Publications
Journal Article
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Morenas-Rodríguez E, Li Y, Nuscher B, Franzmeier N, Xiong C, Suárez-Calvet M, Fagan AM, Schultz S, Gordon BA, Benzinger TLS, Hassenstab J, McDade E, Feederle R, Karch CM, Schlepckow K, Morris JC, Kleinberger G, Nellgard B, Vöglein J, Blennow K, Zetterberg H, Ewers M, Jucker M, Levin J, Bateman RJ, Haass C, on behalf of the Dominantly Inherited Alzheimer Network
(2022)
Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer´s disease: a longitudinal observational study
The Lancet Neurology Volume 21, Issue 4, April 2022, Pages 329-341 -
Kai Schlepckow, Kathryn M. Monroe, Gernot Kleinberger, Ludovico Cantuti-Castelvetri, Samira Parhizkar, Dan Xia, Michael Willem, Georg Werner, Nadine Pettkus, Bettina Brunner, Alice Sülzen, Brigitte Nuscher, Heike Hampel, Xianyuan Xiang, Regina Feederle, Sabina Tahirovic, Joshua I. Park, Rachel Prorok, Cathal Mahon, Chun-Chi Liang, Ju Shi, Do Jin Kim, Hanna Sabelström, Fen Huang, Gilbert Di Paolo, Mikael Simons, Joseph W. Lewcock, Christian Haass
(2020)
Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region
EMBO Mol Med. 2020 Apr 7;12(4):e11227. -
Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Kai Schlepckow, Miguel Ángel Araque Caballero, Nicolai Franzmeier, Anja Capell, Katrin Fellerer, Brigitte Nuscher, Erden Eren, Johannes Levin, Yuetiva Deming, Laura Piccio, Celeste M. Karch, Carlos Cruchaga, Leslie M. Shaw, John Q. Trojanowski, Michael Weiner, Michael Ewers, Christian Haass, for the Alzheimer’s Disease Neuroimaging Initiative
(2019)
Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology
Mol Neurodegener. 2019 Jan 10;14(1):1 -
Michael Ewers, Nicolai Franzmeier, Marc Suárez-Calvet, Estrella Morenas-Rodriguez, Miguel Angel Araque Caballero, Gernot Kleinberger, Laura Piccio, Carlos Cruchaga, Yuetiva Deming, Martin Dichgans, John Q. Trojanowski, Leslie M. Shaw, Michael W. Weiner, Christian Haass, for the Alzheimer’s Disease Neuroimaging Initiative
(2019)
Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease
Science Translational Medicine, 28 Aug 2019 -
Samira Parhizkar, Thomas Arzberger, Matthias Brendel, Gernot Kleinberger, Maximilian Deussing, Carola Focke, Brigitte Nuscher, Monica Xiong, Alireza Ghasemigharagoz, Natalie Katzmarski, Susanne Krasemann, Stefan F. Lichtenthaler, Stephan A. Müller, Alessio Colombo, Laura Sebastian Monasor, Sabina Tahirovic, Jochen Herms, Michael Willem, Nadine Pettkus, Oleg Butovsky, Peter Bartenstein, Dieter Edbauer, Axel Rominger, Ali Ertürk, Stefan A. Grathwohl, Jonas J. Neher, David M. Holtzman, Melanie Meyer-Luehmann, Christian Haass
(2019)
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
Nat Neurosci. 2019 Feb;22(2):191-204 -
Götzl J, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, Colombo A, Deussing M, Wagner M, Winkelmann J, Diehl-Schmid J, Levin J, Fellerer K, Reifschneider A, Bultmann S, Bartenstein P, Rominger A, Tahirovic S, Smith ST, Madore C, Butovsky O, Capell A, Haass C
(2019)
Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism
EMBO Mol Med. 2019 Jun;11(6):e9711. -
