Ludwig-Maximilians-Universität, Chair of Metabolic Biochemistry

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  1. Kamp F, Exner, N, Lutz A K, Wedner N, Hegermann J, Brunner B, Nuscher B, Bartels T, Giese A, Beyer K, Eimer S, Winklhofer K F, Haass C. 2010. Inhibition of mitochondrial fusion by alpha-synuclein is rescued by PINK1, Parkin and DJ-1. EMBO J. 29: 3571-3589.
  2. Bartels T, Ahlstrom, LS, Leftin A, Kamp F, Haass C, Brown MF, Beyer K. 2010. The N-terminus of α-synuclein triggers helix folding. Biophys J. 99:2116-2124.
  3. Bartels T, Lankalapalli RS, Bittman R, Beyer K, Brown MF. 2008. Raftlike mixtures of sphingomyelin and cholesterol investigated by solid-state 2H NMR spectroscopy. J Am Chem Soc. 130:14521-14532.
  4. Baumgärtner P, Geiger M, Zienseniss S, Malleier J, Huntington JA, Hochrainer K, Bielek E, Stoecklhuber M, Lauber K, Scherfeld D, Schwille P, Wäldele K, Beyer K, Engelmann B. 2007. Phosphatidylethanolamine critically supports internalization of cell-penetrating protein C inhibitor. J Cell Biol 179:793-804
  5. Beyer K. 2007. Mechanistic aspects of Parkinson’s disease: a-synuclein and the biomembrane. Cell Biochem Biophys 47:285-299.
  6. Kramer ER, Aron L, Ramakers GMJ, Seitz S, Zhuang X, Beyer K, Smidt MP, Klein R. 2007. Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system. PLoS Biol 5:e39.
  7. Kamp F, Beyer K. 2006. Binding of α-synuclein affects the lipid packing in bilayers of small vesicles. J Biol Chem 281:9251-9259.
  8. Mehnert T, Jacob K, Bittman R, Beyer K. 2006. Structure and lipid interaction of N-palmitoylsphingomyelin in bilayer membranes as revealed by 2H-NMR spectroscopy. Biophys J 90:939-946.
  9. Nuscher B, Kamp F, Mehnert T, Odoy S, Haass C, Kahle PJ, Beyer K. 2004. -Synuclein has a high affinity for packing defects in a bilayer membrane. A thermodynamics study. J Biol Chem 279:21966-21975.
  10. Görner K, Holtorf E, Odoy S, Nuscher B, Yamamoto A, Regula JT, Beyer K, Haass C, Kahle PJ. 2004. Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1. J Biol Chem 279:6943-6951.
  11. Huber T, Botelho AV, Beyer K, Brown MF. 2004. Membrane model for the G-protein-coupled receptor rhodopsin: hydrophobic interface and dynamical structure. Biophys J 86:2078-2100.
  12. Steinbauer B, Mehnert T, Beyer K. 2003. Hydration and lateral organization in phospholipid bilayers containing sphingomyelin: a 2H-NMR study. Biophys J 85:1013-1024.
  13. Huber T, Rajamoorthi K, Kurze VF, Beyer K, Brown MF. 2002. Structure of docosahexaenoic acid-containing phospholipid bilayers as studied by 2H NMR and molecular dynamics simulations. J Am Chem Soc 124:298-309.
  14. Guo W, Kurze V, Huber T, Afdhal NH, Beyer K, Hamilton JA. 2002. A solid-state NMR study of phospholipid-cholesterol interactions: sphingomyelin-cholesterol binary systems. Biophys J 83:1465-1478.
  15. Brown MF, Thurmond RL, Dodd SW, Otten D, Beyer K. 2002. Elastic deformation of membrane bilayers probed by deuterium NMR relaxation. J Am Chem Soc 124:8471-8484.
