Publications

Journal Article

• Yu Ohki, Andrea Wenninger-Weinzierl, Alexander Hruscha, Kazuhide Asakawa, Koichi Kawakami, Christian Haass, Dieter Edbauer, Bettina Schmid (2017)
  Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration
  Mol Neurodegener. 2017 Jan 14;12(1):6. doi: 10.1186/s13024-016-0146-8.
• Rashi Halder, Magali Hennion, Ramon O Vidal, Orr Shomroni, Raza-Ur Rahman, Ashish Rajput, Tonatiuh Pena Centeno, Frauke van Bebber, Vincenzo Capece, Julio C Garcia Vizcaino, Anna-Lena Schuetz, Susanne Burkhardt, Eva Benito, Magdalena Navarro Sala, Sanaz Bahari Javan, Christian Haass, Bettina Schmid, Andre Fischer, Stefan Bonn (2016)
  DNA methylation changes in plasticity genes accompany the formation and maintenance of memory
  Nat Neurosci. 2016 Jan;19(1):102-10
• Barbara Solchenberger, Claire Russell, Elisabeth Kremmer, Christian Haass, Bettina Schmid (2015)
  Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology
  PLoS One. 2015 Mar 18;10(3):e0118956
• Jonathan Janssens, Stéphanie Philtjens, Gernot Kleinberger, Sara Van Mossevelde, Julie van der Zee, Rita Cacace, Sebastiaan Engelborghs, Anne Sieben, Julia Banzhaf-Strathmann, Lubina Dillen, Céline Merlin, Ivy Cuijt, Caroline Robberecht, Bettina Schmid, Patrick Santens, Adrian Ivanoiu, Mathieu Vandenbulcke, Rik Vandenberghe, Patrick Cras, Peter P. De Deyn, Jean-Jacques Martin, Stuart Maudsley, Christian Haass, Marc Cruts, Christine Van Broeckhoven (2015)
  Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains
  Acta Neuropathol Commun. 2015 Nov 10;3:68
• Fleck D, van Bebber F, Colombo A, Galante C, Rabe L, Hampel H, Novak B, Kremmer E, Tahirovic S, Edbauer D, Lichtenthaler SF, Schmid B, Willem M, Haass C (2013)
  Dual cleavage of neuregulin 1 Type III by BACE1 and ADAM17 Liberates Its EGF-Like Domain and Allows Paracrine Signaling
  J Neurosci. 2013 May 1;33(18):7856-69. doi: 10.1523/JNEUROSCI.3372-12.2013
• Hruscha A, Krawitz P, Rechenberg A, Heinrich V, Hecht J, Haass C, Schmid B (2013)
  Efficient CRISPR/Cas9 genome editing with low off target effects in zebrafish
  Development. 2013 Dec;140(24):4982-7. doi: 10.1242/dev.099085. Epub 2013 Nov 20
• Schmid B, Haass C (2013)
  Genomic editing opens new avenues for zebrafish as a model for neurodegeneration
  J Neurochem. 2013 Nov;127(4):461-70. doi: 10.1111/jnc.12460. Epub 2013 Oct 21
• Panda SK, Wefers B, Ortiz O, Floss T, Schmid B, Haass C, Wurst W, Kühn R (2013)
  Highly Efficient Targeted Mutagenesis in Mice Using TALENs
  Genetics. 2013 Aug 26. [Epub ahead of print]
• Hogl S, van Bebber F, Dislich B, Kuhn PH, Haass C, Schmid B, Lichtenthaler SF (2013)
  Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains
  Proteomics. 2013 Mar 4. doi: 10.1002/pmic.201200582. [Epub ahead of print]
• Schmid B, Hruscha A, Hogl S, Banzhaf-Strathmann J, van der Zee J, Teucke M, Eimer S, Hegermann J, Kittelmann M, Kremmer E, Cruts M, Solchenberger B, van Bebber F, Van Broeckhoven C, Edbauer D, Lichtenthaler SF, Haass C (2013)
  Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth
  Proc Natl Acad Sci U S A. 2013 Mar 1. [Epub ahead of print]
• van Bebber F, Hruscha A, Willem M, Schmid B, Haass C (2013)
  Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes
  J Neurochem. 2013 Feb 14. doi: 10.1111/jnc.12198. [Epub ahead of print]
• Mori K, Weng SM, Arzberger T, Rentzsch K, Kremmer E, Schmid B, Kretzschmar HA, Cruts M, Van Broeckhoven C, Haass C, Edbauer D (2013)
  The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS
  Science. 2013 Feb 7. [Epub ahead of print]
• Plucinska G, Paquet D, Hruscha A, Godinho L, Haass C, Schmid B, Misgeld T (2012)
  In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system
  J Neurosci. 2012 Nov 14;32(46):16203-12. doi: 10.1523/JNEUROSCI.1327-12.2012
• Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IR, Capell A, Schmid B, Neumann M, Haass C (2010)
  ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
  EMBO J. 2010 Aug 18;29(16):2841-57. Epub 2010 Jul 6.
• van Bebber F, Paquet D, Hruscha A, Schmid B, Haass C (2010)
  Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in Zebrafish
  Neurobiol Dis. 2010 Sep;39(3):265-71. Epub 2010 Apr 8.
• Fett ME, Pilsl A, Paquet D, van Bebber F, Haass C, Schmid B, Winklhofer KF (2010)
  Parkin is protective against proteotoxic stress in a transgenic zebrafish model
  PLoS One. 2010 Jul 30;5(7):e11783.
• Paquet D, Schmid B, Haass C (2010)
  Transgenic Zebrafish as a Novel Animal Model to Study Tauopathies and Other Neurodegenerative Disorders in vivo
  Neurodegener Dis. 2010 Feb 18;7(1-3):99-102. [Epub ahead of print]
• Paquet D, Bhat R, Sydow A, Mandelkow EM, Berg S, Hellberg S, Fälting J, Distel M, Köster RW, Schmid B, Haass C (2009)
  A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation
  J Clin Invest. 2009 May;119(5):1382-95. doi: 10.1172/JCI37537. Epub 2009 Apr 13.
• Shankaran SS, Capell A, Hruscha AT, Fellerer K, Neumann M, Schmid B, Haass C (2008)
  Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion
  J Biol Chem 283(3): 1744-53
• Schiffer NW, Broadley SA, Hirschberger T, Tavan P, Kretzschmar HA, Giese A, Haass C, Hartl FU, Schmid B (2007)
  Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model
  J Biol Chem 282(12): 9195-203
• Exner N, Treske B, Paquet D, Holmstrom K, Schiesling C, Gispert S, Carballo-Carbajal I, Berg D, Hoepken HH, Gasser T, Kruger R, Winklhofer KF, Vogel F, Reichert AS, Auburger G, Kahle PJ, Schmid B, Haass C (2007)
  Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin
  J Neurosci 27(45): 12413-8
• Krawitz P, Haffner C, Fluhrer R, Steiner H, Schmid B, Haass C (2005)
  Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3
  J Biol Chem 280(47): 39515-23

Review

• Bettina Schmid, Christian Haass
  Genomic editing opens new avenues for zebrafish as a model for neurodegeneration
  J Neurochem. 2013 Nov;127(4):461-70