The DZNE Munich was founded in September 2009 with the idea to strengthen and increase the existing research efforts of both Universities (LMU and TUM) in the fields of neurobiology and neurodegeneration. Professor Haass was assigned as the speaker of the DZNE Munich. To provide optimal research conditions the state of Bavaria decided to set up a new research building on the high-tech campus of the LMU. more
In their recent publication in the Journal of Biological Chemistry, Bentmann et al. show that FUS and TDP-43 have similar requirements for recruitment to cytoplasmic stress granules. Both protein-RNA and protein-protein interactions are involved in stress granule recruitment of TDP-43 and FUS (see model figure). TDP-43 (left) and FUS (right) bind to UG-rich mRNA sequences via their main RNA binding domain and thus might be recruited into stress granules via their associated mRNAs. In addition, protein-protein interactions with so far unknown proteins X and Y seem to be involved in stress granule recruitment of TDP-43 and FUS. Revealing how FUS and TDP-43 are recruited to stress granules is critical for understanding FTLD/ALS pathology.
more
