Content
Signal Peptide Peptidase (SPP) and their homologues (SPPLs)
[2015] [2014] [2013] [2012] [2011] [2010] [2009] [2008] [2007] [2006] [2005] [2004] [2003] [2002] [2001]
-
Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways (2015)
Mol Cell Proteomics. 2015 Jun;14(6):1584-98. doi: 10.1074/mcp.M115.048298. Epub 2015 Mar 31 -
A Cell-Based Assay Reveals Nuclear Translocation of Intracellular Domains Released by SPPL Proteases (2015)
Traffic. 2015 Aug;16(8):871-92. doi: 10.1111/tra.12287. Epub 2015 May 6. -
Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process (2015)
Biophys J. 2015 Mar 10;108(5):1229-37. doi: 10.1016/j.bpj.2014.12.045.
-
Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation (2014)
EMBO J. 2014 Dec 17;33(24):2890-905. doi: 10.15252/embj.201488375. Epub 2014 Oct 29 -
Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells (2014)
Biochem Biophys Res Commun. 2014 Aug 15;451(1):48-53. doi: 10.1016/j.bbrc.2014.07.051. Epub 2014 Jul 15. PMID: 25035924 Free PMC Article -
Intramembrane cleaving proteases (I-CLiPs) as guardians of shuttling proteins (2014)
Cell Cycle. 2014 Feb 4;13(5). [Epub ahead of print] -
The intramembrane proteases Signal-peptide-peptidase-like 2a and b (SPPL2a/b) have distinct functions in vivo (2014)
Mol Cell Biol. 2014 Feb 3. [Epub ahead of print]
-
Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases
Biochim Biophys Acta. 2013 Dec;1828(12):2828-39. doi: 10.1016/j.bbamem.2013.03.033. -
The intramembrane protease SPPL2A is critical for tooth enamel formation
J Bone Miner Res. 2013 Jul;28(7):1622-30. doi: 10.1002/jbmr.1895. -
The transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2b
FEBS J. 2013 Apr;280(7):1653-63. doi: 10.1111/febs.12176. Epub 2013 Mar 1 -
The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain
J Exp Med. 2013 Jan 14;210(1):41-58. doi: 10.1084/jem.20121069. Epub 2012 Dec 24. -
Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling
Biochim Biophys Acta. 2013 Mar;1833(3):602-12. doi: 10.1016/j.bbamcr.2012.11.009. Epub 2012 Nov 16.
-
Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3)
J Biol Chem. 2012 Dec 21;287(52):43401-9. doi: 10.1074/jbc.M112.371369. Epub 2012 Nov 6.
- The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by Signal Peptide Peptidase-Like 2b (SPPL2b)
J Biol Chem. 2012 Feb 10;287(7):5156-63. Epub 2011 Dec 22
- The Nicastrin ectodomain adopts a highly thermostable structure (2011)
Biochim Biophys Acta. 2013 Dec;1828(12):2828-39. doi: 10.1016/j.bbamem.2013.03.033
- Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis (2010)
J Neurosci. 2010 Jun 9;30(23):7853-62.
- Intramembrane proteolysis by signal peptidepeptidases - a comparative discussion of GxGD-type aspartyl proteases (2009)
J Biol Chem. 2009 May 22;284(21):13975-9. Epub 2009 Feb 3.
- Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation (2008)
- Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b (2008)
- Substrate requirements for SPPL2b dependent regulated intramembrane proteolysis (2008)
- Intramembrane proteolysis by gamma-secretase (2008)
- A structural switch of presenilin 1 by glycogen synthase kinase 3beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling (2007)
- Signal peptide peptidases and gamma-secretase: cousins of the same protease family? (2007)