Content
Biophysics platform
[2019] [2018] [2016] [2015] [2014] [2012] [2011] [2010] [2008] [2007] [2006] [2004] [2003] [2001] [1999] [1998] [1996] [1995] [1994] [1993] [1992] [1990] [1988]
- Ruf VC, Nübling GS, Willikens S, Shi S, Schmidt F, Levin J, Bötzel K, Kamp F and Giese A (2019) Different effects of α-Synuclein mutants on lipid binding and aggregation detected by single molecule fluorescence spectroscopy and ThT fluorescence-based measurements ACS Chem Neurosci, 2019 Jan 3.
- Goetz A, Nadine N Mylonas, Hoegel P, Silber S, Heinel H, Menig S, Vogel A, Freyrer H, Huster D, Luy B, Langosch D, Scharnagl C, Claudia Muhle-Goll C, Kamp F and Steiner H (2018) Modulating hinge flexibility in the APP transmembrane domain alters γ-secretase cleavage bioRxiv 375006.
- Kamp F, Scheidt HA, Winkler E, Basset G, Heinel H, Hutchison JM, LaPointe LM, Sanders CR, Steiner H and Huster D (2018) Bexarotene binds to the Amyloid Precursor Protein transmembrane domain, alters its α-helical conformation, and inhibits γ-secretase nonselectively in liposomes ACS Chem Neurosci 9, 1702-1713.
- Spadaro M, Winklmeier, Beltrán E, Macrini C, Höftberger R, Schuh E, Thaler FS, Gerdes L, Laurent S, Gerhards R, Brändle S, Dornmair K, Breithaupt C, Krumbholz M, Moser M, Kirshnamoorthy G, Kamp F, Jenne D, Hohlfeld R, Kümpfel T, Lassmann H, Kawakami N and Meinl E (2018) Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein Ann Neurol 84, 315-328.
- Echtay, KS, Bienengraeber M, Mayinger P, Heimpel S, Winkler E, Druhmann D, Frischmuth K, Kamp F, and Huang SG (2018) Uncoupling proteins: Martin Klingenberg's contributions for 40 years Arch Biochem Biophys 657, 41-55.
- Mori K, Nihei Y, Arzberger T, Zhou Q, Mackenzie IR, Hermann A, Hanisch F, Kamp F, Nuscher B, Orozco D, D Edbauer D and Haass C (2016) Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition EMBO Rep 17, 1314-1325.
- Ghio S, Kamp F, Cauchi R, Giese A, and Vassallo N (2016) Interaction of α-synuclein with biomembranes in Parkinson's disease — role of cardiolipin Prog Lip Res. 61, 73–82.
- Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Muller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C (2015) eta-Secretase processing of APP inhibits neuronal activity in the hippocampus Nature 2015; 526: 443-7.
- Bachhuber T, Katzmarski N, McCarter JF, Loreth D, Tahirovic S, Kamp F, Abou-Ajram C, Nuscher B, Serrano-Pozo A, Müller A, Prinz M, Steiner H, Hyman BT, Haass C, Meyer-Luehmann M (2015) Inhibition of amyloid-β plaque formation by α-synuclein Nat Med. 2015 Jul;21(7):802-7.
- Kamp F, Winkler E, Trambauer J, Ebke A, Fluhrer F, Steiner H (2015) Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process Biophys J 2015; 108:1229-1237.
- Nübling GS, Levin J, Bader B, Lorenzl S, Hillmer A, Högen T, Kamp F, Giese A (2014) Modelling Ser129 Phosphorylation Inhibits Membrane Binding of Pore-Forming α-Synuclein Oligomers PLoS ONE 9(6): e98906.
- Schmidt F, Levin J, Kamp F, , Kamp F, Kretzschmar H, Giese A, Bötzel K (2012) Single-Channel Electrophysiology Reveals a Distinct and Uniform Pore Complex Formed by α-Synuclein Oligomers in Lipid Membranes PLoS One. 2012;7(8):e42545. Epub 2012 Aug 3.
- Caruana M, Neuner J, Högen T, Schmidt F, Kamp F, Scerri C, Giese A, Vassallo N (2012) Polyphenolic compounds are novel protective agents against lipid membrane damage by α-synuclein aggregates in vitro Biochim Biophys Acta. 2012 May 23;1818(11):2502-2510. [Epub ahead of print]
- Högen T, Levin J, Schmidt F, Caruana M, Vassallo N, Kretzschmar H, Bötzel K, Kamp F, Giese A (2012) Two different binding modes of α-synuclein to lipid vesicles depending on its aggregation state. Biophys J. 2012 Apr 4;102(7):1646-55. Epub 2012 Apr 3
- Winkler E, Kamp F, Scheuring J, Ebke A, Fukumori A, Steiner H. (2012) Generation of Alzheimer disease-associated Aβ42/43 by γ-secretase can directly be inhibited by modulation of membrane thickness. J. Biol. Chem. 287, 21326-34.
- Fluhrer R, Martin L, Klier B, Haug-Kroeper M, Grammer G, Nuscher B, Haass C. (2011) The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by Signal Peptide Peptidase-Like 2b (SPPL2b) J Biol Chem. 2012 Feb 10;287(7):5156-63. Epub 2011 Dec 22.
- Lammich S, Kamp F, Wagner J, Nuscher B, Zilow S, Ludwig AK, Willem M, Haass C. (2011) Translational Repression of the Disintegrin and Metalloprotease ADAM10 by a Stable G-quadruplex Secondary Structure in Its 5'-Untranslated Region. J Biol Chem. 2011 Dec 30;286(52):45063-72. Epub 2011 Nov 7.
