Publications

Journal Article

• Dawkins E, Derks RJE, Schifferer M, Trambauer J, Winkler E, Simons M, Paquet D, Giera M, Kamp F, Steiner H (2023)
  Membrane lipid remodeling modulates γ-secretase processivity
  J Biol Chem. 2023 Apr;299(4):103027.
• Junker J, Kamp F, Winkler E, Steiner H, Bracher F, Müller C (2021)
  Effective sample preparation procedure for the analysis of free neutral steroids, free steroid acids and sterol sulfates in different tissues by GC-MS
  J Steroid Biochem Mol Biol. 2021 Jul;211:105880
• Ariane Schumski, Almudena Ortega-Gómez, Kanin Wichapong, Carla Winter, Patricia Lemnitzer, Joana R Viola, Mayra Pinilla-Vera, Eduardo Folco, Victor Solis-Mezarino, Moritz Völker-Albert, Sanne L Maas, Chang Pan, Laura Perez Olivares, Janine Winter, Tilman Hackeng, Mikael C I Karlsson, Tanja Zeller, Axel Imhof, Rebecca M Baron, Gerry A F Nicolaes, Peter Libby, Lars Maegdefessel, Frits Kamp, Martin Benoit, Yvonne Döring, Oliver Soehnlein (2021)
  Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge-Mediated Monocyte Adhesion
  Circulation. 2021 Jan 19;143(3):254-266
• Colombo A, Sadler RK, Llovera G, Singh V, Roth S, Heindl S, Sebastian Monasor L, Verhoeven A, Peters F, Parhizkar S, Kamp F, Gomez de Aguero M, MacPherson AJ, Winkler E, Herms J, Benakis C, Dichgans M, Steiner H, Giera M, Haass C, Tahirovic S, Liesz A (2021)
  Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
  Elife. 2021 Apr 13;10:e59826
• Tasnim Chakroun, Valentin Evsyukov, Niko-Petteri Nykänen, Matthias Höllerhage, Andreas Schmidt, Frits Kamp, Viktoria C Ruf, Wolfgang Wurst, Thomas W Rösler, Günter U Höglinger (2020)
  Alpha-synuclein fragments trigger distinct aggregation pathways
  Cell Death Dis. 2020 Feb 3;11(2):84
• Georg S Nuebling, Eva Plesch, Viktoria C Ruf, Tobias Högen, Stefan Lorenzl, Frits Kamp, Armin Giese, Johannes Levin (2020)
  Binding of Metal-Ion-Induced Tau Oligomers to Lipid Surfaces Is Enhanced by GSK-3β-Mediated Phosphorylation
  ACS Chem Neurosci. 2020 Mar 18;11(6):880-887
• Kong L, Dawkins E, Campbell F, Winkler E, Derks RJE, Giera M, Kamp F, Steiner H, Kros A (2020)
  Photo-controlled delivery of very long chain fatty acids to cell membranes and modulation of membrane protein function
  Biochim Biophys Acta Biomembr. 2020 May 1;1862(5):183200
• Yoshihiro Nihei, Kohji Mori, Georg Werner, Thomas Arzberger, Qihui Zhou, Barham Khosravi, Julia Japtok, Andreas Hermann, Andreas Sommacal, Markus Weber, German Consortium for Frontotemporal Lobar Degeneration, Bavarian Brain Banking Alliance, Frits Kamp, Brigitte Nuscher, Dieter Edbauer, Christian Haass (2020)
  Poly-glycine-alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3
  Acta Neuropathol 2020 Jan;139(1):99-118.
