Publications
Journal Article
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Georg Werner, Markus Damme, Martin Schludi, Johannes Gnörich, Karin Wind, Katrin Fellerer, Benedikt Wefers, Wolfgang Wurst, Dieter Edbauer, Matthias Brendel, Christian Haass, Anja Capell
(2020)
Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice
EMBO Rep. 2020 Oct 5;21(10):e50241. -
Samira Parhizkar, Thomas Arzberger, Matthias Brendel, Gernot Kleinberger, Maximilian Deussing, Carola Focke, Brigitte Nuscher, Monica Xiong, Alireza Ghasemigharagoz, Natalie Katzmarski, Susanne Krasemann, Stefan F. Lichtenthaler, Stephan A. Müller, Alessio Colombo, Laura Sebastian Monasor, Sabina Tahirovic, Jochen Herms, Michael Willem, Nadine Pettkus, Oleg Butovsky, Peter Bartenstein, Dieter Edbauer, Axel Rominger, Ali Ertürk, Stefan A. Grathwohl, Jonas J. Neher, David M. Holtzman, Melanie Meyer-Luehmann, Christian Haass
(2019)
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
Nat Neurosci. 2019 Feb;22(2):191-204 -
Yu Ohki, Andrea Wenninger-Weinzierl, Alexander Hruscha, Kazuhide Asakawa, Koichi Kawakami, Christian Haass, Dieter Edbauer, Bettina Schmid
(2017)
Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration
Mol Neurodegener. 2017 Jan 14;12(1):6. doi: 10.1186/s13024-016-0146-8. -
Kohji Mori, Yoshihiro Nihei, Thomas Arzberger, Qihui Zhou, Ian R Mackenzie, Andreas Hermann, Frank Hanisch, German Consortium for Frontotemporal Lobar Degeneration, Bavarian Brain Banking Alliance, Frits Kamp, Brigitte Nuscher, Denise Orozco, Dieter Edbauer, Christian Haass
(2016)
Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition
EMBO Reports, published online 26.07.2016 -
Schwenk BM, Lang CM, Hogl S, Tahirovic S, Orozco D, Rentzsch K, Lichtenthaler SF, Hoogenraad CC, Capell A, Haass C, Edbauer D
(2014)
The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes
EMBO J. 2014 Jan 8. [Epub ahead of print] -
Mori K, Arzberger T, Grässer FA, Gijselinck I, Rentzsch K, Weng SM, Schludi HM, van der Zee J, Cruts M, Van Broeckhoven C, Kremmer E, Kretzschmar HA, Haass C, Edbauer D
(2013)
Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins.
Acta Neuropathol. 2013 Dec;126(6):881-93. doi: 10.1007/s00401-013-1189-3. Epub 2013 Oct 17. -
Mackenzie IR, Arzberger T, Kremmer E, Troost D, Lorenzl S, Mori K, Weng SM, Haass C, Kretzschmar HA, Edbauer D, Neumann M
(2013)
Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations
Acta Neuropathol. 2013 Dec;126(6):859-79. doi: 10.1007/s00401-013-1181-y. Epub 2013 Oct 6. -
Fleck D, van Bebber F, Colombo A, Galante C, Rabe L, Hampel H, Novak B, Kremmer E, Tahirovic S, Edbauer D, Lichtenthaler SF, Schmid B, Willem M, Haass C
(2013)
Dual cleavage of neuregulin 1 Type III by BACE1 and ADAM17 Liberates Its EGF-Like Domain and Allows Paracrine Signaling
J Neurosci. 2013 May 1;33(18):7856-69. doi: 10.1523/JNEUROSCI.3372-12.2013 -
Mori K, Lammich S, Mackenzie IR, Forne I, Zilow S, Kretzschmar H, Edbauer D, Janssens J, Kleinberger G, Cruts M, Herms J, Neumann M, Van Broeckhoven C, Arzberger T, Haass C
(2013)
hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations
Acta Neuropathol. 2013 Mar;125(3):413-23. doi: 10.1007/s00401-013-1088-7. Epub 2013 Feb 5 -
Schmid B, Hruscha A, Hogl S, Banzhaf-Strathmann J, van der Zee J, Teucke M, Eimer S, Hegermann J, Kittelmann M, Kremmer E, Cruts M, Solchenberger B, van Bebber F, Van Broeckhoven C, Edbauer D, Lichtenthaler SF, Haass C
(2013)
Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth
Proc Natl Acad Sci U S A. 2013 Mar 1. [Epub ahead of print] -
Julia Banzhaf-Strathmann, Rainer Claus, Oliver Mücke, Kristin Rentzsch, Julie van der Zee, Sebastiaan Engelborghs, Peter P De Deyn, Marc Cruts, Christine van Broeckhoven, Christoph Plass, Dieter Edbauer
(2013)
Promoter DNA methylation regulates progranulin expression and is altered in FTLD
Acta Neuropathologica Communications 1 (1):16 -
Mori K, Weng SM, Arzberger T, Rentzsch K, Kremmer E, Schmid B, Kretzschmar HA, Cruts M, Van Broeckhoven C, Haass C, Edbauer D
(2013)
The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS
Science. 2013 Feb 7. [Epub ahead of print] -
Orozco D, Tahirovic S, Rentzsch K, Haass C, Edbauer D
(2012)
Loss of fused in sarcoma (FUS) promotes pathological Tau splicing
EMBO Rep. 2012 Jun 19. doi: 10.1038/embor.2012.90. [Epub ahead of print] -
Lang CM, Fellerer K, Schwenk BM, Kuhn PH, Kremmer E, Edbauer D, Capell A, Haass C
(2012)
Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration
J Biol Chem. 2012 Apr 17. [Epub ahead of print] -
Miller BH, Zeier Z, Xi L, Lanz TA, Deng S, Strathmann J, Willoughby D, Kenny PJ, Elsworth JD, Lawrence MS, Roth RH, Edbauer D, Kleiman RJ, Wahlestedt C
