Content
Alpha- and beta-secretase
[2014] [2013] [2012] [2011] [2010] [2009] [2008] [2007] [2006] [2005] [2004] [2003] [2002] [2001] [2000] [1999] [1998] [1997] [1996] [1995]
- Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles (2013)
- Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions (2013)
- Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling (2013)
- Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes (2013)
- Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease (2013)
- Secretome protein enrichment identifies physiological BACE1 protease substrates in Neurons (2012)
- Retromer regulates postendocytic sorting of ß-secretase in polar (2012)
- Translational repression of the Disintegrin and Metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5′-untranslated region (2011)
- BACE1 Dependent Neuregulin Proteolysis (2011)
- PPARγ Co-Activator-1α (PGC-1α) Reduces Amyloid-β Generation Through a PPARγ-Dependent Mechanism (2011)
- Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase (2011)
- Function, regulation and therapeutic properties of beta-secretase (BACE1) (2009)
- Requirement for Small Side Chain Residues within the GxGD-Motif of Presenilin for gamma-Secretase Substrate Cleavage (2009)
- Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor (2009)
- Function, regulation and therapeutic properties of beta-secretase (BACE1) (2009)
- Masking of Transmembrane-Based Retention Signals Controls ER Export of gamma-Secretase (2009)
- Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin (2009)
- Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion (2008)
- Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment (2008)
- Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis (2008)
- Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content (2007)
- Macrocyclic statine-based inhibitors of BACE-1 (2007)
- Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy (2006)
- Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity (2006)
- Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface (2006)
- Control of peripheral nerve myelination by the beta-secretase BACE1 (2006)
- A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration (2006)
- Gamma-secretase complex assembly within the early secretory pathway (2005)
- Basement membrane-dependent survival of retinal ganglion cells (2005)
- Cyclic phenylstatine-based tetrapeptides as inhibitors of beta-secretase (2005)
- beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice (2004)
- Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme (2004)
- Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region (2004)
- The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity (2004)
- Gamma-secretase activity is associated with a conformational change of nicastrin (2003)
- Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain (2003)
- Constitutive properties, not molecular adaptations, mediate extraocular muscle sparing in dystrophic mdx mice (2003)
- Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation (2003)
- Defective integrin switch and matrix composition at alpha 7-deficient myotendinous junctions precede the onset of muscular dystrophy in mice (2003)
- Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation (2003)
- A critical function of the pial basement membrane in cortical histogenesis (2002)
- A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish (2002)
- A non-amyloidogenic function of BACE-2 in the secretory pathway (2002)
- Constitutive properties, not cellular/molecular adaptations, mediate extraocular muscle sparing in MDX mice (2002)
- Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD) (2002)
- Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane (2002)
- Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide (2002)
- Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development (2002)
- Apical sorting of beta-secretase limits amyloid beta-peptide production (2002)
- Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production (2002)
- Phosphorylation regulates intracellular trafficking of beta-secretase (2001)
- Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch (2001)
- Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis (2001)
- Phosphorylation regulates intracellular trafficking of beta-secretase (2001)
- Impaired axonal regeneration in alpha7 integrin-deficient mice (2000)
- Maturation and pro-peptide cleavage of beta-secretase (2000)
- Neuronal FasL induces cell death of encephalitogenic T lymphocytes (2000)
- A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells (2000)
- Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases (2000)
- Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch (2000)
- Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch (2000)
- A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling (1999)
- Gene transfer into CD4+ T lymphocytes: green fluorescent protein-engineered, encephalitogenic T cells illuminate brain autoimmune responses (1999)
- Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease (1999)
- Organization of the myotendinous junction is dependent on the presence of alpha7beta1 integrin (1999)
- Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease (1999)
- Proteolytic processing and degradation of Alzheimer's disease relevant proteins (1999)
- Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation (1998)
- Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain (1998)
- The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex (1998)
- Truncated presenilin 2 derived from differentially spliced mRNA does not affect the ratio of amyloid beta-peptide 1-42/1-40 (1998)
- Proteolytic processing of Alzheimer's disease associated proteins (1998)
- Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation (1997)
- Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations (1997)
- Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42 (1997)
- Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C (1997)
- The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue (1997)
- Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF (1996)
- The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum (1996)
- Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals (1995)
- The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway (1995)
- The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein (1995)