Ludwig-Maximilians-Universität, Chair of Metabolic Biochemistry

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Immune surveillance of intracellular pathogens via autophagy

Cell Death Differ. 2005 Nov;12 Suppl 2:1519-27.

Authors/Editors: Münz C
Publication Date: 2006
Type of Publication: Review
MHC class II molecules are thought to present peptides derived from extracellular proteins to CD4+ T cells, which are important mediators of adaptive immunity to infections. In contrast, autophagy delivers constitutively cytosolic material for lysosomal degradation and has so far been recognized as an efficient mechanism of innate immunity against bacteria and viruses. Recent studies, however, link these two pathways and suggest that intracellular cytosolic and nuclear antigens are processed for MHC class II presentation after autophagy.

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