(2012)
MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function
Journal: PNAS February 6, 2012 -
Zovoilis A, Agbemenyah HY, Agis-Balboa RC, Stilling RM, Edbauer D, Rao P, Farinelli L, Delalle I, Schmitt A, Falkai P, Bahari-Javan S, Burkhardt S, Sananbenesi F, Fischer A
(2011)
microRNA-34c is a novel target to treat dementias
EMBO J. 2011 Sep 23. doi: 10.1038/emboj.2011.327. [Epub ahead of print] -
Mellios N, Sugihara H, Castro J, Banerjee A, Le C, Kumar A, Crawford B, Strathmann J, Tropea D, Levine SS, Edbauer D, Sur M
(2011)
miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity
Nature Neuroscience 2011 Sep 4. [Epub ahead of print] -
Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IR, Capell A, Schmid B, Neumann M, Haass C
(2010)
ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
EMBO J. 2010 Aug 18;29(16):2841-57. Epub 2010 Jul 6. -
Foster KA, McLaughlin N, Edbauer D, Phillips M, Bolton A, Constantine-Paton M, Sheng M
(2010)
Distinct roles of NR2A and NR2B cytoplasmic tails in long-term potentiation
J Neurosci. 2010 Feb 17;30(7):2676-85. -
Edbauer D, Neilson JR, Foster KA, Wang CF, Seeburg DP, Batterton MN, Tada T, Dolan BM, Sharp PA, Sheng M
(2010)
Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132
Neuron. 2010 Feb 11;65(3):373-84. -
Edbauer D, Cheng D, Batterton MN, Wang CF, Duong DM, Yaffe MB, Peng J, Sheng M
(2009)
Identification and characterization of neuronal mitogen-activated protein kinase substrates using a specific phosphomotif antibody
Mol Cell Proteomics. 2009 Apr;8(4):681-95. Epub 2008 Dec 3. -
Tada T, Simonetta A, Batterton M, Kinoshita M, Edbauer D, Sheng M
(2007)
Role of Septin cytoskeleton in spine morphogenesis and dendrite development in neurons
Curr Biol. 2007 Oct 23;17(20):1752-8. Epub 2007 Oct 11. -
Edbauer D, Kaether C, Steiner H, Haass C
(2004)
Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1
J Biol Chem 279(36): 37311-5 -
Shirotani K, Edbauer D, Prokop S, Haass C, Steiner H
(2004)
Identification of distinct γ-secretase complexes with different APH-1 variants
J Biol Chem 279(40): 41340-5 -
Shirotani K, Edbauer D, Kostka M, Steiner H, Haass C
(2004)
Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1
J Neurochem 89(6): 1520-7 -
Prokop S, Shirotani K, Edbauer D, Haass C, Steiner H
(2004)
Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the γ-secretase complex
J Biol Chem 279(22): 23255-61 -
Kaether C, Capell A, Edbauer D, Winkler E, Novak B, Steiner H, Haass C
(2004)
The presenilin C-terminus is required for ER-retention, nicastrin-binding and γ-secretase activity
EMBO J 23(24): 4738-48 -
Capell A, Kaether C, Edbauer D, Shirotani K, Merkl S, Steiner H, Haass C
(2003)
Nicastrin interacts with γ-secretase complex components via the N-terminal part of its transmembrane domain
J Biol Chem 278(52): 52519-23 -
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C
(2003)
Reconstitution of γ-secretase activity
Nat Cell Biol 5(5): 486-8 -
Shirotani K, Edbauer D, Capell A, Schmitz J, Steiner H, Haass C
(2003)
γ-Secretase activity is associated with a conformational change of nicastrin
J Biol Chem 278(19): 16474-7 -
Edbauer D, Willem M, Lammich S, Steiner H, Haass C
(2002)
Insulin-degrading enzyme rapidly removes the β-amyloid precursor protein intracellular domain (AICD)
J Biol Chem 277(16): 13389-93 -
Steiner H, Winkler E, Edbauer D, Prokop S, Basset G, Yamasaki A, Kostka M, Haass C
(2002)
PEN-2 is an integral component of the γ-secretase complex required for coordinated expression of presenilin and nicastrin
J Biol Chem 277(42): 39062-5 -
Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C
(2002)
Presenilin-1 affects trafficking and processing of βAPP and is targeted in a complex with nicastrin to the plasma membrane
J Cell Biol 158(3): 551-61 -
Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, Capell A, Kaether C, Zheng H, Ghetti B, Haass C, Steiner H
(2002)
Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ 42 production
Proc Natl Acad Sci U S A 99(12): 8025-30 -
Edbauer D, Winkler E, Haass C, Steiner H
(2002)
Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation
Proc Natl Acad Sci U S A 99(13): 8666-71 -
Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, Edbauer D, Walter J, Steiner H, Haass C
(2002)
Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Aβ-like peptide
J Biol Chem 277(47): 44754-9
Review
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Dieter Edbauer, Christian Haass
(2016)
An amyloid-like cascade hypothesis for C9orf72 ALS/FTD
Curr Opin Neurobiol. 2016 Feb;36:99-106