  16. Funari SS, Nuscher B, Rapp G, Beyer K. 2001. Detergent-phospholipid mixed micelles with a crystalline phospholipid core. Proc Natl Acad Sci USA 98:8938-8943.
  17. Brown MF, Thurmond RL, Dodd SW, Otten D, Beyer K. 2001. Composite membrane deformation on the mesoscopic length scale. Phys Rev E 64:1063-1067.
  18. Moosmann B, Skutella T, Beyer K, Behl C. 2001. Protective activity of aromatic amines and imines against oxidative nerve cell death. Biol Chem 382:1601-1612.
  19. Otten D, Brown MF, Beyer K. 2000. Softening of bilayers by detergents elucidated by deuterium NMR spectroscopy. J Phys Chem B104:12119-12129.
  20. Kurze V, Steinbauer B, Huber T, Beyer K. 2000. A 2H NMR study of macroscopically aligned bilayer membranes containing interfacial hydroxyl residues. Biophys J 78:2441-51.
  21. Huber T, Klingenberg M, Beyer K. 1999. Binding of nucleotides by the mitochondrial ADP/ATP carrier as studied by 1H nuclear magnetic resonance spectroscopy. Biochemistry 38:762-769.
  22. Hahnel D, Huber T, Kurze V, Beyer K, Engelmann B. 1999. Contribution of copper binding to the inhibition of lipid oxidation by plasmalogen phospholipids. Biochem J 340:377-383.
  23. Beyer K, Huber T. 1999. Mixed micelle formation between gramicidin-S and a nonionic detergent: a nuclear magnetic resonance model study of peptide/detergent aggregation. Eur Biophys J 28:166-173.
  24. Hahnel D, Beyer K, Engelmann B. 1999. Inhibition of peroxyl radical-mediated lipid oxidation by plasmalogen phospholipids and alpha-tocopherol. Free Radic Biol Med 27:1087-1094.
  25. Reiss D, Beyer K, Engelmann B. 1997. Delayed oxidative degration of polyunsaturated diacyl phospholipids in the presence of plasmalogen phospholipids in vitro. Biochem J 323:807-814.
  26. Beyer K. 1997. Packing and bilayer-micelle transitions in mixed surfactant-lipid systems as studied by solid state NMR. Progr Coll Polym Sci 103:78-86.
  27. Beyer K, Nuscher B. 1996. Specific cardiolipin binding interferes with labeling of sulhydryl residues in the adenosine diphosphate/adenosine triphosphate carrier protein from beef heart mitochondria. Biochemistry 35:15784-15790.
  28. Otten D, Löbbecke L, Beyer K. 1995. Stages of the bilayer-micelle transition in the system phosphatidylcholine-C12E8 as studied by deuterium- and phosphorous-NMR, light scattering and calorimetry. Biophys. J. 68:584-597.
  29. Otten D, Beyer K. 1995. Chain length mismatch and packing constraints of free fatty acids in a hexagonal detergent host phase. A wide line deuterium NMR study. Chem Phys Lipids 77:203-215.
  30. Thurmond RL, Otten D, Brown MF, Beyer K. 1994. Structure and packing of phosphatidylcholines in lamellar and hexagonal liquid-crystalline mixtures with a nonionic detergent: a wide-line deuterium and phosphorus-31 NMR study. J Phys Chem 98:972-983.
  31. Hoffmann B, Stöckl A, Schlame M, Beyer K, Klingenberg M. 1994. The reconstituted ADP/ATP carrier activity has an absolute requirement for cardiolipin as shown in cysteine mutants. J Biol Chem 269:1940-1944.
  32. Hayer-Hartl M, Schägger H, v.Jagow G, Beyer K. 1992. Interactions of phospholipids with the mitochondrial cytochrome-c reductase studied by spin-label ESR and NMR spectroscopy. Eur J Biochem 209:423-430.
