Publikationen

Journal Article

• Marvin Reich, Matthew J Simon, Beate Polke, Iñaki Paris, Georg Werner, Christian Schrader, Lena Spieth, Sonnet S Davis, Sophie Robinson, Gabrielly Lunkes de Melo, Lennart Schlaphoff, Katrin Buschmann, Stefan Berghoff, Todd Logan, Brigitte Nuscher , Lis de Weerd, Dieter Edbauer, Mikael Simons, Jung H Suh, Thomas Sandmann, Mihalis S Kariolis, Sarah L DeVos, Joseph W Lewcock, Dominik Paquet , Anja Capell , Gilbert Di Paolo, Christian Haass (2024)
  Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration
  Sci Transl Med. 2024 Jun 5;16(750):eadj7308.
• Georg Werner, Markus Damme, Martin Schludi, Johannes Gnörich, Karin Wind, Katrin Fellerer, Benedikt Wefers, Wolfgang Wurst, Dieter Edbauer, Matthias Brendel, Christian Haass, Anja Capell (2020)
  Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice
  EMBO Rep. 2020 Oct 5;21(10):e50241.
• Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Kai Schlepckow, Miguel Ángel Araque Caballero, Nicolai Franzmeier, Anja Capell, Katrin Fellerer, Brigitte Nuscher, Erden Eren, Johannes Levin, Yuetiva Deming, Laura Piccio, Celeste M. Karch, Carlos Cruchaga, Leslie M. Shaw, John Q. Trojanowski, Michael Weiner, Michael Ewers, Christian Haass, for the Alzheimer’s Disease Neuroimaging Initiative (2019)
  Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology
  Mol Neurodegener. 2019 Jan 10;14(1):1
• Götzl J, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, Colombo A, Deussing M, Wagner M, Winkelmann J, Diehl-Schmid J, Levin J, Fellerer K, Reifschneider A, Bultmann S, Bartenstein P, Rominger A, Tahirovic S, Smith ST, Madore C, Butovsky O, Capell A, Haass C (2019)
  Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism
  EMBO Mol Med. 2019 Jun;11(6):e9711.
• Marc Suárez-Calvet, Anja Capell, Miguel Ángel Araque Caballero, Estrella Morenas-Rodríguez, Katrin Fellerer, Nicolai Franzmeier, Gernot Kleinberger, Erden Eren, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Katrina Paumier, Randall J Bateman, Anne M Fagan, John C Morris, Johannes Levin, Adrian Danek, Mathias Jucker, Colin L Masters, Martin N Rossor, John M Ringman, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers , Christian Haass, for the Dominantly Inherited Alzheimer Network, & for the Alzheimer's Disease Neuroimaging Initiative (2018)
  CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline
  EMBO Mol Med. 2018 Dec;10(12). pii: e9712.
• Julia K. Götzl, Alessio-Vittorio Colombo, Katrin Fellerer, Anika Reifschneider, Georg Werner, Sabina Tahirovic, Christian Haass, Anja Capell (2018)
  Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice
  Mol Neurodegener. 2018 Sep 4;13(1):48
• Gernot Kleinberger, Anja Capell, Nathalie Brouwers, Katrin Fellerer, Kristel Sleegers, Marc Cruts, Christina Van Broeckhoven, Christian Haass (2016)
  Reduced secretion and altered proteolytic processing caused by missense mutations in progranulin
  Neurobiol Aging. 2016 Mar;39:220.e17-26
• Götzl JK, Mori K, Damme M, Fellerer K, Tahirovic S, Kleinberger G, Janssens J, van der Zee J, Lang CM, Kremmer E, Martin JJ, Engelborghs S, Kretzschmar HA, Arzberger T, Van Broeckhoven C, Haass C, Capell A (2014)
  Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis.
  Acta Neuropathol. 2014 Mar 12. [Epub ahead of print]
• Capell A, Fellerer K, Haass C (2014)
  Progranulin transcripts with short and long 5’-untranslated regions (UTR) are differentially expressed via post transcriptional and translational repression
  J Biol Chem. 2014 Jul 23. pii: jbc.M114.560128. [Epub ahead of print]
• Lang CM, Fellerer K, Schwenk BM, Kuhn PH, Kremmer E, Edbauer D, Capell A, Haass C (2012)
  Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration
  J Biol Chem. 2012 Apr 17. [Epub ahead of print]
• Capell A, Liebscher S, Fellerer K, Brouwers N, Willem M, Lammich S, Gijselinck I, Bittner T, Carlson AM, Sasse F, Kunze B, Steinmetz H, Jansen R, Dormann D, Sleegers K, Cruts M, Herms J, Van Broeckhoven C, Haass C. (2011)
  Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase
  J Neurosci. 2011 Feb 2;31(5):1885-1894.