Content
Steiner Lab
Biochemistry of γ-Secretase
Journal Articles Reviews Commentaries Editorials
- Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin (2023)
- Membrane lipid remodeling modulates γ-secretase processivity (2023)
- Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase (2023)
- Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ-secretase activity (2022)
- Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis 2022)
- Modulation of γ-secretase activity by a carborane-based flurbiprofen analogue (2021)
- Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition (2021)
- Effective sample preparation procedure for the analysis of free neutral steroids, free steroid acids and sterol sulfates in different tissues by GC-MS (2021)
- γ-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics (2020)
- Photo-controlled delivery of very long chain fatty acids to cell membranes and modulation of membrane protein function (2020)
- Aβ43-producing PS1 FAD mutants cause altered substrate interactions and respond to γ-secretase modulation (2020)
- Comparison of strategies for the determination of sterol sulfates via GC-MS leading to a novel deconjugation-derivatization protocol (2019)
- Modulating hinge flexibility in the APP transmembrane domain alters γ-secretase cleavage (2019)
- Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-β processing effects (2019)
- Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer’s disease (2019)
- Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis (2018)
- Bexarotene binds to the amyloid precursor protein transmembrane domain, alters its α-helical conformation, and inhibits γ-secretase nonselectively in liposomes (2018)
- A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor (2018)
- An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function (2017)
- Analyzing amyloid-β peptide modulation profiles and binding sites of γ-secretase modulators (2017)
- Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping (2016)
- Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease (2016)
- Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74 (2016)
- Proteolytic processing of neuregulin 1 type III by three intramembrane-cleaving proteases (2016)
- Homodimerization protects the amyloid precursor protein C99 fragment from cleavage by γ-secretase (2015)
- Cleavage and cell adhesion properties of human epithelial cell adhesion molecule (HEPCAM) (2015)
- Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment (2015)
- Inhibition of amyloid-β plaque formation by α-synuclein (2015)
- Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process (2015)
- Cross-sectional comparison of small animal [18F]-florbetaben amyloid-PET between transgenic AD mouse models (2015)
- The yeast ER-intramembrane protease Ypf1 refines nutrient sensing by regulating transporter abundance (2014)
- Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation (2014)
- Chronic γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures (2014)
- Impact of partial volume effect correction on cerebral β-amyloid imaging in APP-Swe mice using [(18)F]-florbetaben PET (2013)
- Regulated intramembrane proteolysis and degradation of murine epithelial cell adhesion molecule mEpCAM (2013)
- Longitudinal assessment of cerebral β-amyloid deposition in mice overexpressing Swedish mutant β-amyloid precursor protein using 18F-florbetaben PET (2013)
- Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase (2013)
- Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments (2012)
- Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3) (2012)
- Generation of Alzheimer disease-associated Aβ42/43 by γ-secretase can directly be inhibited by modulation of membrane thickness (2012)
- Novel γ-secretase modulators directly target presenilin (2011)
- The nicastrin ectodomain adopts a highly thermostable structure (2011)
- Attenuated Aβ42 responses to low potency γ-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds (2011)
- β-amyloid precursor protein mutants respond to γ-secretase modulators (2010)
- Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of γ-secretase-mediated intramembrane proteolysis (2010)
- Inhibition of γ-secretase by the CK1 inhibitor IC261 does not depend on CK1δ (2010)
- γ-Secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway (2009)
- Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human γ-secretase (2009)
- Requirement for small side chain residues within the GxGD-motif of presenilin for γ-secretase substrate cleavage (2009)
- Chemical cross-linking provides a model of the γ-Secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1 (2008)
- Generation of Aβ38 and Aβ42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and γ-secretase modulation (2008)
- Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation (2008)
- Active γ-secretase complexes contain only one of each component (2007)
- Endoplasmic reticulum retention of the γ-secretase complex component Pen2 by Rer1 (2007)
- N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated γ-secretase (2007)
- Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different γ-secretase complexes (2007)
- Sheddases and intramembrane-cleaving proteases: RIPpers of the membrane. Symposium on regulated intramembrane proteolysis (2007)
- Pore-forming scissors? A first structural glimpse of γ-secretase (2006)
- Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer γ-secretase modulators (2006)
- Secretion of the Notch-1 Aβ-like peptide during Notch signaling (2006)
- SorLA signaling by regulated intramembrane proteolysis (2006)
- The GxGD motif of presenilin contributes to catalytic function and substrate identification of γ-secretase (2006)
- Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3 (2005)
- γ-Secretase complex assembly within the early secretory pathway (2005)
- Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments (2005)
- Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1 (2004)
- Identification of distinct γ-secretase complexes with different APH-1 variants (2004)
- Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1 (2004)
- Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the γ-secretase complex (2004)
- The presenilin C-terminus is required for ER-retention, nicastrin-binding and γ-secretase activity (2004)
- γ-Secretase activity is associated with a conformational change of nicastrin (2003)
- Nicastrin interacts with γ-secretase complex components via the N-terminal part of its transmembrane domain (2003)
- Reconstitution of γ-secretase activity (2003)
- A γ-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish (2002)
- Insulin-degrading enzyme rapidly removes the β-amyloid precursor protein intracellular domain (AICD) (2002)
- PEN-2 is an integral component of the γ-secretase complex required for coordinated expression of presenilin and nicastrin (2002)
- Presenilin-1 affects trafficking and processing of βAPP and is targeted in a complex with nicastrin to the plasma membrane (2002)
- Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ 42 production (2002)
- Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation (2002)
- Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Aβ-like peptide (2002)
- Presenilins mediate a dual intramembranous γ-secretase cleavage of Notch-1 (2002)
- A pathogenic presenilin-1 deletion causes abberrant Aβ 42 production in the absence of congophilic amyloid plaques (2001)
- Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins (2001)
- Presenilin-dependent γ-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch (2001)
- Protofibrils, the unifying toxic molecule of neurodegenerative disorders? (2001)
- A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells (2000)
- Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases (2000)
- Maturation and pro-peptide cleavage of β-secretase (2000)
- Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes (2000)
- Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes (2000)
- Presenilin-1 differentially facilitates endoproteolysis of the β-amyloid precursor protein and Notch (2000)
- Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch (2000)
- A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling (1999)
- Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis (1999)
- An in vivo assay for the identification of target proteases which cleave membrane-associated substrates (1999)
- The biological and pathological function of the presenilin-1 Δexon 9 mutation is independent of its defect to undergo proteolytic processing (1999)
- Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation (1998)
- Intracellular generation and accumulation of amyloid β-peptide terminating at amino acid 42 (1997)
- Heme binding to a conserved Cys-Pro-Val motif is crucial for the catalytic function of mitochondrial heme lyases (1996)
- Mitochondrial and cytosolic branched-chain amino acid transaminases from yeast, homologs of the myc oncogene-regulated Eca39 protein (1996)
- Role of the intermembrane-space domain of the preprotein receptor Tom22 in protein import into mitochondria (1996)
- Biogenesis of mitochondrial heme lyases in yeast. Import and folding in the intermembrane space (1995)
- The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane (1995)
- Secretases in Alzheimer´s disease: Novel insights into proteolysis of APP and TREM2 (2022)
- Substrate recruitment by γ-secretase (2020)
- Pathogenic Aβ generation in familial Alzheimer´s disease: Novel mechanistic insights and therapeutic implications (2020)
- Making the final cut: Pathogenic amyloid-β peptide generation by γ-secretase (2018)
- Photoaffinitätsmarkierung: Identifizierung von Substratbindestellen in der γ-Sekretase (2018)
- Substrate processing in intramembrane proteolysis by γ-secretase - the role of protein dynamics (2017)
- Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics (2015)
- Regulated intramembrane proteolysis - lessons from amyloid precursor protein processing (2011)
- Intramembrane proteolysis by signal peptidepeptidases - a comparative discussion of GxGD-type aspartyl proteases (2009)
- Intramembrane proteolysis by γ-secretase (2008)
- The catalytic core of γ-secretase: presenilin revisited (2008)
- Assembly, trafficking and function of γ-secretase (2006)
- Uncovering γ-secretase (2004)
- Alzheimer disease γ-secretase: a complex story of GxGD-type presenilin proteases (2002)
- Nuclear signaling: a common function of presenilin substrates? (2001)
- The cell biology of Alzheimer's disease: uncovering the secrets of secretases (2001)
- Intramembrane proteolysis by presenilins (2000)
- Genes and mechanisms involved in β-amyloid generation and Alzheimer's disease (1999)
- Proteolytic processing and degradation of Alzheimer's disease relevant proteins (1999)