General concept of the DZNE Munich

The DZNE-Munich was founded in September 2009 with the idea to strengthen and increase the existing research efforts of both Munich Universities in the fields of neurobiology and neurodegeneration.To provide optimal research conditions the new Center for Stroke and Dementia research (CSD) will be set up in Munich-Grosshadern. more

Video summary of the CSD foundation stone ceremony

Substrate determinants for intramembrane cleavage by SPPL2b

Fluhrer et al. show that reducing the α-helical content of the Bri2 (a substrate for intramembrane proteolysis by SPPL2b) transmembrane domain increases its intramembrane cleavage by SPPL2b. Destabilization of the Bri2 transmembrane domain is predominantly mediated by G60. This is significant to understand substrate requirements of intramembrane cleaving proteases. more

Cellular Prion Protein Mediates Toxic Signaling of Amyloid Beta

In this minireview Tatzelt and colleagues summarize current work on the role of the cellular pion protein (PrPC) as a mediator of amyloid beta-induced toxicity. more