Marc Suárez-Calvet, Anja Capell, Miguel Ángel Araque Caballero, Estrella Morenas-Rodríguez, Katrin Fellerer, Nicolai Franzmeier, Gernot Kleinberger, Erden Eren, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Katrina Paumier, Randall J Bateman, Anne M Fagan, John C Morris, Johannes Levin, Adrian Danek, Mathias Jucker, Colin L Masters, Martin N Rossor, John M Ringman, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers , Christian Haass, for the Dominantly Inherited Alzheimer Network, & for the Alzheimer's Disease Neuroimaging Initiative
(2018)
CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline
EMBO Mol Med. 2018 Dec;10(12). pii: e9712. -
Kai Schlepckow, Gernot Kleinberger, Akio Fukumori, Regina Feederle, Stefan F. Lichtenthaler, Harald Steiner, Christian Haass
(2017)
An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function
EMBO Mol Med. 2017 Oct;9(10):1356-1365 -
Gernot Kleinberger, Matthias Brendel, Eva Mracsko, Benedikt Wefers, Linda Groeneweg, Xianyuan Xiang, Carola Focke, Maximilian Deußing, Marc Suárez-Calvet, Fargol Mazaheri, Samira Parhizkar, Nadine Pettkus, Wolfgang Wurst, Regina Feederle, Peter Bartenstein, Thomas Mueggler, Thomas Arzberger, Irene Knuesel, Axel Rominger, Christian Haass
(2017)
The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion and glucose metabolism
EMBO J. 2017 Jul 3;36(13):1837-1853 -
Fargol Mazaheri, Nicolas Snaidero, Gernot Kleinberger, Charlotte Madore, Anna Daria, Georg Werner, Susanne Krasemann, Anja Capell, Dietrich Trümbach, Wolfgang Wurst, Bettina Brunner, Sebastian Bultmann, Sabina Tahirovic, Martin Kerschensteiner, Thomas Misgeld, Oleg Butovsky, Christian Haass
(2017)
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury
EMBO Rep. 2017 Jul;18(7):1186-1198 -
Juan Domingo Gispert, Marc Suárez-Calvet, Gemma C. Monte, Alan Tucholka, Carles Falcon, Santiago Rojas, Lorena Rami, Raquel Sanchez-Valle, Albert Lladó, Gernot Kleinberger, Christian Haass, José Luis Molinuevo
(2016)
Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease
Alzheimers Dement. 2016 Jul 13. pii: S1552-5260(16)30026-7. -
Marc Suárez-Calvet, Miguel Ángel Araque Caballero, Gernot Kleinberger, Randall J. Bateman, Anne M. Fagan, John C. Morris, Johannes Levin, Adrian Danek, Michael Ewers, Christian Haass, for the Dominantly Inherited Alzheimer Network
(2016)
Early changes in CSF sTREM2 in dominantly inherited Alzheimer’s disease occur after amyloid deposition and neuronal injury
Science Translational Medicine 14 Dec 2016: Vol. 8, Issue 369, pp. 369ra178 DOI: 10.1126/scitranslmed.aag1767 -
Matthias Brendel, Federico Probst, Anna Jaworska, Felix Overhoff, Viktoria Korzhova, Nathalie L. Albert, Roswitha Beck, Simon Lindner, Franz-Josef Gildehaus, Karlheinz Baumann, Peter Bartenstein, Gernot Kleinberger, Christian Haass, Jochen Herms, Axel Rominger
(2016)
Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple-Tracer PET Study
J Nucl Med. 2016 Jun;57(6):954-60 -
Gernot Kleinberger, Anja Capell, Nathalie Brouwers, Katrin Fellerer, Kristel Sleegers, Marc Cruts, Christina Van Broeckhoven, Christian Haass
(2016)