• Angelique Camilleri, Stephanie Ghio, Mario Caruana, Daniel Weckbecker, Felix Schmidt, Frits Kamp, Andrei Leonov, Sergey Ryazanov, Christian Griesinger, Armin Giese, Ruben J Cauchi, Neville Vassallo (2020)
  Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin
  Biochim Biophys Acta Biomembr. 2020 Feb 1;1862(2):183064
• Stephanie Ghio, Angelique Camilleri, Mario Caruana, Viktoria C Ruf, Felix Schmidt, Andrei Leonov, Sergey Ryazanov, Christian Griesinger, Ruben J Cauchi, Frits Kamp, Armin Giese, Neville Vassallo (2019)
  Cardiolipin Promotes Pore-Forming Activity of Alpha-Synuclein Oligomers in Mitochondrial Membranes
  ACS Chem Neurosci. 2019 Aug 21;10(8):3815-3829
• Junker J, Chong I, Kamp F, Steiner H, Giera M, Müller C, Bracher F (2019)
  Comparison of strategies for the determination of sterol sulfates via GC-MS leading to a novel deconjugation-derivatization protocol
  Molecules. 2019 Jun 26;24(13):2353
• Viktoria C. Ruf, Georg S. Nübling, Sophia Willikens, Song Shi, Felix Schmidt, Johannes Levin, Kai Bötzel, Frits Kamp, Armin Giese (2019)
  Different effects of alpha-Synuclein mutants on lipid binding and aggregation detected by single molecule fluorescence spectroscopy and ThT fluorescence-based measurements
  ACS Chem Neurosci. 2019 Mar 20;10(3):1649-1659
• Carlos Silvestre-Roig, Quinte Braster, Kanin Wichapong, Ernest Y Lee, Jean Marie Teulon, Nihel Berrebeh, Janine Winter, José M Adrover, Giancarlo Santiago Santos, Alexander Froese, Patricia Lemnitzer, Almudena Ortega-Gómez, Raphael Chevre, Julian Marschner, Ariane Schumski, Carla Winter, Laura Perez-Olivares, Chang Pan, Nicole Paulin, Tom Schoufour, Helene Hartwig, Silvia González-Ramos, Frits Kamp, Remco T A Megens, Kerri A Mowen, Matthias Gunzer, Lars Maegdefessel, Tilman Hackeng, Esther Lutgens, Mat Daemen, Julia von Blume, Hans-Joachim Anders, Viacheslav O Nikolaev, Jean-Luc Pellequer, Christian Weber, Andrés Hidalgo, Gerry A F Nicolaes, Gerard C L Wong, Oliver Soehnlein (2019)
  Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death
  Nature. 2019 May;569(7755):236-240
• Iris Marti Fernandez, Caterina Macrini, Markus Krumbholz, Paul J Hensbergen, Agnes L Hipgrave Ederveen, Stephan Winklmeier, Atay Vural, Asli Kurne, Dieter Jenne, Frits Kamp, Lisa Ann Gerdes, Reinhard Hohlfeld, Manfred Wuhrer, Tania Kümpfel, Edgar Meinl (2019)
  The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients
  Front Immunol. 2019 Jun 11;10:1189
• Frits Kamp, Holger A. Scheidt, Edith Winkler, Gabriele Basset, Hannes Heinel, James M. Hutchison, Loren M. LaPointe, Charles R. Sanders, Harald Steiner, Daniel Huster (2018)
  Bexarotene binds to the amyloid precursor protein transmembrane domain, alters its α-helical conformation, and inhibits γ-secretase nonselectively in liposomes
  ACS Chem Neurosci. 2018 Jul 18;9(7):1702-1713.
• Alexander Götz, Nadine Mylonas, Philipp Högel, Mara Silber, Hannes Heinel, Simon Menig, Alexander Vogel, Hannes Feyrer, Daniel Huster, Burkhard Luy, Dieter Langosch, Christina Scharnagl, Claudia Muhle-Goll, Frits Kamp, Harald Steiner (2018)
  Modulating hinge flexibility in the APP transmembrane domain alters γ-secretase
  Biophys J. 2019 Jun 4;116(11):2103-2120
• Melania Spadaro, Stephan Winklmeier, Eduardo Beltrán, Caterina Macrini, Romana Höftberger, Elisabeth Schuh, Franziska S. Thaler, Lisa Ann Gerdes, Sarah Laurent, Ramona Gerhards, Simone Brändle, Klaus Dornmair, Constanze Breithaupt, Markus Krumbholz, Markus Moser, Gurumoorthy Krishnamoorthy, Frits Kamp, Dieter Jenne, Reinhard Hohlfeld, Tania Kümpfel, Hans Lassmann, Naoto Kawakami, Edgar Meinl (2018)
  Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein
  Ann Neurol. 2018 Aug;84(2):315-328.