- Fluhrer R, Kamp F, Grammer G, Nuscher B, Steiner H, Beyer K, Haass C. (2011) The Nicastrin ectodomain adopts a highly thermostable structure. Biol Chem. 2011 Nov;392(11):995-1001.
- Levin J, Högen T, Hillmer AS, Bader B, Schmidt F, Kamp F, Kretzschmar HA, Bötzel K, Giese A (2011) Generation of Ferric Iron Links Oxidative Stress to α-Synuclein Oligomer Formation J. Parkinson’s Disease 1, 205–216.
- Kamp F., Exner N., Lutz AK, Wender N, Hegermann J, Brunner B., Nuscher B, Bartels T, Giese A., Beyer K., Winklhofer K., and Haass C. (2010) Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1 EMBO J. 29, 3571-89.
- Bartels T, Ahlstrom LS, Leftin A, Kamp F, Haass C, Brown MF, and Beyer K (2010) The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding Biophys J. 99 , 2116-24.
- Mitterreiter S, Page RM, Kamp F, Hopson J, Winkler E, Ha H, Hamid R, Herms J, Mayer TU, Nelson DJ, Steiner H, Stahl T, Zeitschel U, Roßner S, Haass C, and Lichtenthaler SF. (2010) Bepridil and Amiodarone Simultaneously Target the Alzheimer’s Disease β- and γ- Secretase via Distinct Mechanisms J. Neuroscience, 30, 8974–8983
- Simard JR, Kamp F and Hamilton JA (2008) Measuring the Adsorption of Fatty Acids to Phospholipids Vesicles by Multiple Fluorescence Probes. Biophys. J. 94, 4493-4503
- Beyer, K. (2007) Mechanistic aspects of Parkinson's disease. a-synuclein and the biomembrane. Cell Biochem. Biophys. 47: 285-299.
- Kamp F and JA Hamilton (2006) How fatty acids of different chain length enter and leave cells by free diffusion Review Article. Prostaglandins, Leukotrienes and Essential Fatty Acids, 75, 149-159
- Kamp F. and Beyer, K. (2006) Binding of α-Synuclein affects the Lipid Packing in Bilayers of Small Vesicles J. Biol. Chem, 281, 9251-9259.
- Nuscher B, Kamp F, Mehnert T, Odoy S, Haass C, Kahle PJ, and Beyer K. (2004) alpha;-Synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study J. Biol. Chem. 279(21),21966-75
- Kamp F., Kizilbash N., Corkey B.E., Berggren P.O., and Hamilton J.A. (2003) Sulfonylureas Rapidly Cross Phospholipid Bilayer Membranes by a Free-Diffusion Mechanism. Diabetes, 52, 2526-2531.
- Kamp F., Guo W., Pilch P., Corkey B.E., and Hamilton, J.A. (2003) Rapid Flip-flop of Oleic Acid across the Plasma Membrane of Adipocytes. J. Biol. Chem, 278, 7988-7995.
- Hamilton J.A., Johnson R., Corkey B.E., and Kamp F. (2001) Fatty acid transport: The diffusion mechanism in model and biological membranes. J. Mol. Neuroscience, 16, 99-108.
- Hamilton, J.A., and F. Kamp. (1999). How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids? Diabetes, 48, 2255-2269.
- Kamp F., Donoso P. and Hidalgo C. (1998) Changes in Internal pH caused by Calcium Release in Vesicles of Endoplasm Reticulum. Biophys. Journal, 74, 290-296.
- Zhang F., Kamp F. and Hamilton J.A. (1996) Dissociation of Long and Very Long Chain Fatty Acids from Phospholipid Bilayers. Biochemistry, 35, 16055-16060.
- Kamp F., Zakim D., Noy N., Zhang F. and Hamilton J.A. (1995) Fatty Acid Flip-Flop in Phospholipid Bilayers is Extremely Fast. Biochemistry, 34, 11928-11937.
- Hamilton J.A., Civelek V.N., Kamp F., Tornheim K. and Corkey B.E. (1994) Changes in Internal pH caused by Movement of Fatty Acids into and out of Clonal Pancreatic -Cells (HIT). J. Biol. Chem., 269, 20852-20856.
- Juretic D., Hendler R.W., Kamp F., Caughey W.S., Zasloff M. and Westerhoff H.W. (1994) Magainin Oligomers reversibly dissipate Proton Motive Force in Cytochrome Oxidase Liposomes. Biochemistry, 33, 4562-4570.
- Kamp F. and Hamilton J.A. (1993) Movement of Fatty Acids, Fatty-Acid Analogues and Bile Acids across Phospholipid Bilayers. Biochemistry, 32, 11074-11084.
- Kamp F. and Hamilton J.A. (1992) pH Gradients across Phospholipid Membranes caused by fast Flip-Flop of Fatty Acids. Proc. Natl. Acad. Sci. USA, 85, 11367-11370.
- Kamp F. (1990) Protons in Bioenergetics, Why, how and where they go. Ph.D. Thesis, University of Amsterdam, The Netherlands. Prof Karel van Dam Promotor, Prof Hans Westerhoff co-promotor.
- Kamp F., Astumian R.D. and Westerhoff H.W. (1988) Coupling of Vectorial Proton Transport to a Biochemical Reaction by Local Electric Interactions. Proc. Natl. Acad. Sci., 85, 3792-3796.