  33. Schlame M, Beyer K, Hayer-Hartl M, Klingenberg M. 1991. Molecular species of cardiolipin in relation to other mitochondrial phospholipids. Is there an acyl specificity of the interaction between cardiolipin and the ADP/ATP carrier? Eur J Biochem 199:459-466.
  34. Horvath LI, Drees M, Beyer K, Klingenberg M, Marsh D. 1990. Lipid-protein-interactions in ADP-ATP carrier/egg phosphatidylcholine recombinants, studied by spin label ESR spectroscopy. Biochemistry 29:10664-10669.
  35. Horvath LI, Munding A, Beyer K, Klingenberg M, Marsh D. 1989. Rotational diffusion of mitochondrial ADP/ATP carrier studied by saturation-transfer electron spin resonance. Biochemistry 28:407-414.
  36. Dieks H, Beyer K. 1989. Synthesis of deuterium labelled analogs of the ubiquinone headgroup. J Labelled Comp Radiopharm 28:1093-1107.
  37. Drees M, Beyer K. 1988. Interaction of phospholipids with the detergent-solubilized ADP/ATP carrier protein as studied by spin-label electron spin resonance. Biochemistry 27:8584-8591.
  38. Munding A, Drees M, Beyer K, Klingenberg M. 1987. Probing of sulfhydryl groups in the adenosine 5'-diphosphate/adenosine 5'-triphosphate carrier by maleimide spin-labels. Biochemistry 26:8637-8644.
  39. Beyer K, Munding A. 1986. Techniques for NMR and ESR Studies on the ADP/ATP Carrier. Methods Enzymol 125:631-639.
  40. Beyer K. 1986. A 31P- and 2H-NMR study on the structural perturbations induced by charged detergents in the headgroup region of phosphatidylcholine bilayers. Biochim Biophys Acta 855:365-374.
  41. Schubert R, Beyer K, Wolburg H, Schmidt KH. 1986. Structural changes in membranes of large unilamellar vesicles after binding of sodium cholate. Biochemistry 25:5263-5269.
  42. Beyer K, Klingenberg M. 1985. ADP/ATP carrier protein from beef heart mitochondria binds high amounts of cardiolipin as revealed by 31P nuclear magnetic resonance. Biochemistry 24:3821-3826.
  43. Beyer K. 1983. A 31P- and 2H-NMR study on lecithins in liquid crystalline polyoxyethylene detergents. Chemistry and Physics of Lipids 34:65-80.
  44. Beyer K, Klingenberg M. 1983. Reincorporation of the adenosine 5'-diphosphate/adenosine 5'-triphospholipid-protein interaction as studied by phosphorous-31 nuclear magnetic resonance and electron microscopy. Biochemistry 22:639-645.
  45. Munding A, Beyer K, Klingenberg M. 1983. Binding of spin labeled carboxyatractylate to the mitochondrial ADP/ATP carrier as studied by electron spin resonance. Biochemistry 22:1941-1947.
  46. Beyer K. 1981. Phase structures, water binding and molecular dynamics in liquid crystalline and frozen states of the system Triton X-100-D2O. J Colloid Interface Sci 86:73-89.
  47. Beyer K, Klingenberg M. 1978. Interaction of an amine oxide detergent with lecithin vesicles as studied by nuclear magnetic resonance. Biochemistry 17:1424-1430.
  48. Babel W, Aquila H, Beyer K, Klingenberg M. 1976. Preparation of 3H-labeled bongkrekate. FEBS Lett. 61:124-127.
  49. Bayer E, Beyer K. 1973. Signalzuordnung in 13C-NMR-Spektren von Oligopeptiden und Sequenzbestimmung mit Hilfe von Pr(ClO4)3 als Verschiebungsreagens. Tetrahedron Letters 15:1209-1212.
  50. Beyer K. 1973. Tris-(4,4,4-trifluoro-1-(-2-thienyl)-1,3-butan-diono)-euorpium(III) als NMR-Verschiebungsreagens. Organic Magn Reson 5:471-472.