allowing the analysis of disease mechanisms and the development of diagnostic and therapeutic strategies.
Finally, the reviews on shadoo, doppel and yeast prions emphasize that certain features and activities of the prion protein can also be found in other proteins and that the phenomenon of self-replicating protein conformers can be of broader biological significance.