Content
Publications
List of all publications – Jörg Tatzelt
[2012] [2011] [2010] [2009] [2008] [2007] [2006] [2005] [2004] [2003] [2001] [2000] [1999] [1998] [1997] [1996] [1995] [1993] [1992]
2013
- Prion disease: a tale of folds and strains.
Brain Pathol. 2013 May;23(3):321-32. doi: 10.1111/bpa.12045. - The alpha-helical structure of prodomains promotes translocation of intrinsically disordered neuropeptide hormones into the endoplasmic reticulum.
J Biol Chem. 2013 Mar 26. [Epub ahead of print] - The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO.
Mol Cell. 2013 Mar 7;49(5):908-21. doi: 10.1016/j.molcel.2013.01.036. Epub 2013 Feb 28 - Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria.
EMBO J. 2013 Mar 12. doi: 10.1038/emboj.2013.46. [Epub ahead of print]. - Anti-prion drug mPPIg5 inhibits PrPC conversion to PrPSc
PLoS One. 2013;8(1):e55282. doi: 10.1371/journal.pone.0055282. Epub 2013 Jan 28.
2012
- The heat shock response is modulated by and interferes with toxic effects of scrapie prion protein and amyloid β
J Biol Chem. 2012 Dec 21;287(52):43765-76. doi: 10.1074/jbc.M112.389007. Epub 2012 Oct 31 - Different effects of Sec61α-, Sec62- and Sec63-depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells
J Cell Sci. 2012 Apr 15;125(Pt 8):1958-69 - Cellular Prion Protein Mediates Toxic Signaling of Amyloid Beta (2012)
Neurodegener Dis, 10, 298-300
2011
- Prion Proteins (2011)
Top Curr Chem. 2011;305:ix-x. - Neuroprotective and Neurotoxic Signaling by the Prion Protein (2011)
Top Curr Chem. 2011;305:101-19. - The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication (2011)
EMBO J. 2011 May 18;30(10):2057-70. Epub 2011 Mar 25. Comment in: EMBO J (2011) 30, 1882–1884 - Conserved stress-protective activity between prion protein and shadoo (2011)
J Biol Chem. 2011 Mar 18;286(11):8901-8. Epub 2011 Jan 21.
2010
- Conditional modulation of membrane protein expression in cultured cells mediated by prion protein recognition of short phosphorothioate oligodeoxynucleotides (2010)
J Biol Chem. 2011 Mar 4;286(9):6911-7. Epub 2010 Dec 14. - Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress (2010)
Cell Death Differ. 2011 May;18(5):769-82. Epub 2010 Nov 26. - Protein immobilization on liposomes and lipid-coated nanoparticles by protein trans-splicing (2010)
J Pept Sci. 2010 Oct;16(10):582-8. - Parkin is protective against proteotoxic stress in a transgenic zebrafish model (2010)
PLoS One. 2010 Jul 30;5(7):e11783. - The Novel Membrane Protein TMEM59 Modulates Complex Glycosylation, Cell Surface Expression and Secretion of the Amyloid Precursor Protein (2010)
J Biol Chem. 2010 Jul 2;285(27):20664-74. Epub 2010 Apr 28. - Synthesis of a GPI anchor module suitable for protein post-translational modification (2010)
Biopolymers. 2010;94(4):457-64.
2009
- Alpha-helical domains promote translocation of intrinsically disordered polypeptides into the endoplasmic reticulum (2009)
J Biol Chem. 2009 Sep 4;284(36):24384-93. Epub 2009 Jun 26. - Loss of parkin or PINK1 function increases DRP1-dependent mitochondrial fragmentation (2009)
J Biol Chem. 2009 Aug 21;284(34):22938-51. Epub 2009 Jun 22. - Targeting of the Prion Protein to the Cytosol: Mechanisms and Consequences (2009)
Curr Issues Mol Biol. 2010;12(2):109-18. Epub 2009 Sep 18. Review. - The Prion Protein: Friend and Foe (2009)
Curr Issues Mol Biol. 2010;12(2):49. Epub 2009 Sep 18. No abstract available.
2008
- Aberrant folding of pathogenic Parkin mutants: aggregation versus degradation (2008)
J Biol Chem. 2008 May 16;283(20):13771-9. Epub 2008 Mar 24. - Genes contributing to prion pathogenesis (2008)
J Gen Virol. 2008 Jul;89(Pt 7):1777-88. - Green tea extracts interfere with the stress-protective activity of PrP and the formation of PrP (2008)
J Neurochem. 2008 Oct;107(1):218-29. Epub 2008 Aug 7. - Observing fibrillar assemblies on scrapie-infected cells (2008)
Pflugers Arch. 2008 Apr;456(1):83-93. Epub 2008 Jan 3. - Stress-protective signalling of prion protein is corrupted by scrapie prions (2008)
EMBO J. 2008 Jul 23;27(14):1974-84. Epub 2008 Jun 19. - The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases (2008)
EMBO J. 2008 Jan 23;27(2):336-49. Review.
2007
- Molecular basis of cerebral neurodegeneration in prion diseases (2007)
FEBS J. 2007 Feb;274(3):606-11. Review. - Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling (2007)
J Neurosci. 2007 Feb 21;27(8):1868-78. - Semisynthetic murine prion protein equipped with a GPI anchor mimic incorporates into cellular membranes (2007)
Chem Biol. 2007 Sep;14(9):994-1006.
