Publications

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• Signal Peptide Peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins
  EMBO Rep. 2019 May;20(5). pii: e48133
• Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis
  J Exp Med. 2019 Apr 1;216(4):807-830
• The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban
  EMBO Rep. 2019 Feb 7. pii: e46449

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• A Unique Family of Intramembrane Proteases
  E-book   https://doi.org/10.26320/SCIENTIA179
• Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments
  EMBO J. 2018 Jul 5. pii: e99456. doi: 10.15252/embj.201899456.

• Signal peptide peptidase and SPP-like proteases - Possible therapeutic targets?
  Biochim Biophys Acta. 2017 Nov;1864(11 Pt B):2169-2182
• CLN5 is cleaved by members of the SPP/SPPL family to produce a mature soluble protein
  Exp Cell Res. 2017 Aug 1;357(1):40-50
• Latest emerging functions of SPP/SPPL intramembrane proteases
  Eur J Cell Biol. 2017 Aug;96(5):372-382

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• Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74
  Biochem J. 2016 May 15;473(10):1405-22.

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• Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways
  Mol Cell Proteomics. 2015 Jun;14(6):1584-98. doi: 10.1074/mcp.M115.048298. Epub 2015 Mar 31
• A Cell-Based Assay Reveals Nuclear Translocation of Intracellular Domains Released by SPPL Proteases
  Traffic. 2015 Aug;16(8):871-92. doi: 10.1111/tra.12287. Epub 2015 May 6.
• Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process
  Biophys J. 2015 Mar 10;108(5):1229-37. doi: 10.1016/j.bpj.2014.12.045.
• Proteolytic processing of Neuregulin 1 type III by three intramembrane cleaving proteases
  J Biol Chem. 2016 Jan 1;291(1):318-33. doi: 10.1074/jbc.M115.697995. Epub 2015 Nov 16.

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• Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation
  EMBO J. 2014 Dec 17;33(24):2890-905. doi: 10.15252/embj.201488375. Epub 2014 Oct 29

• Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells
  Biochem Biophys Res Commun. 2014 Aug 15;451(1):48-53. doi: 10.1016/j.bbrc.2014.07.051. Epub 2014 Jul 15. PMID: 25035924 Free PMC Article

• Intramembrane cleaving proteases (I-CLiPs) as guardians of shuttling proteins
  Cell Cycle. 2014 Feb 4;13(5). [Epub ahead of print]

• The intramembrane proteases Signal-peptide-peptidase-like 2a and b (SPPL2a/b) have distinct functions in vivo
  Mol Cell Biol. 2014 Feb 3. [Epub ahead of print]

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• Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases
  Biochim Biophys Acta. 2013 Dec;1828(12):2828-39. doi: 10.1016/j.bbamem.2013.03.033.

• The intramembrane protease SPPL2A is critical for tooth enamel formation
  J Bone Miner Res. 2013 Jul;28(7):1622-30. doi: 10.1002/jbmr.1895.

• The transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2b
  FEBS J. 2013 Apr;280(7):1653-63. doi: 10.1111/febs.12176. Epub 2013 Mar 1

• The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain
  J Exp Med. 2013 Jan 14;210(1):41-58. doi: 10.1084/jem.20121069. Epub 2012 Dec 24.

• Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling
  Biochim Biophys Acta. 2013 Mar;1833(3):602-12. doi: 10.1016/j.bbamcr.2012.11.009. Epub 2012 Nov 16.

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• Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3)
  J Biol Chem. 2012 Dec 21;287(52):43401-9. doi: 10.1074/jbc.M112.371369. Epub 2012 Nov 6.

• The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by Signal Peptide Peptidase-Like 2b (SPPL2b)
  J Biol Chem. 2012 Feb 10;287(7):5156-63. Epub 2011 Dec 22

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• The Nicastrin ectodomain adopts a highly thermostable structure
  Biochim Biophys Acta. 2013 Dec;1828(12):2828-39. doi: 10.1016/j.bbamem.2013.03.033

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• Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis
  J Neurosci. 2010 Jun 9;30(23):7853-62.

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• Intramembrane proteolysis by signal peptidepeptidases - a comparative discussion of GxGD-type aspartyl proteases
  J Biol Chem. 2009 May 22;284(21):13975-9. Epub 2009 Feb 3.

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• Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation
• Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b
• Substrate requirements for SPPL2b dependent regulated intramembrane proteolysis
• Intramembrane proteolysis by gamma-secretase

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• A structural switch of presenilin 1 by glycogen synthase kinase 3beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling
• Signal peptide peptidases and gamma-secretase: cousins of the same protease family?

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• A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b

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• Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

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• Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis

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• Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation

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• A non-amyloidogenic function of BACE-2 in the secretory pathway
• Apical sorting of beta-secretase limits amyloid beta-peptide production

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• Phosphorylation regulates intracellular trafficking of beta-secretase