Content
Curriculum vitae of Michael Willem
Personal Information
Last Name: Willem
First Name: Michael
Personal Address: Christoph-Rapparini-Bogen 18, 80639 München, Germany
Date and Place of Birth: May 13 th, 1968. Landau in der Pfalz, Germany
Marital Status: Married, 5 kids
Nationality: German
Contact Numbers: +49 89 17117377
+49 163 6859713 (mobile)
E-mail: mwillem@med.uni-muenchen.de
Qualifications
1. 2009: Habilitation at the Medical Faculty, University of Munich (LMU), Germany
2. 1996: Ph. D. in Biology, University of Munich (LMU), Germany
3. 1993; Diploma in Biology, University of Munich (LMU), Germany
4. 1987: Diploma of Graduation, Max-Slevogt Gymnasium Landau, Germany
Education
2009: Habilitation, Medical Faculty University of Munich (LMU), Germany
Since 2009: Assistant Professor, Medical Faculty University of Munich (LMU), Germany
2003-2009: Group leader, Medical Faculty University of Munich (LMU), Germany
2000-2003: Post-doc, Medical Faculty University of Munich (LMU), Germany
1997-2000: Post-doc, Max-Planck-Institute for Biochemistry, Martinsried, Germany
1997: Post-doc, Friedrich-Miescher-Institute, Basel, Switzerland
1993 - 1996: Ph.D Biological Sciences, Faculty of Biology, University of Munich, Germany
Experimental thesis entitled „Specific overexpression of neurotrophic factors in
muscle“; Experimental work in the laboratory of Prof. Dr. Hans Thoenen,
Max-Planck-Institute for Neurobiology, Martinsried, Germany
1987 - 1993: Diploma degree in Biological Sciences, University of Munich, Germany
Experimental work in the laboratory of Prof. Dr. Hans Thoenen,
Max-Planck-Institute for Neurobiology, Martinsried
1974 - 1987: School education completed in Landau/Pfalz, Germany
Qualification: Diploma of graduation; Max-Slevogt Gymnasium Landau
Professional Career
- Since 03/2000: Post Doctoral position at the Ludwig-Maximilians-Universität, München in the
Department of Biochemistry, Laboratory for Neurodegenerative Disease Research (Prof. C. Haass).
Research project: Physiological function of the beta-secretase BACE1
- 10/1997 - 03/2000: Post Doctoral position at the Max-Planck-Institut für Biochemie, Martinsried in the
group of Dr. U. Mayer; Research project 1: “The role of alpha7-Integrin in myotendinous junctions”;
Research project 2: “The interaction of Laminin and Nidogen during branching morphogenesis of
kidney and lung”
- 01/1997 - 09/1997: Post Doctoral at the Friedrich-Miescher Institute in Basel in the laboratory of Prof.
Pico Caroni; Project: The role of agrin in synaptic development
Research Interests
• Alzheimer´s disease
• Schizophrenia and Autism
• Multiple sclerosis and neuroimmunology
• Structure and function of extracellular matrix proteins and their interactions
• Muscular dystrophy and motoneuron diseases
Funding and Grants
2013-2018: Haass, ERC Senior scientist grant, Identification of a novel APP processing pathway (Michael Willem)
2008-2012: Haass, Lammich, Willem: SFB569 B9; Regulation of -secretase (BACE1) and -secretase (ADAM10)
2008-2012: NGFN Plus “The physiological function of BACE1 - is BACE1 a safe therapeutic target?”
2008-2011: HELMA, WP 10 “Effect of Neprilysin overexpression on transgenic AD mice”
2007-2010: Haass & Willem: Virtual Helmholtz Institute: Proeteolysis of NRG1 by BACE1
2005-2007: DFG HA 1737/10-2; Haass & Willem: „Reduktion der Amyloid-Plaque-Akkumulation durch mikrogliale
Neprilysin-Expression in einem transgenen Mausmodell der Alzheimer-Pathologie”
2005: Haass & Willem: Doktorandenprogramm FöFoLe der LMU: Shedding von Neuregulin-1 durch Alzheimer
relevante Sekretasen
2005: Haass & Willem: Doktorandenprogramm FöFoLe der LMU: Regulation von BACE1 in Trisomie 21
Academic Achievements
1999: Poster award of the German Connective Tissue Society
1997: Stipend of the Swiss Foundation for Muscle Research