2006
- The role of chaperones in Parkinson's disease and prion diseases (2006)
Handb Exp Pharmacol. 2006;(172):221-58. Review. - Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP (2006)
Mol Biol Cell. 2006 Aug;17(8):3356-68. Epub 2006 May 17. - Prion protein-related proteins from zebrafish are complex glycosylated and contain a glycosylphosphatidylinositol anchor (2006)
Biochem Biophys Res Commun. 2006 Mar 3;341(1):218-24. Epub 2006 Jan 9. - Structural instability of the prion protein upon M205S/R mutations revealed by molecular dynamics simulations (2006)
Biophys J. 2006 Jun 1;90(11):3908-18. Epub 2006 Mar 2.
2005
- A pathogenic PrP mutation and doppel interfere with polarized sorting of the prion protein (2005)
J Biol Chem. 2005 Feb 18;280(7):5137-40. Epub 2004 Dec 21. - Pathogenic mutations inactivate parkin by distinct mechanisms (2005)
J Neurochem. 2005 Jan;92(1):114-22. - Pathogenic mutations located in the hydrophobic core of the prion protein interfere with folding and attachment of the glycosylphosphatidylinositol anchor (2005)
J Biol Chem. 2005 Mar 11;280(10):9320-9. Epub 2004 Dec 10. - Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets (2005)
J Virol. 2005 Jun;79(12):7785-91. - The polysaccharide scaffold of PrP 27-30 is a common compound of natural prions and consists of alpha-linked polyglucose (2005)
Biol Chem. 2005 Nov;386(11):1149-55.
2004
- Folding and misfolding of the prion protein in the secretory pathway (2004)
Amyloid. 2004 Sep;11(3):162-72. Review. - Misfolding of the prion protein at the plasma membrane induces endocytosis, intracellular retention and degradation (2004)
Traffic. 2004 Jun;5(6):426-36. - The C-terminal globular domain of the prion protein is necessary and sufficient for import into the endoplasmic reticulum (2004)
J Biol Chem. 2004 Feb 13;279(7):5435-43. Epub 2003 Nov 26. - The structural transition of the prion protein into its pathogenic conformation is induced by unmasking hydrophobic sites (2004)
J Mol Biol. 2004 Nov 26;344(3):839-53.
2003
- Determinants of the in vivo folding of the prion protein. A bipartite function of helix 1 in folding and aggregation (2003)
J Biol Chem. 2003 Apr 25;278(17):14961-70. Epub 2003 Jan 29. - Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones (2003)
J Biol Chem. 2003 Nov 21;278(47):47199-208. Epub 2003 Sep 12. - Inhibition of complex glycosylation increases the formation of PrPsc (2003)
Traffic. 2003 May;4(5):313-22. - Post-translational import of the prion protein into the endoplasmic reticulum interferes with cell viability: a critical role for the putative transmembrane domain (2003)
J Biol Chem. 2003 Sep 19;278(38):36139-47. Epub 2003 Jul 8.
2001
- A sensitive filter retention assay for the detection of PrP(Sc) and the screening of anti-prion compounds (2001)
FEBS Lett. 2001 Aug 10;503(1):41-5. - Geldanamycin restores a defective heat shock response in vivo (2001)
J Biol Chem. 2001 Nov 30;276(48):45160-7. Epub 2001 Sep 26. - Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease (2001)
EMBO J. 2001 Aug 1;20(15):3957-66.
2000
- Cationic lipopolyamines induce degradation of PrPSc in scrapie-infected mouse neuroblastoma cells (2000)
Biol Chem. 2000 May-Jun;381(5-6):463-9.
1999
- Kinetics of prion protein accumulation in the CNS of mice with experimental scrapie (1999)
J Neuropathol Exp Neurol. 1999 Dec;58(12):1244-9.
1998
- Abnormalities in stress proteins in prion diseases (1998)
Cell Mol Neurobiol. 1998 Dec;18(6):721-9. Review.
1997
- A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis (1997)
J Virol. 1997 Nov;71(11):8821-31. - Prion protein expression in Chinese hamster ovary cells using a glutamine synthetase selection and amplification system (1997)
Protein Eng. 1997 Dec;10(12):1465-73. - Propagation of prion strains through specific conformers of the prion protein (1997)
J Virol. 1997 Dec;71(12):9032-44.
1996
- Chemical chaperones interfere with the formation of scrapie prion protein (1996)
EMBO J. 1996 Dec 2;15(23):6363-73. - Scrapie in mice deficient in apolipoprotein E or glial fibrillary acidic protein (1996)
Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2944-8.
1995
- The mechanism of adenovirus DNA integration: studies in a cell-free system (1995)
Curr Top Microbiol Immunol. 1995;199 ( Pt 2):109-37. Review. No abstract available. - Scrapie prions selectively modify the stress response in neuroblastoma cells (1995)
Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2944-8.
1993
- Fractionated nuclear extracts from hamster cells catalyze cell-free recombination at selective sequences between adenovirus DNA and a hamster preinsertion site (1993)
Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7356-60.
1992
- Recombination between adenovirus type 12 DNA and a hamster preinsertion sequence in a cell-free system. Patch homologies and fractionation of nuclear extracts (1992)
J Mol Biol. 1992 Jul 5;226(1):117-26. Erratum in: J Mol Biol. 1992 Dec 20;228(4):1275.