• Karim S. Echtay, Martin Bienengraeber, Peter Mayinger, Simone Heimpel, Doerthe Druhmann, Karina Frischmuth, Frits Kamp, Shu-Gui Huang (2018)
  Uncoupling proteins: Martin Klingenberg's contributions for 40 years
  Arch Biochem Biophys. 2018 Nov 1;657:41-55
• Kohji Mori, Yoshihiro Nihei, Thomas Arzberger, Qihui Zhou, Ian R Mackenzie, Andreas Hermann, Frank Hanisch, German Consortium for Frontotemporal Lobar Degeneration, Bavarian Brain Banking Alliance, Frits Kamp, Brigitte Nuscher, Denise Orozco, Dieter Edbauer, Christian Haass (2016)
  Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition
  EMBO Reports, published online 26.07.2016
• Teresa Bachhuber, Natalie Katzmarski, Joanna F McCarter, Desiree Loreth, Sabina Tahirovic, Frits Kamp, Claudia Abou-Ajram, Brigitte Nuscher, Alberto Serrano-Pozo, Alexandra Müller, Marco Prinz, Harald Steiner, Bradley T Hyman, Christian Haass, Melanie Meyer-Luehmann (2015)
  Inhibition of amyloid-β plaque formation by α-synuclein
  Nat Med. 2015 Jul;21(7):802-7
• Frits Kamp, Edith Winkler, Johannes Trambauer, Amelie Ebke, Regina Fluhrer, Harald Steiner (2015)
  Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process
  Biophys J. 2015 Mar 10;108(5):1229-37.
• Georg Sebastian Nübling, Johannes Levin, Benedikt Bader, Stefan Lorenzl, Andreas Hillmer, Tobias Högen, Frits Kamp, Armin Giese (2014)
  Modelling Ser129 phosphorylation inhibits membrane binding of pore-forming alpha-synuclein oligomers
• Winkler E, Kamp F, Scheuring J, Ebke A, Steiner H (2012)
  Generation of Alzheimer disease-associated Aβ42/43 by γ-secretase can directly be inhibited by modulation of membrane thickness
  J. Biol. Chem. 287, 21326-34.
• Caruana M, Neuner J, Högen T, Schmid F, Kamp F, Scerri C, Giese A, Vassallo N (2012)
  Polyphenolic compounds are novel protective agents against lipid membrane damage by α-synuclein aggregates in vitro
  Biochim Biophys Acta. 2012 May 23;1818(11):2502-2510. [Epub ahead of print]
• Schmidt F, Levin J, Kamp F, Kretzschmar H, Giese A, Bötzel K (2012)
  Single-Channel Electrophysiology Reveals a Distinct and Uniform Pore Complex Formed by α-Synuclein Oligomers in Lipid Membranes
  PLoS One. 2012;7(8):e42545. Epub 2012 Aug 3.
• Högen T, Levin J, Schmidt F, Caruana M, Vassallo N, Kretzschmar H, Bötzel K, Kamp F, Giese A (2012)
  Two Different Binding Modes of α-Synuclein to Lipid Vesicles Depending on its Aggregation State
  Biophys J. 2012 Apr 4;102(7):1646-55. Epub 2012 Apr 3
• Levin J, Högen T, Hillmer AS, Bader B, Schmidt F, Kamp F, Kretzschmar HA, Bötzel K, Giese A (2011)
  Generation of Ferric Iron Links Oxidative Stress to α-Synuclein Oligomer Formation
  J Park Dis. 2011 Oct 4. [Epub ahead of print]
• Fluhrer R, Kamp F, Nuscher B, Steiner H, Beyer K, Haass C (2011)
  The nicastrin ectodomain adopts a highly thermostable structure
  Biol Chem. 2011 Aug 18. [Epub ahead of print]
• Lammich S, Kamp F, Wagner J, Nuscher B, Zilow S, Ludwig AK, Willem M, Haass C (2011)
  Translational repression of the Disintegrin and Metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5′-untranslated region
  J Biol Chem. 2011 Dec 30;286(52):45063-72. Epub2011 Nov 7.
• Mitterreiter S, Page RM, Kamp F, Hopson J, Ha HR, Hamid R, Herms J, Mayer TU, Nelson DJ, Steiner H, Stahl T, Zeitschel U, Roßner S, Haass C (2010)
  Bepridil and Amiodarone Simultaneously Target the Alzheimer’s Disease β- and γ-Secretase via Distinct Mechanisms
  J. Neurosci. 2010 Apr 20. [Epub ahead of print]
• Kamp F, Exner N, Lutz AK, Wender N, Hegermann J, Brunner B, Nuscher B, Bartels T, Giese A, Beyer K, Eimer S, Winklhofer KF, Haass C (2010)
  Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1
  EMBO J. 2010 Oct 20;29(20):3571-89. Epub 2010 Sep 14.
