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Published in JNC newest data by Pérez-Revuelta et al. identify a requirement for small side chain residues in the active site domain of g-secretase and suggest that the glycines of the GxGD motif could be evolutionary conserved to allow cleavage of all possible g-secretase substrates, including those, which are highly sensitive to minimal alteration of the PS active site domain. [more] In this timely book, edited by Jörg Tatzelt, leading scientists in the field have come together to highlight the apparently incongruous activities of different PrP conformers. The articles outline current research on celluar pathways implicated in the formation and signaling of neurotoxic and physiological PrP isoforms and delineate future research direction. [more] At this year's Alzheimer conference (Eibsee Meeting) our researcher Dr. Melanie Meyer-Luehmann was endowed with the Alzheimer Research Award of the Hans and Ilse Breuer Foundation. With an amount of Euro 100,000 the foundation supports scientists who have brought outstanding services in the field of Alzheimer’s research or other dementia related diseases. [more] LMU Munich offers a broad spectrum of audio and video podcasts on iTunes U – Apple’s online education portal – for free. At “LMU on iTunes U”, LMU’s multimedia offers are bundled and can easily be stored on any computer or portable audio or video device. Users can subscribe to one of our newest research video - "Search for a cure" - from the Internet TV project "DFG ScienceTV". [more] The image of the DZNE reseacher - Dominik Paquet - showing a 7 day old Tau transgenic zebrafish, which was recently established as a model system for Alzheimer and FTD in our lab, was selected by a scientific jury among more than 2000 images and awarded the 11th prize. Started in 1974, the Nikon International Small World Competition is held anually to recognize excellence in photographs taken through a microscope. Since then, Small World has become a leading showcase for photomicrographers from the widest array of scientific disciplines. [more]