Ludwig-Maximilians-Universität, Chair of Metabolic Biochemistry

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FTLD/ALS‐associated repeat expansions in C9orf72 are translated into dipeptide repeat proteins. Reduction of repeat‐binding hnRNPA3 increases levels of the repeat RNA and enhances production of dipeptide repeat proteins and RNA foci. more

TREM2‐deficient phagocytic cells do not uptake antibody‐bound Aβ well, resulting in reduced clearance of amyloid plaques. This, however, can be compensated by elevated concentrations of immunotherapeutic antibodies, highlighting that monitoring microglia function in Alzheimer's disease is important. more