Dynamics and structure of lamellar lipid mixtures as a function of hydration. A NMR study.
TU Munich, Faculty of Physics, 2001-11-29
| Authors/Editors: |
Bernhard Steinbauer |
|---|---|
| Publication Date: | 2001 |
| Type of Publication: |
Structure and dynamics of oriented lamellar multilayers of both pure lipids and lipid mixtures were studied by solid-state NMR spectroscopy. A special pulse sequence was employed which allowed the determination of exchange rates of labile hydroxyl and amide groups in the lipid-water interface. One focus of the work was sphingomyelin. Particular emphasis was placed on the influence of different phosphatidylcholines and cholesterol on structure and dynamics of sphingomyelin containing membranes. Sphingomyelin can establish a high number of hydrogen bonds both intra- and intermolecularly; one central finding is that this property plays a pivotal role for the interaction with other membrane constituents.
