Publications
Journal Article
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Dawkins E, Derks RJE, Schifferer M, Trambauer J, Winkler E, Simons M, Paquet D, Giera M, Kamp F, Steiner H
(2023)
Membrane lipid remodeling modulates γ-secretase processivity
J Biol Chem. 2023 Apr;299(4):103027. -
Junker J, Kamp F, Winkler E, Steiner H, Bracher F, Müller C
(2021)
Effective sample preparation procedure for the analysis of free neutral steroids, free steroid acids and sterol sulfates in different tissues by GC-MS
J Steroid Biochem Mol Biol. 2021 Jul;211:105880 -
Colombo A, Sadler RK, Llovera G, Singh V, Roth S, Heindl S, Sebastian Monasor L, Verhoeven A, Peters F, Parhizkar S, Kamp F, Gomez de Aguero M, MacPherson AJ, Winkler E, Herms J, Benakis C, Dichgans M, Steiner H, Giera M, Haass C, Tahirovic S, Liesz A
(2021)
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
Elife. 2021 Apr 13;10:e59826 -
Kong L, Dawkins E, Campbell F, Winkler E, Derks RJE, Giera M, Kamp F, Steiner H, Kros A
(2020)
Photo-controlled delivery of very long chain fatty acids to cell membranes and modulation of membrane protein function
Biochim Biophys Acta Biomembr. 2020 May 1;1862(5):183200 -
Frits Kamp, Holger A. Scheidt, Edith Winkler, Gabriele Basset, Hannes Heinel, James M. Hutchison, Loren M. LaPointe, Charles R. Sanders, Harald Steiner, Daniel Huster
(2018)
Bexarotene binds to the amyloid precursor protein transmembrane domain, alters its α-helical conformation, and inhibits γ-secretase nonselectively in liposomes
ACS Chem Neurosci. 2018 Jul 18;9(7):1702-1713. -
Frits Kamp, Edith Winkler, Johannes Trambauer, Amelie Ebke, Regina Fluhrer, Harald Steiner
(2015)
Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process
Biophys J. 2015 Mar 10;108(5):1229-37. -
Liebscher S, Page RM, Käfer K, Winkler E, Quinn K, Goldbach E, Brigham EF, Quincy D, Basi GS, Schenk DB, Steiner H, Bonhoeffer T, Haass C, Meyer-Luehmann M, Hübener M
(2013)
Chronic γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures.
Mol Psychiatry. 2013 Sep 24. doi: 10.1038/mp.2013.122. [Epub ahead of print] -
Winkler E, Kamp F, Scheuring J, Ebke A, Steiner H
(2012)
Generation of Alzheimer disease-associated Aβ42/43 by γ-secretase can directly be inhibited by modulation of membrane thickness
J. Biol. Chem. 287, 21326-34. -
Höttecke N, Liebeck M, Baumann K, Schubenel R, Winkler E, Steiner H, Schmidt B
(2010)
Inhibition of γ-secretase by the CK1 inhibitor IC261 does not depend on CK1δ
Bioorg Med Chem Lett. 2010 Mar 4. [Epub ahead of print] -
Steiner H, Winkler E, Haass C
(2008)
Chemical cross-linking provides a model of the γ-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1
J Biol Chem 283(50): 34677-86 -
Fluhrer R, Martin L, Grammer G, Haug-Kroper M, Klier B, Winkler E, Kremmer E, Condron MM, Teplow DB, Steiner H, Haass C
(2008)
Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation
J Biol Chem 283(44): 30121-8 -
Kaether C, Capell A, Edbauer D, Winkler E, Novak B, Steiner H, Haass C
(2004)
The presenilin C-terminus is required for ER-retention, nicastrin-binding and γ-secretase activity
EMBO J 23(24): 4738-48 -
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C
(2003)
Reconstitution of γ-secretase activity
Nat Cell Biol 5(5): 486-8 -
Steiner H, Winkler E, Edbauer D, Prokop S, Basset G, Yamasaki A, Kostka M, Haass C
(2002)
PEN-2 is an integral component of the γ-secretase complex required for coordinated expression of presenilin and nicastrin
J Biol Chem 277(42): 39062-5 -
Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, Capell A, Kaether C, Zheng H, Ghetti B, Haass C, Steiner H
(2002)
Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ 42 production
Proc Natl Acad Sci U S A 99(12): 8025-30 -
Edbauer D, Winkler E, Haass C, Steiner H
(2002)
Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation
Proc Natl Acad Sci U S A 99(13): 8666-71 -
Steiner H, Winkler E, Shearman MS, Prywes R, Haass C
(2001)
Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins
Neurobiol Dis 8(4): 717-22 -
Winkler E, Julius A, Steiner H, Langosch D
Homodimerization protects the amyloid precursor protein C99 fragment from cleavage by γ-secretase
Biochemistry. 2015 Oct 13;54(40):6149-52.