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10 key papers
- The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes (2014)
EMBO J. 2014 Mar 3;33(5):450-67. doi: 10.1002/embj.201385857. Epub 2013 Dec 19. - Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins. (2013)
Acta Neuropathol. 2013 Dec;126(6):881-93. doi: 10.1007/s00401-013-1189-3. Epub 2013 Oct 17. - The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS. (2013)
Science. 2013 Mar 15;339(6125):1335-8. doi: 10.1126/science.1232927. Epub 2013 Feb 7. - Loss of fused in sarcoma (FUS) promotes pathological Tau splicing. (2012)
EMBO Rep. 2012 Aug;13(8):759-64. doi: 10.1038/embor.2012.90. Epub 2012 Jun 19. - miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity. (2011)
Nat Neurosci. 2011 Sep 4;14(10):1240-2. doi: 10.1038/nn.2909. - Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. (2010)
Neuron. 2010 Feb 11;65(3):373-84. doi: 10.1016/j.neuron.2010.01.005. - Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1. (2004). (2010)
J Biol Chem. 2004 Sep 3;279(36):37311-5. Epub 2004 Jun 21. - Reconstitution of gamma-secretase activity. (2003)
Nat Cell Biol. 2003 May;5(5):486-8. - Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation. (2002)
Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8666-71. Epub 2002 Jun 4. - Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD). (2002)
J Biol Chem. 2002 Apr 19;277(16):13389-93. Epub 2002 Jan 23.