Reduced secretion and altered proteolytic processing caused by missense mutations in progranulin
Neurobiol Aging. 2016 Mar;39:220.e17-26 -
Marc Suárez-Calvet, Gernot Kleinberger, Miguel Ángel Araque Caballero, Matthias Brendel, Axel Rominger, Daniel Alcolea, Juan Fortea, Alberto Lleó, Rafael Blesa, Juan Domingo Gispert, Raquel Sánchez-Valle, Anna Antonell, Lorena Rami, José L. Molinuevo, Frederic Brosseron, Andreas Traschütz, Michael T. Heneka, Hanne Struyfs, Sebastiaan Engelborghs, Kristel Sleegers, Christine Van Broeckhoven, Henrik Zetterberg, Bengt Nellgard, Kaj Blennow, Alexander Crispin, Michael Ewers, Christian Haass
(2016)
sTREM2 cerebrospinal fluid levels are a potent biomarker for microglia activity in early-stage Alzheimer’s disease and associate with neuronal injury markers
EMBO Mol Med. 2016 May 2;8(5):466-76 -
Juan Domingo Gispert, Gemma C. Monté, Marc Suárez-Calvet, Carles Falcon, Alan Tucholka, Santiago Rojas, Lorena Rami, Raquel Sánchez-Valle, Albert Lladó, Gernot Kleinberger, Christian Haass, José Luis Molinuevo
(2016)
The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2
Alzheimers Dement (Amst). 2016 Dec 22;6:50-59 -
Xianyuan Xiang, Georg Werner, Bernd Bohrmann, Arthur Liesz, Fargol Mazaheri, Anja Capell, Regina Feederle, Irene Knuesel, Gernot Kleinberger, Christian Haass
(2016)
TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
EMBO Molecular Medicine (2016) e201606370, Published online 08.07.2016 -
Jonathan Janssens, Stéphanie Philtjens, Gernot Kleinberger, Sara Van Mossevelde, Julie van der Zee, Rita Cacace, Sebastiaan Engelborghs, Anne Sieben, Julia Banzhaf-Strathmann, Lubina Dillen, Céline Merlin, Ivy Cuijt, Caroline Robberecht, Bettina Schmid, Patrick Santens, Adrian Ivanoiu, Mathieu Vandenbulcke, Rik Vandenberghe, Patrick Cras, Peter P. De Deyn, Jean-Jacques Martin, Stuart Maudsley, Christian Haass, Marc Cruts, Christine Van Broeckhoven
(2015)
Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains
Acta Neuropathol Commun. 2015 Nov 10;3:68 -
Götzl JK, Mori K, Damme M, Fellerer K, Tahirovic S, Kleinberger G, Janssens J, van der Zee J, Lang CM, Kremmer E, Martin JJ, Engelborghs S, Kretzschmar HA, Arzberger T, Van Broeckhoven C, Haass C, Capell A
(2014)
Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis.
Acta Neuropathol. 2014 Mar 12. [Epub ahead of print] -
G. Kleinberger, Y. Yamanishi, M. Suarez-Calvet, E. Czirr, E. Lohmann, E. Cuyvers, H. Struyfs, N. Pettkus, F. Mazaheri, S. Tahirovic, A. Lleó, D. Alcolea, J. Fortea, M. Willem, S. Lammich, J. L. Molinuevo, R. Sanchez-Valle, A. Antonell, A. Ramirez, M. Heneka, K. Sleegers, J. van der Zee, J.-J. Martin, S. Engelborghs, A. Demirtas-Tatlidede, H. Zetterberg, C. Van Broeckhoven, H. Gurvit, T. Wyss-Coray, J. Hardy, M. Colonna, C. Haass
(2014)
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
Sci Transl Med 2 July 2014: Vol. 6, Issue 243, p. 243ra86
Review
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Kleinberger G, Capell A, Haass C, Van Broeckhoven C
(2013)
Mechanisms of granulin deficiency: lessons from cellular and animal models
Mol Neurobiol. 2013 Feb;47(1):337-60. doi: 10.1007/s12035-012-8380-8. Epub 2012 Dec 13