Ludwig-Maximilians-Universität, Chair of Metabolic Biochemistry

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TREM2‐deficient phagocytic cells do not uptake antibody‐bound Aβ well, resulting in reduced clearance of amyloid plaques. This, however, can be compensated by elevated concentrations of immunotherapeutic antibodies, highlighting that monitoring microglia function in Alzheimer's disease is important. more

A crosslinking approach reveals the substrate binding sites of the Alzheimer´s-disease-associated γ-secretase complex and provides insight into how the subunits of this pivotal intramembrane protease interact in substrate recruitment. more