• Bartels T, Ahlstrom LS, Leftin A, Kamp F, Haass C, Brown MF, Beyer K (2010)
  The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding
  Biophys J. 2010 Oct 6;99(7):2116-24.
• Simard JR, Kamp F, Hamilton JA (2008)
  Measuring the adsorption of Fatty acids to phospholipid vesicles by multiple fluorescence probes
  Biophys J. 2008 Jun;94(11):4493-503. Epub 2008 Feb 22.
• Kamp F, Beyer K (2006)
  Binding of alpha-synuclein affects the lipid packing in bilayers of small vesicles
  J Biol Chem. 2006 Apr 7;281(14):9251-9. Epub 2006 Feb 1.
• Kamp F, Hamilton JA (2006)
  How fatty acids of different chain length enter and leave cells by free diffusion
  Prostaglandins Leukot Essent Fatty Acids. 2006 Sep;75(3):149-59. Epub 2006 Jul 7.
• Nuscher B, Kamp F, Mehnert T, Odoy S, Haass C, Kahle PJ, Beyer K (2004)
  Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study
  J Biol Chem 279(21): 21966-75
• Kamp F, Guo W, Souto R, Pilch PF, Corkey BE, Hamilton JA (2003)
  Rapid flip-flop of oleic acid across the plasma membrane of adipocytes
  J Biol Chem. 2003 Mar 7;278(10):7988-95. Epub 2002 Dec 23.
• Kamp F, Kizilbash N, Corkey BE, Berggren PO, Hamilton JA (2003)
  Sulfonylureas rapidly cross phospholipid bilayer membranes by a free-diffusion mechanism
  Diabetes. 2003 Oct;52(10):2526-31.
• Hamilton JA, Johnson RA, Corkey B, Kamp F (2001)
  Fatty acid transport: the diffusion mechanism in model and biological membranes
  J Mol Neurosci. 2001 Apr-Jun;16(2-3):99-108; discussion 151-7.
• Hamilton JA, Kamp F (1999)
  How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids?
  Diabetes. 1999 Dec;48(12):2255-69.
• Kamp F, Donoso P, Hidalgo C (1998)
  Changes in luminal pH caused by calcium release in sarcoplasmic reticulum vesicles
  Biophys J. 1998 Jan;74(1):290-6.
• Kamp F, Zhang F, Hamilton JA. (1996)
  Dissociation of long and very long chain fatty acids from phospholipid bilayers
  Biochemistry. 1996 Dec 17;35(50):16055-60.
• Kamp F, Zakim D, Zhang F, Noy N, Hamilton JA (1995)
  Fatty acid flip-flop in phospholipid bilayers is extremely fast
  Biochemistry. 1995 Sep 19;34(37):11928-37.
• Hamilton JA, Civelek VN, Kamp F, Tornheim K, Corkey BE (1994)
  Changes in internal pH caused by movement of fatty acids into and out of clonal pancreatic beta-cells (HIT)
  J Biol Chem. 1994 Aug 19;269(33):20852-6.
• Juretić D, Hendler RW, Kamp F, Caughey WS, Zasloff M, Westerhoff HV (1994)
  Magainin oligomers reversibly dissipate delta microH+ in cytochrome oxidase liposomes
  Biochemistry. 1994 Apr 19;33(15):4562-70.
• Kamp F, Hamilton JA, Westerhoff HV (1993)
  Movement of fatty acids, fatty acid analogues, and bile acids across phospholipid bilayers
  Biochemistry. 1993 Oct 19;32(41):11074-86.
• Kamp F, Hamilton JA. (1992)
  pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acids
  Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11367-70.
• Kamp F, Astumian RD, Westerhoff HV. (1988)
  Coupling of vectorial proton flow to a biochemical reaction by local electric interactions
  Proc Natl Acad Sci U S A. 1988 Jun;85(11):3792-6.

Review

• Stephanie Ghio, Frits Kamp, Ruben Cauchi, Armin Giese, Neville Vassallo (2016)
  Interaction of α-synuclein with biomembranes in Parkinson's disease -role of cardiolipin